UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	R05C11.3	R05C11.3	0	chrIV 2,087,977	R05C11.3 encodes a calcium-transporting ATPase; large-scale RNAi screens indicate that R05C11.3 activity is required for locomotion and normal rates of postembryonic growth.
2	hex-2	C14C11.3	n/a	chrV 5,656,509	hex-2 encodes a beta-N-acetylhexosaminidase.
3	F40F4.6	F40F4.6	n/a	chrX 3,239,686	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) , PF07974 (EGF-like domain) contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR016187 (C-type lectin fold), IPR001881 (EGF-like calcium-binding), IPR016186 (C-type lectin-like), IPR013032 (EGF-like region, conserved site), IPR001304 (C-type lectin), IPR013111 (EGF, extracellular), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans), IPR002035 (von Willebrand factor, type A)
4	pmp-1	C44B7.8	n/a	chrII 6,882,170	pmp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the peroxisomal membrane proteins; pmp-1 activity is required for efficient RNA interference (RNAi) of a germline-expressed target, pop-1.
5	daf-6	F31F6.5	n/a	chrX 14,891,298	daf-6 is required for an unidentified function of the nonneuronal amphidial sheath cells that promotes correct morphology of both the amphid and the outer labial sensilla; daf-6 mutants disrupt the joining of the amphid sheath and socket cells to form the receptor channel, and display defects in several distinct functions including formation of dauer larvae, chemotaxis, osmotic avoidance, male mating, negative regulation of lifespan, negative regulation of ASJ's axonal growth late in development, and dye uptake by amphids and phasmids; daf-6 has recently been reported to be identical to the coding sequence ptr-7/F31F6.5, but this assertion has not yet been verified by transgenic rescue.
6	cdh-7	R05H10.6	n/a	chrII 14,846,930	cdh-7 encodes a protein that contains a cadherin domain.
7	T14G11.3	T14G11.3	n/a	chrX 2,684,999	contains similarity to Homo sapiens inner membrane protein, mitochondrial isoform 2; ENSEMBL:ENSP00000366526
8	lst-2	R160.7	n/a	chrX 4,380,673	C. elegans LST-2 protein; contains similarity to Pfam domain PF01363 FYVE zinc finger contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
9	prp-8	C50C3.6	n/a	chrIII 8,168,465	prp-8 is orthologous to the human gene SIMILAR TO U5 SNRNP-SPECIFIC PROTEIN (220 KD), ORTHOLOG OF S.
10	gst-38	F35E8.8	n/a	chrV 15,915,638	C. elegans GST-38 protein; contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
11	F35C11.4	F35C11.4	n/a	chrII 8,250,751	contains similarity to Homo sapiens Uncharacterized protein C9orf125; ENSEMBL:ENSP00000363980
12	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
13	T20D4.3	T20D4.3	n/a	chrV 3,420,496	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
14	gei-18	Y37A1B.15	n/a	chrIV 13,981,773	C. elegans GEI-18 protein ;
15	cyc-1	C54G4.8	n/a	chrI 8,023,821	cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial
16	M01G12.9	M01G12.9	n/a	chrI 12,111,806	contains similarity to Lactococcus lactis ORF (Fragment).; TR:Q48730
17	M02F4.3	M02F4.3	n/a	chrX 3,038,574	M02F4.3 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6, C33D12.2, C52D10.12, R04E5.2, and R13G10.4; by orthology with MAM3, M02F4.3 may participate in metal homoeostasis; M02F4.3, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; M02F4.3 has no obvious function in RNAi assays.
18	pgp-4	F42E11.1	n/a	chrX 11,361,531	pgp-4 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-4 activity via deletion mutations or RNAi results in no obvious defects, the precise role of PGP-4 in C. elegans development and/or behavior is not yet known; pgp-4 promoter-gfp fusion proteins are expressed in the larval excretory cell.
