UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nph-4	R13H4.1	0	chrV 11,837,428	nph-4 encodes an ortholog of human NPHP4 (OMIM:607215, mutated in juvenile nephronophthisis and Senior-Loken syndrome-4) that is required for normal chemotaxis, lifespan, and male mating behavior; NPH-4 is expressed in diverse neurons (amphid and phasmid sensory, URX, labial, male lumbar and cloacal ganglia, and male-specific CEM, HOB and RnB); within neurons, NPH-4 is a ciliary protein, localized to the transistion zone at cilial bases rather than ciliary axonemes, and absent from somata, axons, or dendrites; NPH-4 colocalizes with NPH-1 and PKD-2 in male-specific sensory cilia, and is required for the normal ciliary localization of NPH-1; NPH-4 expression requires DAF-19, and mutating an X-box in nph-4's promoter abolishes nph-4 expression; NPH-4 is required for NPH-1's localization to transistion zones; morphologically, nph-4 mutant cilia are normal, indicating a function for NPH-4 in signal transduction.
2	C03E10.1	C03E10.1	n/a	chrV 11,291,855	contains similarity to Anopheles quadrimaculatus NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3).; SW:NU4M_ANOQU
3	F55D1.2	F55D1.2	n/a	chrX 5,488,910
4	R12B2.2	R12B2.2	n/a	chrIII 5,808,424	contains similarity to Homo sapiens Isoform 1 of Golgin-45; ENSEMBL:ENSP00000327541
5	F59B2.11	F59B2.11	n/a	chrIII 9,014,893	contains similarity to Homo sapiens hypothetical protein; VG:OTTHUMP00000025312
6	fkh-5	F26A1.2	n/a	chrIII 4,845,567	fkh-5 encodes a member of the forkhead domain transcription factor family.
7	ZK218.4	ZK218.4	n/a	chrV 17,100,011	contains similarity to Interpro domain IPR000434 (Polycystic kidney disease type 1 protein)
8	T08G5.9	T08G5.9	n/a	chrV 14,045,861	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
9	srx-46	E02C12.2	n/a	chrV 9,353,867	C. elegans SRX-46 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
10	C32B5.7	C32B5.7	n/a	chrII 962,400	contains similarity to Pfam domain PF00112 Papain family cysteine protease contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000668 (Peptidase C1A, papain C-terminal)
11	sfxn-1.1	AH6.2	n/a	chrII 9,518,171	C. elegans SFXN-1.1 protein; contains similarity to Pfam domain PF03820 Tricarboxylate carrier contains similarity to Interpro domain IPR004686 (Tricarboxylate/iron carrier)
12	C46H11.3	C46H11.3	n/a	chrI 5,041,773	contains similarity to Pfam domain PF04699 ARP2/3 complex 16 kDa subunit (p16-Arc) contains similarity to Interpro domains IPR006789 (ARP2/3 complex 16 kDa subunit (p16-Arc)), IPR002052 (N-6 adenine-specific DNA methylase, conserved site)
13	srz-70	C09G12.6	n/a	chrIV 3,478,198	C. elegans SRZ-70 protein ;
14	str-264	C06B8.4	n/a	chrV 15,491,810	C. elegans STR-264 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	T20H12.1	T20H12.1	n/a	chrII 3,950,365
16	sri-39	F33H12.2	n/a	chrII 2,588,572	C. elegans SRI-39 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
17	str-14	T08G3.2	n/a	chrV 16,454,252	C. elegans STR-14 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	C04C3.6	C04C3.6	n/a	chrIV 3,421,207	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
19	srab-6	C36C5.10	n/a	chrV 3,151,224	C. elegans SRAB-6 protein ;
20	C50H11.17	C50H11.17	n/a	chrV 3,097,908	contains similarity to Pfam domain PF03236 Domain of unknown function DUF263 contains similarity to Interpro domain IPR004920 (Protein of unknown function DUF263)
21	Y7A5A.7	Y7A5A.7	n/a	chrX 15,802,663	contains similarity to Murine herpesvirus 72 Membrane virion glycoprotein 150.; TR:Q9DYE3
22	Y43F8B.13	Y43F8B.13	n/a	chrV 19,459,852	contains similarity to Puumala virus Nucleocapsid protein (Fragment).; TR:Q8B3A4
23	uvt-2	C24H10.5	n/a	chrX 5,076,202	uvt-2 encodes a protein that contains four EF-hand calcium binding motifs with similarity to human calmodulin; mRNA weakly expressed in L1 through L4 larval stages and in the adult hermaphrodite.
