UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	H37A05.1	H37A05.1	0	chrV 13,652,199	H37A05.1 encodes a putative phosphatidic acid phosphatase orthologous to budding yeast PAH1 and human LPIN1 (OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays, H37A05.1 is required for the osmotic integrity of eggs and for normal larval growth, body thickness, locomotion, and fertility; by orthology, H37A05.1 is expected to be dephosphorylated by SCPL-2.
2	C32H11.11	C32H11.11	n/a	chrIV 12,938,618	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domain IPR003677 (Protein of unknown function DUF148)
3	ZK1290.5	ZK1290.5	n/a	chrII 7,530,168	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
4	T27C4.2	T27C4.2	n/a	chrV 3,729,612
5	T10B5.2	T10B5.2	n/a	chrV 1,849,449
6	B0280.2	B0280.2	n/a	chrIII 7,126,452	contains similarity to Interpro domain IPR000697 (EVH1)
7	F55C12.6	F55C12.6	n/a	chrII 5,875,271	contains similarity to Pfam domain PF06852 Protein of unknown function (DUF1248) contains similarity to Interpro domain IPR009658 (Protein of unknown function DUF1248)
8	sre-55	C50E10.7	n/a	chrII 12,330,123	C. elegans SRE-55 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
9	str-99	F10A3.6	n/a	chrV 16,157,886	C. elegans STR-99 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	B0035.13	B0035.13	n/a	chrIV 11,305,691	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
11	srh-265	T06E6.9	n/a	chrV 15,416,909	C. elegans SRH-265 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR003002 (7TM chemoreceptor, subfamily 1)
12	F25H9.1	F25H9.1	n/a	chrV 13,454,521	contains similarity to Interpro domain IPR016054 (Ly-6 antigen / uPA receptor -like)
13	wrt-9	B0344.2	n/a	chrX 1,583,762	wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-9 has no obvious function in RNAi assays.
14	T07D10.2	T07D10.2	n/a	chrI 12,622,116	T07D10.2 is orthologous to the human gene VASOPRESSIN RECEPTOR TYPE 2 (AVPR2; OMIM:304800), which when mutated leads to nephrogenic diabetes insipidus.
15	srg-3	C18F10.6	n/a	chrIII 6,269,673	C. elegans SRG-3 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
16	F27D9.7	F27D9.7	n/a	chrX 7,667,592	contains similarity to Pfam domain PF01421 Reprolysin (M12B) family zinc metalloprotease contains similarity to Interpro domain IPR001590 (Peptidase M12B, ADAM/reprolysin)
17	ugt-41	F10D2.11	n/a	chrV 7,162,312	C. elegans UGT-41 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
18	T15H9.2	T15H9.2	n/a	chrII 9,616,485	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp686J1372; ENSEMBL:ENSP00000341653
19	gro-1	ZC395.6	n/a	chrIII 5,266,087	C. elegans GRO-1 protein; contains similarity to Pfam domain PF01715 IPP transferase contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR002627 (tRNA isopentenyltransferase), IPR003593 (AAA+ ATPase, core), IPR011593 (Isopentenyl transferase-like), IPR007087 (Zinc finger, C2H2-type)
20	B0285.6	B0285.6	n/a	chrIII 4,354,080	B0285.6 encodes a predicted sodium-coupled carboxylate transporter that is one of four C. elegans proteins related to Drosophila Indy and the mammalian NaDC1 and NaDC3 transporters; B0285.6::lacZ reporter fusions are expressed in the excretory cell, from early larval stages through adulthood, with some later expression occasionally seen in two large unidentified structures on the dorsal side of the pharyngeal terminal bulb.
21	R144.5	R144.5	n/a	chrIII 5,000,320	contains similarity to Homo sapiens Isoform 1 of Smith-Magenis syndrome chromosomal region candidate gene 8 protein; ENSEMBL:ENSP00000379048
22	T19B10.9	T19B10.9	n/a	chrV 11,249,483	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	fbxa-183	F44E7.6	n/a	chrV 5,781,921	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
24	ZK673.3	ZK673.3	n/a	chrII 10,451,229	ZK673.3 encodes a protein with a THAP or THAP-like domain required for embryonic development; other proteins with THAP or THAP-like domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
25	ttr-35	F22A3.2	n/a	chrX 6,512,558	C. elegans TTR-35 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
26	T09B9.5	T09B9.5	n/a	chrX 9,778,986	contains similarity to Streptococcus pneumoniae Hypothetical protein.; TR:P96479
27	F39H2.3	F39H2.3	n/a	chrI 8,665,598	contains similarity to Pfam domains PF08669 (Glycine cleavage T-protein C-terminal barrel domain) , PF01571 (Aminomethyltransferase folate-binding domain) contains similarity to Interpro domains IPR006222 (Glycine cleavage T-protein, N-terminal), IPR013977 (Glycine cleavage T-protein, C-terminal barrel)
28	R11E3.2	R11E3.2	n/a	chrIV 4,773,617	contains similarity to Pfam domain PF00860 Permease family contains similarity to Interpro domain IPR006043 (Xanthine/uracil/vitamin C permease)
29	mkk-4	F42G10.2	n/a	chrX 10,028,926	mkk-4 encodes a MAP (mitogen-activated protein) kinase kinase that is a member of the MKK4 family of MAPKK's; MKK-4 activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology; in regulating presynaptic organization, MKK-4 acts upstream of PMK-3/MAPK and downstream of DLK-1/MAPKKK, whose levels are negatively regulated by the RPM-1 ubiquitin ligase; a functional MKK-4::GFP fusion protein is expressed in the cytoplasm of many neurons as well as in other cell types, including the pharyngeal muscles.
