UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	R05D7.4	R05D7.4	8.000000000000001e-175	chrI 12,182,156	contains similarity to Pfam domains PF07819 (PGAP1-like protein) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR012908 (PGAP1-like), IPR000639 (Epoxide hydrolase-like), IPR008262 (Lipase, active site), IPR003089 (Alpha/beta hydrolase)
2	abf-4	Y38H6C.22	n/a	chrV 20,553,545	abf-4 encodes a homolog of the antibacterial factor ASABF from Ascaris suum; ABF-4 may play a role in innate immunity, though at present the only evidence for its having an antimicrobial humoral function is its sequence similarity.
3	fozi-1	K01B6.1	n/a	chrIII 9,291,244	fozi-1 encodes an unusual zinc-finger protein that has two C2H2 zinc-finger motifs that probably mediate transcriptional regulation along with a glutamine-rich region and a vestigial formin homology 2 (FH2) domain that has lost its ability to polymerize actin but retained its ability to dimerize; during postembryonic development, FOZI-1 acts with MAB-5 and redundantly with HLH-1/CeMyoD to autonomously specify coelomocyte and striated body wall muscle fates; in addition, fozi-1 is required for the fully asymmetrical phenotypic distinction of ASER cells from ASEL cells; fozi-1 mutant animals variably express flp-4, gcy-6, gcy-7 and lim-6, genes normally restricted to ASEL, in ASER as well, while maintaining expression of ASER-specific genes; ectopic FOZI-1 expression in ASEL can suppress lim-6 expression; fozi-1 genetically interacts with several regulatory proteins and miRNAs; FOZI-1 is a nuclear protein that is expressed in neuronal lineages beginning at the 2-fold stage of embryogenesis, and then in neurons and cells derived from the M mesoblast during larval development; expression in the M lineage corresponds to cells that will generate coelomocytes and body wall muscles and is not seen in the sex myoblasts (SMs); FOZI-1 expression in the M lineage requires the Hox co-factor CEH-20.
4	F13D2.4	F13D2.4	n/a	chrX 11,188,488	contains similarity to Homo sapiens Isoform 3 of CD109 antigen precursor; HI:HIT000020743
5	K03H6.1	K03H6.1	n/a	chrIV 1,525,035	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
6	sid-2	ZK520.2	n/a	chrIII 13,680,827	sid-2 encodes a novel, single-pass transmembrane protein; SID-2 is required for environmental-mediated (i.e. ingestion or soaking) RNA interference (RNAi); SID-2::GFP is expressed strongly in the intestine where it localizes to the apical (lumenal) membrane; SID-2::GFP is also expressed at much lower levels in the excretory duct cells; when expressed in Caenorhabditis briggsae, a related nematode species deficient for environmental RNAi, SID-2 is able to confer environmental RNAi.
7	nep-2	T05A8.4	n/a	chrII 2,721,578	T05A8.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T05A8.4 is an ortholog of mammalian neutral endopeptidase (NEP), expressed on the brush-border membranes of kidney; more generally, T05A8.4 falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
8	F55A4.2	F55A4.2	n/a	chrX 1,015,147
9	W05B5.2	W05B5.2	n/a	chrI 13,052,842	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002286 (P2 purinoceptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
10	hsp-16.48	T27E4.3	n/a	chrV 9,088,350	hsp-16.48 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.48 reporter fusion, expressed broadly but most strongly in body muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.48 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.
11	E03A3.5	E03A3.5	n/a	chrIII 4,061,679	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold)
12	F58F9.1	F58F9.1	n/a	chrIV 6,251,691	contains similarity to Pfam domain PF00268 Ribonucleotide reductase, small chain contains similarity to Interpro domains IPR012348 (Ribonucleotide reductase-related), IPR000358 (Ribonucleotide reductase), IPR009078 (Ferritin/ribonucleotide reductase-like)
13	K08B12.3	K08B12.3	n/a	chrV 6,236,378	contains similarity to Pfam domain PF00702 haloacid dehalogenase-like hydrolase contains similarity to Interpro domains IPR006355 (HAD-superfamily hydrolase, subfamily IIA, hypothetical 2), IPR006357 (HAD-superfamily hydrolase, subfamily IIA), IPR005834 (Haloacid dehalogenase-like hydrolase)
14	Y37H9A.3	Y37H9A.3	n/a	chrI 13,785,519	contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000694 (Proline-rich region), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR006608 (Protein of unknown function DM14), IPR000008 (C2 calcium-dependent membrane targeting)
15	gur-4	K09E4.5	n/a	chrII 14,106,298	C. elegans GUR-4 protein ;
16	nit-1	ZK1058.6	n/a	chrIII 3,923,096	C. elegans NIT-1 protein; contains similarity to Pfam domain PF00795 Carbon-nitrogen hydrolase contains similarity to Interpro domains IPR003010 (Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase), IPR000132 (Nitrilase/cyanide hydratase, conserved site)
17	K04A8.3	K04A8.3	n/a	chrV 6,559,849
18	C39F7.1	C39F7.1	n/a	chrV 1,261,350
19	Y39A1A.17	Y39A1A.17	n/a	chrIII 10,688,996	contains similarity to Interpro domain IPR001611 (Leucine-rich repeat)
20	T07D3.4	T07D3.4	n/a	chrII 889,513	T07D3.4 is orthologous to the human gene FUKUTIN (FCMD; OMIM:253800), which when mutated leads to disease.
