UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	K02H8.1	K02H8.1	1e-165	chrX 17,004,963	K02H8.1 encodes, by alternative splicing, two isoforms of a putative MUSCLEBLIND-type mRNA splicing regulator required in adults for normal muscle dense body organization, locomotion, and vulval morphogenesis; K02H8.1 is orthologous to Drosophila MBL and human MBNL1 (OMIM:606516), MBNL2 (OMIM:607327), and MBNL3 (OMIM:300413); K02H8.1 is transcribed in larvae and adults; K02H8.1(RNAi) animals show protruding vulvae, progressive uncoordination, and disordered dense bodies; while K02H8.1 is required in adults, it is dispensable in larvae, perhaps reflecting a progressive muscle dystrophy in K02H8.1(RNAi) animals.
2	str-41	R13D7.1	n/a	chrV 7,412,508	C. elegans STR-41 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
3	W02D7.3	W02D7.3	n/a	chrV 8,294,341
4	Y57A10B.1	Y57A10B.1	n/a	chrII 12,362,805	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
5	ceh-12	F33D11.4	n/a	chrI 5,841,090	ceh-12 encodes a homeobox protein orthologous to human HLXB9 (OMIM:142994, mutated in Currarino syndrome) that is required for normal synaptic inputs to motor neurons VA2-VA10 (sisters to VB3-VB11); ceh-12 is expressed in VB motor neurons, but repressed in their VA siblings by UNC-4 and UNC-37; unc-4 or unc-37 mutants show ectopic CEH-12 expression in VA neurons, which is both necessary and sufficient to induce VA neurons to form gap junctions with normally VB-specific interneurons; ceh-12 mutations have no grossly obvious phenotype, and have no effect on del-1 or acr-5 repression in VB neurons, but do suppress the backward movement defect of unc-4 mutants, and do derepress vab-7 (normally restricted to DB and VC motor neurons); CEH-12, like other HLXB9 orthologs, has an N-terminal eh1 domain that may interact with UNC-37/Groucho, and that may indicate CEH-12 to be a transcriptional repressor.
6	B0207.11	B0207.11	n/a	chrI 5,963,581	B0207.11 encodes a nematode-specific protein probably required for a normally high ovulation rate; B0207.11 has no obvious non-nematode homologs, but does have a putative N-terminal coiled-coil domain and an SH2 motif, and is is paralogous to four other C. elegans proteins (F42G4.6, F44F4.10, T08G11.2, and Y81G3A.1); B0207.11(tm322) hermaphrodites show abnormal egg-laying, retaining significantly fewer eggs than wild-type (perhaps due to a lowered ovulation rate) while retaining late-stage embryos; B0207.11 has no obvious phenotype in mass RNAi experiments, possibly because of genetic redundancy with its paralogs.
7	C26H9A.2	C26H9A.2	n/a	chrIV 12,657,776	contains similarity to Interpro domains IPR016024 (Armadillo-type fold), IPR008985 (Concanavalin A-like lectin/glucanase)
8	Y106G6G.2	Y106G6G.2	n/a	chrI 10,325,764	contains similarity to Interpro domain IPR000904 (SEC7-like)
9	ZK180.1	ZK180.1	n/a	chrIV 4,497,817	contains similarity to Pfam domain PF00003 7 transmembrane receptor (metabotropic glutamate family) contains similarity to Interpro domains IPR000337 (GPCR, family 3), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B)
10	nhr-39	F44A2.4	n/a	chrV 9,303,947	C. elegans NHR-39 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
11	K03A11.4	K03A11.4	n/a	chrX 13,080,030	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domains IPR004245 (Protein of unknown function DUF229), IPR017850 (Alkaline-phosphatase-like, core domain)
12	str-39	F37B4.12	n/a	chrV 2,878,851	C. elegans STR-39 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002355 (Multicopper oxidase, copper-binding site)
13	F28C10.4	F28C10.4	n/a	chrX 539,044
14	F10G8.2	F10G8.2	n/a	chrI 10,022,221	contains similarity to Interpro domain IPR011009 (Protein kinase-like)
15	F49B2.6	F49B2.6	n/a	chrI 14,335,445	contains similarity to Pfam domain PF01433 Peptidase family M1 contains similarity to Interpro domains IPR014782 (Peptidase M1, membrane alanine aminopeptidase, N-terminal), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001930 (Peptidase M1, membrane alanine aminopeptidase)
16	F49F1.6	F49F1.6	n/a	chrIV 4,122,198	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
17	T05A1.3	T05A1.3	n/a	chrIV 9,563,673	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype)
18	fbxa-223	ZC513.10	n/a	chrV 8,064,176	fbxa-223 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; FBXA-223 also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
19	cho-1	C48D1.3	n/a	chrIV 13,212,115	cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons.
