UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	acr-3	K11G12.7	0	chrX 6,711,143	acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits.
2	nhr-189	F47C10.8	n/a	chrV 3,859,413	C. elegans NHR-189 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	C08G5.1	C08G5.1	n/a	chrII 736,664	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
4	srw-59	H24D24.1	n/a	chrV 15,950,332	C. elegans SRW-59 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
5	C31E10.5	C31E10.5	n/a	chrX 13,993,587	contains similarity to Homo sapiens Splice isoform 1 of Q92614 Myosin XVIIIA; ENSEMBL:ENSP00000332202
6	F58B3.6	F58B3.6	n/a	chrIV 11,637,391	contains similarity to Pfam domains PF04836 (Interferon-related protein conserved region) , PF05004 (Interferon-related developmental regulator (IFRD)) contains similarity to Interpro domains IPR007701 (Interferon-related developmental regulator), IPR006921 (Interferon-related protein conserved region), IPR016024 (Armadillo-type fold)
7	ikb-1	C04F12.3	n/a	chrI 9,687,053	ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis).
8	ced-3	C48D1.2	n/a	chrIV 13,202,258	The ced-3 gene encodes a protease required for apoptosis.
9	C26C6.8	C26C6.8	n/a	chrI 7,504,574	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (3), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR011511 (Variant SH3)
10	C09B9.1	C09B9.1	n/a	chrIV 5,039,116
11	C41C4.1	C41C4.1	n/a	chrII 8,106,208	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
12	C47E8.3	C47E8.3	n/a	chrV 14,681,957	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
13	B0361.4	B0361.4	n/a	chrIII 7,263,665
14	F53B6.6	F53B6.6	n/a	chrI 8,956,012	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
15	amt-3	M195.3	n/a	chrII 8,366,108	amt-3 encodes one of four C. elegans homologs of AMT1 (AT11_ARATH), a high-affinity ammonium transporter from Arabidopsis thaliana; AMT-3 is closely similar to its paralog AMT-2, with somewhat more distant paralogy to AMT-1 and AMT-4.
16	ZK945.8	ZK945.8	n/a	chrII 10,108,812	contains similarity to Pfam domain PF07491 Protein phosphatase inhibitor contains similarity to Interpro domain IPR011107 (Protein phosphatase inhibitor)
17	spp-19	K04A8.9	n/a	chrV 6,559,648	C. elegans SPP-19 protein; contains similarity to Interpro domains IPR011001 (Saposin-like), IPR008139 (Saposin B)
18	tbx-32	ZK380.1	n/a	chrX 1,656,225	C. elegans TBX-32 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
19	F47G6.3	F47G6.3	n/a	chrI 1,467,585	contains similarity to Homo sapiens Putative uncharacterized protein (Fragment); ENSEMBL:ENSP00000333119
20	Y59C2A.2	Y59C2A.2	n/a	chrII 2,201,637	contains similarity to Interpro domain IPR000694 (Proline-rich region)
21	F41G4.7	F41G4.7	n/a	chrX 16,834,908
22	F56H6.12	F56H6.12	n/a	chrI 12,313,605	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
23	Y75B8A.28	Y75B8A.28	n/a	chrIII 12,320,885	contains similarity to Saccharomyces cerevisiae Required for START A of cell cycle, and glucose and nitrogen repression of sporulation; SGD:YJL005W
24	T22H9.1	T22H9.1	n/a	chrV 361,718	contains similarity to Pfam domain PF06102 Domain of unknown function (DUF947) contains similarity to Interpro domain IPR009292 (Protein of unknown function DUF947)
25	gcy-5	ZK970.6	n/a	chrII 10,313,230	gcy-5 encodes a predicted guanylate cyclase with strong similarity to rat atrial natriuretic peptide receptor A; expressed in ASER.
26	fbxa-37	ZC47.14	n/a	chrIII 1,286,023	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
27	atf-6	F45E6.2	n/a	chrX 12,482,840	atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor required for the unfolded protein response (UPR) in the endoplasmic reticulum (ER); ATF6alpha is a transmembrane protein, with a bZIP transcription factor domain in its cytosolic amino terminus that is released and activated by proteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions are synthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2 larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethal with ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleaves ATF-6; atf-6 regulates few genes that are transcriptionally induced by UPR, but regulates roughly one-quarter of genes that require UPR constitutively; pdr-1 transcripts are strongly upregulated in a atf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) double mutants have a grossly normal phenotype ; atf-6 is dispensable for proper localization of GLR-1 glutamate receptors.
