UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nhr-130	T01G6.8	0	chrV 482,090	C. elegans NHR-130 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
2	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
3	R09D1.12	R09D1.12	n/a	chrII 9,451,202	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
4	top-2	K12D12.1	n/a	chrII 11,877,788	C. elegans TOP-2 protein; contains similarity to Pfam domains PF00521 (DNA gyrase/topoisomerase IV, subunit A) , PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) , PF00204 (DNA gyrase B) contains similarity to Interpro domains IPR002205 (DNA topoisomerase, type IIA, subunit A or C-terminal), IPR013506 (DNA topoisomerase, type IIA, subunit B, region 2), IPR001241 (DNA topoisomerase, type IIA, subunit B or N-terminal), IPR011558 (DNA topoisomerase, type IIA, subunit B, conserved region), IPR013758 (DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta), IPR013757 (DNA topoisomerase, type IIA, subunit A, alpha-helical), IPR003594 (ATP-binding region, ATPase-like), IPR013759 (DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta), IPR003957 (Transcription factor, CBFA/NFYB, DNA topoisomerase), IPR001154 (DNA topoisomerase II, eukaryotic-type), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013760 (DNA topoisomerase, type IIA, central)
5	ubxn-1	F23C8.4	n/a	chrI 2,434,821	C. elegans UBXN-1 protein; contains similarity to Pfam domains PF00789 (UBX domain) , PF00627 (UBA/TS-N domain) contains similarity to Interpro domains IPR001969 (Peptidase aspartic, active site), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote), IPR001012 (UBX), IPR007087 (Zinc finger, C2H2-type)
6	dos-2	K10G6.2	n/a	chrII 3,977,041	C. elegans DOS-2 protein ;
7	clic-1	T05B11.3	n/a	chrV 7,734,247	C. elegans CLIC-1 protein; contains similarity to Interpro domain IPR000996 (Clathrin light chain)
8	F53C11.3	F53C11.3	n/a	chrV 13,783,418	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR000507 (Adrenergic receptor, beta 1), IPR002424 (Insect alcohol dehydrogenase family), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
9	T17H7.7	T17H7.7	n/a	chrIII 756,721
10	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
11	F22G12.4	F22G12.4	n/a	chrI 13,157,287	contains similarity to Pfam domains PF01363 (FYVE zinc finger) , PF00023 (Ankyrin repeat) (17)contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002110 (Ankyrin), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
12	K01G5.3	K01G5.3	n/a	chrIII 10,751,062	contains similarity to Mus musculus Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).; SW:LAD1_MOUSE
13	T20D4.4	T20D4.4	n/a	chrV 3,416,870	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
14	cul-1	D2045.6	n/a	chrIII 10,473,304	cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10).
15	pod-1	Y76A2B.1	n/a	chrIII 13,519,397	The pod-1 gene encodes a coronin-like protein required for asymmetry along the anterior-posterior axis at the beginning of embryonic development.
16	F59F4.3	F59F4.3	n/a	chrX 15,844,928	contains similarity to Interpro domain IPR002038 (Osteopontin)
17	F17C11.1	F17C11.1	n/a	chrV 10,942,089	contains similarity to Methanosarcina mazei Conserved protein.; TR:Q8PT55
18	hcp-4	T03F1.9	n/a	chrI 3,864,358	The hcp-4 gene encodes a centromere protein (CENP)-C homolog, holocentric protein (HCP)-4.
19	T19B10.3	T19B10.3	n/a	chrV 11,224,368	The T19B10.3 gene encodes an ortholog of the human gene GALACTOSIDASE, BETA 1 (GLB1), which when mutated leads to gangliosidosis type I (OMIM:230500).
20	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
21	F13D2.1	F13D2.1	n/a	chrX 11,169,479	contains similarity to Interpro domain IPR008930 (Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)
22	F57B10.1	F57B10.1	n/a	chrI 6,582,350	contains similarity to Pfam domains PF07716 (Basic region leucine zipper) , PF00170 (bZIP transcription factor) contains similarity to Interpro domains IPR002112 (Transcription factor Jun), IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor), IPR002227 (Tyrosinase), IPR008917 (Eukaryotic transcription factor, Skn-1-like, DNA-binding), IPR011616 (bZIP transcription factor, bZIP-1)
23	fbf-2	F21H12.5	n/a	chrII 6,090,134	fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
24	C52G5.2	C52G5.2	n/a	chrX 12,844,270	contains similarity to Pfam domain PF08768 Domain of unknown function (DUF1794) contains similarity to Interpro domain IPR014878 (Region of unknown function DUF1794)
25	T19C3.2	T19C3.2	n/a	chrIII 616,074
26	rab-11.1	F53G12.1	n/a	chrI 109,369	rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary.
