UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	R07E3.6	R07E3.6	2e-165	chrX 10,319,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
2	ptr-15	T07H8.6	n/a	chrV 6,968,181	ptr-15 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-15 has no known function in vivo.
3	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
4	F52F10.2	F52F10.2	n/a	chrV 1,549,423	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
5	F22F4.1	F22F4.1	n/a	chrX 6,005,723
6	M153.1	M153.1	n/a	chrX 12,147,684	contains similarity to Pfam domains PF03807 (NADP oxidoreductase coenzyme F420-dependent) , PF01210 (NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus) contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR011128 (NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal), IPR016040 (NAD(P)-binding)
7	F20G2.3	F20G2.3	n/a	chrV 13,767,197	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
8	zbed-6	F25H8.6	n/a	chrIV 9,919,215	zbed-6 encodes a protein that contains a BED-type zinc finger domain; loss of zbed-6 activity in large-scale RNAi screens indicates that zbed-6 is required for larval development.
9	B0395.2	B0395.2	n/a	chrX 16,032,720	contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)
10	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
11	sym-5	C44H4.2	n/a	chrX 14,579,420	sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth.
12	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
13	C52D10.1	C52D10.1	n/a	chrIV 17,188,302	contains similarity to Interpro domain IPR011935 (Conserved hypothetical protein CHP02231)
14	ZC434.3	ZC434.3	n/a	chrI 10,334,634	contains similarity to Interpro domain IPR000931 (Adenovirus fibre protein)
15	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
16	C26B9.3	C26B9.3	n/a	chrX 5,339,194
17	T03G6.1	T03G6.1	n/a	chrX 2,609,102
18	R05G6.9	R05G6.9	n/a	chrIV 7,515,301	R05G9.6 encodes a protein with a predicted signal sequence and EGF-like repeats that are related to those of Notch family members.
19	F18C5.5	F18C5.5	n/a	chrII 6,566,049	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR002373 (cAMP/cGMP-dependent protein kinase)
20	F46C8.8	F46C8.8	n/a	chrX 7,552,792
21	col-17	F11G11.10	n/a	chrII 4,866,996	col-17 encodes a collagen which is expressed in all developmental stages except eggs, like col-15, col-16, and col-20; collagen genes with this expression pattern may be used for synthesis of cuticles after the L1 stage (e.g., the L4 cuticle).
22	his-41	C50F4.5	n/a	chrV 9,546,148	his-41 encodes an H2B histone.
23	F47B10.2	F47B10.2	n/a	chrX 10,894,920	F47B10.2 is orthologous to the human gene HISTIDASE (HAL; OMIM:235800), which when mutated leads to disease.
24	Y38H8A.1	Y38H8A.1	n/a	chrIV 13,484,496	contains similarity to Homo sapiens NCOR isoform b; ENSEMBL:ENSP00000323172
25	grl-15	Y75B8A.20	n/a	chrIII 12,234,051	grl-15 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-15 is expressed in the reproductive system, vulva, and larval hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
26	W08A12.3	W08A12.3	n/a	chrV 3,683,717
27	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
28	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
29	C06A6.5	C06A6.5	n/a	chrIV 7,833,492	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
30	lgc-22	F15E6.2	n/a	chrIV 4,302,863	C. elegans LGC-22 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR003582 (Metridin-like ShK toxin)
31	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
32	ZK1025.7	ZK1025.7	n/a	chrI 11,466,357	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
33	T22D1.4	T22D1.4	n/a	chrIV 6,911,758	contains similarity to Pfam domain PF04597 Ribophorin I contains similarity to Interpro domain IPR007676 (Ribophorin I)
34	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
35	ifp-1	C43C3.1	n/a	chrX 9,677,940	ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays.
36	mig-23	R07E4.4	n/a	chrX 5,947,305	mig-23 encodes a nucleoside diphosphatase (NDPase); during larval development, MIG-23 activity is required, in body wall muscle cells, for proper dorsalward migration of the gonadal distal tip cells (DTCs) and gonad morphogenesis via regulation of MIG-17 N-glycosylation; animals lacking MIG-23 exhibit weaker UDP-, ADP-, and GDP-hydrolysing activity and when expressed in yeast lacking apyrase genes, MIG-23 can rescue NDPase activity; when expressed in body wall muscle under the control of the unc-54 promoter, MIG-23 rescues DTC migration defects and shows a punctate cytoplasmic expression pattern similar to that of Golgi enzymes.
37	wrt-2	F52E4.6	n/a	chrX 3,093,375	wrt-2 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-2 is expressed in seam cells and hypodermal syncytia; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly required for normal molting; WRT-2 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallel the derepression of Drosophila eyes absent by HEDGEHOG.
38	T16G1.2	T16G1.2	n/a	chrV 12,931,137	contains similarity to Interpro domain IPR000694 (Proline-rich region)
39	ZC13.3	ZC13.3	n/a	chrX 885,679	contains similarity to Interpro domain IPR000998 (MAM)
40	R07G3.6	R07G3.6	n/a	chrII 7,604,709	contains similarity to Interpro domain IPR000694 (Proline-rich region)
41	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
43	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
44	C27C7.2	C27C7.2	n/a	chrI 11,433,261	contains similarity to Pfam domain PF01697 (Domain of unknown function)
45	nas-15	T04G9.2	n/a	chrX 779,117	nas-15 encodes an astacin-like metalloprotease.
46	osr-1	C32E12.3	n/a	chrI 5,201,845	C. elegans OSR-1 protein ; contains similarity to Schizosaccharomyces pombe Uncharacterized protein C29E6.10c.; SW:Q09863
47	pqn-40	F52D1.3	n/a	chrX 454,005	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
48	C34F6.8	C34F6.8	n/a	chrX 11,216,944	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004790 (Isocitrate dehydrogenase NADP-dependent, eukaryotic), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
49	M03F4.6	M03F4.6	n/a	chrX 4,966,692	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR006150 (Cysteine-rich repeat), IPR009030 (Growth factor, receptor), IPR006149 (Nematode-specific EB region)
50	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)