UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	bub-1	R06C7.8	0	chrI 7,253,581	bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages.
2	tac-1	Y54E2A.3	n/a	chrII 14,753,292	tac-1 encodes the sole C. elegans member of the transforming acidic coiled-coil (TACC) protein family whose members contain highly conserved C-terminal coiled-coil domains; during early embryogenesis, TAC-1 activity is essential for such microtubule-based processes as pronuclear migration and mitotic spindle elongation; TAC-1 interacts in vivo with, and mutually stabilizes, ZYG-9, a microtubule-associated protein (MAP) also required for pronuclear migration; TAC-1 also interacts with ZYG-8, a kinase domain-containing MAP required for proper spindle positioning during anaphase of the first embryonic cell division; TAC-1 is a core component of centrosomes, and also localizes to the meiotic spindle poles, the mitotic spindle, and the cytoplasm.
3	T01D3.5	T01D3.5	n/a	chrV 13,714,119	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
4	F17A9.2	F17A9.2	n/a	chrV 6,111,285	contains similarity to Pfam domains PF04676 (Protein similar to CwfJ C-terminus 2) , PF04677 (Protein similar to CwfJ C-terminus 1) contains similarity to Interpro domains IPR006768 (Protein similar to CwfJ, C-terminal 1), IPR006767 (Protein similar to CwfJ, C-terminal 2), IPR011146 (Histidine triad-like motif)
5	F52C9.7	F52C9.7	n/a	chrIII 5,309,798	contains similarity to Interpro domain IPR002226 (Catalase)
6	F17A9.3	F17A9.3	n/a	chrV 6,106,582	contains similarity to Pfam domain PF07716 Basic region leucine zipper contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
7	R08D7.1	R08D7.1	n/a	chrIII 8,966,795	contains similarity to Drosophila pseudoobscura GA12417-PA (Fragment).; TR:Q293H8
8	btf-1	F15D4.1	n/a	chrII 13,207,846	btf-1 encodes a member of the TBP-associated family (TAF), with weak similarity to human TBP-associated factor 172.
9	mat-3	F10C5.1	n/a	chrIII 478,879	mat-3 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of CDC23/APC8, a conserved regulatory subunit of the anaphase-promoting complex; mat-3 activity is required for progression through metaphase of oocyte meiosis I, germline proliferation, and vulval development.
10	rle-1	M142.6	n/a	chrIII 10,941,254	C. elegans RLE-1 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
11	T03G11.6	T03G11.6	n/a	chrX 5,178,330	contains similarity to Pfam domains PF05219 (DREV methyltransferase) , PF08242 (Methyltransferase domain) contains similarity to Interpro domains IPR013217 (Methyltransferase type 12), IPR007884 (DREV methyltransferase)
12	C03H5.3	C03H5.3	n/a	chrII 387,056	contains similarity to Interpro domain IPR002408 (Natriuretic peptide, brain type)
13	M03C11.8	M03C11.8	n/a	chrIII 10,432,042	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR002048 (Calcium-binding EF-hand), IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
14	pqn-20	C37A2.2	n/a	chrI 6,794,248	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
15	T24C4.7	T24C4.7	n/a	chrIII 893,471	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR007087 (Zinc finger, C2H2-type)
16	ZK632.5	ZK632.5	n/a	chrIII 9,810,489	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:O97236
17	T12E12.2	T12E12.2	n/a	chrIV 5,546,641	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like)
18	F44E2.8	F44E2.8	n/a	chrIII 8,849,158	contains similarity to Pfam domain PF08719 Domain of unknown function (DUF1768) contains similarity to Interpro domain IPR012816 (Conserved hypothetical protein CHP02464)
19	ent-1	ZK809.4	n/a	chrIV 11,654,417	ent-1 encodes a predicted equilibrative nucleoside transporter 1 that affects growth.
20	mix-1	M106.1	n/a	chrII 10,832,781	The mix-1 gene encodes a homolog of SMC2 involved in chromosome segregation, X-chromosome gene regulation, and repression of X-linked genes during dosage compensation.
21	abu-3	F31A3.1	n/a	chrX 17,553,848	abu-3 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-3 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum (ER), and ABU-3 may function within the ER to protect the organism from damage by improperly folded nascent protein; abu-3 expression is enhanced in ER-stressed animals in which the unfolded protein response (UPR) is blocked by mutations in xbp-1, a bZIP transcription factor.
