UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lis-1	T03F6.5	0	chrIII 13,373,822	lis-1 encodes an ortholog of human LIS1, which when mutated leads to lissencephaly (OMIM:247200); it also encodes an ortholog of the Aspergillus nidulans nudF, which mediates nuclear migration along Aspergillus hyphae.
2	srh-269	T03E6.5	n/a	chrV 16,591,043	C. elegans SRH-269 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
3	C11D2.2	C11D2.2	n/a	chrIV 6,187,162	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001969 (Peptidase aspartic, active site), IPR001461 (Peptidase A1)
4	K09F5.4	K09F5.4	n/a	chrX 7,710,385
5	T05B4.13	T05B4.13	n/a	chrV 4,126,750	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
6	C24A3.1	C24A3.1	n/a	chrX 9,003,584	contains similarity to Aedes aegypti Condensin, SMC5-subunit, putative (Fragment).; TR:Q16IF0
7	fbxb-79	R07H5.7	n/a	chrIV 11,189,235	C. elegans FBXB-79 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
8	F11C3.1	F11C3.1	n/a	chrI 14,869,588	contains similarity to Xenopus laevis ATP-dependent DNA helicase PIF1 (EC 3.6.1.-).; SW:Q0R4F1
9	Y37E11B.6	Y37E11B.6	n/a	chrIV 3,598,943	Y37E11B.6 encodes an ortholog of Rpp21 (Rpr2), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end.
10	srh-136	F36D3.6	n/a	chrV 16,496,767	C. elegans SRH-136 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
11	C02B8.6	C02B8.6	n/a	chrX 8,134,694	contains similarity to Pfam domains PF00097 (Zinc finger, C3HC4 type (RING finger)) , PF02825 (WWE domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR004170 (WWE), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
12	tbx-8	T07C4.2	n/a	chrIII 10,348,548	C. elegans TBX-8 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR000694 (Proline-rich region), IPR001699 (Transcription factor, T-box)
13	ceh-24	F55B12.1	n/a	chrV 13,814,273	ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease.
14	fbxa-112	Y102A5C.13	n/a	chrV 16,947,523	C. elegans FBXA-112 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
15	Y38H6C.14	Y38H6C.14	n/a	chrV 20,527,484	contains similarity to Leishmania major strain Friedlin Proteophosphoglycan 5.; TR:Q4FX62
16	K09C4.6	K09C4.6	n/a	chrX 3,275,175
17	nspc-14	F42F12.7	n/a	chrX 12,358,778	C. elegans NSPC-14 protein ;
18	ccb-2	W10C8.1	n/a	chrI 2,848,257	C. elegans CCB-2 protein; contains similarity to Pfam domains PF00774 (Dihydropyridine sensitive L-type calcium channel (Beta subunit)) (2), PF00018 (SH3 domain) contains similarity to Interpro domains IPR000584 (Voltage-dependent calcium channel, L-type, beta subunit), IPR001452 (Src homology-3)
19	brc-2	T07E3.5	n/a	chrIII 6,901,783	brc-2 encodes a BRC domain-containing protein that is homologous to human BRCA2 which when mutated leads to early-onset breast cancer 2 or hereditary male breast cancer (OMIM:600185); in C. elegans, BRC-2 activity is essential for RAD-51-mediated repair of meiotic and radiation-induced double-strand breaks (DSBs); BRC-2 physically interacts with RAD-51 and single-stranded DNA and is required for proper localization of RAD-51 to sites of DNA damage and stabilization of RAD-51-DNA filaments; BRC-2 can also promote RAD-51-independent DSB repair via single-strand annealing (SSA) when the homologous recombination (HR) and nonhomologous end joining pathways (NHEJ) are compromised; in nonirradiated animals, BRC-2 is seen at diffuse, low levels in germline nuclei, but upon radiation treatment BRC-2 localizes to discrete foci that coincide with presumptive sites of DNA damage.
20	trxr-2	ZK637.10	n/a	chrIII 8,915,015	C. elegans TRXR-2 protein; contains similarity to Pfam domains PF02852 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain) , PF07992 (Pyridine nucleotide-disulphide oxidoreductase) , PF00070 (Pyridine nucleotide-disulphide oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000447 (FAD-dependent glycerol-3-phosphate dehydrogenase), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR012999 (Pyridine nucleotide-disulphide oxidoreductase, class I, active site), IPR004099 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation), IPR006338 (Thioredoxin and glutathione reductase selenoprotein), IPR016156 (FAD/NAD-linked reductase, dimerisation), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR000815 (Mercuric reductase), IPR016040 (NAD(P)-binding), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
21	srv-8	F53F1.7	n/a	chrV 13,419,959	C. elegans SRV-8 protein; contains similarity to Interpro domains IPR002456 (GPCR, family 3, gamma-aminobutyric acid receptor, type B1), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B)
22	F54F11.1	F54F11.1	n/a	chrII 13,505,368	contains similarity to Interpro domain IPR013830 (Esterase, SGNH hydrolase-type)
23	srh-8	K09D9.8	n/a	chrV 4,006,527	C. elegans SRH-8 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR005394 (P2Y12 purinoceptor)
24	sru-4	C33A12.10	n/a	chrIV 9,498,965	C. elegans SRU-4 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
25	gpa-4	T07A9.7	n/a	chrIV 403,531	gpa-4 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASI.
