UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	klp-15	M01E11.6	0	chrI 5,578,180	C. elegans KLP-15 protein; contains similarity to Pfam domain PF00225 Kinesin motor domain contains similarity to Interpro domain IPR001752 (Kinesin, motor region)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	zyg-11	C08B11.1	n/a	chrII 8,019,153	zyg-11 encodes a protein containing four diverged leucine-rich repeats and an armadillo-like helical domain and is conserved in metazoa, but not found in Drosophila; during development, ZYG-11 functions as the substrate-recognition subunit for a CUL-2-based ubiquitin-ligase complex that is required for a number of biological processes including progression through meiotic anaphase II, mitotic chromosome condensation, and establishment of anterior/posterior polarity in the early embryo; ZYG-11 interacts with CUL-2 in vivo and with ELC-1/elongin C in vitro.
4	klp-16	C41G7.2	0	chrI 9,513,594	klp-16 encodes a C-terminal motor kinesin orthologous to the Drosophila melanogaster Ncd and Saccharomyces cerevisiae Kar3; however KLP-16 along with KLP-3, KLP-15 and KLP-17 form an unique subgroup based on amino acid sequence and secondary structure analysis; klp-16 is involved in development of the nervous system in embryos and in chromosome segregation; in situ RNA hybridization experiments indicate that klp-16 is localized in the anterior nervous system in the head region of late embryos.
5	egg-5	R12E2.10	n/a	chrI 4,170,287	C. elegans EGG-5 protein; contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
6	B0304.2	B0304.2	n/a	chrII 4,524,073
7	kca-1	C10H11.10	n/a	chrI 4,760,571	C. elegans KCA-1 protein ;
8	cyp-31A2	H02I12.8	n/a	chrIV 11,404,949	cyp-31A2 encodes a class 4 cytochrome P450 predicted to hydroxylate polyunsaturated fats (PUFAs); CYP-31A2 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; cyp-31A2(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, class 4 cytochrome P450 is required for the omega hydroxylation of PUFAs, prostaglandins, and leukotrienes.
9	C48B4.6	C48B4.6	n/a	chrIII 9,557,903	contains similarity to Plateumaris constricticollis toyamensis Cytochrome oxidase subunit I (Fragment).; TR:Q85QH2
10	C30F12.4	C30F12.4	n/a	chrI 6,972,971	contains similarity to Triticum aestivum Gamma-gliadin precursor.; SW:P08453
11	egg-2	R01H2.3	n/a	chrIII 7,059,489	C. elegans EGG-2 protein; contains similarity to Pfam domain PF00057 Low-density lipoprotein receptor domain class A contains similarity to Interpro domain IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich)
12	F43G9.4	F43G9.4	n/a	chrI 8,611,732	contains similarity to Brugia malayi Putative uncharacterized protein BMBAC01P19.03a.; TR:Q8IHI9
13	F54F7.2	F54F7.2	n/a	chrX 11,844,424
14	car-1	Y18D10A.17	n/a	chrI 12,905,338	car-1 encodes a putative RNA-binding protein orthologous to budding yeast Scd6p, fission yeast Sum2p, Drosophila TRAL, and human LSM14A and LSM14B; CAR-1 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; independently of apoptosis, CAR-1 is also required for normal oogenesis, early embryonic cytokinesis, and normally organized endoplasmic reticulum (ER); CAR-1 has an N-terminal Sm-related domain that is dispensable for subcellular localization, but directly binds RNA and is critical for CAR-1's function; CAR-1 expressed in the germline; CAR-1 associates with CGH-1, DCAP-1, and CEY-2/3/4, in P granules and other cytoplasmic particles of the early embryo; CAR-1 also localizes to the mitotic spindle of dividing 1-cell embryos, and to ER; CAR-1 requires CGH-1 for normal localization in meiotic germ cells, and binds CGH-1 in an RNA-dependent manner; car-1(tm1753) or car-1(RNAi) embryos display abnormal cytokinesis, with aberrant cleavage furrow ingression and anaphase spindle structure, and mislocalized AIR-2, SPD-1, and ZEN-4; car-1(RNAi) also results in elevated (though not 100%) physiological germ cell apoptosis, reduced fertility, and failed oocyte diakinesis; maternal CAR-1 is sufficient to rescue car-1(tm1753) homozygotes through development to adulthood; in car-1(RNAi) animals, excess physiological apoptosis actually promotes fertility, since car-1(RNAi) hermaphrodites have larger brood sizes than those with apoptosis suppressed by ced-3(n717).