22	aspm-1	C45G3.1	n/a	chrI 9,224,107	The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion.
23	bub-3	Y54G9A.6	n/a	chrII 13,727,744	C. elegans BUB-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
24	K07C5.3	K07C5.3	n/a	chrV 10,344,230	contains similarity to Pfam domain PF00645 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region contains similarity to Interpro domain IPR001510 (Zinc finger, PARP-type)
25	npp-11	F53F10.5	n/a	chrI 3,819,703	C. elegans NPP-11 protein; contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000104 (Antifreeze protein, type I), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR007758 (Nucleoporin, Nsp1-like, C-terminal)
26	C55A6.9	C55A6.9	n/a	chrV 11,522,512	contains similarity to Pfam domain PF03985 Paf1 contains similarity to Interpro domain IPR007133 (RNA polymerase II-associated, Paf1)
27	F58G11.6	F58G11.6	n/a	chrV 13,680,190	F58G11.6 (also known as ccz-1 or hps-4) encodes an ortholog of human C7orf28A and C7orf28B, with more distant similarity to human HPS4 (OMIM:606682) and S. cerevisiae Ccz1p in its N-terminal CHiPS domain; the CHiPS domain of F58G11.6 is predicted to have a longin-like fold; by analogy with Ccz1p and C. elegans SAND-1, F58G11.6 might be required for normal (RAB-7-mediated) traffic between early and late endosomes, or for autophagy; F58G11.6 is bound by SAND-1.
28	F44E7.9	F44E7.9	n/a	chrV 5,791,637	contains similarity to Pfam domain PF07019 Rab5-interacting protein (Rab5ip) contains similarity to Interpro domain IPR010742 (Rab5-interacting)
29	K02B2.1	K02B2.1	n/a	chrIV 5,942,943	contains similarity to Pfam domains PF01591 (6-phosphofructo-2-kinase) , PF00300 (Phosphoglycerate mutase family) contains similarity to Interpro domains IPR016260 (Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase), IPR001345 (Phosphoglycerate/bisphosphoglycerate mutase), IPR003094 (Fructose-2,6-bisphosphatase), IPR013079 (6-phosphofructo-2-kinase), IPR013078 (Phosphoglycerate mutase)
30	K08D10.1	K08D10.1	n/a	chrIV 4,182,875	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
31	K08F4.1	K08F4.1	n/a	chrIV 10,124,631	contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR001199 (Cytochrome b5), IPR003593 (AAA+ ATPase, core)
32	R01H10.7	R01H10.7	n/a	chrIII 10,264,464	contains similarity to Interpro domain IPR001849 (Pleckstrin-like)
33	F32B6.3	F32B6.3	n/a	chrIV 9,883,182	contains similarity to Pfam domains PF02840 (Prp18 domain) , PF08799 (pre-mRNA processing factor 4 (PRP4) like) contains similarity to Interpro domains IPR014906 (Pre-mRNA processing factor 4 (PRP4) like), IPR003648 (Splicing factor motif), IPR004098 (Prp18)
34	cyn-7	Y75B12B.2	n/a	chrV 15,186,997	cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays.
35	tag-135	D1054.15	n/a	chrV 10,807,021	C. elegans TAG-135 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR009146 (Groucho/transducin-like enhancer), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
36	C03H5.2	C03H5.2	n/a	chrII 390,779	C03H5.2 encodes a transporter of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc), orthologous to human SLC35A3 (OMIM:605632); CO3H5.2 is redundantly required, with its paralog SRF-3, for normal progression of oocytes through proximal gonads and for normal gonad morphology; C03H5.2 is expressed in many tissues, including pharynx, intestine, pharyngeal gland cells, seam cells, spermatheca, vulva, various muscles, hypodermis, and neurons; C03H5.2 transports both UDP-GlcNAc and UDP-GalNAc independently and simultaneously, with these two molecules neither competing with one another nor being transported as a heterodimer; C03H5.2's two transport activities are genetically separable, since an internally deleted version of C03H5.2 (lacking only 16 residues) retains normal levels of UDP-GlcNAc transport while losing 85-90% of its UDP-GalNAc transport activity; C03H5.2's activity has been experimentally validated through heterologous expression in budding yeast Golgi apparatus, and mutation of C03H5.2 in conserved residues greatly reduces this activity.
