UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tbb-1	K01G5.7	0	chrIII 10,741,585	This gene encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-1 is redundant for embryonic viability, due to its paralog TBB-2.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
4	C08H9.2	C08H9.2	n/a	chrII 9,888,735	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR004087 (K Homology), IPR004088 (K Homology, type 1)
5	ZK686.3	ZK686.3	n/a	chrIII 7,768,245	ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
6	F38E11.5	F38E11.5	n/a	chrIV 9,461,841	F38E11.5 encodes a beta' (beta-prime) subunit of the coatomer (COPI) complex; in mass RNAi assays, F38E11.5 is required for fertility and general health.
7	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
8	tbb-2	C36E8.5	0	chrIII 4,016,820	tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
9	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
10	F13E6.1	F13E6.1	n/a	chrX 10,676,336	contains similarity to Pfam domain PF04201 Tumour protein D52 family contains similarity to Interpro domain IPR007327 (Tumor protein D52)
11	F57B9.3	F57B9.3	n/a	chrIII 6,940,892	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
12	ile-2	T04G9.3	n/a	chrX 769,684	C. elegans ILE-2 protein; contains similarity to Pfam domains PF03388 (Legume-like lectin family) , PF00139 (Legume lectin domain) contains similarity to Interpro domains IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR001220 (Legume lectin, beta domain), IPR005052 (Legume-like lectin), IPR008985 (Concanavalin A-like lectin/glucanase)
13	hsp-1	F26D10.3	n/a	chrIV 17,280,029	hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
14	sec-24.1	F12F6.6	n/a	chrIV 11,564,055	sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis.
15	R09E12.3	R09E12.3	n/a	chrV 774,205	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (6)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR008940 (Protein prenyltransferase), IPR006636 (Heat shock chaperonin-binding), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
16	gst-13	T26C5.1	n/a	chrII 9,231,840	C. elegans GST-13 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
17	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
18	Y113G7B.16	Y113G7B.16	n/a	chrV 20,268,307	contains similarity to Pfam domain PF05600 Protein of unknown function (DUF773) contains similarity to Interpro domain IPR008491 (Protein of unknown function DUF773)
19	act-2	T04C12.5	n/a	chrV 11,077,425	act-2 encodes an invertebrate actin that may function specifically in the pharynx.
20	spdl-1	C06A8.5	n/a	chrII 7,782,394	C06A8.5 encodes a coiled-coil protein; RNAi screens indicate that C06A8.5 activity is required for proper chromosome segregation, embryonic development, body morphology, and normal growth rates.
21	ZK682.5	ZK682.5	n/a	chrV 9,285,827	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR000480 (Glutelin)
22	F29C12.4	F29C12.4	n/a	chrII 13,119,692	contains similarity to Pfam domains PF03764 (Elongation factor G, domain IV) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) , PF00679 (Elongation factor G C-terminus) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005517 (Translation elongation factor EFG/EF2, domain IV), IPR005225 (Small GTP-binding protein), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009000 (Translation elongation and initiation factors/Ribosomal, beta-barrel), IPR000640 (Translation elongation factor EFG/EF2, C-terminal), IPR004540 (Translation elongation factor EFG/EF2), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR009022 (Elongation factor G, III and V)
23	trap-4	Y56A3A.21	n/a	chrIII 11,920,954	C. elegans TRAP-4 protein; contains similarity to Pfam domain PF05404 Translocon-associated protein, delta subunit precursor (TRAP-delta) contains similarity to Interpro domain IPR008855 (Translocon-associated)
24	K12C11.1	K12C11.1	n/a	chrI 1,343,024	The K12C11.1 gene encodes an ortholog of the human gene PEPTIDASE D (PEPD), which when mutated leads to prolidase deficiency (OMIM:170100).
