UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	unc-14	K10D3.2	0	chrI 7,125,516	The unc-14 gene encodes an activity required for both axonogenesis and sex myoblast migration.
2	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
3	nhr-6	C48D5.1	n/a	chrIII 3,576,162	nhr-6 encodes a nuclear receptor of the NR4A4 subfamily that is orthologous to the mammalian NGFI-B receptors and the Drosophila HR38 nuclear receptor (DHR38) that has been implicated in molting and metamorphosis; by homology, NHR-6 likely functions as a transcription factor that, based upon RNAi experiments, is required for normal ovulation and/or spermathecal development or function; an nhr-6 reporter fusion is expressed primarily in the anterior and posterior spermatheca during L3 and L4 larval stages, with some weak and variable expression also observed in two chemosensory neurons; nhr-6 mRNA is expressed in an oscillating manner throughout larval development, in a pattern that is slightly irregular with respect to the timing of larval molts and that exhibits consistently lower expression at the times when these molts actually occur.
4	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
5	VM106R.1	VM106R.1	n/a	chrII 10,828,708	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
6	nas-25	F46C5.3	n/a	chrII 8,827,065	nas-25 encodes an astacin-like metalloprotease; large-scale expression studies reveal that a nas-25::GFP promoter fusion is expressed in the pharynx and pharyngeal-intestinal valve.
7	lev-1	F09E8.7	n/a	chrIV 13,176,746	lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3.
8	F22E5.13	F22E5.13	n/a	chrII 2,648,208
9	Y43F8A.5	Y43F8A.5	n/a	chrV 19,387,467	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
10	daf-14	F01G10.8	n/a	chrIV 10,254,701	daf-14 encodes a Smad-related protein that is unusual in that while its C-terminus is well-conserved with Smad proteins, it lacks the N-terminal DNA binding domain found in all other known Smads; DAF-14 is predicted to function as a transducer of the DAF-7/TGF-beta-mediated signal that promotes reproductive growth and negatively regulates dauer formation; as reduction of daf-14 function enhances the dauer constitutive phenotype of daf-8 mutants, and overexpression of daf-14 can rescue daf-8 mutant animals, it is likely that the DAF-14 and DAF-8 Smad proteins function in parallel to control dauer formation; further genetic analyses suggest that DAF-14 and DAF-8 function to antagonize the activities of the DAF-3 Smad and DAF-5 Sno/Ski oncoprotein, which are required for dauer formation; a DAF-14::GFP reporter is expressed in a dynamic pattern in tissues, such as the hypodermis, intestine, and pharynx, that are remodeled during dauer development.
11	ptr-5	C53C11.3	n/a	chrX 17,322,508	ptr-5 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-5 is weakly required for normal molting from L4 to adult stages; PTR-5 is also required for normal growth to full size and locomotion; PTR-5 is expressed in head and tail neurons, and in ventral nerve cord.
12	F13A2.4	F13A2.4	n/a	chrV 4,399,097
13	srd-1	F33H1.5	n/a	chrII 10,181,388	srd-1 encodes a seven transmembrane chemosensory receptor; SRD-1 is expressed in the ASI chemosensory neurons; SRD-1 expression in ASI is repressed in the presence of dauer pheromone at concentrations lower than that which induces dauer formation.
14	ifc-1	F37B4.2	n/a	chrV 2,882,485	ifc-1 encodes a nonessential intermediate filament protein; IFC-1 is predicted to function as a structural component of the cytoskeleton; IFC-1 has no function in RNAi assays.
15	F42G9.4	F42G9.4	n/a	chrIII 761,894
16	mec-18	C52B9.9	n/a	chrX 4,272,688	mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 may be involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells.
17	sup-9	F34D6.3	n/a	chrII 2,685,863	sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle.
18	pho-4	T16D1.2	n/a	chrII 5,237,340	C. elegans PHO-4 protein ;
19	F20D6.8	F20D6.8	n/a	chrV 8,166,494	contains similarity to Pfam domain PF00071 Ras family contains similarity to Interpro domains IPR003577 (Ras small GTPase, Ras type), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
20	T28C12.2	T28C12.2	n/a	chrV 6,330,074	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
21	cyp-33C7	F41B5.2	n/a	chrV 2,251,536	C. elegans CYP-33C7 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
22	unc-24	F57H12.2	n/a	chrIV 7,980,963	unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord.
