UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	mab-10	R166.1	0	chrII 10,532,058	C. elegans MAB-10 protein; contains similarity to Pfam domains PF04905 (NAB conserved region 2 (NCD2)) , PF04904 (NAB conserved region 1 (NCD1)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR006988 (Nab, N-terminal), IPR006989 (Nab, central region)
2	F34H10.4	F34H10.4	n/a	chrX 9,649,656	contains similarity to Interpro domain IPR002253 (Flavin-containing monooxygenase (FMO) 1)
3	Y11D7A.8	Y11D7A.8	n/a	chrIV 9,252,608	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
4	R09D1.7	R09D1.7	n/a	chrII 9,455,937	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001574 (Ribosome-inactivating protein)
5	C24H10.2	C24H10.2	n/a	chrX 5,065,438
6	ubh-1	F46E10.8	n/a	chrV 6,510,664	ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1 (OMIM:191342, mutated in Parkinson disease).
7	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
8	F53G2.3	F53G2.3	n/a	chrII 2,480,856
9	R07H5.9	R07H5.9	n/a	chrIV 11,208,377	contains similarity to Saccharomyces cerevisiae involved in septin organization; SGD:YCL024W
10	gpr-2	C38C10.4	n/a	chrIII 9,392,118	gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.
11	dpy-1	M01E10.2	n/a	chrIII 2,041,006	dpy-1 encodes a collagen that affects body length and alae formation; site of action localized to the hyp7 syncytium, based on mosaic analysis.
12	B0554.2	B0554.2	n/a	chrV 435,748	contains similarity to Pfam domain PF02795 Domain of unknown function (DUF225) contains similarity to Interpro domain IPR004024 (Protein of unknown function DUF225)
13	F46G10.4	F46G10.4	n/a	chrX 13,335,352	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domain IPR002921 (Lipase, class 3)
14	pkc-1	F57F5.5	n/a	chrV 12,019,252	pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
15	T28F3.9	T28F3.9	n/a	chrIV 17,310,065	contains similarity to Pfam domain PF02485 Core-2/I-Branching enzyme contains similarity to Interpro domain IPR003406 (Glycosyl transferase, family 14)
16	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
17	F59F5.1	F59F5.1	n/a	chrX 10,530,779	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
18	W03B1.2	W03B1.2	n/a	chrIV 4,329,360	contains similarity to Interpro domains IPR002229 (Blood group Rhesus C/E and D polypeptide), IPR000769 (Regulatory protein Rop)
19	nhr-143	F59E11.11	n/a	chrV 8,974,032	C. elegans NHR-143 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
20	fbxa-111	Y102A5C.14	n/a	chrV 16,949,135	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	W04C9.2	W04C9.2	n/a	chrI 489,263
22	lin-48	F34D10.5	n/a	chrIII 3,746,355	lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor
23	R173.3	R173.3	n/a	chrX 7,033,107	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
24	F59F5.7	F59F5.7	n/a	chrX 10,563,070	contains similarity to Interpro domain IPR006609 (Region of unknown function DM13, Skeletor)
25	F43C1.1	F43C1.1	n/a	chrIII 4,213,606	contains similarity to Pfam domains PF00481 (Protein phosphatase 2C) , PF00560 (Leucine Rich Repeat) (11)contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR001611 (Leucine-rich repeat), IPR000694 (Proline-rich region), IPR003591 (Leucine-rich repeat, typical subtype), IPR014045 (Protein phosphatase 2C, N-terminal)
26	abts-2	F52D10.1	n/a	chrX 11,587,609	abts-2 encodes an anion transporter; when expressed in Xenopus oocytes, ABTS-2 does not exhibit detectable transport of chloride, sulfate, or oxolate anions; ABTS-2::GFP fusion proteins are expressed in the larval excretory cell and the adult ovaries, while an abts-2::gfp promoter fusion is seen in only one tail ganglion neuron; in intestinal cells, the ABTS-2::GFP fusion protein localizes to the basolateral membrane.
