UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	moc-1	T06H11.4	0	chrX 10,137,338	moc-1 encodes an ortholog of human GEPHYRIN (GPHN; OMIM:603930), which when mutated leads to molybdenum cofactor (MoCo) deficiency; MOC-1 is also paralogous to LIN-46.
2	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
3	K09F6.3	K09F6.3	n/a	chrII 2,258,704	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
4	Y54G11A.2	Y54G11A.2	n/a	chrII 14,253,902	contains similarity to Pfam domain PF05670 Domain of unknown function (DUF814) contains similarity to Interpro domain IPR008532 (Protein of unknown function DUF814)
5	arx-5	Y37D8A.1	n/a	chrIII 12,817,350	arx-5 encodes the C. elegans ortholog of the p21Arc subunit of the actin-related protein (Arp) 2/3 complex.
6	smg-5	W02D3.8	n/a	chrI 6,735,096	smg-5 encodes a novel protein that contains two N-terminal tetratricopeptide (TPR) repeats and a C-terminal PINc domain found in nucleotide-binding proteins; SMG-5 is a component of the nonsense-mediated mRNA decay (NMD) pathway and likely functions in regulation of dephosphorylation of SMG-2, the C. elegans UPF1 ortholog, an ATPase and RNA helicase required for NMD in worms, yeast, and mammals; SMG-5 physically interacts with SMG-7, SMG-2, and the PAA-1 and LET-92 structural and catalytic subunits, respectively, of a protein phosphatase 2A (PP2A), suggesting that SMG-5 may function to direct SMG-2 to a PP2A phosphatase that regulates its activity in vivo; SMG-5 also interacts, in vivo, with components of the RNA interference (RNAi) pathway, suggesting a potential link between RNAi and NMD; SMG-5::GFP fusion proteins localize to both the nucleus and the cytoplasm.
7	srx-108	F40H7.2	n/a	chrII 3,706,336	C. elegans SRX-108 protein ;
8	orc-2	F59E10.1	n/a	chrII 10,875,816	C. elegans ORC-2 protein; contains similarity to Pfam domain PF04084 Origin recognition complex subunit 2 contains similarity to Interpro domain IPR007220 (Origin recognition complex subunit 2)
9	F39B2.3	F39B2.3	n/a	chrI 14,788,812	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
10	rabn-5	F01F1.4	n/a	chrIII 5,865,475	C. elegans RABN-5 protein; contains similarity to Pfam domains PF09311 (Rab5 binding) , PF01363 (FYVE zinc finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type), IPR015390 (Rabaptin, GTPase-Rab5 binding), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
11	pps-1	T14G10.1	n/a	chrIV 10,163,166	pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
12	C35A5.3	C35A5.3	n/a	chrV 10,500,362	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
13	cul-4	F45E12.3	n/a	chrII 7,303,864	cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
14	ergo-1	R09A1.1	n/a	chrV 1,013,580	C. elegans ERGO-1 protein; contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
15	F35H12.4	F35H12.4	n/a	chrX 922,380	contains similarity to Pfam domain PF00454 Phosphatidylinositol 3- and 4-kinase contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR000403 (Phosphatidylinositol 3- and 4-kinase, catalytic), IPR015433 (Phosphatidylinositol Kinase)
16	B0285.4	B0285.4	n/a	chrIII 4,344,312	contains similarity to Pfam domain PF04072 Leucine carboxyl methyltransferase contains similarity to Interpro domains IPR016651 (Leucine carboxyl methyltransferase, LCTM1 1), IPR007213 (Leucine carboxyl methyltransferase)
17	R186.3	R186.3	n/a	chrV 12,966,597	contains similarity to Interpro domains IPR006687 (GTP-binding protein SAR1), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR006688 (ADP-ribosylation factor), IPR003593 (AAA+ ATPase, core)
18	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
19	ugt-60	C07A9.6	n/a	chrIII 9,677,585	C. elegans UGT-60 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
20	ula-1	C26E6.8	n/a	chrIII 4,919,320	The ula-1 gene encodes a component of the enzyme that activates NED-8, which in turn is a ubiquitin-like protein whose conjugating enzyme is UBC-12.
