UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	zim-1	T07G12.6	0	chrIV 10,551,197	zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
2	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
3	zhp-3	K02B12.8	n/a	chrI 8,530,344	zhp-3 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); ZHP-3 activity is required during meiosis for crossover recombination and chiasma formation; ZHP-3 activity is thus essential for proper chromosome segregation and normal levels of fertility; a ZHP-3::GFP fusion protein localizes along synapsed chromosomes in a manner that is dependent upon the presence of mature synaptonemal complexes; ZHP-3 is paralogous to D1081.9, F55A12.10, and Y39B6A.16.
4	sun-1	F57B1.2	n/a	chrV 13,192,605	sun-1 encodes a paralog of UNC-84, also called matefin, whose general domain organization (one or more central transmembrane and coiled-coil domains, followed by a C-terminal SUN domain) is shared by Sad1p from Schizosaccharomyces pombe and UNC-84 from C. elegans; SUN-1 is a nuclear envelope receptor for CED-4 during apoptosis, and is bound by CED-4 in vitro; SUN-1 is partially required for apoptosis, since sun-1(RNAi) animals have a moderate defect in normal cell death; SUN-1 is strongly expressed in the nuclear envelope of all early embryonic cells, the primordial germ cells Z2 and Z3, and the germ cell lineage (but not in sperm); early (embryonic) SUN-1 protein is provided maternally, while germ line SUN-1 is zygotic; SUN-1 colocalizes with the nuclear lamin LMN-1 in vivo and binds it in vitro; SUN-1 is required for localization of the hook protein ZYG-12 to the nuclear envelope, and thus for the attachment of centrosomes to nuclei; SUN-1 and UNC-84 may define a class of proteins localized to the outer nuclear envelope but not the endoplasmic reticulum.
5	fbxa-197	T06C12.4	n/a	chrV 15,868,291	C. elegans FBXA-197 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
6	C31H1.8	C31H1.8	n/a	chrIV 5,812,882	contains similarity to Homo sapiens Protocadherin 15; ENSEMBL:ENSP00000378832
7	syn-4	T01B11.3	n/a	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
8	dnj-22	T23B12.7	n/a	chrV 8,461,579	This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial.
9	try-1	ZK546.15	n/a	chrII 4,948,807	C. elegans TRY-1 protein; contains similarity to Pfam domain PF00089 Trypsin contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR009003 (Peptidase, trypsin-like serine and cysteine), IPR008256 (Peptidase S1B, glutamyl endopeptidase I)
10	C15C6.4	C15C6.4	n/a	chrI 12,214,144	C15C6.4 encodes an ortholog of Pop4 (Rpp29), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end; C15C6.4 is evolutionarily ubiquitous among eukaryotes.
11	hop-1	C18E3.8	n/a	chrI 4,209,468	hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex.
12	B0393.6	B0393.6	n/a	chrIII 4,781,174	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
13	his-46	B0035.9	n/a	chrIV 11,326,144	his-46 encodes an H4 histone.
14	H21P03.2	H21P03.2	n/a	chrIV 11,481,604	contains similarity to Pfam domain PF08743 Nse4 contains similarity to Interpro domain IPR014854 (Nse4)
15	pie-1	Y49E10.14	n/a	chrIII 12,427,870	pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
16	ZK1058.3	ZK1058.3	n/a	chrIII 3,919,762	ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease.
17	T20D3.8	T20D3.8	n/a	chrIV 9,342,540	contains similarity to Pfam domain PF06432 Phosphatidylinositol N-acetylglucosaminyltransferase contains similarity to Interpro domain IPR009450 (Phosphatidylinositol N-acetylglucosaminyltransferase)
18	W01A8.5	W01A8.5	n/a	chrI 7,070,051	contains similarity to Interpro domain IPR009057 (Homeodomain-like)
19	F52C6.4	F52C6.4	n/a	chrII 1,923,563	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
20	C48B6.3	C48B6.3	n/a	chrI 6,915,508	contains similarity to Homo sapiens UPF0472 protein C16orf72; ENSEMBL:ENSP00000331720
21	Y18D10A.16	Y18D10A.16	n/a	chrI 12,903,539	contains similarity to Homo sapiens Uncharacterized protein C2orf64; ENSEMBL:ENSP00000330730
22	F26F12.2	F26F12.2	n/a	chrV 5,838,075
23	pfn-1	Y18D10A.20	n/a	chrI 12,922,763	C. elegans PFN-1 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
24	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
25	Y52B11A.8	Y52B11A.8	n/a	chrI 11,033,190	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
26	uri-1	C55B7.5	n/a	chrI 6,495,201	uri-1 encodes a molecular chaperone orthologous to the unconventional prefoldin RPB5 (RNA polymerase subunit 5) interactor, URI; in C.elegans, URI-1 activity is required for suppressing endogenous genotoxic DNA damage and thus, is essential for maintenance of genome integrity (DNA stability) and progression through the mitotic and meiotic cell cycles, particularly during germ cell development; URI-1 activity is also required for development of some somatic structures, such as the vulva, and for RNA interference; uri-1 mRNA is germline-enriched.
