UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K09C4.10	K09C4.10	0	chrX 3,278,116	contains similarity to Staphylococcus aureus Serine-rich adhesin for platelets precursor (Staphylococcus aureusssurface protein A).; SW:Q7A362
2	F38B6.4	F38B6.4	n/a	chrX 6,677,310	contains similarity to Pfam domains PF02844 (Phosphoribosylglycinamide synthetase, N domain) , PF02769 (AIR synthase related protein, C-terminal domain) , PF02843 (Phosphoribosylglycinamide synthetase, C domain) , PF01071 (Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain) , PF00551 (Formyl transferase) , PF00586 (AIR synthase related protein, N-terminal domain) contains similarity to Interpro domains IPR016185 (PreATP-grasp-like fold), IPR011761 (ATP-grasp fold), IPR004733 (Phosphoribosylformylglycinamidine cyclo-ligase), IPR002376 (Formyl transferase, N-terminal), IPR016188 (PurM, N-terminal-like), IPR000728 (AIR synthase related protein), IPR004607 (Phosphoribosylglycinamide formyltransferase), IPR013815 (ATP-grasp fold, subdomain 1), IPR010918 (AIR synthase related protein, C-terminal), IPR013816 (ATP-grasp fold, subdomain 2), IPR013817 (Pre-ATP-grasp fold), IPR011054 (Rudiment single hybrid motif), IPR000115 (Phosphoribosylglycinamide synthetase)
3	C33G3.4	C33G3.4	n/a	chrX 14,073,660	C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease.
4	pxn-2	K09C8.5	n/a	chrX 10,975,651	C. elegans PXN-2 protein; contains similarity to Pfam domains PF00047 (Immunoglobulin domain) (2), PF00560 (Leucine Rich Repeat) (3), PF01462 (Leucine rich repeat N-terminal domain) , PF07679 (Immunoglobulin I-set domain) (2), PF03098 (Animal haem peroxidase) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR013098 (Immunoglobulin I-set), IPR010255 (Haem peroxidase), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR003591 (Leucine-rich repeat, typical subtype), IPR007110 (Immunoglobulin-like), IPR002007 (Haem peroxidase, animal), IPR000372 (Leucine-rich repeat, cysteine-rich flanking region, N-terminal), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
5	F52C6.13	F52C6.13	n/a	chrII 1,930,469
6	F28C1.1	F28C1.1	n/a	chrV 12,452,041	contains similarity to Drosophila melanogaster Flybase gene name is CG6695-PA;; FLYBASE:CG6695
7	cul-6	K08E7.7	n/a	chrIV 12,588,438	cul-6 encodes a member of the cullin family that may physically interact with SKR-3.
8	W04C9.2	W04C9.2	n/a	chrI 489,263
9	fbxa-51	T12B5.1	n/a	chrIII 962,902	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
10	twk-26	C33D12.3	n/a	chrX 3,052,381	C. elegans TWK-26 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)
11	F43C1.1	F43C1.1	n/a	chrIII 4,213,606	contains similarity to Pfam domains PF00481 (Protein phosphatase 2C) , PF00560 (Leucine Rich Repeat) (11)contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR001611 (Leucine-rich repeat), IPR000694 (Proline-rich region), IPR003591 (Leucine-rich repeat, typical subtype), IPR014045 (Protein phosphatase 2C, N-terminal)
12	F13B6.2	F13B6.2	n/a	chrIV 7,459,793
13	pqn-29	F10F2.9	n/a	chrIII 4,645,137	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
14	T09E8.3	T09E8.3	n/a	chrV 13,180,913	contains similarity to Pfam domain PF03311 Cornichon protein contains similarity to Interpro domain IPR003377 (Cornichon)
15	ZK488.6	ZK488.6	n/a	chrV 591,473	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
16	W03G1.3	W03G1.3	n/a	chrIV 512,107
17	T22F3.7	T22F3.7	n/a	chrV 3,599,159	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
18	smg-5	W02D3.8	n/a	chrI 6,735,096	smg-5 encodes a novel protein that contains two N-terminal tetratricopeptide (TPR) repeats and a C-terminal PINc domain found in nucleotide-binding proteins; SMG-5 is a component of the nonsense-mediated mRNA decay (NMD) pathway and likely functions in regulation of dephosphorylation of SMG-2, the C. elegans UPF1 ortholog, an ATPase and RNA helicase required for NMD in worms, yeast, and mammals; SMG-5 physically interacts with SMG-7, SMG-2, and the PAA-1 and LET-92 structural and catalytic subunits, respectively, of a protein phosphatase 2A (PP2A), suggesting that SMG-5 may function to direct SMG-2 to a PP2A phosphatase that regulates its activity in vivo; SMG-5 also interacts, in vivo, with components of the RNA interference (RNAi) pathway, suggesting a potential link between RNAi and NMD; SMG-5::GFP fusion proteins localize to both the nucleus and the cytoplasm.
