UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	str-84	F59E11.13	0	chrV 8,980,200	C. elegans STR-84 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
2	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
3	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
4	pop-1	W10C8.2	n/a	chrI 2,826,881	pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
5	twk-32	F53C11.6	n/a	chrV 13,798,574	C. elegans TWK-32 protein; contains similarity to Pfam domains PF00041 (Fibronectin type III domain) (2), PF07885 (Ion channel) (2)contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR009147 (Cystic fibrosis transmembrane conductance regulator), IPR013099 (Ion transport 2)
6	F39H12.2	F39H12.2	n/a	chrX 832,122	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
7	sel-2	F10F2.1	n/a	chrIII 4,604,205	sel-2 encodes a PH, BEACH and WD40 domain-containing protein that is homologous to mammalian neurobeachin/BCL8B and LRBA (LPS-responsive, beige-like anchor protein); during development, SEL-2 functions to regulate endosomal traffic in polarized epithelial cells such as the vulval precursor cells (VPCs) and intestinal cells; specifically, in a subset of the VPCs, SEL-2 activity is required for proper levels and apical localization of LIN-12/Notch and for LET-23/EGFR downregulation; sel-2::yfp reporters are expressed in a number of cell types, including the VPCs and intestinal cells; a rescuing SEL-2::GFP reporter is expressed most strongly in the rectal epithelial cells and hypodermal seam cells where it localizes to the cytoplasm and the perinuclear region.
8	srh-67	T21B4.6	n/a	chrII 12,509,457	C. elegans SRH-67 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
9	unc-40	T19B4.7	n/a	chrI 5,685,676	The unc-40 gene encodes a netrin receptor that is required to guide dorsal-ventral cell and axon migrations, and is required for correct polarization and migration of the neuroblasts QL and QR.
10	F41G4.1	F41G4.1	n/a	chrX 16,841,928	contains similarity to Strongylocentrotus purpuratus 33 kDa inner dynein arm light chain, axonemal (p33).; SW:Q26630
11	hlh-19	F57C12.3	n/a	chrX 556,516	C. elegans HLH-19 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
12	sru-2	C33A12.13	n/a	chrIV 9,486,898	C. elegans SRU-2 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
13	K07E8.7	K07E8.7	n/a	chrII 645,697	contains similarity to Pfam domain PF00849 RNA pseudouridylate synthase contains similarity to Interpro domains IPR006145 (Pseudouridine synthase), IPR006224 (Pseudouridine synthase, conserved site), IPR002942 (RNA-binding S4), IPR006225 (Pseudouridine synthase, RluD)
14	F36A4.11	F36A4.11	n/a	chrIV 4,245,281
15	F58E1.13	F58E1.13	n/a	chrII 1,695,343
16	nhr-33	ZK455.6	n/a	chrX 11,319,573	C. elegans NHR-33 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
17	sri-4	C05E4.4	n/a	chrV 749,407	C. elegans SRI-4 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	K04F1.10	K04F1.10	n/a	chrV 1,663,542	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domains IPR002048 (Calcium-binding EF-hand), IPR000494 (EGF receptor, L domain)
19	B0207.6	B0207.6	n/a	chrI 5,936,242	contains similarity to Pfam domain PF03029 Conserved hypothetical ATP binding protein contains similarity to Interpro domain IPR004130 (Protein of unknown function, ATP binding)
20	srx-133	F09F3.4	n/a	chrV 13,849,303	C. elegans SRX-133 protein ;
21	F27D9.3	F27D9.3	n/a	chrX 7,651,282
22	tsp-15	F53B6.1	n/a	chrI 8,929,911	C. elegans TSP-15 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
23	K09E3.1	K09E3.1	n/a	chrX 17,126,661
24	trx-2	B0024.9	n/a	chrV 10,314,942	C. elegans TRX-2 protein; contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012335 (Thioredoxin fold), IPR015467 (Thioredoxin family), IPR001200 (Phosducin), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related), IPR012336 (Thioredoxin-like fold)
25	F53H4.3	F53H4.3	n/a	chrX 15,886,572	contains similarity to Mus musculus Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).; SW:ATX1_MOUSE
26	K04E7.1	K04E7.1	n/a	chrX 6,462,585
27	srd-74	C24H11.4	0.000004	chrIII 11,782,974	C. elegans SRD-74 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
