UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	apc-2	K06H7.6	0	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
2	ZK1058.3	ZK1058.3	n/a	chrIII 3,919,762	ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease.
3	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
4	ZK1067.3	ZK1067.3	n/a	chrII 9,224,144	contains similarity to Mus musculus Serine/threonine-protein kinase Nek9 (EC 2.7.1.37) (NimA-relatedsprotein kinase 9).; SW:NEK9_MOUSE
5	F11A10.5	F11A10.5	n/a	chrIV 12,095,498	contains similarity to Pfam domain PF04184 ST7 protein contains similarity to Interpro domain IPR007311 (ST7)
6	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
7	W02D9.3	W02D9.3	n/a	chrI 12,536,484	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
8	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
9	C48B4.10	C48B4.10	n/a	chrIII 9,563,945	contains similarity to Homo sapiens Transmembrane 9 superfamily protein member 2 precursor; ENSEMBL:ENSP00000245361
10	C29H12.5	C29H12.5	n/a	chrII 6,111,947	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR000953 (Chromo domain), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR016197 (Chromo domain-like)
11	ehbp-1	F25B3.1	n/a	chrV 9,553,309	C. elegans EHBP-1 protein; contains similarity to Pfam domain PF00307 Calponin homology (CH) domain contains similarity to Interpro domains IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding)
12	F46F11.6	F46F11.6	n/a	chrI 5,617,576	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
13	spd-3	H34C03.1	n/a	chrIV 6,763,933	C. elegans SPD-3 protein ;
14	rrt-2	C29H12.1	n/a	chrII 6,126,706	C. elegans RRT-2 protein; contains similarity to Pfam domains PF05746 (DALR anticodon binding domain) , PF00750 (tRNA synthetases class I (R)) contains similarity to Interpro domains IPR015945 (Arginyl-tRNA synthetase, class Ic, core), IPR008909 (DALR anticodon binding), IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding), IPR001278 (Arginyl-tRNA synthetase, class Ic), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
15	H14A12.3	H14A12.3	n/a	chrIII 7,464,450	H14A12.3 encodes an ortholog of S. cerevisiae RAV2; like RAV2, H14A12.3 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
16	sna-2	T13F2.7	n/a	chrIV 9,776,092	sna-2 encodes an snRNP-binding protein (SNA-2/SL75p) homologous to Ascaris SL95p (SL 175kd); SNA-2 is found in at least two Sm snRNPs, SL1 and Y, but not in SL2; in snRNP SL1, SNA-2 associates with the SNA-1/SL21p protein, while associating with SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-2(RNAi) is lethal; SNA-2 can bind either SNA-1 or SUT-1 even in the absence of RNA.
17	cdd-2	F49E8.4	n/a	chrIV 7,547,502	A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages.
18	cas-2	C18E3.6	n/a	chrI 4,191,639	C. elegans CAS-2 protein; contains similarity to Pfam domains PF01213 (Adenylate cyclase associated (CAP) N terminal) , PF08603 (DE Adenylate cyclase associated (CAP) C terminal) contains similarity to Interpro domains IPR001837 (Adenylate cyclase-associated CAP), IPR000694 (Proline-rich region), IPR013992 (Adenylate cyclase-associated CAP, N-terminal), IPR003073 (Orphan nuclear receptor, NURR type), IPR016098 (Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal), IPR006599 (CARP motif), IPR013912 (Adenylate cyclase-associated CAP, C-terminal)
19	CD4.8	CD4.8	n/a	chrV 5,600,286	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
20	F43G9.10	F43G9.10	n/a	chrI 8,639,367	contains similarity to Pfam domain PF06991 Micro-fibrillar-associated protein 1 C-terminus contains similarity to Interpro domains IPR009730 (Micro-fibrillar-associated 1, C-terminal), IPR000533 (Tropomyosin)
21	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
22	T01B7.6	T01B7.6	n/a	chrII 8,723,943	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	F45E4.11	F45E4.11	n/a	chrIV 7,652,864	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
24	C34B7.2	C34B7.2	n/a	chrI 8,339,396	contains similarity to Pfam domain PF02383 SacI homology domain contains similarity to Interpro domain IPR002013 (Synaptojanin, N-terminal)
25	vps-33.2	C56C10.1	n/a	chrII 6,602,269	C. elegans VPS-33.2 protein; contains similarity to Pfam domain PF00995 Sec1 family contains similarity to Interpro domain IPR001619 (Sec1-like protein)
26	tbg-1	F58A4.8	n/a	chrIII 9,627,816	tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
27	C27A12.2	C27A12.2	n/a	chrI 6,043,841	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
28	K12D12.5	K12D12.5	n/a	chrII 11,862,086	contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
29	D1043.1	D1043.1	n/a	chrII 11,585,601	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
30	Y106G6H.8	Y106G6H.8	n/a	chrI 10,452,513	contains similarity to Pfam domain PF04241 Protein of unknown function (DUF423) contains similarity to Interpro domain IPR006696 (Protein of unknown function DUF423)
31	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
32	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
33	C01G10.7	C01G10.7	n/a	chrV 15,086,381	contains similarity to Pfam domain PF03328 HpcH/HpaI aldolase/citrate lyase family contains similarity to Interpro domains IPR011206 (Citrate lyase, beta subunit), IPR005000 (HpcH/HpaI aldolase), IPR015813 (Pyruvate/Phosphoenolpyruvate kinase, catalytic core)
34	dcr-1	K12H4.8	n/a	chrIII 8,076,021	The dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing.
