UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	gpn-1	F59D12.4	0	chrX 15,684,484	gpn-1 encodes a glypican, a heparan sulfate proteoglycan anchored to the cell membrane by a GPI linkage, that is orthologous to Drosophila Dally-like (Dlp) and mammalian glypicans (OMIM:312870, mutated in Simpson-Golabi-Behmel overgrowth syndrome); by homology, GPN-1 is predicted to function as a cell surface protein that regulates intercellular signaling, perhaps within the context of cell division and growth regulation; however, as loss of gpn-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GPN-1 in C. elegans development and/or behavior is not yet known.
2	Y51H1A.2	Y51H1A.2	n/a	chrII 13,867,372	contains similarity to Pfam domain PF02759 RUN domain contains similarity to Interpro domain IPR004012 (RUN)
3	C41H7.4	C41H7.4	n/a	chrII 3,004,748	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
4	C35B1.2	C35B1.2	n/a	chrIV 4,094,546	n/a
5	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
6	clec-187	ZK896.6	n/a	chrIV 12,870,360	C. elegans CLEC-187 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
7	set-6	C49F5.2	n/a	chrX 11,972,276	set-6 encodes a putative histone H3 lysine-9 methyltransferase; SET-6 has no non-nematode orthologs, but several paralogs (SET-13, SET-15, SET-19, SET-20, SET-21, and SET-32); neither set-6(tm1611) nor set-6(RNAi) have any obvious phenotypes.
8	gcy-20	F21H7.9	n/a	chrV 16,251,158	gcy-20 encodes a predicted guanylate cyclase.
9	fbxb-100	Y63D3A.2	n/a	chrI 14,093,529	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
10	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
11	Y4C6B.6	Y4C6B.6	n/a	chrIV 5,347,749	The Y4C6B.6 gene encodes a homolog of the human gene GLCM, which when mutated leads to Gaucher disease type I (OMIM:230800).
12	mdt-29	K08E3.8	n/a	chrIII 13,776,056	mdt-29 encodes a putative mediator subunit with a prion-like (asparagine- or glutamine-rich) domain; note that K08E3.8 is allegedly an ortholog of Drosophila INTERSEX/IX, but the actual C. elegans IX ortholog appears to be PQN-15); in yeast two-hybrid screens, MDT-29 interacts with SEL-7 and SEL-8; MDT-29 protein also self-associates; RNAi of K08E3.8 weakly enhances the two-anchor-cell phenotype of lin-12(ar170), roughly as much as sel-7 RNAi; since SEL-7 is a novel nuclear protein, MDT-29/SEL-7/SEL-8 is likely to form a nuclear complex formed in response to LIN-12 activation.
13	C18A3.2	C18A3.2	n/a	chrII 5,719,035	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
14	T13F2.9	T13F2.9	n/a	chrIV 9,768,468	contains similarity to Interpro domain IPR003071 (Orphan nuclear receptor, HMR type)
15	rha-1	T07D4.3	n/a	chrII 8,880,999	rha-1 encodes an ATP-dependent DEAD/H box RNA helicase orthologous to human RNA helicase A and Drosophila Maleless, an essential component of the dosage compensation machinery required for increased X-linked transcription in males; by homology, RHA-1 is predicted to function in regulation of transcription, translation, RNA processing, and/or RNA replication; in C. elegans, RHA-1 is required for germ cell proliferation, normal germ cell nuclear morphology, RNA-mediated interference (RNAi) of germline-expressed genes, and silencing of germline-expressed transgenes; RHA-1 is reported to localize to the nucleus and the cytoplasm.
16	dmd-5	F10C1.5	n/a	chrII 5,773,110	C. elegans DMD-5 protein; contains similarity to Pfam domain PF00751 DM DNA binding domain contains similarity to Interpro domain IPR001275 (DM DNA-binding)
17	T01C3.2	T01C3.2	n/a	chrV 14,991,380	T01C3.2 encodes a divergent ortholog of Drosophila melanogaster E(Y)2 and budding yeast Sus1p; by orthology, T01C3.2 is predicted to enable both transcriptional activation and silencing in chromatin; however, T01C3.2 has no obvious function in mass RNAi assays.