25	R03D7.1	R03D7.1	n/a	chrII 10,928,740	R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
26	D2085.3	D2085.3	n/a	chrII 8,663,227	D2085.3 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:9947) (EIF2B5; OMIM:603945), which when mutated leads to disease.
27	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.
28	B0334.5	B0334.5	n/a	chrII 11,498,118	contains similarity to Interpro domain IPR008949 (Terpenoid synthase)
29	ost-1	C44B12.2	n/a	chrIV 1,109,128	ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells.
30	nhr-45	F16H11.5	n/a	chrX 4,658,348	C. elegans NHR-45 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
31	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
32	Y45G12C.3	Y45G12C.3	n/a	chrV 2,556,848	contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
33	nol-5	W01B11.3	n/a	chrI 3,268,107	C. elegans NOL-5 protein; contains similarity to Pfam domains PF01798 (Putative snoRNA binding domain) , PF08060 (NOSIC (NUC001) domain) , PF08156 (NOP5NT (NUC127) domain) contains similarity to Interpro domains IPR012974 (NOP5, N-terminal), IPR005819 (Histone H5), IPR002687 (Pre-mRNA processing ribonucleoprotein, binding region), IPR012976 (NOSIC)
34	D2045.2	D2045.2	n/a	chrIII 10,456,470	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
35	T04A8.5	T04A8.5	n/a	chrIII 4,690,700	contains similarity to Pfam domains PF00310 (Glutamine amidotransferases class-II) , PF00156 (Phosphoribosyl transferase domain) contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR005854 (Amidophosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
36	F01F1.9	F01F1.9	n/a	chrIII 5,862,653	contains similarity to Pfam domain PF02127 Aminopeptidase I zinc metalloprotease (M18) contains similarity to Interpro domain IPR001948 (Peptidase M18, aminopeptidase I)
37	F53A2.7	F53A2.7	n/a	chrIII 13,345,704	contains similarity to Pfam domains PF02803 (Thiolase, C-terminal domain) , PF00108 (Thiolase, N-terminal domain) contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
38	Y49A3A.1	Y49A3A.1	n/a	chrV 14,349,107	Y49A3A.1 encodes a homolog of choline/ethanolaminephosphotransferase choline phosphotransferase 1; Y49A3A.1 shares an operon with vha-13, and thus might be a previously undescribed V-ATPase component or ancillary protein.
39	hsp-4	F43E2.8	n/a	chrII 7,351,305	hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress.
40	ile-1	K07A1.8	n/a	chrI 9,610,665	ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300).
41	W03F9.10	W03F9.10	n/a	chrV 129,988	contains similarity to Pfam domains PF04046 (PSP) , PF04037 (Domain of unknown function (DUF382)) contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR007180 (Protein of unknown function DUF382)
42	F23C8.5	F23C8.5	n/a	chrI 2,419,472	The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
43	W09D10.3	W09D10.3	n/a	chrIII 10,708,021	contains similarity to Pfam domain PF00542 Ribosomal protein L7/L12 C-terminal domain contains similarity to Interpro domains IPR013823 (Ribosomal protein L7/L12, C-terminal), IPR014719 (Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like), IPR008932 (Ribosomal protein L7/L12, oligomerisation)
44	F27D4.1	F27D4.1	n/a	chrI 7,703,501	The F27D4.1 gene encodes an ortholog of the human gene ELECTRON-TRANSFER-FLAVOPROTEIN, ALPHA POLYPEPTIDE (ETFA), which when mutated leads to glutaricaciduria type IIA (OMIM:231680).
45	pat-6	T21D12.4	n/a	chrIV 263,062	pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality.
46	T03G6.1	T03G6.1	n/a	chrX 2,609,102
47	gstk-1	ZK1320.1	n/a	chrII 9,657,127	C. elegans GSTK-1 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)
48	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
49	atf-5	T04C10.4	n/a	chrX 14,809,925	atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
50	chc-1	T20G5.1	n/a	chrIII 10,206,656	chc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.