27	F21F8.2	F21F8.2	n/a	chrV 8,275,167	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001461 (Peptidase A1)
28	F56B3.3	F56B3.3	n/a	chrIV 770,778
29	F33G12.2	F33G12.2	n/a	chrII 5,030,810	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
30	fipr-8	C12D8.6	n/a	chrV 10,240,388	C. elegans FIPR-8 protein ; contains similarity to Homo sapiens Keratin-associated protein 19-8; ENSEMBL:ENSP00000372272
31	C52B11.4	C52B11.4	n/a	chrX 1,285,532
32	W05G11.4	W05G11.4	n/a	chrIII 37,457	contains similarity to Pfam domain PF00648 Calpain family cysteine protease contains similarity to Interpro domain IPR001300 (Peptidase C2, calpain)
33	F48E8.2	F48E8.2	n/a	chrIII 5,466,142	contains similarity to Mus musculus E2F-associated phosphoprotein (EAPP).; SW:Q5BU09
34	F57C9.7	F57C9.7	n/a	chrI 4,825,902
35	C39E9.11	C39E9.11	n/a	chrIV 13,092,485	C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease.
36	bath-4	F52C6.8	n/a	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
37	fbxa-108	F59A1.7	n/a	chrV 17,657,524	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
38	coq-4	T03F1.2	n/a	chrI 3,869,644	coq-4 encodes an ortholog of S. cerevisiae COQ4; while COQ-4 is conserved between eukaryotes and bacteria, its biochemical function is unknown; by orthology, COQ-4 is predicted to peripherally associate with the matrix face of the mitochondrial inner membrane, in a complex with COQ-3 (and perhaps COQ-6), and to be required to maintain a steady-state level of CLK-1/COQ-7 protein; COQ-4 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-4(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.
39	C56C10.9	C56C10.9	n/a	chrII 6,591,647	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
40	C36F7.2	C36F7.2	n/a	chrI 9,551,413	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
41	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
42	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
43	tbx-36	ZK829.5	n/a	chrIV 11,951,305	C. elegans TBX-36 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
44	C01F6.9	C01F6.9	n/a	chrIV 9,095,971	The C01F6.9 gene resides in an operon that also contains the genes icl-1 and lpl-1.
45	kup-1	F10C2.2	n/a	chrV 12,036,541	kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known.
46	F56H6.4	F56H6.4	n/a	chrI 12,291,320	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
47	D1086.4	D1086.4	n/a	chrV 14,091,601	contains similarity to Saccharomyces cerevisiae GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2; SGD:YAL035W
48	gei-14	K01C8.5	n/a	chrII 8,274,744	gei-14 encodes a novel protein that interacts with GEX-3 in yeast two-hybrid assays.
49	cas-2	C18E3.6	n/a	chrI 4,191,639	C. elegans CAS-2 protein; contains similarity to Pfam domains PF01213 (Adenylate cyclase associated (CAP) N terminal) , PF08603 (DE Adenylate cyclase associated (CAP) C terminal) contains similarity to Interpro domains IPR001837 (Adenylate cyclase-associated CAP), IPR000694 (Proline-rich region), IPR013992 (Adenylate cyclase-associated CAP, N-terminal), IPR003073 (Orphan nuclear receptor, NURR type), IPR016098 (Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal), IPR006599 (CARP motif), IPR013912 (Adenylate cyclase-associated CAP, C-terminal)
50	grd-10	F09D12.1	n/a	chrIV 3,441,427	grd-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-10 is expressed in seam cells; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10 is weakly required for normal molting; GRD-10 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.