UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T04A8.8	T04A8.8	4e-170	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
2	skr-17	C06A8.4	n/a	chrII 7,784,177	skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs.
3	R02F2.4	R02F2.4	n/a	chrIII 5,485,028	R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
4	cpar-1	F54C8.2	n/a	chrIII 9,434,486	cpar-1 encodes one of two C. elegans proteins homologous to the inner kinetochore histone H3 variant CENP-A (the other is encoded by hcp-3); loss of cpar-1 and hcp-3 activity via RNAi results in mitotic chromosome segregation defects, but no significant defects in meiotic chromosome segregation; when expressed in the germline using the pie-1 promoter, a CPAR-1::GFP fusion protein localizes to meiotic chromosomes during late prophase/prometaphase of meiosis I, but is not seen on chromosomes during meiosis II.
5	ZC477.5	ZC477.5	n/a	chrIV 7,102,332
6	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
7	T05B9.1	T05B9.1	n/a	chrII 11,260,588	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
8	F26H11.4	F26H11.4	n/a	chrII 14,410,374	contains similarity to Saccharomyces cerevisiae Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane; SGD:YMR089C
9	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
10	C30F12.4	C30F12.4	n/a	chrI 6,972,971	contains similarity to Triticum aestivum Gamma-gliadin precursor.; SW:P08453
11	T23D8.7	T23D8.7	n/a	chrI 9,991,647	contains similarity to Pfam domains PF02170 (PAZ domain) , PF08699 (Domain of unknown function (DUF1785)) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR014811 (Region of unknown function DUF1785), IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
12	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
13	bir-2	C50B8.2	n/a	chrV 13,569,366	The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.
14	rmd-1	T05G5.7	n/a	chrIII 9,759,548	C. elegans RMD-1 protein; contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
15	C38D4.4	C38D4.4	n/a	chrIII 4,794,206	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
16	nos-1	R03D7.7	n/a	chrII 10,952,444	nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification.
17	B0304.2	B0304.2	n/a	chrII 4,524,073
18	F32D1.6	F32D1.6	n/a	chrV 4,374,245
19	nasp-2	C50B6.2	n/a	chrV 13,311,278	C. elegans NASP-2 protein ; contains similarity to Halocynthia roretzi Protein HGV2.; SW:Q02508
20	C27D9.1	C27D9.1	n/a	chrII 4,754,512	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domain IPR009497 (Protein of unknown function DUF1114)
21	W03C9.2	W03C9.2	n/a	chrII 11,963,758	contains similarity to Schizosaccharomyces pombe Transcription elongation factor S-II (TFIIS).; SW:TFS2_SCHPO
22	spo-11	T05E11.4	n/a	chrIV 11,123,963	spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.
23	cyp-31A2	H02I12.8	n/a	chrIV 11,404,949	cyp-31A2 encodes a class 4 cytochrome P450 predicted to hydroxylate polyunsaturated fats (PUFAs); CYP-31A2 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; cyp-31A2(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, class 4 cytochrome P450 is required for the omega hydroxylation of PUFAs, prostaglandins, and leukotrienes.
24	Y53C12A.6	Y53C12A.6	n/a	chrII 9,717,654	contains similarity to Bacteriophage RB69 Hypothetical protein RB69ORF024c.; TR:Q7Y5B4
25	hus-1	H26D21.1	n/a	chrI 3,698,705	hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
26	C27C12.3	C27C12.3	n/a	chrX 14,864,682	C27C12.3 encodes a novel protein that is conserved in C. elegans; three other genes related to C27C12.3 are present in tandem on the X chromosome; in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline.
27	C17F4.5	C17F4.5	n/a	chrII 3,247,215	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
28	D2030.7	D2030.7	n/a	chrI 7,589,605	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
29	C48B4.6	C48B4.6	n/a	chrIII 9,557,903	contains similarity to Plateumaris constricticollis toyamensis Cytochrome oxidase subunit I (Fragment).; TR:Q85QH2
30	C31H1.8	C31H1.8	n/a	chrIV 5,812,882	contains similarity to Homo sapiens Protocadherin 15; ENSEMBL:ENSP00000378832
31	rnh-1.2	ZK938.7	n/a	chrII 9,840,817	C. elegans RNH-1.2 protein; contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF00075 (RNase H) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011021 (Arrestin-like, N-terminal), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
32	F52B5.2	F52B5.2	n/a	chrI 8,317,068	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
33	tag-319	C30B5.1	n/a	chrII 6,200,135	C. elegans TAG-319 protein ;
34	C16C8.13	C16C8.13	n/a	chrII 3,451,870	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
35	fem-3	C01F6.4	n/a	chrIV 9,106,267	fem-3 encodes a novel protein that promotes male development in all tissues.
36	egg-5	R12E2.10	n/a	chrI 4,170,287	C. elegans EGG-5 protein; contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
37	K03H1.7	K03H1.7	n/a	chrIII 9,947,654	contains similarity to Saccharomyces cerevisiae major low affinity 55 kDa Centromere/microtubule binding protein; SGD:YLR175W
38	dhs-5	F56D1.5	n/a	chrII 5,454,878	dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE).
39	C36B1.11	C36B1.11	n/a	chrI 8,756,734	contains similarity to Interpro domain IPR001576 (Phosphoglycerate kinase)
40	C41G7.3	C41G7.3	n/a	chrI 9,516,858	contains similarity to Pfam domains PF00013 (KH domain) , PF03073 (TspO/MBR family) contains similarity to Interpro domains IPR004307 (TspO/MBR-related protein), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
41	F45F2.11	F45F2.11	n/a	chrV 8,520,032	contains similarity to Interpro domain IPR000694 (Proline-rich region)
42	C29A12.1	C29A12.1	n/a	chrV 10,812,876	contains similarity to Mesocricetus auratus Synaptonemal complex protein 1 (SCP-1 protein) (Meiotic chromosomessynaptic protein) (Fragment).; SW:SCP1_MESAU
43	K03H4.2	K03H4.2	n/a	chrV 13,153,453	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:O96209
44	F17C11.10	F17C11.10	n/a	chrV 10,963,667	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR009071 (High mobility group box, HMG), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
45	F22E5.9	F22E5.9	n/a	chrII 2,638,698
46	F43G9.4	F43G9.4	n/a	chrI 8,611,732	contains similarity to Brugia malayi Putative uncharacterized protein BMBAC01P19.03a.; TR:Q8IHI9
47	F21F3.4	F21F3.4	n/a	chrI 4,896,773	contains similarity to Homo sapiens Uncharacterized protein ENSP00000372122; ENSEMBL:ENSP00000372122
48	F57C9.3	F57C9.3	n/a	chrI 4,838,180
49	R09B3.2	R09B3.2	n/a	chrI 11,909,721	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
50	lrr-1	F33G12.4	n/a	chrII 5,035,345	F33G12.4 encodes a leucine rich repeat-containing protein; loss of F33G12.4 activity via large-scale RNAi indicates that F33G12.4 is essential for embryonic and larval development.