26	tag-83	F46F11.3	n/a	chrI 5,602,718	C. elegans TAG-83 protein ; contains similarity to Homo sapiens TNS1 protein; ENSEMBL:ENSP00000308321
27	W02B8.1	W02B8.1	n/a	chrII 13,900,226
28	rog-1	F54D12.6	n/a	chrII 1,374,343	rog-1 encodes a protein with an insulin receptor substrate-1 (IRS-type) phosphotyrosine-binding (PTB) domain that is required for the progression from pachytene to diakinesis in meiosis; rog-1 is primarily transcribed in germ cells, and this expression is required for oocyte development; ROG-1 is orthologous to human FRS2 (OMIM:607743) and FRS3 (OMIM:607744); rog-1(tm1031) mutant oocytes fail to progress from pachytene to diakinesis, a phenotype reminiscent of let-60 or mpk-1 mutant oocytes, and rog-1(tm1031) gonads lack phosphorylated MPK-1; rog-1(tm1031) and rog-1(RNAi) hermaphrodites show reduced brood sizes and increased embryonic lethality, with rog-1(tm1031) being more phenotypically severe than rog-1(RNAi); rog-1(tm1031) germ cell, brood size, and MPK-1 phosphorylation phenotypes are suppressed by the gain-of-function mutations let-60(n1046) or let-60(ga89ts); during meiosis, ROG-1 may function as an adaptor downstream of LET-23 and upstream of LET-60.
29	Y49F6C.8	Y49F6C.8	n/a	chrII 3,369,682
30	cdh-1	R10F2.1	n/a	chrIII 2,923,253	cdh-1 encodes a cadherin that is similar, in the extracellular domain, to the Drosophila cadherin Dachsous (Ds); although the precise role of cdh-1 in C. elegans development and/or behavior is not yet known, loss of cdh-1 activity via RNAi using the hypersensitive rrf-3 strain can result in locomotion and growth defects, as well as larval lethality.
31	C18G1.7	C18G1.7	n/a	chrV 4,746,815	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR008166 (Protein of unknown function DUF23)
32	K10D2.4	K10D2.4	n/a	chrIII 5,173,569
33	C31E10.1	C31E10.1	n/a	chrX 13,985,013	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000238 (Ribosome-binding factor A)
34	T17A3.9	T17A3.9	n/a	chrIII 152,890
35	K02D7.2	K02D7.2	n/a	chrIV 312,624	K02D7.2 encodes an ortholog of human SNAI2/SLUG (OMIM:602150, mutated in Waardenburg syndrome type IID) and Drosophila ESCARGOT; based on its orthology to SNAI2, K02D7.2 is predicted to be a transcriptional inhibitor.
36	ztf-8	ZC395.8	n/a	chrIII 5,271,035	C. elegans ZTF-8 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR004355 (Type IV secretion system CagA exotoxin), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
37	F29D10.2	F29D10.2	n/a	chrI 8,842,038	contains similarity to Interpro domains IPR000853 (Nematoda metallothionein, family 6), IPR000006 (Metallothionein, vertebrate), IPR002952 (Eggshell protein), IPR004035 (Endonuclease III, iron-sulphur binding, conserved site-1), IPR001396 (Echinodermata metallothionein, family 4), IPR001008 (Mollusc metallothionein, family 2)
38	T08A9.5	T08A9.5	n/a	chrX 7,312,937
39	F59E12.8	F59E12.8	n/a	chrII 5,635,699	contains similarity to Interpro domain IPR015683 (Glutamate receptor-related)
40	C25A1.5	C25A1.5	n/a	chrI 10,178,041	contains similarity to Pfam domains PF04116 (Fatty acid hydroxylase superfamily) , PF00173 (Cytochrome b5-like Heme/Steroid binding domain) contains similarity to Interpro domains IPR006694 (Fatty acid hydroxylase), IPR001199 (Cytochrome b5)
41	nhr-116	F09C6.9	n/a	chrV 16,913,761	C. elegans NHR-116 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
42	F52E1.9	F52E1.9	n/a	chrV 8,398,736	contains similarity to Interpro domain IPR011332 (Ribosomal protein, zinc-binding)
43	F54E4.4	F54E4.4	n/a	chrX 14,643,359	contains similarity to Pfam domain PF03931 Skp1 family, tetramerisation domain contains similarity to Interpro domains IPR001232 (SKP1 component), IPR011333 (BTB/POZ fold), IPR016073 (SKP1 component, POZ)
44	F47G4.8	F47G4.8	n/a	chrI 14,053,124
45	smf-2	K11G12.3	n/a	chrX 6,717,366	C. elegans SMF-2 protein; contains similarity to Pfam domain PF01566 Natural resistance-associated macrophage protein contains similarity to Interpro domain IPR001046 (Natural resistance-associated macrophage protein)
46	ces-1	F43G9.11	n/a	chrI 8,634,989	ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo
47	T10G3.4	T10G3.4	n/a	chrV 13,483,233	contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
48	hlh-8	C02B8.4	n/a	chrX 8,118,315	The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying.
49	tor-2	Y37A1B.13	n/a	chrIV 13,983,393	tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA, mutations in which are associated with torsion dystonia (OMIM:605204); overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation.
50	srj-40	F38H12.2	n/a	chrV 4,102,865	C. elegans SRJ-40 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)