UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F59H6.5	F59H6.5	0	chrII 2,005,814	contains similarity to Pfam domain PF05970 Eukaryotic protein of unknown function (DUF889) contains similarity to Interpro domains IPR010285 (Protein of unknown function DUF889, eukaryote), IPR003593 (AAA+ ATPase, core), IPR006034 (Asparaginase/glutaminase)
2	fbxb-52	K05F6.6	n/a	chrII 1,548,512	C. elegans FBXB-52 protein; contains similarity to Pfam domains PF02214 (K+ channel tetramerisation domain) , PF07735 (F-box associated) contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR012885 (F-box associated type 2), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
3	R02D5.1	R02D5.1	n/a	chrV 14,508,925	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
4	F46F5.11	F46F5.11	n/a	chrII 810,328	contains similarity to Pfam domain PF03385 Protein of unknown function, DUF288 contains similarity to Interpro domain IPR005049 (Protein of unknown function DUF288)
5	let-381	F26B1.7	n/a	chrI 6,322,210	let-381 encodes a forkhead transcription factor and was identified in a screen for essential genes; let-381 is essential for development at different times as mutants exhibit embryonic and early larval lethality, with a few developing to sterile adults; inactivation of let-381 using RNA interference results in adults with mesodermal cell lineage defects and a reduced number of coelomocytes; reporter-gene assays indicate LET-318 is expressed when the embryo starts to elongate and continues to be expressed through all larval stages and into the adult.
6	F09B12.2	F09B12.2	n/a	chrX 15,099,156	contains similarity to Pfam domain PF01529 DHHC zinc finger domain contains similarity to Interpro domain IPR001594 (Zinc finger, DHHC-type)
7	C41G7.7	C41G7.7	n/a	chrI 9,534,916	contains similarity to Plasmodium falciparum S-antigen (Fragment).; TR:Q9GZB4
8	F58B4.2	F58B4.2	n/a	chrV 10,918,030	contains similarity to Pfam domain PF00173 Cytochrome b5-like Heme/Steroid binding domain contains similarity to Interpro domain IPR001199 (Cytochrome b5)
9	clec-141	EEED8.11	n/a	chrII 5,406,695	C. elegans CLEC-141 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
10	F16C3.2	F16C3.2	n/a	chrI 10,152,680	contains similarity to Clostridium acetobutylicum DNA repair protein recN, ATPase.; TR:Q97HD9
11	T25G12.5	T25G12.5	n/a	chrX 17,216,027	contains similarity to Pfam domains PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02770 (Acyl-CoA dehydrogenase, middle domain) , PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) contains similarity to Interpro domains IPR013107 (Acyl-CoA dehydrogenase, type 2, C-terminal), IPR006090 (Acyl-CoA oxidase/dehydrogenase, type 1), IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR006089 (Acyl-CoA dehydrogenase, conserved site), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal), IPR006092 (Acyl-CoA dehydrogenase, N-terminal)
12	T11A5.1	T11A5.1	n/a	chrV 9,859,109	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR008162 (Inorganic pyrophosphatase)
13	ZK1290.10	ZK1290.10	n/a	chrII 7,552,859	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003582 (Metridin-like ShK toxin)
14	C05E11.3	C05E11.3	n/a	chrX 4,580,554	contains similarity to Mus musculus Lysosomal-associated transmembrane protein 4A (Golgi 4-transmembranesspanning transporter) (Mouse transporter protein) (MTP).; SW:Q60961
15	srz-29	C08F11.9	n/a	chrIV 13,645,161	C. elegans SRZ-29 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
16	F08D12.2	F08D12.2	n/a	chrII 2,782,368	contains similarity to Pfam domain PF04942 CC domain contains similarity to Interpro domain IPR007026 (Domian of unknown function, DUF-CC)
17	Y43F8B.10	Y43F8B.10	n/a	chrV 19,475,668
18	F07C3.2	F07C3.2	n/a	chrV 9,226,731
19	C08G5.5	C08G5.5	n/a	chrII 756,602	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003882 (Pistil-specific extensin-like protein)
20	C44B11.1	C44B11.1	n/a	chrIII 3,156,820	contains similarity to Pfam domain PF06905 Fas apoptotic inhibitory molecule (FAIM1) contains similarity to Interpro domain IPR010695 (Fas apoptotic inhibitory molecule)
21	srb-19	C54F6.11	n/a	chrV 7,518,912	C. elegans SRB-19 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
22	C06C3.9	C06C3.9	n/a	chrII 9,377,271
23	tag-19	C09G9.4	n/a	chrIV 8,875,605	tag-19 superficially resembles aromatic-L-amino-acid/L-histidine decarboxylases; however, it is distantly related, being no closer to them than to glutamine decarboxylase/sphingosinge lyase (e.g., tag-38, spl-1); tag-19 thus might be termed a Pyridoxal-phosphate (PLP) dependent decarboxylase-like protei, but is missing the absolutely conserved Lys residue of all PLP-DCs (hence the -like would be needed); tag-19 is dispensable in mass RNAi assays.
