UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K08F11.1	K08F11.1	7e-74	chrIV 4,725,078
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	chn-1	T09B4.10	n/a	chrI 6,182,743	chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock; chn-1 overexpression causes either embryonic lethality (if strong) or defective egg-laying and locomotion, along with constitutive dauer formation (if weak); chn-1(by155) mutations suppress viable unc-45(e286ts) and unc-45(m94ts) mutations, but not lethal unc-45(st604) ones; chn-1(by155) mutants, unlike wild-type, show defective sarcomeres if overexpressing unc-45 from a extrachromosomal array; CHN-1 binds the ubiquitin conjugating enzyme UFD-2, which in turn binds the Hsp90 cochaperone UNC-45; UNC-45 is a substrate for CHN-1- and UFD-2-dependent multiubiquitination; the parkin ortholog PDR-1 binds CHN-1, and requires CHN-1 for self-ubiquitination; chn-1(RNAi) animals accumulate abnormally phosphorylated tau proteins.
4	M02D8.3	M02D8.3	n/a	chrX 8,734,954	contains similarity to Dictyostelium discoideum PHD Zn finger-containing protein.; TR:Q1ZXQ2
5	K08B5.1	K08B5.1	n/a	chrX 16,560,293
6	Y39A1C.1	Y39A1C.1	n/a	chrIII 10,857,346	contains similarity to Xylella fastidiosa Hypothetical protein Xf0776.; TR:Q9PFA2
7	cpn-1	F43G9.9	n/a	chrI 8,636,741	cpn-1 encodes a calponin homolog, more closely related to calponin per se than to its paralogs transgelin (SM22 alpha) or neuronal protein NP25, that is is dispensable for viability and gross morphology in mass RNAi screens, and that has no obvious mutant phenotype in a rearrangement that probably disrupts cpn-1.
8	dpm-3	F28D1.11	n/a	chrIV 12,391,825	dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health.
9	F38H4.1	F38H4.1	n/a	chrIV 11,838,167
10	nhr-181	F38H12.3	n/a	chrV 4,097,665	nhr-181 encodes a putative nuclear hormone receptor (NHR), belonging to a large nematode-specific expanded family of NHRs, that inhibits CEP-1- and HUS-1-dependent germline apoptosis as do BMK-1, RAD-50, and RAD-51.
11	C03F11.2	C03F11.2	n/a	chrX 5,395,712	contains similarity to Pfam domain PF00753 Metallo-beta-lactamase superfamily contains similarity to Interpro domain IPR001279 (Beta-lactamase-like)
12	K09H11.5	K09H11.5	n/a	chrV 5,728,063
13	F22B7.1	F22B7.1	n/a	chrIII 8,666,020
14	F48B9.5	F48B9.5	n/a	chrX 2,148,428	contains similarity to Pfam domain PF00292 'Paired box' domain contains similarity to Interpro domains IPR001523 (Paired box protein, N-terminal), IPR011991 (Winged helix repressor DNA-binding), IPR009057 (Homeodomain-like)
15	F38E11.9	F38E11.9	n/a	chrIV 9,443,446	contains similarity to Musca domestica Transposase.; TR:Q25442
16	Y38H6C.8	Y38H6C.8	n/a	chrV 20,510,594	contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR002350 (Proteinase inhibitor I1, Kazal), IPR003990 (Pancreatitis-associated protein), IPR002352 (Eosinophil major basic protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
17	K08H2.2	K08H2.2	n/a	chrX 13,234,539	contains similarity to Homo sapiens Hypothetical protein KIAA0144; ENSEMBL:ENSP00000271877
18	R05D7.5	R05D7.5	n/a	chrI 12,186,205	contains similarity to Ascaris suum P40.; TR:Q7YXJ9
19	B0511.5	B0511.5	n/a	chrI 10,630,197	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
20	apx-1	K08D9.3	n/a	chrV 3,216,670	apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, integral transmembrane and secreted proteins that function as signaling ligands for the Notch family receptors GLP-1 and LIN-12; in the 4-cell embryo, maternally supplied APX-1 functions as a GLP-1 ligand for an inductive interaction that specifies the fate of the ABp blastomere; later in embryogenesis, APX-1 is required for formation of the LIN-12-dependent, invariant asymmetrical twist that occurs as part of normal gut morphogenesis; during larval development, APX-1 is required redundantly with DSL-1 and LAG-2 for the LIN-12-mediated lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the early embryo, APX-1 is first detected at the anterior edge of the P1 blastomere, with later expression visible in P2 at sites of contact with ABp, and in the cytoplasm of the EMS and P3 blastomeres; expression in the vulval precursor cells (VPCs) is detected in the primary VPC, P6.p, and its descendants; embryonic APX-1 expression is dependent upon PIE-1 activity, while later vulval expression is mediated by the Ras signaling pathway and the SUR-2 transcriptional cofactor.
21	nas-12	C24F3.3	n/a	chrIV 10,225,155	nas-12 encodes an astacin-like metalloprotease; large-scale expression studies reveal that a nas-12::GFP promoter fusion is expressed in the intestine and in the pharyngeal and rectal gland cells.
22	C03C10.5	C03C10.5	n/a	chrIII 4,090,398	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IEF0
23	his-56	F54E12.3	n/a	chrIV 11,338,648	his-56 encodes an H4 histone.