20	K08C9.6	K08C9.6	n/a	chrI 11,499,274	contains similarity to Archaeoglobus fulgidus Hypothetical protein AF0327.; TR:O29920
21	D1044.1	D1044.1	n/a	chrIII 5,545,251	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
22	T06C12.9	T06C12.9	n/a	chrV 15,885,834	contains similarity to Pfam domain PF01679 Uncharacterized protein family UPF0057 contains similarity to Interpro domain IPR000612 (Protein of unknown function UPF0057)
23	ZC404.7	ZC404.7	n/a	chrV 6,779,108
24	C43F9.5	C43F9.5	n/a	chrIV 10,590,044	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
25	fbxa-188	F47H4.8	n/a	chrV 17,343,887	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
26	ndx-2	W02G9.1	n/a	chrV 2,664,041	ndx-2 encodes a NUDIX hydrolase; by sequence comparison, NDX-2 is predicted to be orthologous to human NUDT5 which, in vitro, possesses ADP-sugar diphosphatase activity; in C. elegans, loss of ndx-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
27	spe-19	Y113G7A.10	n/a	chrV 20,039,581	C. elegans SPE-19 protein ;
28	aat-7	F54D12.3	n/a	chrII 1,389,233	aat-7 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-7 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-7 does not require this residue for heterodimer formation or alternatively, does not require the glycoprotein subunit for function.
29	C09D4.3	C09D4.3	n/a	chrI 5,489,487	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
30	C08G5.5	C08G5.5	n/a	chrII 756,602	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003882 (Pistil-specific extensin-like protein)
31	irk-1	R03E9.4	n/a	chrX 6,769,400	C. elegans IRK-1 protein; contains similarity to Pfam domain PF01007 Inward rectifier potassium channel contains similarity to Interpro domains IPR013521 (Potassium channel, inwardly rectifying, Kir, conserved region 2), IPR014756 (Immunoglobulin E-set), IPR013518 (Potassium channel, inwardly rectifying, Kir, cytoplasmic), IPR001838 (Potassium channel, inwardly rectifying, Kir-like)
32	C45G9.11	C45G9.11	n/a	chrIII 5,066,320
33	C50D2.6	C50D2.6	n/a	chrII 86,096
34	amt-2	F49E11.3	n/a	chrIV 13,044,619	amt-2 encodes a transmembrane protein that is one of four C. elegans members of the ammonium transporter AMT/Rh family of proteins predicted to function in transport of ammonium ions across the plasma membrane.
35	F19B2.6	F19B2.6	n/a	chrV 20,155,401	contains similarity to Tetrahymena thermophila SB210 Putative uncharacterized protein.; TR:Q23A89
36	C43G2.4	C43G2.4	n/a	chrIV 6,562,982	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domain IPR000615 (Bestrophin)
37	W04E12.5	W04E12.5	n/a	chrV 19,742,714	contains similarity to Interpro domain IPR000750 (Proenkephalin B)
38	F26A1.3	F26A1.3	n/a	chrIII 4,827,878	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
39	R13.4	R13.4	n/a	chrIV 10,819,150	contains similarity to Pfam domain PF02891 MIZ/SP-RING zinc finger contains similarity to Interpro domain IPR004181 (Zinc finger, MIZ-type)
40	F07C3.2	F07C3.2	n/a	chrV 9,226,731
41	Y113G7B.15	Y113G7B.15	n/a	chrV 20,226,741	contains similarity to Pfam domains PF08246 (Cathepsin propeptide inhibitor domain (I29)) , PF00112 (Papain family cysteine protease) contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR013201 (Proteinase inhibitor I29, cathepsin propeptide), IPR000668 (Peptidase C1A, papain C-terminal)
42	C29F9.6	C29F9.6	n/a	chrIII 115,990	contains similarity to Pfam domain PF02135 TAZ zinc finger contains similarity to Interpro domains IPR003101 (Coactivator CBP, KIX), IPR000197 (Zinc finger, TAZ-type)
43	nfyb-1	W10D9.4	n/a	chrII 464,524	C. elegans NFYB-1 protein; contains similarity to Pfam domain PF00808 Histone-like transcription factor (CBF/NF-Y) and archaeal histone contains similarity to Interpro domains IPR009072 (Histone-fold), IPR003957 (Transcription factor, CBFA/NFYB, DNA topoisomerase), IPR003958 (Transcription factor CBF/NF-Y/archaeal histone)
44	lgc-4	F18G5.4	n/a	chrX 9,238,639	C. elegans LGC-4 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
45	R05A10.3	R05A10.3	n/a	chrIV 14,175,025	contains similarity to Saccharomyces cerevisiae <b><u>C</u></b>onserved <b><u>O</u></b>ligomeric <b><u>G</u></b>olgi complex <b><u>1</u></b><br> Complexed with Cog8p; interacts with Cog2p; SGD:YGL223C
46	Y7A9A.1	Y7A9A.1	n/a	chrIV 16,199,192	contains similarity to Pfam domain PF01019 Gamma-glutamyltranspeptidase contains similarity to Interpro domain IPR000101 (Gamma-glutamyltranspeptidase)
47	srt-8	C50H11.2	n/a	chrV 3,087,272	C. elegans SRT-8 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
48	C34G6.3	C34G6.3	n/a	chrI 5,897,020	contains similarity to Interpro domain IPR005819 (Histone H5)
49	Y113G7A.12	Y113G7A.12	n/a	chrV 20,140,914
50	lact-3	M28.6	n/a	chrII 10,654,998	lact-3 encodes a beta-lactamase domain-containing protein that contains a predicted signal sequence; loss of lact-3 activity via RNAi has been reported to result in reduced fat content.