UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K10D11.2	K10D11.2	0	chrIV 12,980,447	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
2	F56A6.4	F56A6.4	n/a	chrI 622,086
3	C40H5.2	C40H5.2	n/a	chrX 11,754,976	contains similarity to Bifidobacterium longum Possible magnesium and cobalt transport protein.; TR:Q8G4E0
4	srz-90	C18D4.9	n/a	chrV 17,528,936	C. elegans SRZ-90 protein
5	tag-179	T24D1.4	n/a	chrI 9,961,143	C. elegans TAG-179 protein; contains similarity to Pfam domain PF04922 DIE2/ALG10 family contains similarity to Interpro domains IPR016900 (Alpha-1, 2 glucosyltransferase Alg10), IPR007006 (DIE2/ALG10)
6	mes-2	R06A4.7	n/a	chrII 14,386,115	mes-2 encodes a SET domain-containing protein that is orthologous to the Drosophila Polycomb group protein Enhancer of zeste [E(Z)]; as a member of a Polycomb-like chromatin repressive complex with MES-3 and MES-6, MES-2 is required maternally for normal germline development and during larval development, for anteroposterior patterning; during germline development, the MES-2/MES-3/MES-6 complex is believed to be essential for maintaining repression of the X chromosome, and in transgenic animals, the complex is necessary for germline repression of repetitive transgenes; in axial patterning, the MES-2/MES-3/MES-6 complex is required in somatic tissues for maintaining homeotic gene repression, acting upstream of the Hox genes lin-39, mab-5, and egl-5, as well as the egl-5 target gene lin-32; in addition, MES-2 activity is required for normal levels and localization of MES-3 in >24-cell-stage embryos; MES-2 expression is detected in the primordial germ cells and germline nuclei throughout development, in all nuclei in early embryos, and in somatic nuclei, including those of the male tail, in L2 and L3 larvae; in the nucleus, MES-2 appears to localize to chromatin.
7	K09B11.10	K09B11.10	n/a	chrIV 13,439,731	contains similarity to Interpro domain IPR000998 (MAM)
8	T07D3.3	T07D3.3	n/a	chrII 895,627	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
9	F25B4.7	F25B4.7	n/a	chrV 5,686,614	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR002030 (Mitochondrial brown fat uncoupling protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
10	fbxa-200	T07D3.1	n/a	chrII 905,248	C. elegans FBXA-200 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
11	mrt-2	Y41C4A.14	n/a	chrIII 11,748,489	mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
12	srw-8	F59D6.5	n/a	chrV 3,033,490	C. elegans SRW-8 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
13	F41C3.1	F41C3.1	n/a	chrII 4,752,652	contains similarity to Pfam domain PF06887 Protein of unknown function (DUF1265) contains similarity to Interpro domain IPR009676 (Protein of unknown function DUF1265)
14	srx-53	T27C5.2	n/a	chrV 17,400,916	C. elegans SRX-53 protein; contains similarity to Interpro domain IPR010989 (t-SNARE)
15	W10G6.1	W10G6.1	n/a	chrX 16,245,293	contains similarity to Babesia bovis Merozoite surface antigen-2a2.; TR:Q95UH0
16	F53G12.3	F53G12.3	n/a	chrI 141,205	F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
17	ZK596.3	ZK596.3	n/a	chrIV 10,903,190	contains similarity to Mus musculus DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA-sPKcs) (P460).; SW:PRKD_MOUSE
18	K11E4.2	K11E4.2	n/a	chrX 13,718,299	contains similarity to Pfam domain PF00017 SH2 domain contains similarity to Interpro domains IPR006020 (Phosphotyrosine interaction region), IPR000980 (SH2 motif)
19	F48C1.4	F48C1.4	n/a	chrI 5,313,536
20	F08F1.9	F08F1.9	n/a	chrX 8,410,171	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
21	srt-1	C13B7.1	n/a	chrV 2,436,754	C. elegans SRT-1 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
22	C27B7.2	C27B7.2	n/a	chrIV 8,893,280	contains similarity to Arabidopsis thaliana F3O9.12 protein (At1g16320/F3O9_12).; TR:Q9SA31
23	nas-8	C34D4.9	n/a	chrIV 7,117,415	nas-8 encodes an astacin-like metalloprotease.
24	srg-61	C24B9.11	n/a	chrV 2,739,518	C. elegans SRG-61 protein; contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
25	Y48B6A.1	Y48B6A.1	n/a	chrII 14,152,681	Y48B6A.1 encodes an ortholog of human BOP1 (OMIM:610596, overexpressed in colon cancer) and S. cerevisiae ERB1; Y48B6A.1 may suppress tumorous growth in the germline; like PRO-1, -2, and -3, Y48B6A.1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline; however, BOP1 is also a phosphoprotein in mitotic spindles and required for normal chromosomal segregation, raising the possibility that Y48B6A.1 is multifunctional.
26	dpm-1	Y66H1A.2	n/a	chrIV 447,058	dpm-1 encodes a putative catalytic subunit of dolichol phosphate mannosyltransferase, orthologous to budding yeast and human DPM1 (OMIM:603503, mutated in congenital disorder of glycosylation type Ie); in mass RNAi assays, DPM-1 is required for embryonic viability and proper cortical motion in the early embryo.