37	bag-1	F57B10.11	n/a	chrI 6,564,081	A homolog of the human BAG-family of co-chaperone proteins, negatively regulates Hsp70 and affects cell stress and cell growth.
38	ath-1	K04G2.5	n/a	chrI 8,037,923	C. elegans ATH-1 protein; contains similarity to Pfam domain PF02230 Phospholipase/Carboxylesterase contains similarity to Interpro domains IPR003140 (Phospholipase/carboxylesterase), IPR003089 (Alpha/beta hydrolase)
39	C27A12.9	C27A12.9	n/a	chrI 6,064,908	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
40	Y47H9C.8	Y47H9C.8	n/a	chrI 11,895,073	contains similarity to Streptococcus pneumoniae Magnesium transporter, CorA family.; TR:Q97SX8
41	cash-1	K07C5.8	n/a	chrV 10,364,141	cash-1 encodes an ortholog of Drosophila CKA and the human striatins STRN, STRN3, and STRN4 that is required for vulval development; CASH-1 has an N-terminal region which may bind caveolin or calmodulin, and a C-terminal region with five tandem WD domains; by its orthology with CKA and striatins, CASH-1 is predicted to act as a scaffold linking signal transduction proteins (such as JKK-1 and JNK-1) to transcription factors (such as JUN-1 or FOS-1); CASH-1 is expressed broadly, in both larval and adult pharynx, intestine, rectal epithelium, hypodermis, and neurons, as well as the developing vulva and the adult reproductive system.
42	F25H2.4	F25H2.4	n/a	chrI 10,552,463	contains similarity to Pfam domain PF03665 Uncharacterised protein family (UPF0172) contains similarity to Interpro domain IPR005366 (Protein of unknown function UPF0172)
43	Y54E5A.7	Y54E5A.7	n/a	chrI 14,713,042	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR006594 (LisH dimerisation motif), IPR006595 (CTLH, C-terminal to LisH motif), IPR003877 (SPla/RYanodine receptor SPRY)
44	tag-72	C25A1.3	n/a	chrI 10,160,921	C. elegans TAG-72 protein; contains similarity to Pfam domains PF03291 (mRNA capping enzyme) , PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR004971 (mRNA capping enzyme, large subunit), IPR016899 (mRNA (guanine-N(7))-methyltransferase), IPR002296 (N6 adenine-specific DNA methyltransferase, N12 class), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
45	T07F8.4	T07F8.4	n/a	chrII 7,131,218	contains similarity to Pfam domain PF01448 ELM2 domain contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR000949 (ELM2)
46	vps-37	CD4.4	n/a	chrV 5,593,134	C. elegans VPS-37 protein; contains similarity to Pfam domain PF07200 Modifier of rudimentary (Mod(r)) protein contains similarity to Interpro domain IPR009851 (Modifier of rudimentary, Modr)
47	Y106G6D.7	Y106G6D.7	n/a	chrI 10,126,327	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
48	R12E2.1	R12E2.1	n/a	chrI 4,183,608	contains similarity to Pfam domains PF01344 (Kelch motif) (5), PF00651 (BTB/POZ domain) , PF07707 (BTB And C-terminal Kelch) , PF07646 (Kelch motif) (3)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR017096 (Kelch-like protein, gigaxonin), IPR000210 (BTB/POZ-like), IPR006652 (Kelch repeat type 1), IPR011333 (BTB/POZ fold), IPR011498 (Kelch repeat type 2), IPR015916 (Galactose oxidase, beta-propeller), IPR013069 (BTB/POZ), IPR011705 (BTB/Kelch-associated), IPR013089 (Kelch related), IPR006651 (Kelch), IPR015915 (Kelch-type beta propeller)
49	K10B2.4	K10B2.4	n/a	chrII 6,360,595	contains similarity to Pfam domain PF03669 Uncharacterised protein family (UPF0139) contains similarity to Interpro domain IPR005351 (Protein of unknown function UPF0139)
50	arx-7	M01B12.3	n/a	chrI 3,069,767	arx-7 encodes the C. elegans ortholog of the p16Arc subunit of the actin-related protein (Arp)2/3 complex.