24	Y79H2A.4	Y79H2A.4	n/a	chrIII 12,041,576	contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
25	K07C11.4	K07C11.4	n/a	chrV 8,204,685	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
26	R10E11.9	R10E11.9	n/a	chrIII 9,792,971	contains similarity to Brachydanio rerio Hypothetical protein.; TR:Q7T2Z9
27	ttb-1	W03F9.5	n/a	chrV 160,090	C. elegans TTB-1 protein; contains similarity to Pfam domains PF00382 (Transcription factor TFIIB repeat) (2), PF08271 (TFIIB zinc-binding) contains similarity to Interpro domains IPR006670 (Cyclin), IPR000812 (Transcription factor TFIIB related), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR013150 (Transcription factor TFIIB, cyclin-related), IPR013137 (Zinc finger, TFIIB-type)
28	F46C8.1	F46C8.1	n/a	chrX 7,550,722
29	clec-230	C29F3.5	n/a	chrV 15,348,475	C. elegans CLEC-230 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR001202 (WW/Rsp5/WWP)
30	T02H6.3	T02H6.3	n/a	chrII 692,115
31	ZK430.5	ZK430.5	n/a	chrII 4,411,199	contains similarity to Pfam domain PF03568 Peptidase family C50 contains similarity to Interpro domain IPR005314 (Peptidase C50, separase)
32	grl-1	C24G6.7	n/a	chrV 5,532,342	grl-1 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich region, and a C-terminal Ground-like (Grl) domain; GRL-1 is expressed in intestine, neurons, and larval arcade cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
33	prx-6	F39G3.7	n/a	chrV 4,717,742	C. elegans PRX-6 protein; contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
34	F55F8.3	F55F8.3	n/a	chrI 5,651,700	contains similarity to Pfam domains PF04047 (Periodic tryptophan protein 2 WD repeat associated presumed domain) , PF00400 (WD domain, G-beta repeat) (5)contains similarity to Interpro domains IPR000009 (Protein phosphatase 2A, regulatory subunit PR55), IPR017441 (Protein kinase ATP binding, conserved site), IPR011046 (WD40 repeat-like), IPR007190 (Periodic tryptophan protein-associated region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
35	T15B7.12	T15B7.12	n/a	chrV 6,818,884	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
36	W04C9.6	W04C9.6	n/a	chrI 485,237	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
37	str-154	Y45G12C.12	n/a	chrV 2,559,268	C. elegans STR-154 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR001046 (Natural resistance-associated macrophage protein), IPR000276 (GPCR, rhodopsin-like)
38	ver-4	F59F3.5	n/a	chrX 10,985,087	C. elegans VER-4 protein; contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) , PF00047 (Immunoglobulin domain) (2), PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF07679 (Immunoglobulin I-set domain) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR013098 (Immunoglobulin I-set), IPR011009 (Protein kinase-like), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR000719 (Protein kinase, core), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site), IPR013151 (Immunoglobulin)
39	tag-236	R11B5.1	n/a	chrX 2,528,819	C. elegans TAG-236 protein; contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
40	ndx-6	EEED8.8	n/a	chrII 5,389,360	The ndx-6 gene encodes a NUDIX hydrolase.
41	C03B1.9	C03B1.9	n/a	chrX 6,346,694
42	immp-1	C24H11.6	n/a	chrIII 11,775,731	C. elegans IMMP-1 protein; contains similarity to Pfam domain PF00717 Peptidase S24-like contains similarity to Interpro domains IPR001733 (Peptidase S26B, eukaryotic signal peptidase), IPR015927 (Peptidase S24, S26A, S26B and S26C), IPR014037 (Peptidase S26A), IPR011056 (Peptidase S24, S26A and S26B, C-terminal), IPR000223 (Peptidase S26A, signal peptidase I)
43	C56G2.15	C56G2.15	n/a	chrIII 6,367,144	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase), IPR008125 (Streptothricin acetyltransferase)
44	T08H10.3	T08H10.3	n/a	chrV 4,472,476
45	zyg-8	Y79H2A.11	n/a	chrIII 12,066,888	The zyg-8 gene encodes a protein with a doublecortin-like domain and a protein kinase domain; mutations of zyg-8 impair mitosis at the one-cell embryonic stage, which is normally asymmetrical, but which fails to show proper asymmetry in zyg-8 mutant embryos.
46	E04A4.6	E04A4.6	n/a	chrIV 4,746,804	contains similarity to Homo sapiens Isoform 5 of Tectonic-1 precursor; ENSEMBL:ENSP00000380771
47	F55C9.3	F55C9.3	n/a	chrV 19,287,274	contains similarity to Pfam domain PF02170 PAZ domain contains similarity to Interpro domain IPR003100 (Argonaute and Dicer protein, PAZ)
48	ZK899.6	ZK899.6	n/a	chrX 9,463,973	contains similarity to Saccharomyces cerevisiae Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function; SGD:YPL195W
49	fbxa-45	F09C6.6	n/a	chrV 16,898,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
50	air-2	B0207.4	n/a	chrI 5,938,181	air-2 encodes an aurora/Ipl1-related serine/threonine protein kinase that affects embryonic viability and chromosome segregation during meiosis and mitosis and is required for cytokinesis; AIR-2 has two functions during mitosis, one in chromosome segregation, and a second, independent function in cytokinesis through ZEN-4; AIR-2 and ZEN-4 may act in parallel to a second pathway that includes CYK-1; AIR-2 phosphorylates two adjacent, evolutionarily conserved C-terminal serines of the inner centromere protein ICP-1; AIR-2 forms a robust complex with CSC-1, BIR-1, and ICP-1; air-2 is expressed highly in embryos, in the mature oocytes, spermatocytes, and extruded polar bodies.