UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cki-1	T05A6.1	3e-79	chrII 7,811,601	cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	F42H10.2	F42H10.2	n/a	chrIII 8,490,759	contains similarity to Pfam domain PF06747 CHCH domain contains similarity to Interpro domains IPR010625 (CHCH), IPR013032 (EGF-like region, conserved site)
4	K02E10.1	K02E10.1	n/a	chrX 2,498,552	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras)
5	EEED8.2	EEED8.2	n/a	chrII 5,417,509	contains similarity to Interpro domains IPR012674 (Calycin), IPR011038 (Calycin-like), IPR000463 (Cytosolic fatty-acid binding)
6	C05D9.7	C05D9.7	n/a	chrX 1,118,323
7	R07B1.9	R07B1.9	n/a	chrX 9,879,387	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g15170).; TR:Q8L731
8	col-121	F56D5.1	n/a	chrIV 9,395,553	col-121 encodes a cuticle collagen required for resistance to the endocrine disrupting chemical bisphenol A (BPA); col-121(nx3) and col-121(RNAi) animals are hypersensitive to BPA, but are otherwise wild-type (e.g., they have normal body shape); BPA hypersensitivity has also been observed for dpy-2(e8), dpy-7(e88) and dpy-10(e128) mutants.
9	tza-2	K03E6.4	n/a	chrX 1,067,909	C. elegans TZA-2 protein; contains similarity to Pfam domain PF07162 B9 protein contains similarity to Interpro domain IPR010796 (B9)
10	ZK218.8	ZK218.8	n/a	chrV 17,116,486	contains similarity to Pfam domain PF02171 Piwi domain contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
11	F31D4.5	F31D4.5	n/a	chrV 20,851,509	contains similarity to Pfam domain PF00169 PH domain contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR010997 (HRDC-like), IPR011993 (Pleckstrin homology-type)
12	K08H2.4	K08H2.4	n/a	chrX 13,239,283
13	Y65A5A.3	Y65A5A.3	n/a	chrIV 16,416,285	contains similarity to Human papillomavirus type 13 Probable E4 protein.; SW:VE4_HPV13
14	F21D5.9	F21D5.9	n/a	chrIV 8,724,343	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
15	M106.2	M106.2	n/a	chrII 10,847,185	contains similarity to Homo sapiens Lamin B2; ENSEMBL:ENSP00000264564
16	C43H6.3	C43H6.3	n/a	chrX 2,408,512	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
17	srx-47	E02C12.3	n/a	chrV 9,350,632	C. elegans SRX-47 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
18	lact-7	C40H5.4	n/a	chrX 11,762,779	lact-7 encodes a beta-lactamase domain-containing protein.
19	tab-1	F31E8.3	n/a	chrII 6,804,197	tab-1 encodes a homeodomain protein homologous to Drosophila bsh (brain-specific homeodomain protein) and the vertebrate BarH-like homeodomain protein 1; TAB-1 is required, during early larval development, for backward movement in response to anterior touch with a wire, while during later larval stages, TAB-1 is required for response to gentle touch with a hair; TAB-1 expression begins in the early embryo in approximately 20-30 cells and is then restricted to a subset of neurons including AIB, AVJ, and RIV; TAB-1 expression in AIB may be controlled by the UNC-42 homeodomain protein and TAB-1 may autoregulate in the AVJ and RIV neurons.
20	ceh-13	R13A5.5	n/a	chrIII 7,556,858	a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae.
21	K02E7.7	K02E7.7	n/a	chrII 1,055,525
22	F46C8.3	F46C8.3	n/a	chrX 7,526,360
23	C05D12.5	C05D12.5	n/a	chrII 11,434,516	contains similarity to Homo sapiens Isoform 1 of Cingulin-like protein 1; ENSEMBL:ENSP00000281282
24	gpc-2	F08B6.2	n/a	chrI 6,757,967	gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles).
25	F28H1.1	F28H1.1	n/a	chrI 3,996,331
26	Y57A10C.1	Y57A10C.1	n/a	chrII 12,411,984	contains similarity to Macaca mulatta Thyrotropin receptor (Fragment).; TR:Q8HY53
27	Y116A8B.1	Y116A8B.1	n/a	chrIV 17,216,790	contains similarity to Oryza sativa P0660F12.13 protein (P0614D08.10 protein).; TR:Q94CR6
28	F29F11.3	F29F11.3	n/a	chrV 10,658,900	contains similarity to Drosophila melanogaster Flybase gene name is CG10189-PA;; FLYBASE:CG10189
29	fbxb-61	F55C9.10	n/a	chrV 19,304,563	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
30	cdh-8	F18F11.3	n/a	chrIV 351,612	cdh-8 encodes a cadherin that may be nematode specific; CDH-8 is predicted to function as a membrane protein that plays a role in cell adhesion and/or morphogenesis, but as loss of cdh-8 activity via mutation or large-scale RNAi experiments results in no obvious abnormalities, the precise role of cdh-8 in C. elegans development and/or behavior is not yet known.
