UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	R02D3.1	R02D3.1	0	chrIV 248,522	The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700).
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	abu-6	C03A7.7	n/a	chrV 5,161,266	abu-6 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-6 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-6 may help protect the organism from damage by improperly folded nascent protein.
4	dpyd-1	C25F6.3	n/a	chrX 5,470,240	The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270).
5	ers-3	T07A9.2	n/a	chrIV 389,575	ers-3 encodes a a glutamine (E)/glutaminyl (Q) tRNA synthetase.
6	C06A8.3	C06A8.3	n/a	chrII 7,790,994	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domain IPR003677 (Protein of unknown function DUF148)
7	Y48A6C.4	Y48A6C.4	n/a	chrIII 11,121,345	Y48A6C.4 encodes an ortholog of S. cerevisiae IPI1 that may suppress tumorous growth in the germline; like PRO-1, -2, and -3, Y48A6C.4 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline.
8	ifd-2	F25E2.4	n/a	chrX 814,890	ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays.
9	C44B7.11	C44B7.11	n/a	chrII 6,895,805	contains similarity to Pfam domain PF04389 Peptidase family M28 contains similarity to Interpro domain IPR007484 (Peptidase M28)
10	ZK1098.7	ZK1098.7	n/a	chrIII 9,523,311	contains similarity to Drosophila melanogaster Flybase gene name is mRpS23-PA;; FLYBASE:CG31842
11	D2085.3	D2085.3	n/a	chrII 8,663,227	D2085.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9947) (EIF2B5; OMIM:603945), which when mutated leads to disease.
12	ZK6.8	ZK6.8	n/a	chrV 383,222	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR016196 (MFS general substrate transporter)
13	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
14	R12E2.11	R12E2.11	n/a	chrI 4,173,045	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR004467 (Orotate phosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
15	tag-231	ZK430.2	n/a	chrII 4,421,285	C. elegans TAG-231 protein; contains similarity to Pfam domain PF00459 Inositol monophosphatase family contains similarity to Interpro domains IPR000760 (Inositol monophosphatase), IPR000146 (Inositol phosphatase/fructose-1,6-bisphosphatase)
16	daf-36	C12D8.5	n/a	chrV 10,224,591	daf-36 encodes a protein homologous to the catalytic subunit of Rieske-like oxygenases; DAF-36 functions in a hormone biosynthetic pathway producing a ligand for the DAF-12 nuclear receptor that regulates the developmental decision between reproductive growth and dauer formation; a daf-36::gfp reporter fusion is expressed in the intestine, the head mesodermal cell, two unidentified head neurons (not XXXR/L) and, in dauers, the lateral seam cells; DAF-36 localizes to the cytoplasm in the intestine and to a cytosolic meshwork in dauer seam cells.
17	tag-264	B0511.8	n/a	chrI 10,637,866	C. elegans TAG-264 protein; contains similarity to Pfam domain PF07147 Mitochondrial 28S ribosomal protein S30 (PDCD9) contains similarity to Interpro domain IPR010793 (Ribosomal protein S30, mitochondrial)
18	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
19	T19D12.1	T19D12.1	n/a	chrII 6,670,282	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
20	T07A9.10	T07A9.10	n/a	chrIV 391,835	contains similarity to Pfam domain PF00995 Sec1 family contains similarity to Interpro domain IPR001619 (Sec1-like protein)
21	C06B8.7	C06B8.7	n/a	chrV 15,505,052	contains similarity to Pfam domain PF00530 Scavenger receptor cysteine-rich domain contains similarity to Interpro domains IPR002160 (Proteinase inhibitor I3, Kunitz legume), IPR001190 (Speract/scavenger receptor), IPR011050 (Pectin lyase fold/virulence factor), IPR006626 (Parallel beta-helix repeat), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR017448 (Speract/scavenger receptor related)
22	abu-7	C03A7.8	n/a	chrV 5,164,061	abu-7 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-7 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-7 may help protect the organism from damage by improperly folded nascent protein.
23	tufm-2	C43E11.4	n/a	chrI 4,248,543	C. elegans TUFM-2 protein; contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005225 (Small GTP-binding protein), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
24	mel-46	T06A10.1	n/a	chrIV 16,859,204	C. elegans MEL-46 protein; contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
25	ZK512.5	ZK512.5	n/a	chrIII 9,128,227	ZK512.5 encodes a novel protein that has similarity to mammalian SEC16 homologs; RNAi screens indicate that ZK512.5 activity is required for embryogenesis, particularly for maintaining the osmotic integrity of the early embryo.
