UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K05C4.7	K05C4.7	2e-161	chrI 14,738,206	contains similarity to Interpro domains IPR016617 (Uncharacterised conserved protein UCP013899, metal binding), IPR016024 (Armadillo-type fold)
2	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	mcm-3	C25D7.6	n/a	chrV 15,058,134	mcm-3 encodes a member of the MCM2/3/5 family with similarity to human DNA replication licensing factor, MCM3, and affects embryonic viability.
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	C02B8.2	C02B8.2	n/a	chrX 8,144,673
6	srh-128	Y47G7B.1	n/a	chrII 2,704,344	C. elegans SRH-128 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
7	Y4C6B.1	Y4C6B.1	n/a	chrIV 5,355,504	contains similarity to Interpro domain IPR000694 (Proline-rich region)
8	C17E4.6	C17E4.6	n/a	chrI 9,426,826	contains similarity to Pfam domains PF05764 (YL1 nuclear protein) , PF08265 (YL1 nuclear protein C-terminal domain) contains similarity to Interpro domains IPR013272 (YL1 nuclear, C-terminal), IPR008895 (YL1 nuclear)
9	Y54E5A.7	Y54E5A.7	n/a	chrI 14,713,042	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR006594 (LisH dimerisation motif), IPR006595 (CTLH, C-terminal to LisH motif), IPR003877 (SPla/RYanodine receptor SPRY)
10	F45C12.2	F45C12.2	n/a	chrII 1,732,740	contains similarity to Interpro domains IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
11	M151.4	M151.4	n/a	chrII 3,625,534	contains similarity to Interpro domain IPR000533 (Tropomyosin)
12	Y48A6C.3	Y48A6C.3	n/a	chrIII 11,118,099	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR015880 (Zinc finger, C2H2-like), IPR013026 (Tetratricopeptide region), IPR007087 (Zinc finger, C2H2-type)
13	unc-71	Y37D8A.13	n/a	chrIII 12,886,268	unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva.
14	T24G10.2	T24G10.2	n/a	chrIII 5,441,718	contains similarity to Pfam domain PF02201 SWIB/MDM2 domain contains similarity to Interpro domain IPR003121 (SWIB/MDM2)
15	pqn-45	F56F3.1	n/a	chrIII 4,473,243	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
16	sdz-30	T04D3.2	n/a	chrI 13,307,433	C. elegans SDZ-30 protein; contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
17	F23A7.4	F23A7.4	n/a	chrX 16,212,627	contains similarity to Mus musculus MKIAA0554 protein (Fragment).; TR:Q80TY0
18	Y106G6H.15	Y106G6H.15	n/a	chrI 10,473,965	contains similarity to Pfam domain PF07160 Protein of unknown function (DUF1395) contains similarity to Interpro domain IPR009829 (Protein of unknown function DUF1395)
19	F10G2.2	F10G2.2	n/a	chrV 7,331,479
20	C14C11.4	C14C11.4	n/a	chrV 5,649,282	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
21	hcf-1	C46A5.9	n/a	chrIV 7,772,495	C. elegans HCF-1 protein; contains similarity to Pfam domains PF01344 (Kelch motif) (3), PF00041 (Fibronectin type III domain) , PF07646 (Kelch motif) (4)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015915 (Kelch-type beta propeller)
22	C43H8.2	C43H8.2	n/a	chrI 10,623,645	contains similarity to Pfam domain PF09174 Maf1 regulator contains similarity to Interpro domains IPR017152 (RNA polymerase III transcriptional repressor, MAF1), IPR015257 (Maf1 regulator)
23	F30A10.3	F30A10.3	n/a	chrI 9,493,712	contains similarity to Pfam domain PF03770 Inositol polyphosphate kinase contains similarity to Interpro domain IPR005522 (Inositol polyphosphate kinase)
24	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
25	T19B4.5	T19B4.5	n/a	chrI 5,675,326
26	F32E10.5	F32E10.5	n/a	chrIV 7,576,352	contains similarity to Pfam domain PF00567 Tudor domain contains similarity to Interpro domains IPR008191 (Maternal tudor protein), IPR002011 (Receptor tyrosine kinase, class II, conserved site), IPR002999 (Tudor)
27	abu-3	F31A3.1	n/a	chrX 17,553,848	abu-3 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-3 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum (ER), and ABU-3 may function within the ER to protect the organism from damage by improperly folded nascent protein; abu-3 expression is enhanced in ER-stressed animals in which the unfolded protein response (UPR) is blocked by mutations in xbp-1, a bZIP transcription factor.