27	C50D2.2	C50D2.2	n/a	chrII 110,283	contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR004841 (Amino acid permease-associated region), IPR002293 (Amino acid/polyamine transporter I)
28	C04G6.2	C04G6.2	n/a	chrII 5,093,709	contains similarity to Pfam domain PF03380 Caenorhabditis protein of unknown function, DUF282 contains similarity to Interpro domain IPR005044 (Protein of unknown function DUF282, Caenorhabditis species)
29	H05C05.3	H05C05.3	n/a	chrIII 2,967,980
30	str-48	C34D4.8	n/a	chrIV 7,123,053	C. elegans STR-48 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
31	pqn-53	R07B7.3	n/a	chrV 12,064,393	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
32	K04G11.3	K04G11.3	n/a	chrX 14,346,393	contains similarity to Pfam domain PF07547 RSD-2 N-terminal domain contains similarity to Interpro domain IPR011508 (RSD-2, N-terminal)
33	T10E10.4	T10E10.4	n/a	chrX 6,318,637	T10E10.4 encodes a large (966-residue) protein, predicted to be secreted, with two N-terminal chitin-binding peritrophin-A domains followed by 14 cysteine-rich domains and one C-terminal EB module; the general organization of T10E10.4 protein resembles that of K04H4.2; T10E10.4 has no obvious function in mass RNAi assays but, like CEJ-1 and CPG-2, might participate in chitin synthesis.
34	srh-105	T27A1.7	n/a	chrII 508,784	C. elegans SRH-105 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
35	ctg-1	H06O01.3	n/a	chrI 7,007,341	C. elegans CTG-1 protein; contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001071 (Cellular retinaldehyde binding/alpha-tocopherol transport), IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
36	F21H12.6	F21H12.6	n/a	chrII 6,095,139	F21H12.6 encodes the C. elegans tripeptidyl peptidase II ortholog; loss of F21H12.6 activity via RNAi indicates that the product of F21H12.6 promotes fat formation; an F21H12.6::GFP reporter fusion is expressed in the intestine, the site of fat storage, and in a subset of nerve ring neurons.
37	F52H2.7	F52H2.7	n/a	chrX 2,569,600	contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR001565 (Synaptotagmin), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
38	klp-8	C15C7.2	n/a	chrX 3,162,174	klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus; the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain.
39	F55A12.8	F55A12.8	n/a	chrI 5,351,713	contains similarity to Pfam domains PF05127 (Putative ATPase (DUF699)) , PF08351 (Domain of unknown function (DUF1726)) contains similarity to Interpro domains IPR013562 (Region of unknown function DUF1726), IPR007807 (Protein of unknown function DUF699, ATPase putative), IPR016181 (Acyl-CoA N-acyltransferase), IPR013324 (RNA polymerase sigma factor, regions 3 and 4)
40	F55A4.5	F55A4.5	n/a	chrX 1,031,456	contains similarity to Pfam domain PF00035 Double-stranded RNA binding motif contains similarity to Interpro domains IPR001159 (Double-stranded RNA binding), IPR014720 (Double-stranded RNA-binding-like)
41	ZK488.6	ZK488.6	n/a	chrV 591,473	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
42	C26D10.4	C26D10.4	n/a	chrII 8,331,544	contains similarity to Pfam domains PF08544 (GHMP kinases C terminal) , PF00288 (GHMP kinases N terminal domain) contains similarity to Interpro domains IPR006206 (Mevalonate and galactokinase), IPR001174 (Galactokinase/homoserine kinase), IPR006204 (GHMP kinase), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013750 (GHMP kinase, C-terminal)
43	D1014.7	D1014.7	n/a	chrV 8,119,293	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
44	F32A11.1	F32A11.1	n/a	chrII 13,158,777	contains similarity to Interpro domains IPR016071 (Staphylococcal nuclease (SNase-like), OB-fold), IPR006021 (Staphylococcal nuclease (SNase-like))
45	F28C1.1	F28C1.1	n/a	chrV 12,452,041	contains similarity to Drosophila melanogaster Flybase gene name is CG6695-PA;; FLYBASE:CG6695
46	C09B8.3	C09B8.3	n/a	chrX 6,009,216
47	srh-27	W05H5.4	n/a	chrII 12,449,129	C. elegans SRH-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
48	glr-4	C06A8.9	n/a	chrII 7,789,680	glr-4 encodes a putative non-NMDA ionotropic glutamate receptor subunit, most closely related to GLR-3 and less so to GLR-7, possibly of the kainate subfamily; glr-4 is expressed in various sensory neurons and interneurons from embyrogenesis onward; glr-4 expression requires UNC-42, as well as CFI-1 in URA cells.
49	F40A3.2	F40A3.2	n/a	chrV 7,880,134	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
50	gcy-8	C49H3.1	n/a	chrIV 7,930,918	gcy-8 encodes a receptor-type guanylyl cyclase that, along with gcy-18 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-8 functions redundantly with gcy-18 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; GCY-8 is expressed exclusively in the AFD thermosensory neurons where it localizes to sensory endings; GCY-8 expression in the AFD neurons requires activity of the TAX-2/4 cyclic nucleotide gated channel and the CMK-1 Ca2+/calmodulin-dependent protein kinase I, while maintenance of GCY-8 expression requires the OTD/OTX homeodomain protein TTX-1.