UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	srf-3	M02B1.1	2.0000000000000003e-175	chrIV 12,852,213	C. elegans SRF-3 protein; contains similarity to Pfam domains PF08449 (UAA transporter family) , PF04142 (Nucleotide-sugar transporter) contains similarity to Interpro domains IPR004689 (UDP-galactose transporter), IPR013657 (UAA transporter), IPR007271 (Nucleotide-sugar transporter)
2	moe-3	F32A11.6	n/a	chrII 13,163,070	moe-3 encodes a CCCH tandem zinc finger (TZF) protein; while loss of moe-3 activity via RNAi alone results in no obvious abnormalities, animals triply mutant for moe-3, oma-1, and oma-2 demonstrate oocyte maturation defects, indicating that these genes likely function redundantly during germline development; in situ hybridization experiments indicate that moe-3 mRNA expression is relatively weak and restricted to the distal region of the gonad; based upon its sequence similarity to other TZF proteins, such as MEX-5 and POS-1, the product of MOE-3 is predicted to function as an RNA-binding protein.
3	ZK896.1	ZK896.1	n/a	chrIV 12,874,056	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
4	srd-60	C13B7.3	n/a	chrV 2,420,332	C. elegans SRD-60 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
5	T20D4.5	T20D4.5	n/a	chrV 3,414,578	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
6	str-150	T03E6.4	n/a	chrV 16,584,195	C. elegans STR-150 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
7	ZK1225.2	ZK1225.2	n/a	chrI 13,209,439	contains similarity to Pfam domain PF02485 Core-2/I-Branching enzyme contains similarity to Interpro domain IPR003406 (Glycosyl transferase, family 14)
8	C15B12.3	C15B12.3	n/a	chrX 6,467,380
9	ZK112.5	ZK112.5	n/a	chrIII 7,738,805
10	sre-43	W07G1.6	n/a	chrII 13,967,710	C. elegans SRE-43 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR000344 (Nematode chemoreceptor, Sra)
11	F11G11.4	F11G11.4	n/a	chrII 4,861,326
12	unc-75	C17D12.2	n/a	chrI 11,596,943	unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission.
13	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
14	C03H5.7	C03H5.7	n/a	chrII 381,414	contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR001958 (Tetracycline resistance protein, TetA)
15	str-97	F10A3.8	n/a	chrV 16,154,443	C. elegans STR-97 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
16	hlh-14	C18A3.8	n/a	chrII 5,738,759	hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa.
17	F31A9.1	F31A9.1	n/a	chrX 1,797,616
18	C01B12.2	C01B12.2	n/a	chrII 20,848	contains similarity to Pfam domain PF01342 SAND domain contains similarity to Interpro domains IPR010919 (SAND-like), IPR000770 (SAND)
19	Y43F8C.11	Y43F8C.11	n/a	chrV 19,670,774	contains similarity to Mus sp Interleukin-3 receptor beta subunit (Fragment).; TR:Q64130
20	srh-192	ZC132.7	n/a	chrV 4,313,561	C. elegans SRH-192 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
21	F23C8.3	F23C8.3	n/a	chrI 2,440,875
22	snt-6	C08G5.4	n/a	chrII 747,906	C. elegans SNT-6 protein; contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR001565 (Synaptotagmin), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
23	M05B5.6	M05B5.6	n/a	chrI 7,184,379	contains similarity to Homo sapiens Transient receptor potential cation channel subfamily A member 1; ENSEMBL:ENSP00000262209
24	C01A2.6	C01A2.6	n/a	chrI 13,382,132	contains similarity to Dictyostelium discoideum Putative uncharacterized protein.; TR:Q54BK4
25	F18E9.4	F18E9.4	n/a	chrX 8,582,026
26	scd-2	T10H9.2	n/a	chrV 6,636,446	C. elegans SCD-2 protein; contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR000998 (MAM), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
27	Y51A2B.5	Y51A2B.5	n/a	chrV 18,390,243	contains similarity to Interpro domain IPR014044 (SCP-like extracellular)
28	clec-3	C41H7.7	n/a	chrII 3,018,651	C. elegans CLEC-3 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
29	inx-20	T23H4.1	n/a	chrI 9,877,813	C. elegans INX-20 protein; contains similarity to Pfam domain PF00876 Innexin contains similarity to Interpro domain IPR000990 (Innexin)
30	nhr-194	F59E11.8	n/a	chrV 8,969,321	C. elegans NHR-194 protein; contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
31	sto-2	F32A6.5	n/a	chrX 5,309,627	C. elegans STO-2 protein; contains similarity to Pfam domain PF01145 SPFH domain / Band 7 family contains similarity to Interpro domains IPR001107 (Band 7 protein), IPR001972 (Stomatin)
32	C34E7.3	C34E7.3	n/a	chrX 12,931,101	contains similarity to Plasmodium falciparum Ribonuclease, putative.; TR:Q8ICL5
33	aqp-6	C32C4.2	n/a	chrV 10,651,251	apq-6 encodes an aquaporin whose expression in Xenopus oocytes increases water permeability five- to seven-fold; aqp-6 has no function in mass RNAi assays, perhaps reflecting genetic redundancy with its paralogs AQP-4 and AQP-5; AQP-6 is expressed in the cilia and cell bodies of IL1 sensory neurons; AQP-6 is orthologous to human AQP8 (OMIM:603750).
