UCSC C. elegans Gene Sorter

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

UCSC C. elegans Gene Sorter

genome assembly search

sort by display output

#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ttr-3	K03H1.3	8e-83	chrIII 9,926,034	K03H1.3 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; the product of K03H1.3 belongs to a family of apparently nematode-specific proteins whose function is not yet known.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	ttr-4	F40F12.1	2e-67	chrIII 9,916,526	sdz-17 encodes a protein that contains a transthyretin-like domain; SDZ-17 belongs to a family of apparently nematode-specific proteins whose function is not yet known; early zygotic expression of sdz-17 is dependent upon the SKN-1 transcription factor.
5	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
6	old-2	ZK938.5	n/a	chrII 9,848,462	old-2 encodes a transmembrane protein tyrosine kinase (also known as 'kin-28') that affects mean and maximum life span with multiple paralogs in C. elegans; the expression of old-2 was experimentally verified by RT-PCR.
7	inx-9	ZK792.3	n/a	chrIV 11,677,349	inx-9 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; although the precise role of INX-9 in C. elegans development and/or behavior is not yet known, INX-9 may play a role in gonad or germline development, as INX-9 expression is detected solely in the sheath cells of the somatic gonad and particularly, the sheath cells in contact with proximal oocytes.
8	K08F4.3	K08F4.3	n/a	chrIV 10,129,732	contains similarity to Pfam domain PF05753 Translocon-associated protein beta (TRAPB) contains similarity to Interpro domain IPR008856 (Translocon-associated beta)
9	hdl-1	ZK829.2	n/a	chrIV 11,947,905	C. elegans HDL-1 protein; contains similarity to Pfam domain PF00282 Pyridoxal-dependent decarboxylase conserved domain contains similarity to Interpro domains IPR002129 (Pyridoxal phosphate-dependent decarboxylase), IPR010977 (Aromatic-L-amino-acid decarboxylase), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
10	acl-1	F59F4.4	n/a	chrX 15,850,758	acl-1 encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase; ACL-1 is predicted to be a membrane protein that plays a role in phospholipid biosynthesis, but as loss of acl-1 activity via large-scale RNAi experiments results in no obvious defects, the precise role of ACL-1 in C. elegans development and/or behavior is not yet known.
11	ech-5	F56B3.5	n/a	chrIV 798,439	C. elegans ECH-5 protein; contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domain IPR001753 (Crotonase, core)
12	ilys-3	C45G7.3	n/a	chrIV 2,464,939	C. elegans ILYS-3 protein; contains similarity to Pfam domain PF05497 Destabilase contains similarity to Interpro domain IPR008597 (Destabilase)
13	C01G10.1	C01G10.1	n/a	chrV 15,102,337	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00023 (Ankyrin repeat) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR002110 (Ankyrin), IPR003125 (Protein of unknown function WSN), IPR001357 (BRCT)
14	F58A4.2	F58A4.2	n/a	chrIII 9,600,293	contains similarity to Musca domestica Hexamerin (Fragment).; TR:Q9U6B2
15	W02D7.4	W02D7.4	n/a	chrV 8,297,041	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
16	lact-2	ZK945.1	n/a	chrII 10,096,751	lact-2 encodes a beta-lactamase domain-containing protein that contains a predicted transmembrane domain in its N terminus.
17	cpr-3	T10H4.12	n/a	chrV 15,297,739	C. elegans CPR-3 protein; contains similarity to Pfam domain PF00112 Papain family cysteine protease contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR000668 (Peptidase C1A, papain C-terminal)
18	nhr-26	T07C5.5	n/a	chrX 12,696,713	C. elegans NHR-26 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
19	pax-3	F27E5.2	n/a	chrII 10,149,568	pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes).
20	Y43F8C.5	Y43F8C.5	n/a	chrV 19,631,978	contains similarity to Dictyostelium discoideum Myb-like protein (Fragment).; SW:MYBH_DICDI
21	gna-2	T23G11.2	n/a	chrI 7,700,248	gna-2 encodes a glucosamine 6-phosphate N-acetyltransferase required for synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), N-acetylgalactosamine (UDP-GalNAc), alpha-GalNAc-modifications of mucin-like proteins, and chitin; GNA-2 is also required for eggshell synthesis and osmotic integrity, progression past meiosis metaphase I, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; gna-2 transcription is elevated during oogenesis; gna-2 mRNA is posttranslationally inhibited both by GLD-1 repression and by nonsense-mediated mRNA decay (NMD), with GLD-1 predominating in distal gonads and NMD (incompletely) predominating in proximal ones; gna-2 mRNA has two upstream open reading frames (uORFs) with premature stop codons, which normally cause NMD of this mRNA unless it is protected by GLD-1 binding to the gna-2 mRNA's 5' UTR; conversely, gna-2 mRNA is translationally repressed by bound GLD-1 during pachytene meiosis, and must be freed from this repression during diplotene meiosis for eggshell synthesis to proceed; gna-2(qa705) is suppressed by sup-46 mutations, but only in a gna-1(+) background.