35	fem-2	T19C3.8	n/a	chrIII 633,323	A CB5161 ortholog of fem-2, Cbn-fem-2, has been isolated from the sibling Caenorhabditis species CB5161.
36	C48E7.2	C48E7.2	n/a	chrI 6,256,337	contains similarity to Pfam domains PF08221 (RNA polymerase III subunit RPC82 helix-turn-helix domain) , PF05645 (RNA polymerase III subunit RPC82) contains similarity to Interpro domains IPR013197 (RNA polymerase III subunit RPC82-related, helix-turn-helix), IPR008806 (RNA polymerase III Rpc82, C -terminal)
37	F13G3.6	F13G3.6	n/a	chrI 7,304,082	contains similarity to Pfam domain PF00535 Glycosyl transferase family 2 contains similarity to Interpro domains IPR001173 (Glycosyl transferase, family 2), IPR016040 (NAD(P)-binding)
38	F58G11.6	F58G11.6	n/a	chrV 13,680,190	F58G11.6 (also known as ccz-1 or hps-4) encodes an ortholog of human C7orf28A and C7orf28B, with more distant similarity to human HPS4 (OMIM:606682) and S. cerevisiae Ccz1p in its N-terminal CHiPS domain; the CHiPS domain of F58G11.6 is predicted to have a longin-like fold; by analogy with Ccz1p and C. elegans SAND-1, F58G11.6 might be required for normal (RAB-7-mediated) traffic between early and late endosomes, or for autophagy; F58G11.6 is bound by SAND-1.
39	K10C8.1	K10C8.1	n/a	chrV 12,693,876	contains similarity to Pfam domain PF04857 CAF1 family ribonuclease contains similarity to Interpro domains IPR006941 (Ribonuclease CAF1), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
40	C32D5.3	C32D5.3	n/a	chrII 6,319,574	C32D5.3 encodes an ortholog of ROLLING BLACKOUT (RBO; also called CMP44E or STAMPHA), a eukaryotic protein required for sustained phospholipase C activity during Drosophila phototransduction; RBO homologs have two predicted transmembrane helices, are significantly similar to several acylglycerol lipases, and share motifs characteristic of carboxyesterases and lipases.
41	ZK1236.7	ZK1236.7	n/a	chrIII 8,441,581	contains similarity to Drosophila melanogaster Flybase gene name is CG5862-PA;; FLYBASE:CG5862
42	Y102A5C.2	Y102A5C.2	n/a	chrV 16,919,147	contains similarity to Saccharomyces cerevisiae anti-silencing protein that causes depression of silent loci when overexpressed; SGD:YJL115W
43	H21P03.2	H21P03.2	n/a	chrIV 11,481,604	contains similarity to Pfam domain PF08743 Nse4 contains similarity to Interpro domain IPR014854 (Nse4)
44	bch-1	F25H2.13	n/a	chrI 10,574,565	C. elegans BCH-1 protein; contains similarity to Pfam domain PF06733 DEAD_2 contains similarity to Interpro domains IPR014013 (Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type), IPR010614 (DEAD2), IPR002464 (DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site), IPR006554 (Helicase-like, DEXD box c2 type), IPR006555 (Helicase, ATP-dependent, c2 type), IPR014001 (DEAD-like helicase, N-terminal), IPR013020 (DNA helicase (DNA repair), Rad3 type)
45	F20A1.9	F20A1.9	n/a	chrV 7,050,345	contains similarity to Pfam domains PF04326 (Divergent AAA domain) , PF00622 (SPRY domain) contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR003877 (SPla/RYanodine receptor SPRY), IPR007421 (ATPase associated with various cellular activities, AAA-4)
46	cutc-1	ZK353.7	n/a	chrIII 8,402,774	C. elegans CUTC-1 protein; contains similarity to Pfam domain PF03932 CutC family contains similarity to Interpro domain IPR005627 (CutC)
47	T02G5.12	T02G5.12	n/a	chrII 7,097,415	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR001411 (Tetracycline resistance protein, TetB), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
48	wdfy-2	D2013.2	n/a	chrII 9,320,794	wdfy-2 encodes a WD40- and FYVE-domain containing protein that is orthologous to mammalian WDFY2; WDFY-2 is one of twelve C. elegans FYVE-domain-containing proteins; wdfy-2 activity is essential for wild-type levels of endocytosis.
49	F57C9.7	F57C9.7	n/a	chrI 4,825,902
50	B0024.4	B0024.4	n/a	chrV 10,298,103	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)