19	nfyc-1	F23F1.1	n/a	chrII 44,432	C. elegans NFYC-1 protein; contains similarity to Pfam domains PF00808 (Histone-like transcription factor (CBF/NF-Y) and archaeal histone) , PF00125 (Core histone H2A/H2B/H3/H4) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR007125 (Histone core), IPR003958 (Transcription factor CBF/NF-Y/archaeal histone)
20	K04G11.3	K04G11.3	n/a	chrX 14,346,393	contains similarity to Pfam domain PF07547 RSD-2 N-terminal domain contains similarity to Interpro domain IPR011508 (RSD-2, N-terminal)
21	pink-1	EEED8.9	n/a	chrII 5,394,469	pink-1 encodes a predicted serine/threonine protein kinase that is most similar to the Drosophila and human PINK1 (PTEN-induced kinase) protein kinases, the latter of which has been implicated in familial forms of Parkinson's disease; although loss of C. elegans pink-1 activity via large-scale RNAi screens results in no obvious abnormalities, studies in Drosophila indicate that Drosophila PINK1 is a mitochondrial protein that genetically interacts with Drosophila parkin and is essential for maintaining mitochondrial function and integrity in several tissues, including flight muscles and dopaminergic neurons.
22	nas-38	F57C12.1	n/a	chrX 560,901	C. elegans NAS-38 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00090 (Thrombospondin type 1 domain) , PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001506 (Peptidase M12A, astacin), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR013032 (EGF-like region, conserved site)
23	F32B4.6	F32B4.6	n/a	chrI 11,516,108	contains similarity to Pfam domains PF07819 (PGAP1-like protein) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR012908 (PGAP1-like)
24	K10D11.3	K10D11.3	n/a	chrIV 12,984,093	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
25	F19C7.2	F19C7.2	n/a	chrIV 4,601,343	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
26	ZC504.3	ZC504.3	n/a	chrX 10,418,158	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
27	elt-2	C33D3.1	n/a	chrX 10,482,266	elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation
28	D1081.3	D1081.3	n/a	chrI 8,466,325	contains similarity to Pfam domain PF03761 Domain of unknown function (DUF316) contains similarity to Interpro domains IPR005514 (Protein of unknown function DUF316), IPR009003 (Peptidase, trypsin-like serine and cysteine)
29	C49A9.2	C49A9.2	n/a	chrIV 6,226,732	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
30	F55C10.4	F55C10.4	n/a	chrV 11,387,665	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
31	F53G2.3	F53G2.3	n/a	chrII 2,480,856
32	T05E12.3	T05E12.3	n/a	chrV 17,077,410	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
33	abu-2	F19G12.7	n/a	chrX 1,409,740	abu-2 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-2 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-2 may help protect the organism from damage by improperly folded nascent protein.
34	K02G10.5	K02G10.5	n/a	chrX 4,689,524	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF03137 (Organic Anion Transporter Polypeptide (OATP) family) contains similarity to Interpro domains IPR004156 (Organic anion transporter polypeptide OATP), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
35	pps-1	T14G10.1	n/a	chrIV 10,163,166	pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
36	Y11D7A.8	Y11D7A.8	n/a	chrIV 9,252,608	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
37	D1054.1	D1054.1	n/a	chrV 10,769,166	contains similarity to Pfam domain PF01734 Patatin-like phospholipase contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR002641 (Patatin)
38	H28O16.2	H28O16.2	n/a	chrI 12,649,720	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR000253 (Forkhead-associated)
39	ZK673.1	ZK673.1	n/a	chrII 10,444,162	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR003582 (Metridin-like ShK toxin)
40	klp-8	C15C7.2	n/a	chrX 3,162,174	klp-8 encodes an atypical kinesin-like motor protein with the motor domain in the N-terminus; the motor domain of KLP-8 exhibits poor homology to the globular motor domain of the kinesin heavy chain.
41	C35A11.4	C35A11.4	n/a	chrV 5,391,300	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
42	F31A3.3	F31A3.3	n/a	chrX 17,533,568
43	C05E11.7	C05E11.7	n/a	chrX 4,583,603
44	T15B7.13	T15B7.13	n/a	chrV 6,827,999	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
45	B0285.6	B0285.6	n/a	chrIII 4,354,080	B0285.6 encodes a predicted sodium-coupled carboxylate transporter that is one of four C. elegans proteins related to Drosophila Indy and the mammalian NaDC1 and NaDC3 transporters; B0285.6::lacZ reporter fusions are expressed in the excretory cell, from early larval stages through adulthood, with some later expression occasionally seen in two large unidentified structures on the dorsal side of the pharyngeal terminal bulb.
46	C26D10.4	C26D10.4	n/a	chrII 8,331,544	contains similarity to Pfam domains PF08544 (GHMP kinases C terminal) , PF00288 (GHMP kinases N terminal domain) contains similarity to Interpro domains IPR006206 (Mevalonate and galactokinase), IPR001174 (Galactokinase/homoserine kinase), IPR006204 (GHMP kinase), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013750 (GHMP kinase, C-terminal)
47	B0495.9	B0495.9	n/a	chrII 7,708,071
48	B0554.2	B0554.2	n/a	chrV 435,748	contains similarity to Pfam domain PF02795 Domain of unknown function (DUF225) contains similarity to Interpro domain IPR004024 (Protein of unknown function DUF225)
49	nhr-210	R11G11.12	n/a	chrV 518,366	C. elegans NHR-210 protein; contains similarity to Pfam domain PF00105 Zinc finger, C4 type (two domains) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
50	srz-64	Y57G7A.7	n/a	chrII 1,291,002	C. elegans SRZ-64 protein ;