19	Y18D10A.8	Y18D10A.8	n/a	chrI 12,848,697	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR016021 (MIF4-like, type 1/2/3), IPR004087 (K Homology), IPR000694 (Proline-rich region), IPR004088 (K Homology, type 1), IPR016024 (Armadillo-type fold)
20	tufm-2	C43E11.4	n/a	chrI 4,248,543	C. elegans TUFM-2 protein; contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005225 (Small GTP-binding protein), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
21	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
22	ldh-1	F13D12.2	n/a	chrII 11,725,839	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
23	twk-42	W06D12.2	n/a	chrV 17,728,557	C. elegans TWK-42 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
24	cyp-37A1	F01D5.9	n/a	chrII 14,015,298	C. elegans CYP-37A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV)
25	nuo-1	C09H10.3	n/a	chrII 11,099,005	nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
26	E02A10.1	E02A10.1	n/a	chrV 12,564,567	contains similarity to Pfam domains PF00333 (Ribosomal protein S5, N-terminal domain) , PF03719 (Ribosomal protein S5, C-terminal domain) contains similarity to Interpro domains IPR014720 (Double-stranded RNA-binding-like), IPR013810 (Ribosomal protein S5, N-terminal), IPR005324 (Ribosomal protein S5, C-terminal), IPR000851 (Ribosomal protein S5), IPR014721 (Ribosomal protein S5 domain 2-type fold)
27	Y45G12C.1	Y45G12C.1	n/a	chrV 2,567,280	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
28	C11E4.6	C11E4.6	n/a	chrX 9,613,728	contains similarity to Pfam domains PF07647 (SAM domain (Sterile alpha motif)) , PF00640 (Phosphotyrosine interaction domain (PTB/PID)) , PF00023 (Ankyrin repeat) (5), PF00536 (SAM domain (Sterile alpha motif)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR011993 (Pleckstrin homology-type), IPR002110 (Ankyrin), IPR013761 (Sterile alpha motif-type), IPR001660 (Sterile alpha motif SAM), IPR011510 (Sterile alpha motif homology 2), IPR006020 (Phosphotyrosine interaction region)
29	F23H12.5	F23H12.5	n/a	chrV 12,361,146	contains similarity to Interpro domains IPR008085 (Thrombospondin, subtype 1), IPR000884 (Thrombospondin, type I)
30	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
31	abt-4	Y39D8C.1	n/a	chrV 327,261	abt-4 encodes a predicted ATP-binding cassette (ABC) transporter that is a member of the ABCA subfamily of transport proteins; ABT-4 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of abt-4 activity via RNAi results in no obvious defects, the precise role of abt-4 in C. elegans development and/or behavior is not yet known; abt-4 promoter-gfp fusion proteins are widely expressed in larvae and adults, with expression seen in the pharynx, the pharyngeal-intestinal valve, the intestine, renal gland cells, hypodermis, various neurons, and unidentified cells in the head and tail.
32	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
33	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
34	W10G11.19	W10G11.19	n/a	chrII 3,552,038	contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR000886 (Endoplasmic reticulum, targeting sequence)
35	F37H8.5	F37H8.5	n/a	chrII 11,188,743	contains similarity to Pfam domain PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT) contains similarity to Interpro domain IPR004911 (Gamma interferon inducible lysosomal thiol reductase GILT)
36	abu-7	C03A7.8	n/a	chrV 5,164,061	abu-7 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-7 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-7 may help protect the organism from damage by improperly folded nascent protein.
37	pgp-3	ZK455.7	n/a	chrX 11,354,551	pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells; loss of pgp-3 activity via large-scale RNAi screens does not result in any obvious abnormalities.
38	xrn-1	Y39G8C.1	n/a	chrII 14,076,171	xrn-1 encodes a 5'-3' exoribonuclease that is orthologous to Saccharomyces cerevisiae Xrnp1, a key component of the yeast 5'-3' mRNA degradation pathway; in C. elegans, XRN-1 activity is required during embryogenesis for completion of ventral enclosure, the morphogenetic process whereby the ventral epithelial cells cover and seal the interior cells of the embryo; in addition, XRN-1 also plays a role in facilitating RNA interference (RNAi), likely acting in the same pathway as the DCR-1/Dicer ribonuclease; to date, XRN-1 expression has been reported in adult hypodermal and rectal cells.
39	F07A11.4	F07A11.4	n/a	chrII 11,607,658	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF01753 (MYND finger) contains similarity to Interpro domains IPR002893 (Zinc finger, MYND-type), IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR000694 (Proline-rich region)
40	K02B12.3	K02B12.3	n/a	chrI 8,510,282	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
41	R06A4.8	R06A4.8	n/a	chrII 14,354,036	R06A4.8 is orthologous to the human gene GLYCOGEN DEBRANCHING ENZYME ISOFORM 6 (AGL; OMIM:232400), which when mutated leads to glycogen storage disease, type III.
42	ifp-1	C43C3.1	n/a	chrX 9,677,940	ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays.
43	F43G9.1	F43G9.1	n/a	chrI 8,607,769	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004434 (Isocitrate dehydrogenase NAD-dependent, mitochondrial), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
44	cyp-33A1	C12D5.7	n/a	chrV 7,680,386	C. elegans CYP-33A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
45	pgp-1	K08E7.9	n/a	chrIV 12,595,402	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
46	F55H12.2	F55H12.2	n/a	chrI 8,868,112	contains similarity to Interpro domain IPR000242 (Tyrosine specific protein phosphatase)
47	ppk-1	F55A12.3	n/a	chrI 5,361,848	ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine and vulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2.
48	F59A1.10	F59A1.10	n/a	chrV 17,661,006	contains similarity to Pfam domain PF03982 Diacylglycerol acyltransferase contains similarity to Interpro domain IPR007130 (Diacylglycerol acyltransferase)
49	Y17G7B.11	Y17G7B.11	n/a	chrII 12,061,387	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
50	C39E9.10	C39E9.10	n/a	chrIV 13,088,275	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR006052 (Tumor Necrosis Factor), IPR016196 (MFS general substrate transporter)