UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rpl-9	R13A5.8	2.9999999999999996e-104	chrIII 7,572,403	rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	rps-13	C16A3.9	n/a	chrIII 6,374,498	rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development.
4	ptr-24	F46G10.5	n/a	chrX 13,345,071	ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo.
5	tag-18	T14G12.3	n/a	chrX 3,732,674	C. elegans TAG-18 protein ;
6	Y17G7B.11	Y17G7B.11	n/a	chrII 12,061,387	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
7	cyp-36A1	C34B7.3	n/a	chrI 8,343,858	C. elegans CYP-36A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I)
8	abcf-1	F18E2.2	n/a	chrV 12,762,189	C. elegans ABCF-1 protein; contains similarity to Pfam domain PF00005 ABC transporter contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core)
9	rps-30	C26F1.4	n/a	chrV 7,776,842	rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
10	R10H10.3	R10H10.3	n/a	chrIV 10,390,865	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00431 (CUB domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016857 (Uncharacterised conserved protein UCP027682, CUB, vWA), IPR002035 (von Willebrand factor, type A)
11	pmp-1	C44B7.8	n/a	chrII 6,882,170	pmp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the peroxisomal membrane proteins; pmp-1 activity is required for efficient RNA interference (RNAi) of a germline-expressed target, pop-1.
12	cpn-4	F49D11.8	n/a	chrI 10,925,036	cpn-4 encodes a calponin homolog, most closely related to its paralog CPN-3 in C. elegans; CPN-4 is somewhat more similar to calponins per se (such as CLP1 and CLP2 in humans) than to the to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25.
13	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
14	F44D12.9	F44D12.9	n/a	chrIV 10,020,215	contains similarity to Pfam domain PF01733 Nucleoside transporter contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR016196 (MFS general substrate transporter)
15	F59F5.2	F59F5.2	n/a	chrX 10,534,095	contains similarity to Cryptosporidium parvum Exonuclease ii, possible.; TR:Q7YYI5
16	F35E12.10	F35E12.10	n/a	chrV 13,747,215	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
17	rpl-6	R151.3	n/a	chrIII 7,209,034	rpl-6 encodes a large ribosomal subunit L6 protein.
18	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
19	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
20	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
21	C01B10.3	C01B10.3	n/a	chrIV 6,620,429	C01B10.3 encodes a paralog of IPP-5, and thus may functionally overlap with ipp-5 in vivo.
22	M03B6.2	M03B6.2	n/a	chrX 13,855,038	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR016196 (MFS general substrate transporter)
23	ldh-1	F13D12.2	n/a	chrII 11,725,839	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
24	lgc-50	T20B12.9	n/a	chrIII 7,393,409	C. elegans LGC-50 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
25	tag-314	F15H10.4	n/a	chrV 10,427,635	C. elegans TAG-314 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type)
26	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
27	rps-18	Y57G11C.16	n/a	chrIV 14,825,992	rps-18 encodes a small ribosomal subunit S18 protein.
28	D2096.8	D2096.8	n/a	chrIV 8,378,494	D2096.8 encodes a protein related in sequence to the conserved NAP (Nucleosome Assembly Protein) family of proteins involved in chromatin remodeling; loss of D2096.8 activity in wild-type and various mutant backgrounds suggests that in C. elegans the product of D2096.8 is required for proper transcriptional regulation that affects a number of biological processes including embryonic and larval development, body morphology, locomotion, and vulval formation.
29	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
30	ifd-2	F25E2.4	n/a	chrX 814,890	ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays.
31	F29C12.4	F29C12.4	n/a	chrII 13,119,692	contains similarity to Pfam domains PF03764 (Elongation factor G, domain IV) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) , PF00679 (Elongation factor G C-terminus) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005517 (Translation elongation factor EFG/EF2, domain IV), IPR005225 (Small GTP-binding protein), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009000 (Translation elongation and initiation factors/Ribosomal, beta-barrel), IPR000640 (Translation elongation factor EFG/EF2, C-terminal), IPR004540 (Translation elongation factor EFG/EF2), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR009022 (Elongation factor G, III and V)
32	spon-1	F10E7.4	n/a	chrII 7,118,495	C. elegans SPON-1 protein; contains similarity to Pfam domains PF06468 (Spondin_N) , PF00090 (Thrombospondin type 1 domain) (5), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) , PF02014 (Reeler domain) contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR003067 (Plasmodium circumsporozoite protein), IPR009465 (Spondin, N-terminal), IPR002861 (Reeler region)
33	ZK1321.4	ZK1321.4	n/a	chrII 9,772,248	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domains IPR006643 (ZASP), IPR001478 (PDZ/DHR/GLGF)
34	F43G9.1	F43G9.1	n/a	chrI 8,607,769	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004434 (Isocitrate dehydrogenase NAD-dependent, mitochondrial), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
35	eft-2	F25H5.4	n/a	chrI 9,165,168	eft-2 encodes a homolog of translation elongation factor 2 (EF-2), a GTP-binding protein essential for the elongation phase of protein synthesis; eft-2 is required for embryogenesis and vulval morphogenesis, and is expressed during all stages of development, including the dauer larval stage.
36	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
37	ugt-16	ZC443.6	n/a	chrV 12,826,207	C. elegans UGT-16 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
38	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
39	Y48A6B.10	Y48A6B.10	n/a	chrIII 11,041,221	contains similarity to Interpro domain IPR000694 (Proline-rich region)
40	cdr-4	K01D12.11	n/a	chrV 12,407,975	C. elegans CDR-4 protein; contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR010987 (Glutathione S-transferase, C-terminal-like)
41	rps-25	K02B2.5	n/a	chrIV 5,947,351	rps-25 encodes a small ribosomal subunit S25 protein.
42	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
43	mppb-1	ZC410.2	n/a	chrIV 9,075,567	C. elegans MPPB-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
44	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
45	F38B2.4	F38B2.4	n/a	chrX 11,287,008	F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia.
46	rps-10	D1007.6	n/a	chrI 4,584,217	rps-10 encodes a small (40S) ribosomal subunit S10 protein; loss of rps-10 activity in adult animals extends lifespan.
47	hsp-1	F26D10.3	n/a	chrIV 17,280,029	hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
48	rpl-30	Y106G6H.3	n/a	chrI 10,436,561	rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
49	pqn-57	R09F10.7	n/a	chrX 8,320,224	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
50	tag-210	W08E3.3	n/a	chrI 13,342,122	C. elegans TAG-210 protein; contains similarity to Pfam domains PF01926 (GTPase of unknown function) , PF06071 (Protein of unknown function (DUF933)) contains similarity to Interpro domains IPR012675 (Beta-grasp fold, ferredoxin-type), IPR013029 (Protein of unknown function DUF933), IPR004396 (Conserved hypothetical protein CHP00092), IPR002917 (GTP-binding protein, HSR1-related), IPR012676 (TGS-like), IPR006073 (GTP1/OBG)