28	T04F8.2	T04F8.2	n/a	chrX 11,654,994	contains similarity to Anopheles gambiae str PEST AGAP011701-PA (Fragment).; TR:Q7PZ34
29	F59H6.3	F59H6.3	n/a	chrII 2,018,441
30	Y48E1B.4	Y48E1B.4	n/a	chrII 13,562,596	contains similarity to Buchnera aphidicola Flagellar hook-length control protein.; SW:FLIK_BUCAP
31	Y102A5C.2	Y102A5C.2	n/a	chrV 16,919,147	contains similarity to Saccharomyces cerevisiae anti-silencing protein that causes depression of silent loci when overexpressed; SGD:YJL115W
32	taf-6.1	W09B6.2	n/a	chrII 1,130,167	C. elegans TAF-6.1 protein; contains similarity to Pfam domains PF07571 (Protein of unknown function (DUF1546)) , PF02969 (TATA box binding protein associated factor (TAF)) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR004823 (TATA box binding protein associated factor (TAF)), IPR011442 (Protein of unknown function DUF1546)
33	cogc-5	C43E11.1	n/a	chrI 4,272,014	cogc-5 encodes an ortholog of mammalian COG-5, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-5 is also orthologous to Drosophila FOUR WAY STOP (required for fly spermatogenesis); COGC-5 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-5 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
34	zfp-2	F35H8.3	n/a	chrII 9,558,501	zfp-2 encodes a zinc-finger transcription factor; loss of zfp-2 and lin-35/Rb results in almost complete sterility accompanied by defects in somatic gonad development and vulval morphology, as well as polyploidization of somatic cell nuclei; loss of zfp-2 activity by itself reveals that zfp-2 is also required for cosuppression, inhibition of RNAi of some genes, and wild-type levels of expression of a rol-6 extrachromosomal array; a zfp-2::GFP promoter fusion construct is expressed in vulval cells and all somatic gonad structures, such as the spermatheca, sheath cells, uterine cells and distal tip cells (DTCs).
35	vet-6	F44F1.7	n/a	chrI 13,271,377	vet-6 encodes a protein that contains a spectrin repeat; vet-6 is preferentially transcribed in embryos prior to gastrulation.
36	ceh-5	C16C2.1	n/a	chrI 9,727,604	ceh-5 encodes a homeodomain protein, similar to the human VENTRAL ANTERIOR HOMEO BOX 2 gene (VAX2; OMIM:604295); CEH-5 is dispensable for viability and gross morphology.
37	F10G2.4	F10G2.4	n/a	chrV 7,327,473
38	T11B7.1	T11B7.1	n/a	chrIV 8,841,747	contains similarity to Mus musculus Girdin (Girders of actin filament) (Coiled-coil domain-containingsprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedsprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)s(GIV).; SW:Q5SNZ0
39	C41D11.5	C41D11.5	n/a	chrI 4,450,433
40	sec-5	T23G7.4	n/a	chrII 9,175,083	The sec-5 gene encodes an ortholog of SEC5 in S. cerevisiae, a component of the exocyst complex required genetically for endocytosis and for normal cellular morphology in the intestine.
41	C01G6.3	C01G6.3	n/a	chrII 9,270,502	contains similarity to Pichia etchellsii Hypothetical protein.; TR:Q9HFH3
42	R05D11.5	R05D11.5	n/a	chrI 8,592,502	contains similarity to Pfam domain PF05620 Protein of unknown function (DUF788) contains similarity to Interpro domain IPR008506 (Protein of unknown function DUF788)
43	fem-2	T19C3.8	n/a	chrIII 633,323	A CB5161 ortholog of fem-2, Cbn-fem-2, has been isolated from the sibling Caenorhabditis species CB5161.
44	elb-1	Y41C4A.10	n/a	chrIII 11,719,034	elb-1 encodes an Elongin B ortholog required for chromosome condensation and segregation during mitosis and meiotic division II, and also for cell proliferation (probably through degradation of CKI-1); elb-1(RNAi) animals tend to arrest at the second meiotic cell division, with escapers showing many other defects in chromosomal dynamics and cell cycle control such as abnormal pronuclear rotation and cortical protrusion, aberrant chromosomal structures in the intestine, and deficient germ cell proliferation; ELB-1 interacts with ELC-1 and ELC-2 in bacterial two-hybrid experiments.
45	mop-25.2	Y53C12A.4	n/a	chrII 9,702,750	mop-25.2 encodes a Mo25 protein that inhibits DHC-1 in vivo; MOP-25.2 is orthologous to fission yeast Mo25p, budding yeast Hym1p, Aspergillus nidulans HymA, human CAB39, and human CAB39L; MOP-25.2 is paralogous to MOP-25.1 and (more distantly) MOP-25.3; mop-25.2(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that MOP-25.2 negatively regulates dynein; in early embryos, MOP-25.2 is associated with the midbody and spindle poles after cytokinesis; MOP-25.2 shares a redundant function with MOP-25.1 in fertility and embryonic viability; in mass RNAi assays, MOP-25.2 is required for normal locomotion, body coloration, speed, and body size.
46	rnp-3	K08D10.3	n/a	chrIV 4,175,171	rnp-3 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-3/U2B''; genetically, rnp-3 appears to function redundantly with rnp-2/U1A: loss of rnp-3 activity alone results in low levels of embryonic and total lethality, while animals doubly mutant for rnp-3 and rnp-2/U1A show much higher levels of embryonic and total lethality; in addition, animals doubly mutant for SAP-1/U2A' and RNP-3/U2B'', display a much more severe phenotype than either single mutation, indicating that in vivo, these proteins have some independent functions; immunoprecipitation experiments indicate that RNP-3 associates with U2 RNA in vivo and that this association does not require the presence of SAP-1/U2A'.
47	hda-2	C08B11.2	n/a	chrII 8,021,602	hda-2 encodes a Class I histone deacetylase; by homology, HDA-2 is predicted to function in deacetylation of histone residues and transcriptional regulation; loss of hda-2 activity via RNAi results in an increased spontaneous mutation rate, suggesting that hda-2 also plays a role in regulating genome stability.
48	ncbp-2	F26A3.2	n/a	chrI 7,642,924	ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope.
49	M01E5.4	M01E5.4	n/a	chrI 13,288,518	contains similarity to Homo sapiens Isoform 1 of UPF0561 protein; ENSEMBL:ENSP00000304410
50	T21C9.1	T21C9.1	n/a	chrV 10,577,614	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)