27	K09F6.3	K09F6.3	n/a	chrII 2,258,704	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
28	F56D5.6	F56D5.6	n/a	chrIV 9,407,298	contains similarity to Plasmodium falciparum Putative uncharacterized protein PFD0207c.; TR:Q8I1Y6
29	his-13	ZK131.7	n/a	chrII 13,820,324	his-13 encodes an H3 histone; his-13 is contained within the histone gene cluster HIS3.
30	C44C1.2	C44C1.2	n/a	chrX 959,222	contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
31	C01B10.10	C01B10.10	n/a	chrIV 6,626,165	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002410 (Peptidase S33, prolyl aminopeptidase), IPR002018 (Carboxylesterase, type B)
32	F41G3.3	F41G3.3	n/a	chrII 6,757,638
33	C18E9.7	C18E9.7	n/a	chrII 8,980,548	contains similarity to Pfam domain PF00041 Fibronectin type III domain contains similarity to Interpro domains IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III)
34	T28F4.6	T28F4.6	n/a	chrI 7,493,740	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
35	C56C10.11	C56C10.11	n/a	chrII 6,599,683
36	pqn-40	F52D1.3	n/a	chrX 454,005	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
37	F59F5.7	F59F5.7	n/a	chrX 10,563,070	contains similarity to Interpro domain IPR006609 (Region of unknown function DM13, Skeletor)
38	his-57	F54E12.5	n/a	chrIV 11,340,574	his-57 encodes an H2A histone.
39	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
40	gpdh-1	F47G4.3	n/a	chrI 14,077,014	gpdh-1 encodes one of two C. elegans glycerol 3-phosphate dehydrogenases; although loss of gpdh-1 activity via large-scale RNAi screens results in no obvious defects, gpdh-1 mRNA expression is upregulated in response to hypertonicity, suggesting that GPDH-1 does play a role in osmotic stress adaptation in C. elegans.
41	plx-2	K04B12.1	n/a	chrII 14,421,292	C. elegans PLX-2 protein; contains similarity to Pfam domains PF01833 (IPT/TIG domain) (3), PF01437 (Plexin repeat) (3), PF08337 (Plexin cytoplasmic region) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR002165 (Plexin), IPR008936 (Rho GTPase activation protein), IPR002909 (Cell surface receptor IPT/TIG), IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR013548 (Plexin cytoplasmic region), IPR015943 (WD40/YVTN repeat-like)
42	cyk-4	K08E3.6	n/a	chrIII 13,769,892	cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo.
43	C24B5.4	C24B5.4	n/a	chrV 9,196,537	contains similarity to Pfam domain PF08925 Domain of Unknown Function (DUF1907) contains similarity to Interpro domain IPR015021 (Region of unknown function DUF1907)
44	ZK899.5	ZK899.5	n/a	chrX 9,460,355	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
45	C32D5.12	C32D5.12	n/a	chrII 6,357,672	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) contains similarity to Interpro domains IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
46	lin-23	K10B2.1	n/a	chrII 6,372,870	lin-23 encodes an F-box- and WD-repeat-containing protein orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 also functions cell autonomously in some neurons to regulate neurite outgrowth; LIN-23 expression is first detected broadly during gastrulation, with expression continuing postembryonically in body wall and enteric muscle, hypodermal cells, and many but not all neurons; LIN-23 localizes to the cytoplasm.
47	T13B5.3	T13B5.3	n/a	chrII 1,099,395	contains similarity to Pfam domain PF00328 Histidine acid phosphatase contains similarity to Interpro domains IPR000560 (Histidine acid phosphatase), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
48	F21G4.6	F21G4.6	n/a	chrX 9,913,063	F21G4.6 is orthologous to the human gene HUNTINGTIN (HD; OMIM:143100), which when mutated leads to disease.
49	F49E8.1	F49E8.1	n/a	chrIV 7,557,976	contains similarity to Pfam domain PF06218 Nitrogen permease regulator 2 contains similarity to Interpro domain IPR009348 (Nitrogen permease regulator 2)
50	sel-7	K04G11.2	n/a	chrX 14,336,558	sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.