34	W07G1.1	W07G1.1	n/a	chrII 13,938,717	contains similarity to Pfam domain PF03607 Doublecortin contains similarity to Interpro domain IPR003533 (Doublecortin)
35	fbxa-153	B0391.5	n/a	chrV 15,608,029	fbxa-153 encodes a protein with an N-terminal F-box domain and a C-terminal FTH domain; FBXA-153 has no obvious non-nematode orthologs; FBXA-153 shares N-terminal UNC-13 binding, and thus may share at least some functions, with ERI-1, W04D2.6, and Y55F3AM.13; FBXA-153 has no obvious function in mass RNAi assays.
36	che-12	B0024.8	n/a	chrV 10,303,399	che-12 encodes a conserved protein that contains at least seven predicted HEAT repeats; CHE-12 activity is required continuously in sensory neurons for formation of distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis to a subset of attractants, including sodium chloride; a che-12::gfp promoter fusion is expressed in the two phasmid neurons and the subset of amphid neurons that contain relatively simple cilia; a CHE-12::GFP protein localizes to cilia in a manner suggesting that it requires intraflagellar transport for proper localization, but is unlikely to be a core IFT particle component; che-12 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor.
37	asic-2	T28F4.2	n/a	chrI 7,481,759	C. elegans ASIC-2 protein; contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domains IPR001873 (Na+ channel, amiloride-sensitive), IPR004726 (Degenerin)
38	F37C12.1	F37C12.1	n/a	chrIII 7,186,028	contains similarity to Pfam domain PF04502 Family of unknown function (DUF572) contains similarity to Interpro domain IPR007590 (Protein of unknown function DUF572)
39	adt-1	C02B4.1	n/a	chrX 12,683,974	The adt-1 gene encodes a metalloproteinase with disintegrin-like and metalloproteinase with thrombospondin type I motifs (ADAMTS) that is required for male tail morphogenesis.
40	F13A2.3	F13A2.3	n/a	chrV 4,394,967
41	F49D11.2	F49D11.2	n/a	chrI 10,922,443	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
42	F30B5.7	F30B5.7	n/a	chrIV 4,230,520	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
43	T05E11.2	T05E11.2	n/a	chrIV 11,115,881	T05E11.2 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; T05E11.2 is worm-specific, with a with highly divergent sequence lacking obvious homologs; T05E11.2 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
44	C17A2.3	C17A2.3	n/a	chrII 3,844,552	contains similarity to Drosophila melanogaster Flybase gene name is CG2975-PA;; FLYBASE:CG2975
45	F36H5.8	F36H5.8	n/a	chrII 1,749,990	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
46	W03A5.1	W03A5.1	n/a	chrIII 5,410,601	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR001452 (Src homology-3), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
47	nhr-113	ZK1025.9	n/a	chrI 11,474,430	nhr-113 encodes a nuclear receptor that is most highly conserved amongst nematode species.
48	K12C11.3	K12C11.3	n/a	chrI 1,336,076	contains similarity to Pfam domain PF04145 Ctr copper transporter family contains similarity to Interpro domain IPR007274 (Ctr copper transporter)
49	F45F2.6	F45F2.6	n/a	chrV 8,527,305	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domain IPR004878 (Protein of unknown function DUF270)
50	ZK688.7	ZK688.7	n/a	chrIII 7,911,165