23	Y39A3A.4	Y39A3A.4	n/a	chrIII 2,074,752	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type)
24	R13D7.2	R13D7.2	n/a	chrV 7,410,557	contains similarity to Pfam domain PF03236 Domain of unknown function DUF263 contains similarity to Interpro domain IPR004920 (Protein of unknown function DUF263)
25	gst-12	F37B1.2	n/a	chrII 13,617,244	C. elegans GST-12 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
26	lin-33	H32C10.2	n/a	chrIV 5,931,939	C. elegans LIN-33 protein; contains similarity to Interpro domain IPR002873 (Non-structural protein NSP3, Rotavirus)
27	nca-2	C27F2.2	n/a	chrIII 4,972,657	nca-2 encodes a novel, four-domain alpha1U Ca2+ channel subunit; nca-2 functions redundantly with a paralog, nca-1, to regulate locomotion and the response to specific volatile anesthetics; in regulating these processes, nca-1 and nca-2 function in the same pathway as unc-79, which encodes a conserved novel protein that positively regulates levels of NCA-1 and NCA-2 protein; nca-2::gfp reporters are expressed in the nervous system in a few pharyngeal neurons, many nerve ring interneurons, most ventral nerve motor cord neurons, and in neurons and muscles in the tail; diffuse expression is also seen in vulval muscles and the intestine.
28	lgc-4	F18G5.4	n/a	chrX 9,238,639	C. elegans LGC-4 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
29	C18H7.6	C18H7.6	n/a	chrIV 590,772	contains similarity to Interpro domain IPR000817 (Prion protein)
30	F55A4.2	F55A4.2	n/a	chrX 1,015,147
31	gpa-2	F38E1.5	n/a	chrV 8,372,499	gpa-2 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in dauer formation and chemotaxis to water-soluble odorants; it is expressed in the phasmid neurons PHA and PHB, three pharyngeal neurons, one interneuron, three pairs of head neurons, and the anal sphincter muscle.
32	ugt-38	F10D2.7	n/a	chrV 7,146,544	C. elegans UGT-38 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR003567 (Cytochrome c-type biogenesis protein), IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
33	C31B8.7	C31B8.7	n/a	chrV 2,901,878	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
34	ttr-28	R90.3	n/a	chrV 12,904,670	C. elegans TTR-28 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
35	K03A11.5	K03A11.5	n/a	chrX 13,066,078	contains similarity to Enterobacteria phage RB49 Hypothetical protein.; TR:Q7Y3J5
36	ins-5	ZK84.3	n/a	chrII 5,998,628	ins-5 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-5 is one of 38 insulin-like peptides in C. elegans and is expressed in the amphid sensory neurons, labial neurons, the nerve ring, other neurons, and the vulva; the precise role of INS-5 in C. elegans development is not yet clear as loss of function does not result in a mutant phenotype.
37	rbc-1	F54E4.1	n/a	chrX 14,617,784	rbc-1 encodes an ortholog of S. cerevisiae RAV1; like RAV1, RBC-1 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
38	F53A9.9	F53A9.9	n/a	chrX 8,720,477	contains similarity to Bacillus subtilis Uncharacterized protein yeeK.; SW:O31510
39	glb-3	C06H2.5	n/a	chrV 11,139,410	glb-3 encodes a globin with no obvious function in mass RNAi assays.
40	C01B10.7	C01B10.7	n/a	chrIV 6,638,773	contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
41	C06G3.4	C06G3.4	n/a	chrIV 7,029,714	contains similarity to Interpro domains IPR002110 (Ankyrin), IPR001357 (BRCT)
42	F22E5.6	F22E5.6	n/a	chrII 2,650,293	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
43	F55C12.6	F55C12.6	n/a	chrII 5,875,271	contains similarity to Pfam domain PF06852 Protein of unknown function (DUF1248) contains similarity to Interpro domain IPR009658 (Protein of unknown function DUF1248)
44	tag-278	C02F12.7	n/a	chrX 3,686,384	C. elegans TAG-278 protein; contains similarity to Interpro domain IPR000533 (Tropomyosin)
45	R08C7.4	R08C7.4	n/a	chrIV 4,436,206	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
46	R02F2.8	R02F2.8	n/a	chrIII 5,494,067	contains similarity to Pfam domain PF01490 Transmembrane amino acid transporter protein contains similarity to Interpro domains IPR002091 (Aromatic amino acid permease), IPR013057 (Amino acid transporter, transmembrane)
47	F47G4.5	F47G4.5	n/a	chrI 14,061,493	F47G4.5 encodes a paralog of MEI-2 that, like MEI-2, binds MEI-1 in vitro; F47G4.5 might thus be an alternative ligand of MEI-1 in vivo.
48	F47G3.1	F47G3.1	n/a	chrX 2,389,225
49	clec-89	C09D1.2	n/a	chrI 4,072,314	C. elegans CLEC-89 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
50	F14B6.2	F14B6.2	n/a	chrI 12,220,319	contains similarity to Homo sapiens hypothetical protein; ENSEMBL:ENSP00000352916