22	F21D9.3	F21D9.3	n/a	chrV 19,257,632	contains similarity to Hepatitis B virus Large S protein (Major surface antigen).; TR:Q8JXA0
23	fat-5	W06D12.3	n/a	chrV 17,725,852	fat-5 encodes a delta-9 fatty acid desaturase that is predicted to be mitochondrial; when expressed heterologously in S. cerevisiae, FAT-5 rescues the fatty acid auxotrophy of the yeast delta-9 desaturase mutant ole1.
24	srp-1	C05E4.3	n/a	chrV 754,193	srp-1 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily; by homology, SRP-1 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases; however, as loss of srp-1 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-1 in C. elegans development and/or behavior is not yet known.
25	ZK596.2	ZK596.2	n/a	chrIV 10,908,696	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
26	C06A5.6	C06A5.6	n/a	chrI 5,984,551
27	srx-56	C03G6.2	n/a	chrV 7,374,979	C. elegans SRX-56 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
28	F15E6.4	F15E6.4	n/a	chrIV 4,291,666
29	K12B6.8	K12B6.8	n/a	chrV 6,310,389	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
30	ZK218.11	ZK218.11	n/a	chrV 17,107,962	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
31	M176.8	M176.8	n/a	chrII 9,437,409	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
32	R12E2.8	R12E2.8	n/a	chrI 4,157,147	contains similarity to Galaxea fascicularis Galaxin.; TR:Q8I6S1
33	grl-22	W03A5.3	n/a	chrIII 5,413,566	grl-22 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
34	C13G5.2	C13G5.2	n/a	chrIII 8,617,549	contains similarity to Interpro domain IPR001680 (WD40 repeat)
35	clec-38	T25E12.10	n/a	chrV 16,734,718	C. elegans CLEC-38 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
36	T16A9.3	T16A9.3	n/a	chrV 14,208,326	contains similarity to Pfam domain PF06887 Protein of unknown function (DUF1265) contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR009676 (Protein of unknown function DUF1265)
37	nspa-1	H12D21.1	n/a	chrV 14,886,813	C. elegans NSPA-1 protein ;
38	C42C1.2	C42C1.2	n/a	chrIV 12,266,886	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
39	ins-7	ZK1251.2	n/a	chrIV 9,682,219	ins-7 encodes an insulin/IGF-1-like peptide; INS-7 is one of 40 insulin-like peptides in C. elegans; INS-7 likely functions as an agonist for the DAF-2 insulin/IGF-1 receptor, as loss of ins-7 activity via RNAi results in: 1) a significantly increased lifespan that is not further extended in long-lived daf-2 mutant animals, and 2) an increased frequency of dauer formation in animals containing an incompletely penetrant daf-2 mutation; an ins-7 promoter fusion is expressed in amphid sensory neurons, labial neurons, the nerve ring, and ventral cord and tail neurons; ins-7 expression is positively regulated by DAF-2-mediated insulin signaling, suggesting that a positive feedback loop involving INS-7 may amplify DAF-2 pathway activity.
40	F44D12.7	F44D12.7	n/a	chrIV 10,035,774	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
41	F42A9.6	F42A9.6	n/a	chrIV 8,610,474
42	mat-2	W10C6.1	n/a	chrII 11,116,985	mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo.
43	sago-1	K12B6.1	n/a	chrV 6,306,024	sago-1 encodes an Argonaute homolog that is partially required for the amplification phase of RNAi responses; a multiply mutant strain (MAGO), consisting of ppw-1(tm914), sago-1(tm1195), sago-2(tm894), F58G1.1(tm1019), C06A1.4(tm887), and M03D4.6(tm1144) alleles, is completely resistant to both germline and somatic RNAi; sago-1 is genetically redundant with ppw-1 and sago-2, with any one of these genes being able to transgenically partially restore the deficiency of MAGO worms; GFP-tagged SAGO-1 binds small secondary siRNAs produced by RNAi against GFP; MAGO is not transgenically rescued by rde-1; strains overexpressing GFP::SAGO-1 exhibited an enhanced level of RNAi overall, suggesting that SAGO-1 and its congeners are rate-limiting in vivo for RNAi.
44	F43G6.8	F43G6.8	n/a	chrII 11,813,118	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
45	thn-1	F28D1.3	n/a	chrIV 12,380,448	C. elegans THN-1 protein; contains similarity to Pfam domain PF00314 Thaumatin family contains similarity to Interpro domain IPR001938 (Thaumatin, pathogenesis-related)
46	F25E2.2	F25E2.2	n/a	chrX 808,888	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
47	mex-5	W02A2.7	n/a	chrIV 13,354,881	mex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon wild-type activity of the PAR and OMA-1 proteins.
48	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
49	C24F3.2	C24F3.2	n/a	chrIV 10,223,062	contains similarity to Pfam domain PF00782 Dual specificity phosphatase, catalytic domain contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016278 (Tyrosine protein phosphatase, dual specificity, 12), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
50	twk-37	C48E7.9	n/a	chrI 6,270,306	C. elegans TWK-37 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR003938 (Potassium channel, voltage-dependent, EAG/ELK/ERG), IPR013099 (Ion transport 2)