UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	asp-3	H22K11.1	0	chrX 6,791,899	asp-3 encodes an aspartyl protease homolog that is required, in parallel with ASP-4 but downstream of CLP-1 and TRA-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
2	clec-48	C14A6.1	n/a	chrV 18,158,762	C. elegans CLEC-48 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002353 (Type II antifreeze protein)
3	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	ZK1321.4	ZK1321.4	n/a	chrII 9,772,248	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domains IPR006643 (ZASP), IPR001478 (PDZ/DHR/GLGF)
5	tag-18	T14G12.3	n/a	chrX 3,732,674	C. elegans TAG-18 protein ;
6	clec-186	ZK896.7	n/a	chrIV 12,867,615	C. elegans CLEC-186 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
7	T28F3.8	T28F3.8	n/a	chrIV 17,306,594	contains similarity to Interpro domain IPR013032 (EGF-like region, conserved site)
8	C49C3.4	C49C3.4	n/a	chrIV 17,324,683	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
9	C05D2.8	C05D2.8	n/a	chrIII 5,608,885	contains similarity to Aedes aegypti Putative uncharacterized protein (Fragment).; TR:Q16Z88
10	rpt-6	Y49E10.1	n/a	chrIII 12,371,416	rpt-6 encodes a triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle (RP) base subcomplex; RPT-6 is required for embryonic and larval development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
11	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
12	K09C6.9	K09C6.9	n/a	chrV 854,272
13	pas-4	C36B1.4	n/a	chrI 8,727,906	pas-4 encodes a proteasome alpha-type seven subunit of the core 20S proteasome subcomplex; loss of pas-4 activity via RNAi results in a wide variety of defects including embryonic and larval lethality, sterility, abnormal locomotion, slow growth, and abnormal transgene expression and subcellular localization; loss of pas-4 activity also results in activation of SKN-1, a transcription factor required in adult worms for the acute response to oxidative stress and maternally for embryonic development.
14	C17H12.4	C17H12.4	n/a	chrIV 6,800,609	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
15	gsnl-1	K06A4.3	n/a	chrV 9,498,184	C. elegans GSNL-1 protein; contains similarity to Pfam domain PF00626 Gelsolin repeat contains similarity to Interpro domains IPR007122 (Gelsolin), IPR007123 (Gelsolin region)
16	K02C4.2	K02C4.2	n/a	chrII 8,076,226	contains similarity to Brugia pahangi Alt-1 protein.; TR:O96781
17	ZK829.4	ZK829.4	n/a	chrIV 11,954,203	ZK829.4 is orthologous to the human gene GLYCINE DECARBOXYLASE PRECURSOR (GLUD1; OMIM:238300), which when mutated leads to disease.
18	C47E8.4	C47E8.4	n/a	chrV 14,684,638	contains similarity to Pfam domain PF04921 XAP5 protein contains similarity to Interpro domains IPR007005 (XAP5 protein), IPR000533 (Tropomyosin)
19	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
20	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
21	chc-1	T20G5.1	n/a	chrIII 10,206,656	chc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.
22	pgk-1	T03F1.3	n/a	chrI 3,868,329	T03F1.3 is orthologous to the human gene PHOSPHOGLYCERETE KINASE 1 (PGK1; OMIM:311800), which when mutated leads to hemolytic anemia and neurologic disturbances.
23	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
24	clec-166	F38A1.5	n/a	chrIV 1,250,233	C. elegans CLEC-166 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
25	Y48A6B.10	Y48A6B.10	n/a	chrIII 11,041,221	contains similarity to Interpro domain IPR000694 (Proline-rich region)
26	F43G9.3	F43G9.3	n/a	chrI 8,613,923	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR002167 (Graves disease carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
27	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
28	cdr-2	C54D10.1	n/a	chrV 12,415,171	C. elegans CDR-2 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
29	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
30	T01C8.5	T01C8.5	n/a	chrX 16,792,168	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR004838 (Aminotransferases, class-I, pyridoxal-phosphate-binding site), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR000796 (Aspartate/other aminotransferase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