21	sec-10	C33H5.9	n/a	chrIV 7,780,928	C. elegans SEC-10 protein; contains similarity to Pfam domain PF07393 Exocyst complex component Sec10 contains similarity to Interpro domain IPR009976 (Exocyst complex component Sec10)
22	F55G1.9	F55G1.9	n/a	chrIV 7,476,741	contains similarity to Pfam domain PF03807 NADP oxidoreductase coenzyme F420-dependent contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR016040 (NAD(P)-binding)
23	Y39A3A.2	Y39A3A.2	n/a	chrIII 2,057,188	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold)
24	T01G1.3	T01G1.3	n/a	chrIV 11,368,676	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR002110 (Ankyrin), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
25	ulp-2	Y38A8.3	n/a	chrII 4,957,746	C. elegans ULP-2 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
26	C07D8.6	C07D8.6	n/a	chrX 7,342,092	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
27	C33G3.4	C33G3.4	n/a	chrX 14,073,660	C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease.
28	ZK1098.4	ZK1098.4	n/a	chrIII 9,543,651	contains similarity to Pfam domain PF01008 Initiation factor 2 subunit family contains similarity to Interpro domain IPR000649 (Initiation factor 2B related)
29	F28H6.4	F28H6.4	n/a	chrX 14,130,605	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domains IPR006570 (SPK), IPR012287 (Homeodomain-related), IPR009057 (Homeodomain-like)
30	cid-1	K10D2.3	n/a	chrIII 5,177,184	cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
31	nhr-177	F16B4.1	n/a	chrV 1,611,519	C. elegans NHR-177 protein; contains similarity to Pfam domain PF00105 Zinc finger, C4 type (two domains) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
32	cup-4	C02C2.3	n/a	chrIII 7,867,528	The primary phenotype of cup-4 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes.
33	dnc-2	C28H8.12	n/a	chrIII 5,925,025	dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration.
34	F54C9.9	F54C9.9	n/a	chrII 8,579,712	contains similarity to Pfam domain PF05178 Krr1 family contains similarity to Interpro domain IPR007851 (Kri1)
35	hrd-1	F55A11.3	n/a	chrV 11,768,584	C. elegans HRD-1 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
36	C23H3.5	C23H3.5	n/a	chrII 48,839
37	pink-1	EEED8.9	n/a	chrII 5,394,469	pink-1 encodes a predicted serine/threonine protein kinase that is most similar to the Drosophila and human PINK1 (PTEN-induced kinase) protein kinases, the latter of which has been implicated in familial forms of Parkinson's disease; although loss of C. elegans pink-1 activity via large-scale RNAi screens results in no obvious abnormalities, studies in Drosophila indicate that Drosophila PINK1 is a mitochondrial protein that genetically interacts with Drosophila parkin and is essential for maintaining mitochondrial function and integrity in several tissues, including flight muscles and dopaminergic neurons.
38	W05G11.2	W05G11.2	n/a	chrIII 58,191	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
39	C27H6.3	C27H6.3	n/a	chrV 9,981,996	contains similarity to Homo sapiens Acidic (Leucine-rich) nuclear phosphoprotein 32 family, member E; ENSEMBL:ENSP00000358111
40	evl-14	H38K22.1	n/a	chrIII 4,308,081	evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects.
41	R05H11.1	R05H11.1	n/a	chrIII 6,796,617	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
42	gro-1	ZC395.6	n/a	chrIII 5,266,087	C. elegans GRO-1 protein; contains similarity to Pfam domain PF01715 IPP transferase contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR002627 (tRNA isopentenyltransferase), IPR003593 (AAA+ ATPase, core), IPR011593 (Isopentenyl transferase-like), IPR007087 (Zinc finger, C2H2-type)
43	C50F7.4	C50F7.4	n/a	chrIV 7,729,765	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
44	cul-6	K08E7.7	n/a	chrIV 12,588,438	cul-6 encodes a member of the cullin family that may physically interact with SKR-3.
45	T24A6.1	T24A6.1	n/a	chrV 3,559,431
46	F49E8.1	F49E8.1	n/a	chrIV 7,557,976	contains similarity to Pfam domain PF06218 Nitrogen permease regulator 2 contains similarity to Interpro domain IPR009348 (Nitrogen permease regulator 2)
47	ddb-1	M18.5	n/a	chrIV 12,117,957	M18.5 is orthologous to the human gene DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (127KD) (DDB1; OMIM:600045), which when mutated leads to disease.
48	F17A9.4	F17A9.4	n/a	chrV 6,109,818	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal), IPR002343 (Paraneoplastic encephalomyelitis antigen)
49	ned-8	F45H11.2	n/a	chrI 10,373,604	The ned-8 gene encodes a ubiquitin-like protein that is required for both embryogenesis and terminal hypodermal differentiation.
50	B0019.2	B0019.2	n/a	chrI 12,777,941	contains similarity to Pfam domains PF04435 (Domain of unknown function (DUF545)) , PF02178 (AT hook motif) contains similarity to Interpro domains IPR006570 (SPK), IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR009057 (Homeodomain-like)