UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	sel-7	K04G11.2	6e-173	chrX 14,336,558	sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.
2	plx-2	K04B12.1	n/a	chrII 14,421,292	C. elegans PLX-2 protein; contains similarity to Pfam domains PF01833 (IPT/TIG domain) (3), PF01437 (Plexin repeat) (3), PF08337 (Plexin cytoplasmic region) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR002165 (Plexin), IPR008936 (Rho GTPase activation protein), IPR002909 (Cell surface receptor IPT/TIG), IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR013548 (Plexin cytoplasmic region), IPR015943 (WD40/YVTN repeat-like)
3	gon-1	F25H8.3	n/a	chrIV 9,940,393	gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis; sequence homology with other metalloproteases suggests that it functions by remodelling the extracellular matrix; GON-1 is expressed at high levels within the gonadal distal tip cell during migration.
4	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
5	arr-1	F53H8.2	n/a	chrX 952,505	arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis.
6	C36A4.10	C36A4.10	n/a	chrIII 3,830,011
7	lrx-1	T04H1.6	n/a	chrV 12,253,997	lrx-1 encodes a protein that contains four class A low-density lipoprotein receptor domains.
8	C30F12.5	C30F12.5	n/a	chrI 6,995,898	contains similarity to Interpro domain IPR000694 (Proline-rich region)
9	Y45F3A.8	Y45F3A.8	n/a	chrIII 10,591,217	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
10	ssr-2	C14A11.7	n/a	chrX 2,825,197	C. elegans SSR-2 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily)
11	T19B10.3	T19B10.3	n/a	chrV 11,224,368	The T19B10.3 gene encodes an ortholog of the human gene GALACTOSIDASE, BETA 1 (GLB1), which when mutated leads to gangliosidosis type I (OMIM:230500).
12	F35D2.1	F35D2.1	n/a	chrII 7,577,252
13	T05B11.1	T05B11.1	n/a	chrV 7,750,009	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
14	tba-9	F40F4.5	n/a	chrX 3,254,559	tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport.
15	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
16	fbxb-85	R17.1	n/a	chrIII 10,848,088	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
17	T07H6.5	T07H6.5	n/a	chrX 6,288,966	contains similarity to Pfam domain PF00084 Sushi domain (SCR repeat) contains similarity to Interpro domains IPR000436 (Sushi/SCR/CCP), IPR016060 (Complement control module)
18	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
19	F54C9.11	F54C9.11	n/a	chrII 8,584,206	contains similarity to Interpro domain IPR008126 (Outer membrane adhesion, Yersinia)
20	C08H9.1	C08H9.1	n/a	chrII 9,876,448	contains similarity to Pfam domain PF00450 Serine carboxypeptidase contains similarity to Interpro domain IPR001563 (Peptidase S10, serine carboxypeptidase)
21	T20F7.5	T20F7.5	n/a	chrX 16,850,352	contains similarity to Interpro domain IPR000694 (Proline-rich region)
22	T28F4.6	T28F4.6	n/a	chrI 7,493,740	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
23	clec-241	F49H6.2	n/a	chrV 17,012,698	C. elegans CLEC-241 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
24	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
25	sri-18	Y22F5A.2	n/a	chrV 10,259,578	C. elegans SRI-18 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	K06H7.2	K06H7.2	n/a	chrIII 8,094,871	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
27	R90.1	R90.1	n/a	chrV 12,893,678	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
28	rhgf-1	F13E6.6	n/a	chrX 10,704,787	rhgf-1 encodes an RGS RhoGEF (Regulator of G-protein Signaling Rho Guanine Nucleotide Exchange Factor); RHGF-1 functions within cholingergic motor neurons in one of four G-protein-mediated signaling pathways that control locomotion via regulation of acetylcholine (ACh) release at neuromuscular junctions; in regulating ACh release, RHGF-1 functions downstream of the C. elegans Galpha12 ortholog, GPA-12, and upstream of the Rho GTPase ortholog, RHO-1; additionally, rhgf-1 activity is required for normal mechanosensory behavior, egg laying, and embryonic development; an rhgf-1 reporter fusion is expressed in ventral cord motor neurons as well as several head neurons.