31	Y51A2B.2	Y51A2B.2	n/a	chrV 18,375,467	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
32	C45B11.2	C45B11.2	n/a	chrV 11,043,313	contains similarity to Pfam domain PF06441 ()
33	C06G3.6	C06G3.6	n/a	chrIV 7,018,898	contains similarity to Pfam domain PF00569 Zinc finger, ZZ type contains similarity to Interpro domains IPR000315 (Zinc finger, B-box), IPR000433 (Zinc finger, ZZ-type)
34	str-148	M01D1.1	n/a	chrII 1,047,396	C. elegans STR-148 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002091 (Aromatic amino acid permease)
35	F34D6.1	F34D6.1	n/a	chrII 2,680,190	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
36	T01A4.3	T01A4.3	n/a	chrI 4,465,379	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
37	ndx-6	EEED8.8	n/a	chrII 5,389,360	The ndx-6 gene encodes a NUDIX hydrolase.
38	F07H5.6	F07H5.6	n/a	chrII 8,792,268	contains similarity to Interpro domain IPR002952 (Eggshell protein)
39	kal-1	K03D10.1	n/a	chrI 14,135,394	kal-1 encodes a cell surface protein that contains a WAP-type protease inhibitor domain and Type III fibronectin domains and is the C. elegans ortholog of human KAL-1, mutated in the X-linked form of the neurological disorder Kallmann syndrome; in C. elegans, both kal-1 loss-of-function mutations and kal-1 overexpression result in similar phenotypes that indicate KAL-1 activity is required for epithelial morphogenesis and axon branching; kal-1 transcriptional reporters reveal expression beginning in the 50-cell stage embryo in 2-3 cells with later embryonic expression in at least 8-10 AB-derived ventral neuroblasts that are a substrate for migrating epidermal cells during ventral enclosure; later expression in larvae and adults is restricted to anterior neurons, including AIY, AIZ, RID, M5, ASI, and labial sensory neurons, ventral nerve cord motorneurons, midbody neurons HSN, CAN, and PVM, tail neurons DVB, DVC, and PDB, and the nonneuronal excretory cell as well as in uterine muscles; in the AIY interneurons, kal-1 is part of a gene battery whose expression is under the control of the CEH-10 and TTX-3 Paired and LIM-type homeodomains, respectively.
40	F55F8.3	F55F8.3	n/a	chrI 5,651,700	contains similarity to Pfam domains PF04047 (Periodic tryptophan protein 2 WD repeat associated presumed domain) , PF00400 (WD domain, G-beta repeat) (5)contains similarity to Interpro domains IPR000009 (Protein phosphatase 2A, regulatory subunit PR55), IPR017441 (Protein kinase ATP binding, conserved site), IPR011046 (WD40 repeat-like), IPR007190 (Periodic tryptophan protein-associated region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
41	clec-230	C29F3.5	n/a	chrV 15,348,475	C. elegans CLEC-230 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR001202 (WW/Rsp5/WWP)
42	mec-6	W02D3.3	n/a	chrI 6,726,624	mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes.
43	M28.1	M28.1	n/a	chrII 10,624,279	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
44	W01C9.1	W01C9.1	n/a	chrII 8,533,713	contains similarity to Brugia pahangi Heat shock protein 90.; SW:HS90_BRUPA
45	F38A5.7	F38A5.7	n/a	chrIV 6,602,016
46	T23F11.4	T23F11.4	n/a	chrIII 4,664,270	contains similarity to Interpro domain IPR007087 (Zinc finger, C2H2-type)
47	C24H12.1	C24H12.1	n/a	chrII 444,212	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
48	C24H12.8	C24H12.8	n/a	chrII 422,729	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
49	F14B4.1	F14B4.1	n/a	chrI 9,268,427	contains similarity to Pfam domains PF00008 (EGF-like domain) (2), PF07645 (Calcium binding EGF domain) , PF00057 (Low-density lipoprotein receptor domain class A) , PF00058 (Low-density lipoprotein receptor repeat class B) (4)contains similarity to Interpro domains IPR000033 (), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR001881 (EGF-like calcium-binding), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR013032 (EGF-like region, conserved site), IPR013091 (EGF calcium-binding), IPR015943 (WD40/YVTN repeat-like)
50	unc-122	F11C3.2	n/a	chrI 14,873,757	unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known.