UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	kcc-1	R13A1.2	0	chrIV 7,215,841	C. elegans KCC-1 protein; contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR000076 (K-Cl co-transporter), IPR004841 (Amino acid permease-associated region), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
2	F40F12.4	F40F12.4	n/a	chrIII 9,895,687	contains similarity to Interpro domain IPR000998 (MAM)
3	ggr-1	C09G5.1	n/a	chrII 10,698,711	ggr-1 encodes a predicted member of the GABA/ glycine receptor family of ligand-gated chloride channels that affects thermotaxis; expressed in AIB, PVR, PVQ, AVH, and SMDV neurons and in some motor neurons in the ventral cord, and in the egg-laying muscles.
4	cpz-1	F32B5.8	n/a	chrI 2,688,057	cpz-1 encodes a homolog of cathepsin z-like cysteine protease cyclically expressed in hypodermal cells throughout development (along with adult gonad and pharynx) and required for normal molting; CPZ-1 protein is present in cuticle regions shortly before their degradation during ecydsis, and this expression pattern is conserved in Onchocerca volvulus; cpz-1(ok497) and cpz-1(RNAi) worms have defective molting, along with misshapen heads and tails, defective gonads, and embryonic lethality.
5	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
6	C36E8.4	C36E8.4	n/a	chrIII 4,014,026	contains similarity to Pfam domain PF00018 SH3 domain contains similarity to Interpro domains IPR001060 (Cdc15/Fes/CIP4), IPR001452 (Src homology-3)
7	K11H12.4	K11H12.4	n/a	chrIV 674,988	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
8	C26B9.2	C26B9.2	n/a	chrX 5,341,141
9	F18A12.4	F18A12.4	n/a	chrII 3,405,348	F18A12.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.4 has no clear orthologs in other organisms.
10	F16B12.7	F16B12.7	n/a	chrX 14,109,051	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
11	R01H2.4	R01H2.4	n/a	chrIII 7,062,521	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
12	gcy-33	F57F5.2	n/a	chrV 11,998,799	gcy-33 encodes a soluble guanylyl cyclase; a gcy-33::GFP reporter is expressed in the ciliated BAG head sensory neurons.
13	T05E11.7	T05E11.7	n/a	chrIV 11,103,651	contains similarity to Pfam domain PF03057 Protein of unknown function contains similarity to Interpro domains IPR004296 (Protein of unknown function DUF236), IPR005819 (Histone H5)
14	gcy-18	ZK896.8	n/a	chrIV 12,863,005	gcy-18 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-23, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-18 functions redundantly with gcy-8 and gcy-23, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, microarray experiments indicate that gcy-18 expression is induced in daf-16(RNAi); daf-2(RNAi) double mutants and repressed in daf-2(RNAi) mutants, suggesting that GCY-18 activity may contribute to a shortened lifespan; consistent with this, loss of gcy-18 activity via RNAi does result in lifespan extension; GCY-18 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
15	F29A7.3	F29A7.3	n/a	chrII 2,753,579	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
16	C04E7.1	C04E7.1	n/a	chrX 359,435
17	C34F11.1	C34F11.1	n/a	chrII 5,213,423	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
18	irk-1	R03E9.4	n/a	chrX 6,769,400	C. elegans IRK-1 protein; contains similarity to Pfam domain PF01007 Inward rectifier potassium channel contains similarity to Interpro domains IPR013521 (Potassium channel, inwardly rectifying, Kir, conserved region 2), IPR014756 (Immunoglobulin E-set), IPR013518 (Potassium channel, inwardly rectifying, Kir, cytoplasmic), IPR001838 (Potassium channel, inwardly rectifying, Kir-like)
19	wht-6	T26A5.1	n/a	chrIII 6,473,428	C. elegans WHT-6 protein; contains similarity to Pfam domains PF01061 (ABC-2 type transporter) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core), IPR013525 (ABC-2 type transporter)
20	T27D1.3	T27D1.3	n/a	chrIII 3,684,552	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008365 (Prostanoid receptor), IPR001991 (Sodium:dicarboxylate symporter), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR000276 (GPCR, rhodopsin-like)
21	nhr-131	T01G6.2	n/a	chrV 495,899	C. elegans NHR-131 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