26	pgp-1	K08E7.9	n/a	chrIV 12,595,402	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
27	T01E8.6	T01E8.6	n/a	chrII 10,241,373	contains similarity to Pfam domain PF00253 Ribosomal protein S14p/S29e contains similarity to Interpro domain IPR001209 (Ribosomal protein S14)
28	M01G12.9	M01G12.9	n/a	chrI 12,111,806	contains similarity to Lactococcus lactis ORF (Fragment).; TR:Q48730
29	C45B2.6	C45B2.6	n/a	chrX 6,055,182	contains similarity to Pfam domains PF01734 (Patatin-like phospholipase) , PF00023 (Ankyrin repeat) (3)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR002641 (Patatin), IPR002110 (Ankyrin)
30	sel-1	F45D3.5	n/a	chrV 12,562,037	sel-1 encodes two isoforms of a highly conserved transmembrane protein orthologous to human SEL1 (OMIM:602329) and Saccharomyces cerevisiae HRD3, a member of the HMG-CoA Reductase Degradation (HRD) complex that degrades malfolded endoplasmic reticulum (ER)-resident proteins; SEL-1 functions as a negative regulator of the LIN-12/GLP-1 Notch-like signaling pathway in C. elegans where it appears to function cell autonomously to regulate LIN-12 turnover; along with ABU-1, an ER-associated Type I transmembrane protein, SEL-1 may be a component of a cell survival pathway induced when unfolded proteins accumulate in the ER; SEL-1 is expressed throughout larval and adult stages of development, and detected in all tissues except the pharynx; within cells, SEL-1 appears to localize to intracellular vesicles, consistent with its proposed role in protein turnover.
31	D2092.6	D2092.6	n/a	chrI 6,597,924	contains similarity to Homo sapiens Ubiquitin carboxyl-terminal hydrolase 8; ENSEMBL:ENSP00000302239
32	col-69	K01A2.7	n/a	chrII 304,726	C. elegans COL-69 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
33	fbf-2	F21H12.5	n/a	chrII 6,090,134	fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
34	C13C4.5	C13C4.5	n/a	chrV 12,116,190	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
35	F01G4.3	F01G4.3	n/a	chrIV 11,138,937	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF08148 (DSHCT (NUC185) domain) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR016438 (RNA helicase, ATP-dependent, SK12/DOB1), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR012961 (DSH, C-terminal), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
36	srx-105	F40H7.8	n/a	chrII 3,700,613	C. elegans SRX-105 protein ;
37	clec-262	ZC15.2	n/a	chrV 20,309,111	C. elegans CLEC-262 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
38	mif-2	C52E4.2	n/a	chrV 11,977,505	C. elegans MIF-2 protein; contains similarity to Pfam domain PF01187 Macrophage migration inhibitory factor (MIF) contains similarity to Interpro domains IPR014347 (Tautomerase), IPR001398 (Macrophage migration inhibitory factor)
39	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
40	E02A10.1	E02A10.1	n/a	chrV 12,564,567	contains similarity to Pfam domains PF00333 (Ribosomal protein S5, N-terminal domain) , PF03719 (Ribosomal protein S5, C-terminal domain) contains similarity to Interpro domains IPR014720 (Double-stranded RNA-binding-like), IPR013810 (Ribosomal protein S5, N-terminal), IPR005324 (Ribosomal protein S5, C-terminal), IPR000851 (Ribosomal protein S5), IPR014721 (Ribosomal protein S5 domain 2-type fold)
41	F36A2.3	F36A2.3	n/a	chrI 8,800,214	contains similarity to Pfam domain PF02615 Malate/L-lactate dehydrogenase contains similarity to Interpro domain IPR003767 (Malate/L-lactate dehydrogenase)
42	tag-314	F15H10.4	n/a	chrV 10,427,635	C. elegans TAG-314 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type)
43	F10D11.6	F10D11.6	n/a	chrI 8,448,214	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
44	B0464.2	B0464.2	n/a	chrIII 9,494,244	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (8)contains similarity to Interpro domains IPR001440 (Tetratricopeptide TPR-1), IPR011990 (Tetratricopeptide-like helical), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region), IPR008940 (Protein prenyltransferase)
45	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
46	T24C12.3	T24C12.3	n/a	chrX 2,200,203	contains similarity to Pfam domains PF00294 (pfkB family carbohydrate kinase) , PF04227 (Indigoidine synthase A like protein) contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR002139 (Ribokinase), IPR007342 (Indigoidine synthase A like protein), IPR002173 (Carbohydrate/puine kinase, PfkB, conserved site)
47	pmp-1	C44B7.8	n/a	chrII 6,882,170	pmp-1 encodes an ATP-binding cassette (ABC) transporter most closely related to the peroxisomal membrane proteins; pmp-1 activity is required for efficient RNA interference (RNAi) of a germline-expressed target, pop-1.
48	H19N07.1	H19N07.1	n/a	chrV 11,111,736	contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
49	K08D8.6	K08D8.6	n/a	chrIV 12,888,793	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003492 (Batten's disease protein Cln3), IPR003366 (CUB-like region)
50	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.