31	F35E12.10	F35E12.10	n/a	chrV 13,747,215	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
32	F38B2.4	F38B2.4	n/a	chrX 11,287,008	F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia.
33	nhr-81	C47F8.8	n/a	chrI 12,328,787	C. elegans NHR-81 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
34	F57F5.1	F57F5.1	n/a	chrV 12,003,793	contains similarity to Pfam domain PF00112 Papain family cysteine protease contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR000668 (Peptidase C1A, papain C-terminal)
35	gstk-1	ZK1320.1	n/a	chrII 9,657,127	C. elegans GSTK-1 protein; contains similarity to Pfam domain PF01323 DSBA-like thioredoxin domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR001853 (DSBA oxidoreductase), IPR014440 (HCCA isomerase/glutathione S-transferase kappa)
36	asp-5	F21F8.3	2e-40	chrV 8,273,166	C. elegans ASP-5 protein; contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001969 (Peptidase aspartic, active site), IPR001461 (Peptidase A1)
37	clec-262	ZC15.2	n/a	chrV 20,309,111	C. elegans CLEC-262 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
38	T04A8.5	T04A8.5	n/a	chrIII 4,690,700	contains similarity to Pfam domains PF00310 (Glutamine amidotransferases class-II) , PF00156 (Phosphoribosyl transferase domain) contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR005854 (Amidophosphoribosyl transferase), IPR000836 (Phosphoribosyltransferase), IPR002375 (Purine/pyrimidine phosphoribosyl transferase, conserved site)
39	R05F9.12	R05F9.12	n/a	chrII 4,919,859	contains similarity to Pfam domains PF01055 (Glycosyl hydrolases family 31) , PF00088 (Trefoil (P-type) domain) contains similarity to Interpro domains IPR000519 (P-type trefoil), IPR017853 (Glycoside hydrolase, catalytic core), IPR000322 (Glycoside hydrolase, family 31)
40	R05F9.6	R05F9.6	n/a	chrII 4,890,420	contains similarity to Pfam domains PF02879 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II) , PF02878 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I) , PF02880 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III) , PF00408 (Phosphoglucomutase/phosphomannomutase, C-terminal domain) contains similarity to Interpro domains IPR016066 (Alpha-D-phosphohexomutase, conserved site), IPR005843 (Alpha-D-phosphohexomutase, C-terminal), IPR016055 (Alpha-D-phosphohexomutase, alpha/beta/alpha I, II and III), IPR005841 (Alpha-D-phosphohexomutase, N-terminal), IPR005844 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain I), IPR005846 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain III), IPR005845 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain II)
41	F44B9.2	F44B9.2	n/a	chrIII 8,023,742	contains similarity to Interpro domain IPR000694 (Proline-rich region)
42	H03A11.2	H03A11.2	n/a	chrX 15,228,166	contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q57WE8
43	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
44	C14C6.2	C14C6.2	n/a	chrV 563,724	contains similarity to Pfam domains PF04942 (CC domain) , PF01549 (ShK domain-like) (2)contains similarity to Interpro domains IPR007026 (Domian of unknown function, DUF-CC), IPR003582 (Metridin-like ShK toxin)
45	C18E9.9	C18E9.9	n/a	chrII 8,988,878	contains similarity to Thermoplasma volcanium Hypothetical protein TV1312.; TR:Q978V3
46	K08E3.4	K08E3.4	n/a	chrIII 13,760,645	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00241 (Cofilin/tropomyosin-type actin-binding protein) contains similarity to Interpro domains IPR002108 (Actin-binding, cofilin/tropomyosin type), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3)
47	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
48	C01B10.3	C01B10.3	n/a	chrIV 6,620,429	C01B10.3 encodes a paralog of IPP-5, and thus may functionally overlap with ipp-5 in vivo.
49	C49C3.9	C49C3.9	n/a	chrIV 17,340,941	contains similarity to Brassaiopsis tripteris NADH dehydrogenase subunit F (Fragment).; TR:Q85UX5
50	C28H8.3	C28H8.3	n/a	chrIII 5,911,573	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) , PF04851 (Type III restriction enzyme, res subunit) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR006935 (Restriction endonuclease, type I, R subunit/Type III, Res subunit), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR008162 (Inorganic pyrophosphatase), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)