22	T06E4.5	T06E4.5	n/a	chrV 9,631,723	contains similarity to Interpro domains IPR001046 (Natural resistance-associated macrophage protein), IPR001266 (Ribosomal protein S19e)
23	H35B03.1	H35B03.1	n/a	chrIV 5,727,641
24	C56C10.12	C56C10.12	n/a	chrII 6,606,347	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
25	F02E11.2	F02E11.2	n/a	chrII 3,267,119
26	T21G5.2	T21G5.2	n/a	chrI 6,870,894
27	T19D2.1	T19D2.1	n/a	chrX 3,935,349	contains similarity to Pfam domains PF00090 (Thrombospondin type 1 domain) (4), PF01421 (Reprolysin (M12B) family zinc metalloprotease) contains similarity to Interpro domains IPR008085 (Thrombospondin, subtype 1), IPR000884 (Thrombospondin, type I), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR013273 (Peptidase M12B, ADAM-TS), IPR001590 (Peptidase M12B, ADAM/reprolysin)
28	F59A3.7	F59A3.7	n/a	chrI 5,517,931
29	C25G4.8	C25G4.8	n/a	chrIV 12,461,585	contains similarity to Pfam domain PF06887 Protein of unknown function (DUF1265) contains similarity to Interpro domain IPR009676 (Protein of unknown function DUF1265)
30	C10A4.1	C10A4.1	n/a	chrX 7,417,182	contains similarity to Pfam domain PF05699 hAT family dimerisation domain contains similarity to Interpro domain IPR008906 (HAT dimerisation)
31	W06A7.4	W06A7.4	n/a	chrV 14,826,907	contains similarity to Interpro domains IPR002129 (Pyridoxal phosphate-dependent decarboxylase), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
32	eat-2	Y48B6A.4	n/a	chrII 14,169,168	eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.
33	W02B8.4	W02B8.4	n/a	chrII 13,922,543	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
34	Y51A2D.1	Y51A2D.1	n/a	chrV 18,510,717	contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
35	srab-9	C36C5.6	n/a	chrV 3,140,609	C. elegans SRAB-9 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
36	srbc-34	Y113G7B.9	n/a	chrV 20,202,676	C. elegans SRBC-34 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
37	F21C3.6	F21C3.6	n/a	chrI 7,284,859	contains similarity to Homo sapiens Isoform 1 of Caldesmon; ENSEMBL:ENSP00000354826
38	pat-2	F54F2.1	n/a	chrIII 8,821,993	pat-2 encodes an alpha integrin subunit; during embryogenesis, pat-2 is essential for body wall muscle assembly and function and hence, proper elongation and hatching.
39	ugt-59	R11A8.3	n/a	chrIV 10,362,030	C. elegans UGT-59 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
40	ins-24	ZC334.3	n/a	chrI 14,031,394	ins-24 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-24 is one of 38 insulin-like peptides in C. elegans, but as loss of INS-24 function via RNA-mediated interference does not result in any abnormalities, the precise role of INS-24 in C. elegans development is not yet clear.
41	F56D5.2	F56D5.2	n/a	chrIV 9,397,813	contains similarity to Bacillus subtilis Hypothetical protein yxcE.; SW:YXCE_BACSU
42	srbc-44	ZC455.9	n/a	chrV 12,787,889	C. elegans SRBC-44 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
43	acy-3	C44F1.5	n/a	chrIII 3,778,374	acy-3 encodes a predicted member of the adenylyl cyclase family with highest similarity to human adenylate cyclase type 5; expressed in the support cells of ciliated neurons, in the head and tail ganglia, in two pairs of neurons in the retrovesicular ganglia, and in the spermatheca.
44	F22G12.5	F22G12.5	n/a	chrI 13,172,567	contains similarity to Interpro domain IPR001765 (Carbonic anhydrase)
45	sdz-4	C32B5.16	n/a	chrII 959,537	C. elegans SDZ-4 protein ;
46	CD4.1	CD4.1	n/a	chrV 5,608,204
47	T06G6.8	T06G6.8	n/a	chrI 12,725,522	contains similarity to Pfam domain PF03761 Domain of unknown function (DUF316) contains similarity to Interpro domain IPR005514 (Protein of unknown function DUF316)
48	T28D9.7	T28D9.7	n/a	chrII 6,478,174	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
49	aha-1	C25A1.11	n/a	chrI 10,195,452	aha-1 encodes an ortholog of human aryl-hydrocarbon receptor nuclear translocator; interacts with AHR-1 and HIF-1 in vitro, requires HIF-1 for proper localization, and is expressed ubiquitously.
50	R09D1.13	R09D1.13	n/a	chrII 9,444,567	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)