UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K04A8.1	K04A8.1	0	chrV 6,567,604	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	T01E8.5	T01E8.5	n/a	chrII 10,245,041	contains similarity to Pfam domain PF08424 Protein of unknown function (DUF1740) contains similarity to Interpro domain IPR013633 (Protein of unknown function DUF1740)
4	hum-5	T02C12.1	n/a	chrIII 4,032,950	C. elegans HUM-5 protein; contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) , PF06017 (Myosin tail) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010926 (Myosin tail 2), IPR000048 (IQ calmodulin-binding region), IPR001609 (Myosin head, motor region)
5	pcca-1	F27D9.5	n/a	chrX 7,659,204	The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000).
6	C06A8.3	C06A8.3	n/a	chrII 7,790,994	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domain IPR003677 (Protein of unknown function DUF148)
7	maoc-1	E04F6.3	n/a	chrII 7,196,834	maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens.
8	abu-9	R09F10.2	n/a	chrX 8,322,700	abu-9 encodes a transmembrane protein (identical to that predicted for the pqn-57 gene) with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-9 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-9 may help protect the organism from damage by improperly folded nascent protein.
9	H03A11.2	H03A11.2	n/a	chrX 15,228,166	contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q57WE8
10	cdr-2	C54D10.1	n/a	chrV 12,415,171	C. elegans CDR-2 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
11	gly-13	B0416.6	n/a	chrX 9,295,081	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14.
12	irs-1	R11A8.6	n/a	chrIV 10,370,700	irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development.
13	T19D12.1	T19D12.1	n/a	chrII 6,670,282	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
14	kqt-2	M60.5	n/a	chrX 8,244,691	kqt-2 encodes one of three C. elegans KCNQ-like potassium channel subunits for which mutations in humans are associated with heredity diseases that affect epithelial cells, cardiac muscle and neurons; a KQT-2::GFP fusion protein is expressed exclusively in the intestine.
15	pmp-4	T02D1.5	n/a	chrIV 17,404,001	The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100).
16	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
17	ugt-1	AC3.7	n/a	chrV 10,396,677	C. elegans UGT-1 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
18	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
19	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
20	K02B12.7	K02B12.7	n/a	chrI 8,528,009	contains similarity to Pfam domain PF01412 Putative GTPase activating protein for Arf contains similarity to Interpro domain IPR001164 (Arf GTPase activating protein)
21	ugt-16	ZC443.6	n/a	chrV 12,826,207	C. elegans UGT-16 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
22	W02B12.11	W02B12.11	n/a	chrII 11,474,835	contains similarity to Pfam domain PF02709 Galactosyltransferase contains similarity to Interpro domain IPR003859 (Metazoa galactosyltransferase)
23	F15E11.2	F15E11.2	n/a	chrV 2,335,582	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
24	pgp-1	K08E7.9	n/a	chrIV 12,595,402	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
25	F33E2.4	F33E2.4	n/a	chrI 12,582,781	contains similarity to Schizosaccharomyces pombe Elongation factor 3 (EF-3).; SW:EF3_SCHPO
26	ugt-21	C33A12.6	n/a	chrIV 9,501,385	C. elegans UGT-21 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
27	C03H12.1	C03H12.1	n/a	chrX 15,692,830	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
28	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
29	B0416.1	B0416.1	n/a	chrX 9,307,010	contains similarity to Pfam domain PF07810 TMC domain contains similarity to Interpro domain IPR012496 (TMC)
30	F27D4.1	F27D4.1	n/a	chrI 7,703,501	The F27D4.1 gene encodes an ortholog of the human gene ELECTRON-TRANSFER-FLAVOPROTEIN, ALPHA POLYPEPTIDE (ETFA), which when mutated leads to glutaricaciduria type IIA (OMIM:231680).
31	ZK6.8	ZK6.8	n/a	chrV 383,222	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR016196 (MFS general substrate transporter)
32	abu-6	C03A7.7	n/a	chrV 5,161,266	abu-6 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-6 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-6 may help protect the organism from damage by improperly folded nascent protein.