28	K07D4.2	K07D4.2	n/a	chrII 4,045,127
29	F10A3.7	F10A3.7	5.0000000000000005e-17	chrV 16,156,140	contains similarity to Pfam domain PF01461 (7TM chemoreceptor)
30	srw-94	H06H21.1	n/a	chrIV 4,815,890	C. elegans SRW-94 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
31	srh-281	F11A5.1	0.0001	chrV 16,191,496	C. elegans SRH-281 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR003002 (7TM chemoreceptor, subfamily 1)
32	srbc-61	F08E10.2	n/a	chrV 17,477,416	C. elegans SRBC-61 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
33	str-74	C14H10.4	4e-20	chrX 10,240,354	C. elegans STR-74 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	ces-1	F43G9.11	n/a	chrI 8,634,989	ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo
35	C34D4.10	C34D4.10	n/a	chrIV 7,120,692
36	F57G8.7	F57G8.7	n/a	chrV 16,329,811	contains similarity to Antarctic bacterium str 643 Metalloproteinase precursor.; TR:Q9KH34
37	eat-5	F13G3.8	n/a	chrI 7,310,218	eat-5 encodes an innexin, expressed in pharyngeal muscle cell groups pm4 and pm5, that is required for synchronized pharyngeal muscle contractions, and for normal electrical connections between pharyngeal muscle cells; EAT-5 forms electrically permeable intercellular channels (gap junctions), with a predicted membrane topology analogous to that of connexins, which affects electrical coupling between different parts of the pharynx and thus affects feeding.
38	D1046.3	D1046.3	n/a	chrIV 8,931,564	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier)
39	srh-165	C41G6.9	n/a	chrV 15,220,637	C. elegans SRH-165 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
40	T10G3.4	T10G3.4	n/a	chrV 13,483,233	contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
41	H08J19.1	H08J19.1	n/a	chrX 15,643,559	contains similarity to Homo sapiens formin-like 3 isoform 1; ENSEMBL:ENSP00000335655
42	ZK856.11	ZK856.11	n/a	chrV 10,204,273	contains similarity to Pfam domain PF01176 Translation initiation factor 1A / IF-1 contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR006196 (S1, IF1 type), IPR001253 (Eukaryotic initiation factor 1A (eIF-1A))
43	T24E12.3	T24E12.3	n/a	chrII 3,776,733
44	grd-11	K02E2.2	n/a	chrV 20,356,705	grd-11 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, four Ground domains, an short region of low-complexity sequence, and a Hint/Hog domain; the Hint/Hog domain is predicted to cut GRD-2 into two halves and then covalently link cholesterol to the C-terminus of the Ground domain; the four N-terminal Ground domains are predicted to form one or more cysteine-crosslinked proteins involved in intercellular signalling; Ground domains have subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; grd-11 has no obvious function in RNAi assays.
45	twk-3	M110.2	n/a	chrII 8,211,638	C. elegans TWK-3 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
46	Y45F10D.4	Y45F10D.4	n/a	chrIV 13,784,287	Y45F10D.4 encodes a putative iron-sulfur cluster assembly enzyme that is required for embryonic and larval viability, and that is orthologous to human NIFUN and budding yeast ISU1 and ISU2; Y45F10D.4 expression levels are unusually stable, with relatively little variation between adults, dauers, and L3 larvae, or between wild-type and daf-2(e1370ts) or daf-16(m26) mutant adults; by orthology with yeast ISU1, Y45F10D.4 is predicted to bind FRH-1.
47	F28A10.5	F28A10.5	n/a	chrII 850,172	contains similarity to Pfam domain PF05050 Protein of unknown function (DUF672) contains similarity to Interpro domain IPR007744 (Protein of unknown function DUF672)
48	taf-9	T12D8.7	n/a	chrIII 13,624,992	C. elegans TAF-9 protein; contains similarity to Pfam domain PF02291 Transcription initiation factor IID, 31kD subunit contains similarity to Interpro domains IPR003162 (Transcription factor TAFII-31), IPR009072 (Histone-fold)
49	srj-7	T28A11.10	8e-20	chrV 3,245,861	C. elegans SRJ-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
50	nhr-258	C26B2.4	n/a	chrIV 8,045,986	C. elegans NHR-258 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)