UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	H03A11.2	H03A11.2	0	chrX 15,228,166	contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q57WE8
2	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
3	F15E11.2	F15E11.2	n/a	chrV 2,335,582	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
4	C49C3.9	C49C3.9	n/a	chrIV 17,340,941	contains similarity to Brassaiopsis tripteris NADH dehydrogenase subunit F (Fragment).; TR:Q85UX5
5	cdr-2	C54D10.1	n/a	chrV 12,415,171	C. elegans CDR-2 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
6	C17H12.4	C17H12.4	n/a	chrIV 6,800,609	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
7	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
8	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
9	fbxa-58	C29F9.11	n/a	chrIII 110,182	C. elegans FBXA-58 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
10	hum-5	T02C12.1	n/a	chrIII 4,032,950	C. elegans HUM-5 protein; contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) , PF06017 (Myosin tail) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010926 (Myosin tail 2), IPR000048 (IQ calmodulin-binding region), IPR001609 (Myosin head, motor region)
11	pgp-1	K08E7.9	n/a	chrIV 12,595,402	pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells; loss of pgp-1 activity via large-scale RNAi screens does not result in any obvious abnormalities.
12	ZK1058.9	ZK1058.9	n/a	chrIII 3,924,612	contains similarity to Borrelia burgdorferi Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57)s(Glycoprotease).; SW:GCP_BORBU
13	K04A8.1	K04A8.1	n/a	chrV 6,567,604	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
14	pcca-1	F27D9.5	n/a	chrX 7,659,204	The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000).
15	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
16	abu-1	AC3.3	n/a	chrV 10,381,053	abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein.
17	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
18	F55A3.6	F55A3.6	n/a	chrI 10,784,384	contains similarity to Pfam domain PF00334 Nucleoside diphosphate kinase contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase, core)
19	C26E1.2	C26E1.2	n/a	chrV 13,306,168	contains similarity to Interpro domain IPR000169 (Eukaryotic thiol (cysteine) protease)
20	dhs-7	E04F6.7	n/a	chrII 7,207,642	dhs-7 encodes a short-chain dehydrogenase predicted to be mitochondrial.
21	mrp-3	E03G2.2	n/a	chrX 15,934,560	C. elegans MRP-3 protein; contains similarity to Pfam domains PF00664 (ABC transporter transmembrane region) (2), PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR001140 (ABC transporter, transmembrane region), IPR003593 (AAA+ ATPase, core)
22	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
23	coq-8	C35D10.4	n/a	chrIII 4,865,152	coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) from S. cerevisiae and UbiB from E. coli, and paralogous to C. elegans D2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; alternative hypotheses for COQ-8's biochemical function are that it is a 2-polyprenylphenol 6-hydroxylase, or that it may activate proteins necessary for monooxygenase activity via phosphorylation; coq-8 is expressed in several tissues during larval development, but in later adult life its expression is restricted to neurons; coq-8 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-8(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-8 mutants are not rescued by dietary coenzyme Q.
24	pgp-13	F22E10.2	n/a	chrX 12,741,422	pgp-13 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-13 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-13 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-13 in C. elegans development and/or behavior is not yet known; pgp-13 promoter-gfp fusion proteins are expressed in larvae and adults in the posterior intestine and the amphids.