24	Y116A8C.33	Y116A8C.33	n/a	chrIV 17,113,736	contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
25	B0524.2	B0524.2	n/a	chrIII 1,896,968	contains similarity to Pfam domain PF01734 Patatin-like phospholipase contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR002641 (Patatin)
26	unc-79	E03A3.6	n/a	chrIII 4,074,729	unc-79 encodes a novel, conserved protein; unc-79 functions in a pathway with nca-1 and nca-2, which encode ion channel subunits, to regulate locomotion and the response to specific volatile anesthetics; unc-79 exerts its effects on these processes, at least in part, by regulating the levels of NCA-1 and NCA-2 proteins; an unc-79::gfp reporter is expressed in the nervous system in ventral nerve cord neurons in L2 and L3 larvae and in one or two head neurons in adults.
27	sdz-16	F31E9.4	n/a	chrV 17,327,178	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
28	T02G6.2	T02G6.2	n/a	chrI 11,801,906	contains similarity to Arabidopsis thaliana Hypothetical protein.; TR:Q9C9Y9
29	R04A9.1	R04A9.1	n/a	chrX 405,128
30	F53A3.6	F53A3.6	n/a	chrIII 1,929,496	contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000104 (Antifreeze protein, type I), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal)
31	K09E4.2	K09E4.2	n/a	chrII 14,130,163	contains similarity to Pfam domain PF05208 ALG3 protein contains similarity to Interpro domains IPR007873 (ALG3), IPR013838 (Beta tubulin, autoregulation binding site)
32	srx-90	H12C20.5	n/a	chrV 11,581,770	C. elegans SRX-90 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32), IPR000276 (GPCR, rhodopsin-like)
33	unc-119	M142.1	n/a	chrIII 10,907,547	unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues.
34	ceh-12	F33D11.4	n/a	chrI 5,841,090	ceh-12 encodes a homeobox protein orthologous to human HLXB9 (OMIM:142994, mutated in Currarino syndrome) that is required for normal synaptic inputs to motor neurons VA2-VA10 (sisters to VB3-VB11); ceh-12 is expressed in VB motor neurons, but repressed in their VA siblings by UNC-4 and UNC-37; unc-4 or unc-37 mutants show ectopic CEH-12 expression in VA neurons, which is both necessary and sufficient to induce VA neurons to form gap junctions with normally VB-specific interneurons; ceh-12 mutations have no grossly obvious phenotype, and have no effect on del-1 or acr-5 repression in VB neurons, but do suppress the backward movement defect of unc-4 mutants, and do derepress vab-7 (normally restricted to DB and VC motor neurons); CEH-12, like other HLXB9 orthologs, has an N-terminal eh1 domain that may interact with UNC-37/Groucho, and that may indicate CEH-12 to be a transcriptional repressor.
