UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nac-2	R107.1	0	chrIII 9,040,048	nac-2 encodes a high affinity sodium-coupled citrate transporter that is orthologous to the mammalian citrate transporter NaCT and is one of four C. elegans proteins related to Drosophila Indy; when expressed in a heterologous system, NAC-2 exhibits high affinity sodium/citrate and sodium/succinate cotransporter activity, although the transport rate for citrate is much higher than that for succinate; nac-2::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-2(RNAi) are variable, with reports of a 19% increase in lifespan accompanied by decreased body size and fat content in affected animals and reports of no apparent decrease in average lifespan.
2	fbxb-40	M01D1.9	n/a	chrII 1,049,413	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
3	Y70D2A.1	Y70D2A.1	n/a	chrX 14,922,327	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008365 (Prostanoid receptor), IPR000276 (GPCR, rhodopsin-like)
4	C14A6.8	C14A6.8	n/a	chrV 18,170,317	contains similarity to Gallus gallus Cellular tumor antigen p53 (Tumor suppressor p53).; SW:P53_CHICK
5	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
6	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
7	fbxb-51	K05F6.3	n/a	chrII 1,552,094	C. elegans FBXB-51 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
8	his-45	B0035.10	n/a	chrIV 11,326,794	his-45 encodes an H3 histone.
9	tag-81	T14G12.2	n/a	chrX 3,730,613	C. elegans TAG-81 protein; contains similarity to Interpro domain IPR000727 (Target SNARE coiled-coil region)
10	sri-1	F36G9.8	n/a	chrV 15,966,916	C. elegans SRI-1 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002208 (SecY protein)
11	kin-29	F58H12.1	n/a	chrX 2,848,198	kin-29 encodes a serine/threonine kinase with significant homology in the kinase domain to the AMP-activated protein kinase (AMPK) and SNF1 kinases; the AMP-kinase cascade is activated by cellular stresses that deplete ATP; AMP-kinase is believed to protect the mammalian cell by 'switching off' ATP-consuming pathways like fatty acid synthesis, by phosphorylating key regulatory enzymes, and switching on alternative pathways for ATP generation; kin-29 is involved in regulating the expression of chemosensory receptors and entry into the daur pathway; kin-29 also affects body size via interaction with the Sma/Mab pathway and lifespan, with mutants exhibiting a smaller body size and increased life span; a functional KIN-29-GFP fusion protein is expressed in sensory neurons and many other cell types, and localizes to the cytoplasm; under conditions of cellular stress like heat shock and starvation, KIN-29-GFP translocates to the nucleus.
12	C44H9.4	C44H9.4	n/a	chrV 12,837,723	contains similarity to Interpro domain IPR000839 (Porin, Oms28 type)
13	B0041.3	B0041.3	n/a	chrI 4,645,153	contains similarity to Pfam domain PF01476 LysM domain contains similarity to Interpro domain IPR002482 (Peptidoglycan-binding LysM)
14	srg-3	C18F10.6	n/a	chrIII 6,269,673	C. elegans SRG-3 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
15	T21E12.2	T21E12.2	n/a	chrI 4,414,499	contains similarity to Interpro domain IPR006162 (Phosphopantetheine attachment site)
16	srj-49	T03D3.12	n/a	chrV 2,847,294	C. elegans SRJ-49 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
17	fbxb-9	C08F8.5	n/a	chrIV 11,161,021	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
18	mab-7	ZC13.4	n/a	chrX 895,155	mab-7 encodes a protein with a hydrophobic type II transmembrane region at the N-terminus, an EGF-like motif, a ShKT motif and a long C-terminus; mab-7 is involved in morphogenesis of the male tail, specifically affecting the structural cells, neuronal processes and the hypodermal sheath of the sensory rays, as such, it affects mating in males; a mab-7 promoter-gfp construct is expressed in hypodermis, body seam, ray structural cells, and several neurons in the head and tail region.
19	sdz-31	T11A5.5	n/a	chrV 9,880,568	C. elegans SDZ-31 protein; contains similarity to Interpro domains IPR001376 (Gliadin, alpha/beta), IPR000896 (Hemocyanin, copper-containing)
20	ugt-7	C13D9.9	n/a	chrV 4,998,788	C. elegans UGT-7 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
21	fpn-1.3	R08F11.6	n/a	chrV 3,796,213	C. elegans FPN-1.3 protein; contains similarity to Pfam domain PF06963 Ferroportin1 (FPN1) contains similarity to Interpro domains IPR009716 (Ferroportin1), IPR016196 (MFS general substrate transporter)
22	daf-10	F23B2.4	n/a	chrIV 9,141,552	daf-10 encodes a WD- and WAA-repeat containing protein that is the C. elegans ortholog of intraflagellar transport (IFT) complex A component IFT122; daf-10 activity is required for intraflagellar transport and thus for proper development of amphid and phasmid neurons, dauer development, chemotaxis, and normal lifespan; a DAF-10::GFP fusion protein undergoes both anterograde and retrograde intraflagellar transport in amphid or phasmid sensory neurons.