30	rpt-5	F56H1.4	n/a	chrI 5,742,805	rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
31	col-70	H17B01.2	n/a	chrII 1,471,156	C. elegans COL-70 protein; contains similarity to Interpro domain IPR000694 (Proline-rich region)
32	srv-30	T13A10.7	n/a	chrIV 6,268,435	C. elegans SRV-30 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
33	C16B8.2	C16B8.2	n/a	chrX 3,963,843
34	F59F4.2	F59F4.2	n/a	chrX 15,841,893	contains similarity to Pfam domain PF06624 Ribosome associated membrane protein RAMP4 contains similarity to Interpro domain IPR010580 (Ribosome associated membrane RAMP4)
35	F53F4.12	F53F4.12	n/a	chrV 13,626,710	contains similarity to Plasmodium falciparum Histidine-rich protein.; SW:HRP3_PLAFS
36	R151.1	R151.1	n/a	chrIII 7,218,656
37	let-70	M7.1	n/a	chrIV 11,081,640	let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
38	F31A9.2	F31A9.2	n/a	chrX 1,795,240
39	C14C11.7	C14C11.7	n/a	chrV 5,665,729
40	F52H2.6	F52H2.6	n/a	chrX 2,561,931	F52H2.6 is orthologous to the human gene 3BETA-HYDROXYSTEROL DELTA 24 REDUCTASE (DHCR24; OMIM:606418), which when mutated leads to disease.
41	gtl-2	F54D1.5	n/a	chrIV 11,277,712	gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2.
42	F48E8.3	F48E8.3	n/a	chrIII 5,462,687	contains similarity to Pfam domains PF00890 (FAD binding domain) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR010960 (Flavocytochrome c), IPR006076 (FAD dependent oxidoreductase), IPR003953 (Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal), IPR016040 (NAD(P)-binding)
43	ZC190.2	ZC190.2	n/a	chrV 8,682,033	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR000366 (Fungal pheromone mating factor STE2 GPCR)
44	cgr-1	T27A10.7	n/a	chrX 3,598,867	C. elegans CGR-1 protein; contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
45	hlh-15	C43H6.8	n/a	chrX 2,413,123	C. elegans HLH-15 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
46	ugt-49	AC3.2	n/a	chrV 10,373,259	C. elegans UGT-49 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
47	C26B2.7	C26B2.7	n/a	chrIV 8,016,527
48	C02F5.3	C02F5.3	n/a	chrIII 8,246,494	contains similarity to Pfam domains PF01926 (GTPase of unknown function) , PF02824 (TGS domain) contains similarity to Interpro domains IPR005225 (Small GTP-binding protein), IPR002917 (GTP-binding protein, HSR1-related), IPR006073 (GTP1/OBG), IPR004095 (TGS), IPR006074 (GTP1/OBG, conserved site)
49	F23F12.8	F23F12.8	n/a	chrIII 6,485,986	F23F12.8 encodes a large (980-residue) protein, predicted to be secreted, with two chitin-binding peritrophin-A domains, separated by a low-complexity region; F23F12.8 is synthesized in larval and adult pharynx, a known site of chitin deposition; like CEJ-1 and CPG-2 in embryos, F23F12.8 might participate in chitin synthesis, and its peritrophin-A domains might enable mechanical cross-linking of chitin.
50	dop-4	C52B11.3	n/a	chrX 1,296,964	C. elegans DOP-4 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000929 (Dopamine receptor), IPR002233 (Adrenergic receptor), IPR001671 (Melanocortin/ACTH receptor), IPR000995 (Muscarinic acetylcholine receptor), IPR000276 (GPCR, rhodopsin-like)