18	F16B12.6	F16B12.6	n/a	chrX 14,105,057	contains similarity to Mus musculus Neurofilament triplet H protein (200 kDa neurofilament protein)s(Neurofilament heavy polypeptide) (NF-H).; SW:NFH_MOUSE
19	F23F1.5	F23F1.5	n/a	chrII 30,845	contains similarity to Interpro domains IPR012310 (ATP dependent DNA ligase, central), IPR017336 (Snurportin-1), IPR002652 (Importin-alpha-like, importin-beta-binding region)
20	F09E10.5	F09E10.5	n/a	chrX 1,492,033
21	Y53C12B.6	Y53C12B.6	n/a	chrII 9,723,099	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
22	T14B4.2	T14B4.2	n/a	chrII 6,736,402	contains similarity to Pfam domain PF01084 Ribosomal protein S18 contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
23	chw-1	F22E12.2	n/a	chrV 10,463,355	C. elegans CHW-1 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
24	R02E12.4	R02E12.4	n/a	chrX 4,005,562	contains similarity to Pfam domains PF03148 (Tektin family) , PF00097 (Zinc finger, C3HC4 type (RING finger)) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000435 (Tektin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
25	srt-15	C50H11.10	n/a	chrV 3,060,908	C. elegans SRT-15 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
26	thoc-1	T02H6.2	n/a	chrII 705,367	C. elegans THOC-1 protein ; contains similarity to Danio rerio THO complex 1.; TR:Q7SYB2
27	nlp-17	Y45F10A.5	n/a	chrIV 13,505,484	C. elegans NLP-17 protein ;
28	T27A3.2	T27A3.2	n/a	chrI 6,112,337	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF00627 (UBA/TS-N domain) (2), PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR016652 (Ubiquitinyl hydrolase), IPR005924 (Arginase), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR001607 (Zinc finger, UBP-type), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
29	goa-1	C26C6.2	n/a	chrI 7,524,411	goa-1 encodes an ortholog of the heterotrimeric G protein alpha subunit Go (Go/Gi class) that affects normal locomotion, egg-laying, and male mating; it genetically interacts with the egl-30 pathway, and is expressed in all neurons and sex-specific muscles.
30	Y39F10C.1	Y39F10C.1	n/a	chrII 675,733	contains similarity to Pfam domain PF03762 Vitelline membrane outer layer protein I (VOMI) contains similarity to Interpro domain IPR005515 (Vitelline membrane outer layer protein I (VOMI))
31	R06C7.6	R06C7.6	n/a	chrI 7,246,472	contains similarity to Mus musculus Uncharacterized protein C8orf32 homolog.; SW:Q80WB5
32	Y32B12B.1	Y32B12B.1	n/a	chrV 16,536,916	contains similarity to Leptospira kirschneri serovar grippotyphosa Hypothetical protein.; TR:Q8KWV2
33	T21B4.3	T21B4.3	n/a	chrII 12,495,897	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
34	clec-93	ZK39.4	n/a	chrI 11,143,094	C. elegans CLEC-93 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
35	rpb-4	F43E2.2	n/a	chrII 7,374,771	C. elegans RPB-4 protein; contains similarity to Pfam domain PF03874 RNA polymerase Rpb4 contains similarity to Interpro domains IPR010997 (HRDC-like), IPR005574 (RNA polymerase II, Rpb4), IPR006590 (RNA polymerase II, Rpb4, core)
36	dct-10	Y38H6C.5	n/a	chrV 20,503,211	C. elegans DCT-10 protein; contains similarity to Pfam domains PF03732 (Retrotransposon gag protein) , PF00098 (Zinc knuckle) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR005162 (Retrotransposon gag protein), IPR001878 (Zinc finger, CCHC-type)
37	dpy-26	C25G4.5	n/a	chrIV 12,448,610	dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
38	F12F6.8	F12F6.8	n/a	chrIV 11,556,346	contains similarity to Schizosaccharomyces pombe Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylylscyclase).; SW:CYAA_SCHPO
39	Y49F6C.7	Y49F6C.7	n/a	chrII 3,367,722
40	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
41	T05F1.9	T05F1.9	n/a	chrI 9,646,642	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8ILP3
42	srd-43	R04D3.9	n/a	chrX 13,304,796	C. elegans SRD-43 protein ;
43	ZK1321.1	ZK1321.1	n/a	chrII 9,754,525	contains similarity to Sulfolobus sp NOB8H2 Hypothetical protein.; TR:O93705
44	F53E10.1	F53E10.1	n/a	chrV 2,617,140	contains similarity to Pfam domains PF03473 (MOSC domain) , PF03476 (MOSC N-terminal beta barrel domain) contains similarity to Interpro domains IPR005303 (MOSC, N-terminal beta barrel), IPR005302 (Molybdenum cofactor sulphurase, C-terminal), IPR011037 (Pyruvate kinase, beta-barrel-like)
45	M142.5	M142.5	n/a	chrIII 10,931,599	contains similarity to Homo sapiens Isoform 1 of Protein LSM12 homolog; ENSEMBL:ENSP00000293406
46	Y45F10D.6	Y45F10D.6	n/a	chrIV 13,797,043
47	F28B1.3	F28B1.3	n/a	chrV 17,053,645	contains similarity to Interpro domain IPR009021 ()
48	atgp-2	C38C6.2	n/a	chrII 14,641,992	atgp-2 encodes an amino acid transporter glycoprotein subunit; when co-expressed in Xenopus oocytes with either the AAT-1 or AAT-3 catalytic subunit, ATGP-2 facilitates amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; when co-expressed with AAT-9, ATGP-2 is able to enhance the activity of this catalytic subunit; ATGP-2 can covalently associate with AAT-1 or AAT-3 in the Xenopus expression system; when co-expressed with AAT-1 or AAT-3, ATGP-2 localizes to the cell surface of oocytes, but when expressed alone, ATGP-2 localizes intracellularly.
49	ceh-37	C37E2.5	n/a	chrX 14,203,216	ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell.
50	srw-117	C44C3.6	n/a	chrV 2,982,800	C. elegans SRW-117 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)