UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	syn-4	T01B11.3	1e-141	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
2	his-46	B0035.9	n/a	chrIV 11,326,144	his-46 encodes an H4 histone.
3	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
4	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
5	grd-10	F09D12.1	n/a	chrIV 3,441,427	grd-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-10 is expressed in seam cells; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10 is weakly required for normal molting; GRD-10 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
6	F26F12.2	F26F12.2	n/a	chrV 5,838,075
7	B0564.2	B0564.2	n/a	chrIV 13,107,893	contains similarity to Pfam domain PF03171 2OG-Fe(II) oxygenase superfamily contains similarity to Interpro domain IPR005123 (2OG-Fe(II) oxygenase)
8	Y52B11A.8	Y52B11A.8	n/a	chrI 11,033,190	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
9	Y49E10.21	Y49E10.21	n/a	chrIII 12,458,332	contains similarity to Nanoarchaeum equitans DNA double-strand break repair rad50 ATPase.; SW:P62135
10	R107.2	R107.2	n/a	chrIII 9,044,850	contains similarity to Pfam domain PF01256 Carbohydrate kinase contains similarity to Interpro domain IPR000631 (Carbohydrate kinase)
11	fipr-8	C12D8.6	n/a	chrV 10,240,388	C. elegans FIPR-8 protein ; contains similarity to Homo sapiens Keratin-associated protein 19-8; ENSEMBL:ENSP00000372272
12	T15D6.5	T15D6.5	n/a	chrI 12,382,523	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)
13	C56E6.2	C56E6.2	n/a	chrII 6,525,580	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras), IPR006036 (Potassium uptake protein TrkA), IPR002078 (RNA polymerase sigma factor 54, interaction)
14	spat-1	F57C2.6	n/a	chrII 14,531,337	spat-1 encodes a divergent ortholog of Drosophila melanogaster AURORA BOREALIS (BORA) and human BORA (OMIM:610510); SPAT-1 is specifically required for PAR protein-dependent cell-polarity; RNAi of spat-1 weakly suppresses the embryonic lethality of par-2(it5ts) at restrictive temperature.
15	F18E9.3	F18E9.3	n/a	chrX 8,588,029	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
16	F36H12.2	F36H12.2	n/a	chrIV 5,275,375
17	kup-1	F10C2.2	n/a	chrV 12,036,541	kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known.
18	mxl-2	F40G9.11	n/a	chrIII 187,571	C. elegans MXL-2 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
19	T01C8.3	T01C8.3	n/a	chrX 16,781,536
20	B0035.16	B0035.16	n/a	chrIV 11,295,988	contains similarity to Pfam domain PF03054 tRNA methyl transferase contains similarity to Interpro domains IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold), IPR004506 (tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase)
21	Y57G7A.8	Y57G7A.8	n/a	chrII 1,291,464
22	C48C5.3	C48C5.3	n/a	chrX 8,959,409	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
23	Y18D10A.16	Y18D10A.16	n/a	chrI 12,903,539	contains similarity to Homo sapiens Uncharacterized protein C2orf64; ENSEMBL:ENSP00000330730
24	set-5	C47E8.8	n/a	chrV 14,702,283	set-5 encodes a large (1,675-residue) protein with an N-terminal SET domain and a C-terminal SPK domain; SET-5 has no non-nematode orthologs, but is paralogous to Y57A10A.1; SET-5's domain organization resembles that of SET-24; neither set-5(ok1568) nor set-5(RNAi) have any obvious phenotypes.
25	B0207.6	B0207.6	n/a	chrI 5,936,242	contains similarity to Pfam domain PF03029 Conserved hypothetical ATP binding protein contains similarity to Interpro domain IPR004130 (Protein of unknown function, ATP binding)
26	ani-3	Y43F8C.14	n/a	chrV 19,696,771	ani-3 encodes one of three C. elegans anillins.
27	C36F7.2	C36F7.2	n/a	chrI 9,551,413	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
28	btb-3	B0047.2	n/a	chrII 2,043,575	C. elegans BTB-3 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR000210 (BTB/POZ-like)
29	fbxa-145	F48C1.2	n/a	chrI 5,320,402	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
30	W01C8.1	W01C8.1	n/a	chrX 5,693,921
31	C17H12.2	C17H12.2	n/a	chrIV 6,788,223	contains similarity to Drosophila melanogaster Flybase gene name is CG7289-PA;; FLYBASE:CG7289
32	srxa-9	ZK678.4	n/a	chrX 15,749,493	C. elegans SRXA-9 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domain IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
33	ZK402.1	ZK402.1	n/a	chrX 1,405,182
34	K09C6.3	K09C6.3	n/a	chrV 852,829
35	C05E4.7	C05E4.7	n/a	chrV 742,319
36	M110.3	M110.3	n/a	chrII 8,215,496	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
37	C49F5.3	C49F5.3	n/a	chrX 11,983,268	contains similarity to Phytophthora infestans SECY-independent transporter protein.; TR:Q9T238
38	ape-1	F46F3.4	n/a	chrV 11,680,585	ape-1 encodes an ortholog of inhibitory p53-interacting protein (iASPP); APE-1 binds CEP-1 in vitro, and shares 38% amino-acid identity in its ankyrin repeats and SH3 domain to iASPP, with many iASPP residues contacting p53 being conserved; RNAi of ape-1 induces CEP-1- and HUS-1-dependent apoptosis in the germline, consistent with inhibition of the CEP-1/HUS-1 DNA damage checkpoint by APE-1 in the germline; excess ape-1(RNAi) apoptosis also requires CED-3.
39	srd-17	Y2H9A.2	n/a	chrV 13,431,663	C. elegans SRD-17 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
40	srh-36	T03D3.4	n/a	chrV 2,820,623	C. elegans SRH-36 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	ZK1307.2	ZK1307.2	n/a	chrII 9,653,433	contains similarity to Dictyostelium discoideum Hypothetical protein.; TR:Q8T1G2
42	M02B7.4	M02B7.4	n/a	chrIV 3,802,482	contains similarity to Pfam domain PF08660 Oligosaccharide biosynthesis protein Alg14 like contains similarity to Interpro domain IPR013969 (Oligosaccharide biosynthesis protein Alg14 like)
43	djr-1.1	B0432.2	n/a	chrII 291,212	djr-1.1 encodes an ortholog of DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitors that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2).
44	srx-1	F59E11.1	n/a	chrV 9,004,313	C. elegans SRX-1 protein; contains similarity to Interpro domains IPR000366 (Fungal pheromone mating factor STE2 GPCR), IPR000276 (GPCR, rhodopsin-like)
45	W02D7.5	W02D7.5	n/a	chrV 8,298,506	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
46	Y56A3A.31	Y56A3A.31	n/a	chrIII 11,986,100	contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
47	T05A8.3	T05A8.3	n/a	chrII 2,716,038
48	F31F4.1	F31F4.1	n/a	chrV 685,113	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
49	K11B4.2	K11B4.2	n/a	chrI 14,798,156	contains similarity to Tetraodon nigroviridis UPF0402 protein.; SW:Q4S3C1
50	F58E1.7	F58E1.7	n/a	chrII 1,678,353	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)