15	hus-1	H26D21.1	n/a	chrI 3,698,705	hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
16	puf-7	B0273.2	n/a	chrIV 5,488,347	puf-7 encodes a protein 97% identical to PUF-6 and functions redundantly with the other PUF genes, fbf-1, fbf-2, puf-6, and puf-8, during primordial germ cell development, based on combinatorial RNAi; interacts with NOS-2 in yeast two-hybrid screens.
17	apn-1	T05H10.2	n/a	chrII 8,048,264	apn-1 encodes a member of the AP (apurinic or apyrimidinic) endonuclease family.
18	C27D9.1	C27D9.1	n/a	chrII 4,754,512	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domain IPR009497 (Protein of unknown function DUF1114)
19	T05B9.1	T05B9.1	n/a	chrII 11,260,588	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
20	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
21	skr-17	C06A8.4	n/a	chrII 7,784,177	skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs.
22	H02I12.5	H02I12.5	n/a	chrIV 11,402,613
23	R02F2.4	R02F2.4	n/a	chrIII 5,485,028	R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
24	F32D1.6	F32D1.6	n/a	chrV 4,374,245
25	C50E3.13	C50E3.13	n/a	chrV 7,623,254
26	C31H1.8	C31H1.8	n/a	chrIV 5,812,882	contains similarity to Homo sapiens Protocadherin 15; ENSEMBL:ENSP00000378832
27	hmg-3	C32F10.5	n/a	chrI 5,816,902	C. elegans HMG-3 protein; contains similarity to Pfam domains PF00505 (HMG (high mobility group) box) , PF08512 (Histone chaperone Rttp106-like) , PF03531 (Structure-specific recognition protein (SSRP1)) contains similarity to Interpro domains IPR013719 (Region of unknown function DUF1747, eukaryote), IPR000969 (Structure-specific recognition protein), IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG), IPR000135 (High mobility group box, HMG1/HMG2, subgroup)
28	fem-3	C01F6.4	n/a	chrIV 9,106,267	fem-3 encodes a novel protein that promotes male development in all tissues.
29	ZK1128.4	ZK1128.4	n/a	chrIII 10,119,727	contains similarity to Pfam domain PF03850 Transcription factor Tfb4 contains similarity to Interpro domain IPR004600 (Transcription factor Tfb4)
30	Y53C12A.6	Y53C12A.6	n/a	chrII 9,717,654	contains similarity to Bacteriophage RB69 Hypothetical protein RB69ORF024c.; TR:Q7Y5B4
31	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
32	K03H4.2	K03H4.2	n/a	chrV 13,153,453	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:O96209
33	C27C12.3	C27C12.3	n/a	chrX 14,864,682	C27C12.3 encodes a novel protein that is conserved in C. elegans; three other genes related to C27C12.3 are present in tandem on the X chromosome; in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline.
34	cgh-1	C07H6.5	n/a	chrIII 7,496,952	cgh-1 encodes a putative DEAD-box RNA helicase, orthologous to budding yeast Dhh1p, fission yeast Ste13p, Drosophila ME31B, and human DDX6 (OMIM:600326); CGH-1 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; independently of apoptosis, CGH-1 is also required for sperm function, oocyte fertilization, and early embryonic cytokinesis; by orthology with budding yeast, CGH-1 is expected to enable decapping-dependent mRNA degradation; CGH-1 is expressed in meiotic germ cells, oocytes, sperm, early embryonic P granules, other unidentified cytoplasmic foci of the gonad core and early embryos, and the germline precursors Z2 and Z3; cgh-1(RNAi) hermaphrodites lose ~100% of their oocytes to physiological apoptosis; gonadal CGH-1 accumulation is suppressed by either glh-1/4 RNAi or gld-1(q485);gld-2(q497) mutations, yet physiological apoptosis (which would normally be elevated by loss of CGH-1) is also abnormally low in these genotypes; cgh-1(RNAi) males have sterile sperm with abnormally short pseudopods; CGH-1 associates with CAR-1, DCAP-2, and CEY-2/3/4 in P granules and cytoplasmic particles of the early embryo; CGH-1 is required for normal CAR-1 localization in early embyros, and binds CAR-1 in an RNA-dependent manner.
