UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ncs-3	K03E6.3	9e-104	chrX 1,055,449	ncs-3 encodes a neuronal calcium sensor (NCS) protein with no obvious null phenotype.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	ser-5	F16D3.7	n/a	chrI 8,385,819	F16D3.7 encodes a homolog of mammalian alpha-adrenergic receptors that is expressed in vulval and bodywall muscle cells, intestine, and head neurons; heterologously expressed F16D3.7 has no effect on adenylate cyclase signalling; F16D3.7 has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating.
4	F58H1.4	F58H1.4	n/a	chrV 11,937,362	contains similarity to Interpro domain IPR006207 (Cystine knot, C-terminal)
5	cyp-23A1	B0304.3	n/a	chrII 4,514,151	The B0304.3 gene encodes a homolog of the human gene CYP7B1, which when mutated leads to giant cell hepatitis (OMIM:231100).
6	nhr-176	F14H3.11	n/a	chrV 16,072,040	C. elegans NHR-176 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
7	F08G12.3	F08G12.3	n/a	chrX 11,301,106	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8I5Q0
8	C07G3.2	C07G3.2	n/a	chrV 3,524,079	contains similarity to Pfam domain PF08719 Domain of unknown function (DUF1768) contains similarity to Interpro domain IPR012816 (Conserved hypothetical protein CHP02464)
9	nhr-100	C28D4.1	n/a	chrIV 9,729,825	nhr-100 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain.
10	ZK1086.2	ZK1086.2	n/a	chrX 13,792,979	contains similarity to Shewanella oneidensis Hypothetical protein.; TR:Q8EJA6
11	F23A7.5	F23A7.5	n/a	chrX 16,233,076	contains similarity to Homo sapiens Isoform 3 of Cyclin-L1; VG:OTTHUMP00000173336
12	F54F7.7	F54F7.7	n/a	chrX 11,868,588	contains similarity to Pfam domain PF08123 Histone methylation protein DOT1 contains similarity to Interpro domain IPR013110 (Histone methylation DOT1)
13	fbxa-10	T12B5.3	n/a	chrIII 953,160	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
14	ZC581.9	ZC581.9	n/a	chrI 6,667,794	ZC581.9 encodes a serine/threonine protein kinase related to the vertebrate SCY1-like family of protein kinases; loss of ZC581.9 activity in an RNAi-hypersensitive strain results in axon guidance defects indicating that ZC581.9 likely plays a role in regulation of axon navigation.
15	F56F10.2	F56F10.2	n/a	chrX 861,193	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
16	T04F3.2	T04F3.2	n/a	chrV 11,758,108	contains similarity to Pfam domain PF00086 Thyroglobulin type-1 repeat contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR000716 (Thyroglobulin type-1)
17	tsp-20	B0198.1	n/a	chrX 12,032,731	C. elegans TSP-20 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
18	kqt-3	Y54G9A.3	n/a	chrII 13,704,530	kqt-3 encodes one of three C. elegans KCNQ-like potassium channel subunits and, with respect to humans, is most similar to the KCNQ1 channel protein which when mutated leads to inherited long QT syndrome (OMIM:607542); although loss of KQT-3 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-3 likely functions to regulate cellular excitability as expression of KQT-3 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-3 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs, although KQT-3 is less sensitive to each of these treatments than KQT-1; a KQT-3::GFP fusion protein is expressed in the anterior- and posterior-most intestinal cells, the anterior and posterior mechanosensory neurons ALM and PLM, amphid and phasmid neurons, and in some additional head neurons.
19	D2085.7	D2085.7	n/a	chrII 8,647,166
20	tag-224	B0496.8	n/a	chrIV 7,450,248	tag-224 encodes an ortholog of Drosophila CG6522-PA and of human LMCD1 and TESTIN; TAG-224 is dispensable for Wnt-directed planar cell polarity and the fully asymmetrical division of B.a versus B.p cells.
21	F59A3.1	F59A3.1	n/a	chrI 5,525,077	F59A3.1 encodes one of two C. elegans carboxypeptidase D homologs; loss of F59A3.1 activity via large-scale RNAi screens in a sensitized, rrf-3 mutant background results in larval lethality, abnormal locomotion, and abnormal morphogenesis of the vulval epithelium resulting in rupture; high-throughput expression studies report F59A3.1 expression in the pharynx only.