25	F33E2.4	F33E2.4	n/a	chrI 12,582,781	contains similarity to Schizosaccharomyces pombe Elongation factor 3 (EF-3).; SW:EF3_SCHPO
26	H43E16.1	H43E16.1	n/a	chrII 6,676,762	contains similarity to Interpro domain IPR000082 (SEA)
27	K08E3.4	K08E3.4	0.003	chrIII 13,760,645	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00241 (Cofilin/tropomyosin-type actin-binding protein) contains similarity to Interpro domains IPR002108 (Actin-binding, cofilin/tropomyosin type), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3)
28	T04F3.1	T04F3.1	n/a	chrV 11,747,105	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR001176 (1-aminocyclopropane-1-carboxylate synthase), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
29	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
30	T01E8.5	T01E8.5	n/a	chrII 10,245,041	contains similarity to Pfam domain PF08424 Protein of unknown function (DUF1740) contains similarity to Interpro domain IPR013633 (Protein of unknown function DUF1740)
31	R05F9.12	R05F9.12	n/a	chrII 4,919,859	contains similarity to Pfam domains PF01055 (Glycosyl hydrolases family 31) , PF00088 (Trefoil (P-type) domain) contains similarity to Interpro domains IPR000519 (P-type trefoil), IPR017853 (Glycoside hydrolase, catalytic core), IPR000322 (Glycoside hydrolase, family 31)
32	F19C7.1	F19C7.1	n/a	chrIV 4,606,991	contains similarity to Pfam domain PF06879 Protein of unknown function (DUF1261) contains similarity to Interpro domain IPR009673 (Protein of unknown function DUF1261)
33	ZK370.8	ZK370.8	n/a	chrIII 8,753,333	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
34	F07A11.5	F07A11.5	n/a	chrII 11,613,153	contains similarity to Pfam domain PF00294 pfkB family carbohydrate kinase contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR011877 (Ribokinase, bacterial), IPR002139 (Ribokinase)
35	F53C11.1	F53C11.1	n/a	chrV 13,776,738	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
36	maoc-1	E04F6.3	n/a	chrII 7,196,834	maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens.
37	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
38	C28H8.3	C28H8.3	n/a	chrIII 5,911,573	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) , PF04851 (Type III restriction enzyme, res subunit) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR006935 (Restriction endonuclease, type I, R subunit/Type III, Res subunit), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR008162 (Inorganic pyrophosphatase), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
39	T11G6.3	T11G6.3	n/a	chrIV 10,853,967	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
40	T10E10.4	T10E10.4	n/a	chrX 6,318,637	T10E10.4 encodes a large (966-residue) protein, predicted to be secreted, with two N-terminal chitin-binding peritrophin-A domains followed by 14 cysteine-rich domains and one C-terminal EB module; the general organization of T10E10.4 protein resembles that of K04H4.2; T10E10.4 has no obvious function in mass RNAi assays but, like CEJ-1 and CPG-2, might participate in chitin synthesis.
41	H02F09.3	H02F09.3	n/a	chrX 1,570,762	contains similarity to Interpro domain IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)
42	D2092.6	D2092.6	n/a	chrI 6,597,924	contains similarity to Homo sapiens Ubiquitin carboxyl-terminal hydrolase 8; ENSEMBL:ENSP00000302239
43	C49C8.5	C49C8.5	n/a	chrIV 8,651,156	contains similarity to Pfam domain PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain contains similarity to Interpro domains IPR014716 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1), IPR002181 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular)
44	Y56A3A.19	Y56A3A.19	n/a	chrIII 11,915,313	contains similarity to Pfam domain PF00550 Phosphopantetheine attachment site contains similarity to Interpro domains IPR006163 (Phosphopantetheine-binding), IPR009081 (Acyl carrier protein-like), IPR003231 (Acyl carrier protein (ACP))
45	C15H9.7	C15H9.7	n/a	chrX 6,108,092	contains similarity to Interpro domains IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR010111 (Kynureninase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
46	pxn-1	ZK994.3	n/a	chrV 8,498,505	C. elegans PXN-1 protein; contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) , PF00047 (Immunoglobulin domain) (2), PF00560 (Leucine Rich Repeat) (4), PF01462 (Leucine rich repeat N-terminal domain) , PF07679 (Immunoglobulin I-set domain) (2), PF03098 (Animal haem peroxidase) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR013098 (Immunoglobulin I-set), IPR010255 (Haem peroxidase), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR003591 (Leucine-rich repeat, typical subtype), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR002007 (Haem peroxidase, animal), IPR000372 (Leucine-rich repeat, cysteine-rich flanking region, N-terminal), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
47	F58A6.1	F58A6.1	n/a	chrII 5,143,154	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domains IPR014748 (Crontonase, C-terminal), IPR001753 (Crotonase, core)
48	C47E8.4	C47E8.4	n/a	chrV 14,684,638	contains similarity to Pfam domain PF04921 XAP5 protein contains similarity to Interpro domains IPR007005 (XAP5 protein), IPR000533 (Tropomyosin)
49	C49C3.4	C49C3.4	n/a	chrIV 17,324,683	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
50	F10D11.6	F10D11.6	n/a	chrI 8,448,214	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)