21	sri-10	C54E10.4	n/a	chrV 18,805,260	C. elegans SRI-10 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR016040 (NAD(P)-binding)
22	D2023.3	D2023.3	n/a	chrV 11,804,015	contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
23	frm-7	C51F7.1	n/a	chrV 12,304,705	C. elegans FRM-7 protein; contains similarity to Interpro domains IPR011993 (Pleckstrin homology-type), IPR014352 (FERM/acyl-CoA-binding protein, 3-helical bundle), IPR000299 (Band 4.1, N-terminal)
24	F55G7.1	F55G7.1	n/a	chrX 11,925,643	contains similarity to Galleria mellonella Sericin-2 (Silk gum protein 2) (Fragment).; SW:SER2_GALME
25	fbxa-148	Y102A5C.9	n/a	chrV 16,939,509	C. elegans FBXA-148 protein; contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
26	sprr-1	R03A10.6	n/a	chrX 15,467,342	C. elegans SPRR-1 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
27	C45G7.4	C45G7.4	n/a	chrIV 2,434,709	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
28	srb-6	R05H5.6	n/a	chrII 10,195,792	C. elegans SRB-6 protein; contains similarity to Pfam domains PF02117 (C.elegans Sra family integral membrane protein) , PF02175 (C.elegans integral membrane protein Srb) contains similarity to Interpro domains IPR002184 (Serpentine beta receptor), IPR000344 (Nematode chemoreceptor, Sra)
29	F42G9.4	F42G9.4	n/a	chrIII 761,894
30	tag-96	M01D7.4	n/a	chrI 1,847,837	tag-96 encodes a galactokinase that is a member of the GHMP family of kinases and closely related to the vertebrate galactokinase 2 (GALK2) carbohydrate kinases.
31	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
32	cmk-1	K07A9.2	n/a	chrIV 1,829,288	cmk-1 encodes a Ca+2/calmodulin-dependent protein kinase I (CaMK1); CMK-1 activity is required, cell autonomously and downstream of the cyclic nucleotide-gated channel TAX-4, for several aspects of AFD thermosensory neuron differentiation, including expression of the gcy-8 guanylyl cyclase and nhr-38 nuclear hormone receptor genes and morphology of the AFD sensory endings; cmk-1 activity is thus also required for normal thermosensory behavior; a cmk-1::gfp reporter is expressed in head sensory and interneurons as well as in the ventral nerve cord; expression is seen specifically in the neurons of the thermosensory circuit, AFD, AIY, and AIZ; CMK-1 localizes exclusively to the cytoplasm.
33	ugt-42	F31F4.7	n/a	chrV 648,465	C. elegans UGT-42 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
34	shw-3	R186.5	n/a	chrV 12,974,845	C. elegans SHW-3 protein; contains similarity to Pfam domains PF02214 (K+ channel tetramerisation domain) , PF07885 (Ion channel) , PF00520 (Ion transport protein) contains similarity to Interpro domains IPR005821 (Ion transport), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003973 (Potassium channel, voltage dependent, Kv2), IPR003970 (Potassium channel, voltage dependent, Kv8), IPR003971 (Potassium channel, voltage dependent, Kv9), IPR003968 (Potassium channel, voltage dependent, Kv), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation), IPR003969 (Potassium channel, voltage dependent, Kv6), IPR003091 (Voltage-dependent potassium channel), IPR013099 (Ion transport 2), IPR003974 (Potassium channel, voltage dependent, Kv3)
35	ZK1067.4	ZK1067.4	n/a	chrII 9,211,645	ZK1067.4 is orthologous to the human gene PROTEOLIPID PROTEIN 1 (PLP1; OMIM:300401), encoding the primary constituent of myelin, which when mutated leads to Pelizaeus-Merzbacher disease (OMIM:312080).
36	C32D5.7	C32D5.7	n/a	chrII 6,337,900
37	ugt-20	K08B4.4	n/a	chrIV 6,082,263	C. elegans UGT-20 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
38	F38C2.4	F38C2.4	n/a	chrIV 16,270,980	contains similarity to Pfam domain PF05050 Protein of unknown function (DUF672) contains similarity to Interpro domain IPR007744 (Protein of unknown function DUF672)
39	F40F4.7	F40F4.7	n/a	chrX 3,244,931	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
40	R07A4.3	R07A4.3	n/a	chrX 10,756,469	contains similarity to Interpro domain IPR000694 (Proline-rich region)
41	C01F1.4	C01F1.4	n/a	chrII 4,277,663	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
42	lev-1	F09E8.7	n/a	chrIV 13,176,746	lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3.
43	F59A3.10	F59A3.10	n/a	chrI 5,542,985
44	F19C7.4	F19C7.4	n/a	chrIV 4,604,373	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
45	C36B7.2	C36B7.2	n/a	chrX 7,106,598	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
46	srsx-35	F53F8.2	n/a	chrV 20,677,605	C. elegans SRSX-35 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR013305 (ABC transporter, ABCB2), IPR000276 (GPCR, rhodopsin-like)
47	K01A12.3	K01A12.3	n/a	chrX 8,622,819	contains similarity to Interpro domain IPR000276 (GPCR, rhodopsin-like)
48	unc-120	D1081.2	n/a	chrI 8,461,612	unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.
49	lact-3	M28.6	n/a	chrII 10,654,998	lact-3 encodes a beta-lactamase domain-containing protein that contains a predicted signal sequence; loss of lact-3 activity via RNAi has been reported to result in reduced fat content.
50	rgs-6	C41G11.3	n/a	chrX 5,724,513	rgs-6 encodes a regulator of G protein signaling; by homology, RGS-6 is predicted to function as a GTPase-activating protein that binds G protein alpha subunits and negatively regulates heterotrimeric G protein signaling; loss of rgs-6 activity via RNAi or a deletion mutation results in no obvious defects, and likewise, rgs-6 overexpression has no measurable effect on egg-laying behavior, locomotion, or viability; the rgs-6 expression pattern has not yet been reported.