29	F46F11.7	F46F11.7	n/a	chrI 5,621,853	contains similarity to Interpro domain IPR011061 (Proteinase inhibitor I14/I15, hirudin/antistatin)
30	F14B8.6	F14B8.6	n/a	chrX 6,930,764
31	T11B7.2	T11B7.2	n/a	chrIV 8,844,038	contains similarity to Homo sapiens remodeling and spacing factor 1; ENSEMBL:ENSP00000311513
32	F13D12.8	F13D12.8	n/a	chrII 11,731,826	contains similarity to White spot syndrome virus WSSV473 (Major virion protein VP19).; TR:Q8QTB2
33	F41G3.3	F41G3.3	n/a	chrII 6,757,638
34	sri-48	ZC239.9	n/a	chrII 3,200,257	C. elegans SRI-48 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
35	srg-67	ZC317.4	n/a	chrV 5,462,245	C. elegans SRG-67 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
36	rnp-7	K04G7.10	n/a	chrIII 7,160,025	C. elegans RNP-7 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
37	Y43F4A.4	Y43F4A.4	n/a	chrIII 13,245,650	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp313C0640; ENSEMBL:ENSP00000367438
38	sec-24.2	ZC518.2	n/a	chrIV 12,358,176	C. elegans SEC-24.2 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR000694 (Proline-rich region), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
39	C16D9.4	C16D9.4	n/a	chrV 8,241,945	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domains IPR008068 (Cytochrome P450, E-class, group I, CYP2B-like), IPR012444 (Protein of unknown function DUF1647)
40	dpy-19	F22B7.10	n/a	chrIII 8,663,628	The dpy-19 gene encodes a novel transmembrane protein whose human homolog is expressed in brain, and that is required for correct polarization and migration of the neuroblasts QL and QR.
41	aat-1	F27C8.1	n/a	chrIV 9,600,317	aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly.
42	F27B3.6	F27B3.6	n/a	chrIII 6,578,178
43	K04F10.1	K04F10.1	n/a	chrI 6,365,571	The K04F10.1 gene encodes a homolog of SCA1, which when mutated leads to spinocerebellar ataxia 1 (OMIM:164400).
44	C34C12.6	C34C12.6	n/a	chrIII 3,483,701	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
45	Y41C4A.8	Y41C4A.8	n/a	chrIII 11,707,793	contains similarity to Aedes aegypti Hypothetical conserved protein (Putative uncharacterized protein).; TR:Q1HQM0
46	sru-6	C33A12.8	n/a	chrIV 9,491,282	C. elegans SRU-6 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
47	ire-1	C41C4.4	n/a	chrII 8,118,482	ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.
48	chd-3	T14G8.1	n/a	chrX 12,849,438	chd-3 encodes a PHD-finger SNF2 family member containing a chromo domain and a C-terminal helicase domain that affects Notch-dependent vulval development; expressed in virtually all embryonic cells and in many larval nuclei.
49	clx-1	C50F7.2	n/a	chrIV 7,735,511	clx-1 encodes a protein that contains 23 copies of a 15 amino acid repeat, possibly derived from a collagen triplet; there is no transcript evidence for this locus.
50	dao-3	K07E3.3	n/a	chrX 8,085,329	dao-3 encodes a protein containing tetrahydrofolate dehydrogenase/cyclohydrolase catalytic and NAD(P)-binding domains; by similarity to mammalian enzymes, DAO-3 is predicted to function in one-carbon unit metabolism and thus, in amino acid and nucleotide biosynthesis; dao-3 expression appears to be regulated by daf-2-mediated insulin signaling: microarray experiments suggest that it is upregulated in daf-2 mutant adults, while differential display and Northern analyses suggest that it is down-regulated; a dao-3 promoter gfp fusion is expressed in larvae in the hypodermis and in the nervous system, including tail neurons and phasmids.