23	F26A1.9	F26A1.9	n/a	chrIII 4,825,812
24	F26F2.7	F26F2.7	n/a	chrV 20,581,046	contains similarity to Pfam domain PF05346 Eukaryotic membrane protein family contains similarity to Interpro domain IPR008010 (Protein of unknown function DUF747, CMV receptor)
25	skr-6	Y37H2C.2	n/a	chrV 18,269,765	The skr-6 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-6(RNAi) animals are at least superficially normal.
26	stdh-4	F25G6.5	n/a	chrV 8,550,589	stdh-4 encodes a putative steroid dehydrogenase expressed in larval and adult pharynx; STDH-4 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-1/-3; STDH-4 has no obvious function in mass RNAi assays.
27	F13H6.4	F13H6.4	n/a	chrV 6,367,454	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
28	srj-57	T03D3.14	n/a	chrV 2,854,982	C. elegans SRJ-57 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
29	T27A8.1	T27A8.1	n/a	chrX 16,052,166	T27A8.1 encodes a putative metallocarboxypeptidase orthologous to human AEBP1 (OMIM:602981) and carboxypeptidase D, E, M, N, X2, and Z precursors; T27A8.1 and its human orthologs, along with other proteins, comprise an M14B peptidase subfamily; T27A8.1 has no obvious function in mass RNAi assays.
30	EEED8.12	EEED8.12	n/a	chrII 5,408,624	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
31	R57.2	R57.2	n/a	chrX 298,212	contains similarity to Pfam domain PF01682 DB module contains similarity to Interpro domain IPR002602 (Protein of unknown function DB)
32	knl-2	K06A5.4	n/a	chrI 6,462,350	C. elegans KNL-2 protein; contains similarity to Pfam domain PF09133 SANTA (SANT Associated) contains similarity to Interpro domain IPR015216 (SANT associated)
33	sru-3	C33A12.11	n/a	chrIV 9,497,224	C. elegans SRU-3 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
34	his-5	F45F2.3	n/a	chrV 8,535,370	his-5 encodes an H4 histone.
35	ZK1240.3	ZK1240.3	n/a	chrII 2,321,141	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000315 (Zinc finger, B-box)
36	str-178	R11D1.5	n/a	chrV 12,715,427	C. elegans STR-178 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	C32B5.9	C32B5.9	n/a	chrII 955,198
38	C31G12.3	C31G12.3	n/a	chrV 18,185,300	contains similarity to Rhodopirellula baltica Probable polysaccharide export protein.; TR:Q7UYB3
39	fbxa-57	C29F9.10	n/a	chrIII 106,751	C. elegans FBXA-57 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001986 (3-phosphoshikimate 1-carboxyvinyltransferase, core), IPR002900 (Protein of unknown function DUF38, Caenorhabditis species), IPR001810 (Cyclin-like F-box)
40	T27F6.7	T27F6.7	n/a	chrI 12,496,077	contains similarity to Timmia bavarica NADH dehydrogenase subunit 4 (Fragment).; TR:Q94YV9
41	fbxa-133	C38D9.4	n/a	chrV 17,585,301	C. elegans FBXA-133 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
42	set-12	K09F5.5	n/a	chrX 7,734,685	set-12 encodes a putative histone H3 lysine-9 methyltransferase with no non-nematode orthologs; neither set-12(n4442) nor set-12(RNAi) have any obvious phenotypes.
43	srbc-81	Y45G12C.8	n/a	chrV 2,523,361	C. elegans SRBC-81 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR002229 (Blood group Rhesus C/E and D polypeptide)
44	R151.1	R151.1	n/a	chrIII 7,218,656
45	C39E9.7	C39E9.7	n/a	chrIV 13,074,688	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
46	cdh-3	ZK112.7	n/a	chrIII 7,747,815	cdh-3 encodes a member of the cadherin superfamily that affects morphogenesis of tail epithelia and excretory function; expressed predominantly in developing epithelial cells, and also expressed in the AC, excretory cell, various neurons, and vulval cells during different stages of development.
47	C37E2.3	C37E2.3	n/a	chrX 14,180,268	contains similarity to Pfam domain PF04750 FAR-17a/AIG1-like protein contains similarity to Interpro domains IPR006838 (FAR-17a/AIG1-like protein), IPR002208 (SecY protein)
48	H02F09.2	H02F09.2	n/a	chrX 1,573,611
49	srd-69	H04J21.2	n/a	chrIII 2,364,601	C. elegans SRD-69 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
50	Y102A5C.27	Y102A5C.27	n/a	chrV 16,988,446	contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)