UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	bath-5	F59H6.11	1e-174	chrII 2,031,389	C. elegans BATH-5 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
2	B0001.2	B0001.2	n/a	chrIV 12,148,704	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
3	F49E8.2	F49E8.2	n/a	chrIV 7,549,959	contains similarity to Interpro domains IPR011767 (Glutaredoxin active site), IPR007087 (Zinc finger, C2H2-type)
4	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
5	bath-2	F52C6.11	7e-94	chrII 1,922,182	C. elegans BATH-2 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
6	F21F3.4	F21F3.4	n/a	chrI 4,896,773	contains similarity to Homo sapiens Uncharacterized protein ENSP00000372122; ENSEMBL:ENSP00000372122
7	F08G5.1	F08G5.1	n/a	chrIV 12,409,650	contains similarity to Homo sapiens Putative protein TPRXL; ENSEMBL:ENSP00000322097
8	W05F2.6	W05F2.6	n/a	chrI 3,370,130	contains similarity to Interpro domains IPR000504 (RNA recognition motif, RNP-1), IPR001620 (Dopamine D3 receptor)
9	C55B7.11	C55B7.11	n/a	chrI 6,512,726
10	M01A10.1	M01A10.1	n/a	chrI 5,565,037	M01A10.1 encodes a protein, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that is predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; it is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing.
11	dhs-5	F56D1.5	n/a	chrII 5,454,878	dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE).
12	zim-2	T07G12.10	n/a	chrIV 10,556,907	zim-2 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1, ZIM-3, and C02F5.12; ZIM-2 is specifically required for homolog pairing, synapsis, and segregation of chromosome V during meiosis; zim-2(tm574) oocytes ending prophase have ~5 bivalents and ~2 univalents, the latter of which are consistently chromosome V; zim-2 oocytes fail to begin chromosome V pairing at the start of meiosis; ZIM-2 associates with the right end of chromosome V, which may indicate an association with its pairing center; while the C-terminal region of ZIM-2 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-2 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-2 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
13	K11H3.4	K11H3.4	n/a	chrIII 9,835,521	contains similarity to Pfam domain PF02213 (GYF domain)
14	bath-1	F59H6.9	9.999999999999999e-88	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
15	glh-2	C55B7.1	n/a	chrI 6,515,665	glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
16	hke-4.1	T28F3.3	n/a	chrIV 17,286,682	C. elegans HKE-4.1 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
17	ZK836.2	ZK836.2	n/a	chrV 12,199,854	contains similarity to Pfam domains PF02779 (Transketolase, pyrimidine binding domain) , PF00676 (Dehydrogenase E1 component) contains similarity to Interpro domains IPR011603 (2-oxoglutarate dehydrogenase, E1 component), IPR005475 (Transketolase, central region), IPR001017 (Dehydrogenase, E1 component)
18	C44E4.3	C44E4.3	n/a	chrI 4,639,174	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR004838 (Aminotransferases, class-I, pyridoxal-phosphate-binding site), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR000796 (Aspartate/other aminotransferase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
19	ZK418.8	ZK418.8	n/a	chrIII 7,084,302	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR009019 (K Homology, prokaryotic type), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
20	msh-5	F09E8.3	n/a	chrIV 13,159,611	msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone.
21	F55G1.5	F55G1.5	n/a	chrIV 7,475,614	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
22	T08D2.5	T08D2.5	n/a	chrX 178,809
23	lsl-1	F52F12.4	n/a	chrI 9,902,069	C. elegans LSL-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
24	C35D10.6	C35D10.6	n/a	chrIII 4,859,975	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
25	ZC317.7	ZC317.7	n/a	chrV 5,469,825	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003980 (Histamine H3 receptor)
26	T28A8.5	T28A8.5	n/a	chrIII 13,502,424	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
27	F56C9.3	F56C9.3	n/a	chrIII 7,312,130	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domain IPR002524 (Cation efflux protein)
28	htp-1	F41H10.10	n/a	chrIV 5,390,947	C. elegans HTP-1 protein; contains similarity to Pfam domain PF02301 HORMA domain contains similarity to Interpro domain IPR003511 (DNA-binding HORMA)
29	mut-14	C14C11.6	n/a	chrV 5,659,724	mut-14 mutants exhibit germline transposon activation, a deficient response to RNAi, resistance to co-suppression, and transgene desilencing.