28	clec-188	M199.3	n/a	chrIV 15,117,866	C. elegans CLEC-188 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
29	col-164	T21D9.1	n/a	chrX 2,094,123	C. elegans COL-164 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
30	ZK1307.4	ZK1307.4	n/a	chrII 9,651,306	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
31	srh-248	H05B21.2	n/a	chrV 2,954,922	C. elegans SRH-248 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000215 (Protease inhibitor I4, serpin)
32	C01G6.9	C01G6.9	n/a	chrII 9,294,851	contains similarity to Plasmodium falciparum SET-domain protein, putative.; TR:Q8IC77
33	C25E10.7	C25E10.7	n/a	chrV 9,050,528	C25E10.7 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; C25E10.7 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; C25E10.7 has no obvious function in mass RNAi assays.
34	Y56A3A.16	Y56A3A.16	n/a	chrIII 11,912,267	contains similarity to Homo sapiens Isoform 1 of Pleckstrin homology domain-containing family M member 3; ENSEMBL:ENSP00000373899
35	C10C6.6	C10C6.6	n/a	chrIV 11,476,280	contains similarity to Pfam domains PF00122 (E1-E2 ATPase) , PF00702 (haloacid dehalogenase-like hydrolase) contains similarity to Interpro domains IPR008250 (E1-E2 ATPase-associated region), IPR006069 (ATPase, P-type cation exchange, alpha subunit), IPR006544 (P-type ATPase of unknown pump specificity (type V)), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR005834 (Haloacid dehalogenase-like hydrolase)
36	W09G12.9	W09G12.9	n/a	chrIV 1,217,448
37	grl-14	T03D8.4	n/a	chrV 20,822,062	grl-14 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; GRL-14 is expressed in intestine, head mesodermal cell, hypodermis, seam cells, and uterine muscle, larval arcade cells and reproductive system, and the developing vulva; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
38	F54B11.7	F54B11.7	n/a	chrX 13,600,836	contains similarity to Neurospora crassa GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).; SW:GCH1_NEUCR
39	sdc-2	C35C5.1	n/a	chrX 11,528,006	The sdc-2 gene encodes a protein that represses transcription of X chromosomes to achieve dosage compensation, and that also represses the male sex-determination gene her-1 to elicit hermaphrodite differentiation.
40	E02H4.2	E02H4.2	n/a	chrX 14,279,950	contains similarity to Homo sapiens Type-1 protein phosphatase skeletal muscle glycogen targeting subunit; ENSEMBL:ENSP00000284601
41	R02E4.1	R02E4.1	n/a	chrX 4,103,960
42	ptc-2	F21H12.4	n/a	chrII 6,084,701	ptc-2 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome), which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTC-2 is required for normal fat storage; PTC-2 is also required for normal egg osmotic integrity, locomotion, egg laying, and viability in mass RNAi assays.
43	str-211	C02E7.13	n/a	chrV 4,943,703	C. elegans STR-211 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
44	F49E12.8	F49E12.8	n/a	chrII 8,393,450	contains similarity to Homo sapiens Hypothetical protein KIAA0335; TR:O15044
45	glb-9	C28F5.2	n/a	chrII 7,510,599	glb-9 encodes a globin with no obvious function in mass RNAi assays.
46	F28H6.6	F28H6.6	n/a	chrX 14,121,403	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
47	srw-14	C41G6.8	n/a	chrV 15,226,687	C. elegans SRW-14 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000975 (Interleukin-1)
48	Y66A7A.2	Y66A7A.2	n/a	chrIII 11,486,326	Y66A7A.2 encodes an ortholog of Pop5, a protein subunit shared by the endoribonucleases RNase MRP and RNAse P; RNAse MRP cleaves mitochondrial RNA in mitochondrial DNA synthesis, nucleolar pre-rRNA in ribosome synthesis, and at least one mRNA (CLB2) involved in cell-cycle regulation; RNAse P cleaves tRNA precursors to produce their mature 5' end; Y66A7A.2 is evolutionarily ubiquitous among eukaryotes.
49	F31F7.3	F31F7.3	n/a	chrV 6,269,506
50	AH9.1	AH9.1	n/a	chrX 2,245,299	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)