24	str-205	C02E7.9	n/a	chrV 4,929,096	C. elegans STR-205 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
25	C17A2.5	C17A2.5	n/a	chrII 3,834,625	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
26	F59D6.2	F59D6.2	n/a	chrV 3,028,937	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001461 (Peptidase A1)
27	ZC116.1	ZC116.1	n/a	chrV 12,610,320	contains similarity to Interpro domain IPR001419 (HMW glutenin)
28	Y39A1A.17	Y39A1A.17	n/a	chrIII 10,688,996	contains similarity to Interpro domain IPR001611 (Leucine-rich repeat)
29	gcy-37	C54E4.3	n/a	chrIV 2,154,905	gcy-37 encodes a predicted soluble guanylyl cyclase that is expressed in four candidate sensory neurons connected to the pseudocoelom, URXL, URXR, AQR, and PQR; as loss of gcy-37 activity via RNA-mediated interference does not result in any abnormalities, the precise role of GCY-37 in C. elegans development and/or behavior is not yet known; GCY-37 expression in neurons connected to the pseudocoelom suggests, however, that GCY-37 may play a role in fluid homeostasis.
30	C18H7.1	C18H7.1	n/a	chrIV 618,237	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
31	taf-13	C14A4.10	n/a	chrII 10,605,243	taf-13 encodes a predicted member of the transcription initiation factor IID, 18kDa subunit family with similarity to Drosophila Taf13.
32	F20E11.5	F20E11.5	n/a	chrV 17,461,590	contains similarity to Pfam domain PF03436 Domain of unknown function (DUF281) contains similarity to Interpro domain IPR005098 (Protein of unknown function DUF281)
33	tag-117	C01B7.4	n/a	chrV 8,794,107	C. elegans TAG-117 protein; contains similarity to Pfam domains PF00018 (SH3 domain) , PF00625 (Guanylate kinase) , PF07653 (Variant SH3 domain) , PF00595 (PDZ domain (Also known as DHR or GLGF)) contains similarity to Interpro domains IPR011511 (Variant SH3), IPR008144 (Guanylate kinase), IPR008145 (Guanylate kinase/L-type calcium channel region), IPR001478 (PDZ/DHR/GLGF), IPR001452 (Src homology-3)
34	Y38H6C.17	Y38H6C.17	n/a	chrV 20,537,681	Y38H6C.17 encodes a putative amino acid transporter that inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51; Y38H6C.17 has 11 predicted transmembrane alpha-helices; Y38H6C.17 has multiple C. elegans paralogs and non-nematode orthologs, including budding yeast AVT3 and AVT4 and human SLC36A1 (OMIM:606561).
35	C34D4.1	C34D4.1	n/a	chrIV 7,158,487	contains similarity to Interpro domain IPR000956 (Stathmin)
36	gcy-23	T26C12.4	n/a	chrIV 3,286,107	gcy-23 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-18, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-23 functions redundantly with gcy-8 and gcy-18, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, loss of gcy-23 activity via RNAi results in lifespan extension; GCY-23 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
37	rrf-3	F10B5.7	n/a	chrII 8,165,532	rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.
38	C40A11.5	C40A11.5	n/a	chrII 2,134,686	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
39	Y41C4A.2	Y41C4A.2	n/a	chrIII 11,653,209	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domain IPR000120 (Amidase signature enzyme)
40	scl-20	ZK384.2	n/a	chrV 18,733,634	C. elegans SCL-20 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR002413 (Ves allergen), IPR001283 (Allergen V5/Tpx-1 related)
41	F32B5.2	F32B5.2	n/a	chrI 2,698,698
42	nhr-190	F48G7.11	n/a	chrV 641,845	C. elegans NHR-190 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
43	K10B4.4	K10B4.4	n/a	chrII 124,170	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002286 (P2 purinoceptor), IPR005390 (Neuromedin U receptor), IPR000276 (GPCR, rhodopsin-like)
44	nhr-178	F16B4.9	n/a	chrV 1,605,896	C. elegans NHR-178 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
45	R07B1.8	R07B1.8	n/a	chrX 9,871,676
46	clec-24	F49A5.4	n/a	chrV 16,863,042	C. elegans CLEC-24 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
47	grl-13	F32D1.4	n/a	chrV 4,363,652	grl-13 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-13 is expressed in larval arcade cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
48	C17B7.7	C17B7.7	n/a	chrV 3,326,895	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
49	F28C6.5	F28C6.5	n/a	chrII 8,599,990	contains similarity to Mus musculus Activity-dependent neuroprotector (Activity-dependent neuroprotectivesprotein).; SW:ADNP_MOUSE
50	T07D3.5	T07D3.5	n/a	chrII 886,263	contains similarity to Pfam domain PF06828 Fukutin-related contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR009644 (Fukutin-related)