22	fbxa-52	F07G6.6	n/a	chrX 1,710,748	C. elegans FBXA-52 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
23	C11G10.2	C11G10.2	n/a	chrX 15,142,124	contains similarity to Homo sapiens Thyroid hormone receptor-associated protein complex 240 kDa component; ENSEMBL:ENSP00000262436
24	F45E1.2	F45E1.2	n/a	chrX 8,003,850
25	atg-11	T08A9.1	n/a	chrX 7,337,446	T08A9.1 is orthologous to the human gene LIKELY ORTHOLOG OF MOUSE COILED COIL FORMING PROTEIN 1 (RB1CC1; OMIM:606837), which when mutated leads to disease.
26	ZC15.3	ZC15.3	n/a	chrV 20,299,636	contains similarity to Homo sapiens Myosin heavy chain, smooth muscle isoform; ENSEMBL:ENSP00000300036
27	cdk-2	K03E5.3	n/a	chrI 3,411,552	C. elegans CDK-2 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
28	B0554.5	B0554.5	n/a	chrV 425,501	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR016196 (MFS general substrate transporter)
29	ptr-8	F44F4.4	n/a	chrII 10,891,194	ptr-8 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 is weakly required for normal molting from L4 to adult stages; PTR-8 is also required for normal growth to full size and locomotion; PTR-8 is expressed in hypodermis.
30	F46F11.7	F46F11.7	n/a	chrI 5,621,853	contains similarity to Interpro domain IPR011061 (Proteinase inhibitor I14/I15, hirudin/antistatin)
31	F52D1.2	F52D1.2	n/a	chrX 447,631
32	nhr-226	T27B7.3	n/a	chrV 2,295,897	C. elegans NHR-226 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR000083 (Fibronectin, type I), IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
33	ire-1	C41C4.4	n/a	chrII 8,118,482	ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.
34	C53A5.9	C53A5.9	n/a	chrV 14,557,956	contains similarity to Pfam domains PF01344 (Kelch motif) (5), PF07646 (Kelch motif) (3), PF02984 (Cyclin, C-terminal domain) contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR004367 (Cyclin, C-terminal), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015916 (Galactose oxidase, beta-propeller), IPR013089 (Kelch related), IPR006651 (Kelch), IPR015915 (Kelch-type beta propeller)
35	F23F1.3	F23F1.3	n/a	chrII 32,686
36	clec-182	C33D9.2	n/a	chrIV 8,797,600	C. elegans CLEC-182 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
37	F35E8.2	F35E8.2	n/a	chrV 15,906,320	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2DZ81
38	irk-3	K04G11.5	n/a	chrX 14,356,108	C. elegans IRK-3 protein; contains similarity to Pfam domain PF01007 Inward rectifier potassium channel contains similarity to Interpro domains IPR013521 (Potassium channel, inwardly rectifying, Kir, conserved region 2), IPR014756 (Immunoglobulin E-set), IPR013518 (Potassium channel, inwardly rectifying, Kir, cytoplasmic), IPR001838 (Potassium channel, inwardly rectifying, Kir-like)
39	srh-129	F14F9.7	n/a	chrV 5,143,034	C. elegans SRH-129 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR003002 (7TM chemoreceptor, subfamily 1), IPR001036 (Acriflavin resistance protein), IPR010916 (TonB box, conserved site)
40	srxa-16	F44G3.5	n/a	chrV 16,113,637	C. elegans SRXA-16 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
41	egl-36	R07A4.1	n/a	chrX 10,739,267	egl-36 encodes a Shaw-type voltage-gated potassium channel that regulates egg laying and defecation; expression of egl-36::gfp reporters is observed in several different cell types including muscle cells such as the uterine and vulval egg-laying muscles, sensory, motor and interneurons, and the distal tip cells of the gonad; when expressed in a heterologous system, EGL-36 exhibits channel activity.
42	C28F5.4	C28F5.4	n/a	chrII 7,521,547	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
43	K02D3.2	K02D3.2	n/a	chrX 13,710,264	contains similarity to Pfam domain PF01852 START domain contains similarity to Interpro domain IPR002913 (Lipid-binding START)
44	C39H7.4	C39H7.4	n/a	chrIV 5,613,304
45	C38C3.6	C38C3.6	n/a	chrV 1,485,347	contains similarity to Interpro domain IPR000694 (Proline-rich region)
46	tsp-11	B0563.2	n/a	chrX 9,164,502	C. elegans TSP-11 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
47	H01M10.1	H01M10.1	n/a	chrX 2,579,387
48	R07C12.2	R07C12.2	n/a	chrIV 4,149,092
49	str-46	C31B8.6	n/a	chrV 2,899,200	C. elegans STR-46 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
50	clec-89	C09D1.2	n/a	chrI 4,072,314	C. elegans CLEC-89 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)