35	syg-2	C26G2.1	n/a	chrX 14,658,836	syg-2 encodes a transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-2 activity is required in vulval epithelial cells for proper synaptic specificity of the HSNL neuron; in regulating synapse formation, SYG-2 acts as a guidepost protein for the SYG-1 receptor that interacts with SYG-2 and acts within HSNL to regulate synaptic specificity; a SYG-2::GFP fusion protein is expressed in the primary vulval cell lineages beginning at the L3 larval stage, with expression increasing during the L4 stage and finally disappearing by adulthood; in embryos, SYG-2::GFP expression is detected in some head neurons and body wall muscles, the latter of which also express the reporter during the L1 and L2 larval stages.
36	dyf-5	M04C9.5	n/a	chrI 9,360,991	dyf-5 encodes a putative MAP kinase orthologous to human MAK/ICK (OMIM:154235), Chlamydomonas reinhardtii LF4, and Leishmania mexicana MPK9; DYF-5 negatively regulates cilial length, restricts KAP-1 to middle ciliary segments, is required for normal localization of six IFT components, and is required for OSM-3 to comigrate normally with IFT particles; DYF-5 is also required for dye-filling of amphid and phasmid neurons and for normal chemotaxis, dauer formation, and male mating; DYF-5 is expressed in head neurons (including amphid neurons), tail neurons (including phasmid neurons), CAN cells, excretory canal neurons, posterior lateral ganglion neurons and in many male tail cells; dyf-5 mutant cilia are abnormally elongated, either failing to enter the amphid channel or accumulating IFT proteins at their distal ends, whereas DYF-5 overexpression results in truncated cilia; the dyf-5 promoter region contains an X-box, predicted to be bound and transcriptionally activated by DAF-19, and dyf-5 is regulated by DAF-19 in vivo; dyf-5 animals are slightly shorter than normal.
37	str-41	R13D7.1	n/a	chrV 7,412,508	C. elegans STR-41 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	F46F5.4	F46F5.4	n/a	chrII 805,580	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
39	tag-303	C52B11.2	n/a	chrX 1,304,138	C. elegans TAG-303 protein; contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
40	R04B3.1	R04B3.1	n/a	chrX 2,468,815	contains similarity to Interpro domain IPR000998 (MAM)
41	C54E4.1	C54E4.1	n/a	chrIV 2,176,591
42	F48B9.1	F48B9.1	n/a	chrX 2,183,370	contains similarity to Interpro domain IPR001220 (Legume lectin, beta domain)
43	sdz-3	C29F5.2	n/a	chrII 6,300,414	C. elegans SDZ-3 protein ;
44	AH10.3	AH10.3	n/a	chrV 14,144,698	contains similarity to Tomato yellow leaf curl virus Hypothetical 10.9 kDa protein (C4 protein).; SW:YC4_TYLCU
45	K02D10.3	K02D10.3	n/a	chrIII 8,771,549
46	T05A1.3	T05A1.3	n/a	chrIV 9,563,673	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype)
47	F31B9.2	F31B9.2	n/a	chrX 15,919,200	contains similarity to Mus musculus Radixin (ESP10).; SW:RADI_MOUSE
48	ZK180.1	ZK180.1	n/a	chrIV 4,497,817	contains similarity to Pfam domain PF00003 7 transmembrane receptor (metabotropic glutamate family) contains similarity to Interpro domains IPR000337 (GPCR, family 3), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B)
49	K02H8.1	K02H8.1	n/a	chrX 17,004,963	K02H8.1 encodes, by alternative splicing, two isoforms of a putative MUSCLEBLIND-type mRNA splicing regulator required in adults for normal muscle dense body organization, locomotion, and vulval morphogenesis; K02H8.1 is orthologous to Drosophila MBL and human MBNL1 (OMIM:606516), MBNL2 (OMIM:607327), and MBNL3 (OMIM:300413); K02H8.1 is transcribed in larvae and adults; K02H8.1(RNAi) animals show protruding vulvae, progressive uncoordination, and disordered dense bodies; while K02H8.1 is required in adults, it is dispensable in larvae, perhaps reflecting a progressive muscle dystrophy in K02H8.1(RNAi) animals.
50	cho-1	C48D1.3	n/a	chrIV 13,212,115	cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons.