UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	msh-2	H26D21.2	0	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
2	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
3	B0024.4	B0024.4	n/a	chrV 10,298,103	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
4	M01E11.2	M01E11.2	n/a	chrI 5,580,733	contains similarity to Pfam domain PF08216 Eukaryotic domain of unknown function (DUF1716) contains similarity to Interpro domains IPR013180 (Protein of unknown function DUF1716, eukaryotic), IPR011989 (Armadillo-like helical), IPR000225 (Armadillo), IPR016024 (Armadillo-type fold)
5	ZK1067.3	ZK1067.3	n/a	chrII 9,224,144	contains similarity to Mus musculus Serine/threonine-protein kinase Nek9 (EC 2.7.1.37) (NimA-relatedsprotein kinase 9).; SW:NEK9_MOUSE
6	K02C4.3	K02C4.3	n/a	chrII 8,083,916	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
7	col-141	T15B7.5	n/a	chrV 6,830,181	C. elegans COL-141 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
8	R52.2	R52.2	n/a	chrII 2,127,157	contains similarity to Pfam domains PF03564 (Protein of unknown function (DUF1759)) , PF05585 (Protein of unknown function (DUF1758)) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR008737 (Protein of unknown function DUF1758), IPR005312 (Protein of unknown function DUF1759), IPR001878 (Zinc finger, CCHC-type)
9	htp-1	F41H10.10	n/a	chrIV 5,390,947	C. elegans HTP-1 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
10	F13D12.5	F13D12.5	n/a	chrII 11,727,540	contains similarity to Interpro domain IPR001814 (Filamentous bacteriophage Vg4 protein)
11	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
12	prp-4	C36B1.5	n/a	chrI 8,734,610	C. elegans PRP-4 protein; contains similarity to Pfam domains PF00400 (WD domain, G-beta repeat) (7), PF08799 (pre-mRNA processing factor 4 (PRP4) like) contains similarity to Interpro domains IPR014906 (Pre-mRNA processing factor 4 (PRP4) like), IPR003648 (Splicing factor motif), IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001632 (G-protein, beta subunit), IPR015943 (WD40/YVTN repeat-like)
13	cul-4	F45E12.3	n/a	chrII 7,303,864	cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
14	C48B4.10	C48B4.10	n/a	chrIII 9,563,945	contains similarity to Homo sapiens Transmembrane 9 superfamily protein member 2 precursor; ENSEMBL:ENSP00000245361
15	R02D3.7	R02D3.7	n/a	chrIV 254,500	contains similarity to Interpro domains IPR009060 (UBA-like), IPR015880 (Zinc finger, C2H2-like)
16	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
17	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
18	stl-1	F30A10.5	n/a	chrI 9,487,412	C. elegans STL-1 protein; contains similarity to Pfam domain PF01145 SPFH domain / Band 7 family contains similarity to Interpro domains IPR001107 (Band 7 protein), IPR001972 (Stomatin)
19	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
20	ehbp-1	F25B3.1	n/a	chrV 9,553,309	C. elegans EHBP-1 protein; contains similarity to Pfam domain PF00307 Calponin homology (CH) domain contains similarity to Interpro domains IPR016146 (Calponin-homology), IPR001715 (Calponin-like actin-binding)
21	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
22	R11A8.1	R11A8.1	n/a	chrIV 10,356,114	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000299601
23	set-14	R06F6.4	n/a	chrII 10,794,856	set-14 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-14 is paralogous to SET-10, SET-18, and SET-30; SET-14 has no obvious function in individual RNAi assays of vulval development, or in mass RNAi assays.
24	B0035.15	B0035.15	n/a	chrIV 11,297,591	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
25	T28A8.3	T28A8.3	n/a	chrIII 13,507,200	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
26	D1043.1	D1043.1	n/a	chrII 11,585,601	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
27	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
28	ZK1058.3	ZK1058.3	n/a	chrIII 3,919,762	ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease.
29	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
30	sas-4	F10E9.8	n/a	chrIII 8,316,386	sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad.
31	T24A6.1	T24A6.1	n/a	chrV 3,559,431
32	W02D9.3	W02D9.3	n/a	chrI 12,536,484	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
33	F56D1.1	F56D1.1	n/a	chrII 5,479,410	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
34	K10C8.1	K10C8.1	n/a	chrV 12,693,876	contains similarity to Pfam domain PF04857 CAF1 family ribonuclease contains similarity to Interpro domains IPR006941 (Ribonuclease CAF1), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
35	cutc-1	ZK353.7	n/a	chrIII 8,402,774	C. elegans CUTC-1 protein; contains similarity to Pfam domain PF03932 CutC family contains similarity to Interpro domain IPR005627 (CutC)
36	trm-1	ZC376.5	n/a	chrV 14,184,351	C. elegans TRM-1 protein; contains similarity to Pfam domain PF02005 N2,N2-dimethylguanosine tRNA methyltransferase contains similarity to Interpro domain IPR002905 (N2,N2-dimethylguanosine tRNA methyltransferase)
37	T19B10.8	T19B10.8	n/a	chrV 11,243,290	contains similarity to Pfam domain PF07819 PGAP1-like protein contains similarity to Interpro domain IPR012908 (PGAP1-like)
38	F20A1.9	F20A1.9	n/a	chrV 7,050,345	contains similarity to Pfam domains PF04326 (Divergent AAA domain) , PF00622 (SPRY domain) contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR003877 (SPla/RYanodine receptor SPRY), IPR007421 (ATPase associated with various cellular activities, AAA-4)
39	T01G1.3	T01G1.3	n/a	chrIV 11,368,676	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR002110 (Ankyrin), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
40	cdd-2	F49E8.4	n/a	chrIV 7,547,502	A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages.
41	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
42	F59E12.1	F59E12.1	n/a	chrII 5,655,915	contains similarity to Pfam domain PF00439 Bromodomain contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001487 (Bromodomain)
43	ZK836.2	ZK836.2	n/a	chrV 12,199,854	contains similarity to Pfam domains PF02779 (Transketolase, pyrimidine binding domain) , PF00676 (Dehydrogenase E1 component) contains similarity to Interpro domains IPR011603 (2-oxoglutarate dehydrogenase, E1 component), IPR005475 (Transketolase, central region), IPR001017 (Dehydrogenase, E1 component)
44	bath-4	F52C6.8	n/a	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
45	nasp-1	C09H10.6	n/a	chrII 11,107,270	C. elegans NASP-1 protein; contains similarity to Interpro domain IPR013026 (Tetratricopeptide region)
46	B0273.3	B0273.3	n/a	chrIV 5,485,115	contains similarity to Tetraodon nigroviridis Chromosome 18 SCAF15038, whole genome shotgun sequence. (Fragment).; TR:Q4RJG8
47	T28A8.5	T28A8.5	n/a	chrIII 13,502,424	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
48	fbxa-114	Y113G7B.7	n/a	chrV 20,197,592	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
49	T09A5.9	T09A5.9	n/a	chrII 7,858,979	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR003603 (U2A'/phosphoprotein 32 family A, C-terminal)
50	C38C10.2	C38C10.2	n/a	chrIII 9,388,833	C38C10.2 is orthologous to the human gene SOLUTE CARRIER FAMILY 17 (ANION/SUGAR TRANSPORTER), MEMBER 5 (SLC17A5; OMIM:604322), which when mutated leads to disease.