27	kin-4	C10C6.1	n/a	chrIV 11,441,819	C. elegans KIN-4 protein; contains similarity to Pfam domains PF08926 (Domain of unknown function (DUF1908)) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR015022 (Region of unknown function DUF1908), IPR000719 (Protein kinase, core), IPR001478 (PDZ/DHR/GLGF), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
28	btb-5	W05G11.5	n/a	chrIII 60,257	C. elegans BTB-5 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
29	his-62	F55G1.3	n/a	chrIV 7,486,714	his-62 encodes an H2B histone.
30	Y17G7B.3	Y17G7B.3	n/a	chrII 11,990,838	Y17G7B.3 is orthologous to the human gene HYDROXYACYLGLUTATHIONE HYDROLASE (HAGH; OMIM:138760), which when mutated leads to disease.
31	srsx-8	F52F10.5	n/a	chrV 1,552,074	C. elegans SRSX-8 protein ;
32	cdk-8	F39H11.3	n/a	chrI 8,704,132	cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development.
33	T22F7.1	T22F7.1	n/a	chrIII 544,286	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR006655 (Molybdopterin oxidoreductase, prokaryotic, conserved site), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
34	mys-1	VC5.4	n/a	chrV 7,083,085	mys-1 encodes a MYST family histone acetyltransferase orthologous to Drosophila EG0007.7, human TIP60, and S. cerevisiae Esa1p; during vulval development, mys-1 acts as Class C synMuv gene: mys-1 mutations enhance mutations in components of the C. elegans NuRD and Rb repressor complexes that negatively regulate expression of genes required for vulval induction; in addition, mys-1(RNAi) enhances mutations in pha-4, which encodes a FoxA transcription factor required for pharyngeal organogenesis; mys-1 mutations also cause a synthetic slow growth phenotype in combination with mutations in the MCD-1 zinc-finger protein; thus, mys-1 activity is essential for proper cell fate specification of different cell types at different times during C. elegans development.
35	F56G4.4	F56G4.4	n/a	chrI 11,377,362	contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR000533 (Tropomyosin), IPR001202 (WW/Rsp5/WWP)
36	F52E10.3	F52E10.3	n/a	chrX 16,283,853	contains similarity to Salmonella typhimurium Secretion system apparatus protein ssaM.; SW:SSAM_SALTY
37	F52B11.2	F52B11.2	n/a	chrIV 14,084,140	F52B11.2 is orthologous to the human gene PHOSPHOMANNOMUTASE 2 (PMS2; OMIM:601785), which when mutated leads to congenital disorder of glycosylation, type Ia.
38	F08F8.4	F08F8.4	n/a	chrIII 7,358,292	contains similarity to Interpro domain IPR001126 (UMUC-like DNA-repair protein)
39	F56G4.6	F56G4.6	n/a	chrI 11,369,184	contains similarity to Interpro domain IPR001623 (Heat shock protein DnaJ, N-terminal)
40	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
41	F42A6.1	F42A6.1	n/a	chrIV 3,356,300
42	rpb-4	F43E2.2	n/a	chrII 7,374,771	C. elegans RPB-4 protein; contains similarity to Pfam domain PF03874 RNA polymerase Rpb4 contains similarity to Interpro domains IPR010997 (HRDC-like), IPR005574 (RNA polymerase II, Rpb4), IPR006590 (RNA polymerase II, Rpb4, core)
43	efl-1	Y102A5C.18	n/a	chrV 16,962,099	efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition.
44	wve-1	R06C1.3	n/a	chrI 11,927,136	wve-1 encodes a homolog of the mammalian WAVE protein; based on homology WVE-1 might be involved in actin cytoskeletal dynamics; wve-1 is required for early cell migrations in the epidermis during embryonic morphogenesis and may require gex-2 and gex-3 for its function.
45	hsr-9	T05F1.6	n/a	chrI 9,628,707	hsr-9 encodes a protein containing a BRCT (BRCA 1 C terminus) domain that is found in proteins that regulate the cell cycle checkpoint in response to DNA damage; HSR-9 activity is required for a normal response to DNA damage caused by gamma-irradiation; loss of HSR-9 function via RNA-mediated interference after gamma-irradiation results in defects in mitotic cell cycle arrest, reduction of apoptosis of pachytene nuclei, and radiation sensitivity of progeny; the expression pattern and subcellular localization of HSR-9 are not yet known.
46	F13H8.3	F13H8.3	n/a	chrII 6,264,731	contains similarity to Pfam domain PF01156 Inosine-uridine preferring nucleoside hydrolase contains similarity to Interpro domain IPR001910 (Inosine/uridine-preferring nucleoside hydrolase)
47	T23E1.2	T23E1.2	n/a	chrIV 3,144,252
48	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
49	srt-63	T28A11.15	n/a	chrV 3,255,375	C. elegans SRT-63 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
50	pqn-51	K11D12.2	n/a	chrV 5,050,974	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).