33	F55B11.1	F55B11.1	n/a	chrIV 14,406,976	The F55B11.1 gene encodes an ortholog of the human gene XANTHINE DEHYDROGENASE (XDH), which when mutated leads to xanthinuria (OMIM:278300).
34	Y56A3A.19	Y56A3A.19	n/a	chrIII 11,915,313	contains similarity to Pfam domain PF00550 Phosphopantetheine attachment site contains similarity to Interpro domains IPR006163 (Phosphopantetheine-binding), IPR009081 (Acyl carrier protein-like), IPR003231 (Acyl carrier protein (ACP))
35	B0286.3	B0286.3	n/a	chrII 4,371,091	contains similarity to Pfam domains PF01259 (SAICAR synthetase) , PF00731 (AIR carboxylase) contains similarity to Interpro domains IPR001636 (SAICAR synthetase), IPR000031 (1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase), IPR013816 (ATP-grasp fold, subdomain 2)
36	C34F6.8	C34F6.8	n/a	chrX 11,216,944	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004790 (Isocitrate dehydrogenase NADP-dependent, eukaryotic), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
37	B0393.5	B0393.5	n/a	chrIII 4,772,641	contains similarity to Pfam domains PF00008 (EGF-like domain) (2), PF07645 (Calcium binding EGF domain) (6), PF06119 (Nidogen-like) (2)contains similarity to Interpro domains IPR003886 (Nidogen, extracellular region), IPR001438 (EGF-like, type 2), IPR001881 (EGF-like calcium-binding), IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR013091 (EGF calcium-binding), IPR006210 (EGF)
38	B0272.3	B0272.3	n/a	chrX 9,432,002	contains similarity to Pfam domains PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) , PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) contains similarity to Interpro domains IPR013328 (Dehydrogenase, multihelical), IPR008927 (6-phosphogluconate dehydrogenase, C-terminal-like), IPR006176 (3-hydroxyacyl-CoA dehydrogenase, NAD binding), IPR006168 (NAD-dependent glycerol-3-phosphate dehydrogenase), IPR006108 (3-hydroxyacyl-CoA dehydrogenase, C-terminal), IPR006180 (3-hydroxyacyl-CoA dehydrogenase, conserved site), IPR016040 (NAD(P)-binding), IPR006036 (Potassium uptake protein TrkA)
39	F08A8.3	F08A8.3	n/a	chrI 12,948,957	contains similarity to Pfam domains PF01756 (Acyl-CoA oxidase) , PF02770 (Acyl-CoA dehydrogenase, middle domain) contains similarity to Interpro domains IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR012258 (Acyl-CoA oxidase), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR002655 (Acyl-CoA oxidase, C-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal)
40	Y45G12C.1	Y45G12C.1	n/a	chrV 2,567,280	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
41	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
42	F15D4.5	F15D4.5	n/a	chrII 13,246,445	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
43	D2085.3	D2085.3	n/a	chrII 8,663,227	D2085.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9947) (EIF2B5; OMIM:603945), which when mutated leads to disease.
44	H34C03.2	H34C03.2	n/a	chrIV 6,759,933	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR006615 (Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)
45	W06A7.2	W06A7.2	n/a	chrV 14,822,585	contains similarity to Salmonella typhi;Salmonella typhimurium Hypothetical protein (Putative inner membrane protein).; TR:Q8XEW6
46	his-3	T10C6.12	n/a	chrV 16,040,965	his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V.
47	his-7	F45F2.4	n/a	chrV 8,533,548	his-7 encodes an H2A histone.
48	Y113G7B.16	Y113G7B.16	n/a	chrV 20,268,307	contains similarity to Pfam domain PF05600 Protein of unknown function (DUF773) contains similarity to Interpro domain IPR008491 (Protein of unknown function DUF773)
49	lgc-50	T20B12.9	n/a	chrIII 7,393,409	C. elegans LGC-50 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
50	F44B9.2	F44B9.2	n/a	chrIII 8,023,742	contains similarity to Interpro domain IPR000694 (Proline-rich region)