35	ZC477.5	ZC477.5	n/a	chrIV 7,102,332
36	C08F8.3	C08F8.3	n/a	chrIV 11,155,803	contains similarity to Gallus gallus Dosal neuron-tube nuclear protein.; TR:Q8QHJ7
37	F31C3.5	F31C3.5	n/a	chrI 15,053,308	contains similarity to Pfam domain PF04128 Partner of SLD five, PSF2 contains similarity to Interpro domains IPR016906 (GINS complex, PSF2 component, subgroup), IPR007257 (GINS complex, Psf2 component)
38	Y18D10A.11	Y18D10A.11	n/a	chrI 12,862,741	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp779H0156; ENSEMBL:ENSP00000344380
39	T24D1.3	T24D1.3	n/a	chrI 9,959,459	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
40	dhs-5	F56D1.5	n/a	chrII 5,454,878	dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE).
41	cpar-1	F54C8.2	n/a	chrIII 9,434,486	cpar-1 encodes one of two C. elegans proteins homologous to the inner kinetochore histone H3 variant CENP-A (the other is encoded by hcp-3); loss of cpar-1 and hcp-3 activity via RNAi results in mitotic chromosome segregation defects, but no significant defects in meiotic chromosome segregation; when expressed in the germline using the pie-1 promoter, a CPAR-1::GFP fusion protein localizes to meiotic chromosomes during late prophase/prometaphase of meiosis I, but is not seen on chromosomes during meiosis II.
42	B0365.1	B0365.1	n/a	chrV 13,118,299	contains similarity to Pfam domains PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR016143 (Citrate synthase-like, small alpha subdomain), IPR014608 (ATP-citrate synthase), IPR016142 (Citrate synthase-like, large alpha subdomain), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR016040 (NAD(P)-binding), IPR013816 (ATP-grasp fold, subdomain 2), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR016141 (Citrate synthase-like, core), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
43	try-1	ZK546.15	n/a	chrII 4,948,807	C. elegans TRY-1 protein; contains similarity to Pfam domain PF00089 Trypsin contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR009003 (Peptidase, trypsin-like serine and cysteine), IPR008256 (Peptidase S1B, glutamyl endopeptidase I)
44	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
45	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
46	F27C8.6	F27C8.6	n/a	chrIV 9,587,998	F27C8.6 encodes a putative arylacetamide deacetylase and microsomal lipase; F27C8.6 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; F27C8.6(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
47	T03F6.3	T03F6.3	n/a	chrIII 13,390,012	contains similarity to Pfam domain PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase contains similarity to Interpro domains IPR006148 (Glucosamine/galactosamine-6-phosphate isomerase), IPR004547 (Glucosamine-6-phosphate isomerase)
48	F54D5.9	F54D5.9	n/a	chrII 11,543,652	F54D5.9 encodes an F-box protein orthologous to to human FBXO47 (OMIM:609498, deleted in renal cell carcinoma) and paralogous to PROM-1, that suppresses excess embryonic cell division; F54D5.9(RNAi) animals show hyperproliferating embryonic tissues, while having no obvious meiotic defects.
49	F21F8.2	F21F8.2	n/a	chrV 8,275,167	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001461 (Peptidase A1)
50	E02H9.7	E02H9.7	n/a	chrIII 2,445,442	contains similarity to Homo sapiens Uncharacterized protein MUC17 (Fragment); ENSEMBL:ENSP00000368750