30	D2030.7	D2030.7	n/a	chrI 7,589,605	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
31	syp-1	F26D2.2	n/a	chrV 16,406,704	C. elegans SYP-1 protein ; contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_7, whole genome shotgun sequence.; TR:A0DYW0
32	C16C8.14	C16C8.14	n/a	chrII 3,450,118	C16C8.14 encodes a Caenorhabditis-specific protein, with a central predicted coiled-coil and a C-terminal ubiqutin-like domain; C16C8.14 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51; C16C8.14 is paralogous to C16C8.4, C16C8.11, C16C8.12, C16C8.13, C16C8.15, C16C8.16, and F54D10.7.
33	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
34	klp-18	C06G3.2	n/a	chrIV 7,041,936	klp-18 encodes a kinesin motor protein whose motor domain is most similar to that of the Xenopus and human klp2 proteins; loss of klp-18 activity via RNAi indicates that KLP-18 is required for the assembly of a disordered array of acentrosomal (female meiotic) microtubules into an organized, functional, bipolar spindle; in addition, KLP-18 may also play a role in cortex dynamics during post-meiotic development; antibody staining indicates that during meiosis and mitosis (early embryonic) KLP-18 localizes to: 1) spindles, and especially spindle poles, during prometaphase, metaphase, and early anaphase, and 2) the interzone during late anaphase and telophase; in early embryos, KLP-18 is also seen around the nucleus and cell cortex at sites of cell-cell contact; KLP-18 expression in later embryos and larvae is confined to the germ line which, in adults, stains brightly in both distal and proximal regions.
35	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
36	let-99	K08E7.3	n/a	chrIV 12,569,200	let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position).
37	F35G12.5	F35G12.5	n/a	chrIII 4,585,670	contains similarity to Wigglesworthia glossinidia brevipalpis RpoD protein.; TR:Q8D286
38	F29C4.6	F29C4.6	n/a	chrIV 120,551	contains similarity to Pfam domain PF01171 PP-loop family contains similarity to Interpro domains IPR011063 (PP-loop), IPR012089 (PP-loop ATPase, YdaO-related), IPR000541 (Protein of unknown function UPF0021), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
39	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
40	T01C3.9	T01C3.9	n/a	chrV 15,005,731	contains similarity to Foot-and-mouth disease virus O Polyprotein.; TR:Q80B22
41	T28A8.4	T28A8.4	n/a	chrIII 13,504,444	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
42	C36A4.4	C36A4.4	n/a	chrIII 3,842,530	C36A4.4 encodes a putative UDP-N-acetylglucosamine pyrophosphorylase, paralogous to K06B9.2 and orthologous to human UAP1 (OMIM:602862) and UAP1L1; C36A4.4 is thought to catalyse the fourth step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; C36A4.4 transcripts are enriched during oogenesis; C36A4.4(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
43	zhp-3	K02B12.8	n/a	chrI 8,530,344	zhp-3 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); ZHP-3 activity is required during meiosis for crossover recombination and chiasma formation; ZHP-3 activity is thus essential for proper chromosome segregation and normal levels of fertility; a ZHP-3::GFP fusion protein localizes along synapsed chromosomes in a manner that is dependent upon the presence of mature synaptonemal complexes; ZHP-3 is paralogous to D1081.9, F55A12.10, and Y39B6A.16.
44	F07H5.10	F07H5.10	n/a	chrII 8,807,812	contains similarity to Arabidopsis thaliana Myosin heavy chain-like protein.; TR:Q9FJ35
45	T21B10.4	T21B10.4	n/a	chrII 8,941,726
46	C35D10.5	C35D10.5	n/a	chrIII 4,862,879	contains similarity to Pfam domain PF03981 Ubiquinol-cytochrome C chaperone contains similarity to Interpro domain IPR007129 (Ubiquinol-cytochrome C chaperone)
47	C41G7.3	C41G7.3	n/a	chrI 9,516,858	contains similarity to Pfam domains PF00013 (KH domain) , PF03073 (TspO/MBR family) contains similarity to Interpro domains IPR004307 (TspO/MBR-related protein), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
48	K12D12.5	K12D12.5	n/a	chrII 11,862,086	contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
49	bath-4	F52C6.8	5.999999999999999e-100	chrII 1,917,377	C. elegans BATH-4 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
50	spo-11	T05E11.4	n/a	chrIV 11,123,963	spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.