UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	clec-206	F59A7.1	0	chrV 2,002,373	C. elegans CLEC-206 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
2	try-10	F15B9.5	n/a	chrV 13,011,526	C. elegans TRY-10 protein; contains similarity to Pfam domain PF00089 Trypsin contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR009003 (Peptidase, trypsin-like serine and cysteine)
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	C02G6.1	C02G6.1	n/a	chrV 5,878,092	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
5	dis-3	C04G2.6	n/a	chrIV 10,101,854	C. elegans DIS-3 protein; contains similarity to Pfam domains PF00773 (RNB domain) , PF08206 (Ribonuclease B OB domain) contains similarity to Interpro domains IPR013223 (Ribonuclease B, OB region N-terminal), IPR001356 (Homeobox), IPR006596 (Nucleotide binding protein, PINc), IPR006058 (2Fe-2S ferredoxin, iron-sulphur binding site), IPR001900 (Ribonuclease II and R)
6	C42C1.7	C42C1.7	n/a	chrIV 12,297,231	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
7	F17A9.5	F17A9.5	n/a	chrV 6,112,116	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal)
8	C15C8.7	C15C8.7	n/a	chrV 12,744,584	contains similarity to Rhizobium loti Hypothetical protein mll2265.; TR:Q98IT0
9	clec-160	F09G8.8	n/a	chrIII 8,274,384	C. elegans CLEC-160 protein; contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)
10	VT23B5.2	VT23B5.2	n/a	chrIV 12,671,338	VT23B5.2 encodes a BEACH-WD40 domain-containing protein that is orthologous to human WDFY3 (WD repeat and FYVE domain containing 3); loss of VT23B5.2 activity via mutation or large-scale RNAi screens in a wild-type background results in no obvious abnormalities.
11	str-209	F26G5.5	n/a	chrV 4,949,965	C. elegans STR-209 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	F58G11.2	F58G11.2	n/a	chrV 13,667,324	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR002952 (Eggshell protein), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
13	srg-25	T09D3.5	n/a	chrV 5,343,042	C. elegans SRG-25 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
14	H11E01.2	H11E01.2	n/a	chrX 1,623,360	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
15	lig-4	C07H6.1	n/a	chrIII 7,523,062	lig-4 encodes an ortholog of DNA ligase IV in budding yeast (DNL4) and human (LIG4; OMIM:601837, mutated in LIG4 syndrome); LIG-4 is required for resistance to ionizing radiation (IR) in somatic tissues (such as motor neurons, vulva, or uterus) and in endoreduplicating intestinal cells, but not in the germline (e.g., in dog-1-induced lesions); LIG-4 is required for non-homologous end-joining of double-stranded breaks (DSB) in somatic genomic DNA; although LIG-4 is not strongly required in the germline, it is active on DSB of DNA injected into syncytial gonads, and its absence enhances the hypersensitivity of rad-51(RNAi) germlines to ionizing radiation; in meiotic cells deprived of homologous DNA repair by a rad-51(Ig08701) mutation, both LIG-4 and BRC-2 can promote chromosomal aggregation (presumably by repairing meiotic double-stranded breaks in DNA), but they do so independently; mutant lig-4 late-stage embryos or dauer larvae are hypersensitive to radiation-induced DNA damage in somatic cells; after irradiation, lig-4 mutants tend to display various postembryonic phenotypes (such as slow growth, uncoordinated locomotion, impaired egg-laying, or vulval defects) that are thought to reflect missegregation of fragmented chromosomes; LIG-4 is N-terminally acetylated on a serine residue.
16	fbxa-82	C25D7.4	n/a	chrV 15,051,980	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
17	lgc-21	C33G3.3	n/a	chrX 14,065,977	C. elegans LGC-21 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
18	C05C9.3	C05C9.3	n/a	chrX 11,148,023	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
19	W07E11.1	W07E11.1	n/a	chrX 10,093,967	contains similarity to Pfam domains PF04898 (Glutamate synthase central domain) , PF01645 (Conserved region in glutamate synthase) , PF01266 (FAD dependent oxidoreductase) , PF00310 (Glutamine amidotransferases class-II) , PF07992 (Pyridine nucleotide-disulphide oxidoreductase) , PF00070 (Pyridine nucleotide-disulphide oxidoreductase) , PF01493 (GXGXG motif) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000583 (Glutamine amidotransferase, class-II), IPR013785 (Aldolase-type TIM barrel), IPR006076 (FAD dependent oxidoreductase), IPR006005 (Glutamate synthase, NADH/NADPH, small subunit 1), IPR000759 (Adrenodoxin reductase), IPR006982 (Glutamate synthase, central-N), IPR002932 (Glutamate synthase, central-C), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR002489 (Glutamate synthase, alpha subunit, C-terminal), IPR012285 (Fumarate reductase, C-terminal), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR016040 (NAD(P)-binding), IPR012220 (Glutamate synthase, eukaryotic), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
20	nas-36	C26C6.3	n/a	chrI 7,529,499	nas-36 encodes an astacin-like protease; nas-36 activity is required for molting; a nas-36::gfp reporter is expressed in hypodermal cells.
21	C04C3.3	C04C3.3	n/a	chrIV 3,401,683	contains similarity to Pfam domains PF02780 (Transketolase, C-terminal domain) , PF02779 (Transketolase, pyrimidine binding domain) contains similarity to Interpro domains IPR005476 (Transketolase, C-terminal), IPR005475 (Transketolase, central region), IPR015941 (Transketolase C-terminal-like)
22	F28B1.3	F28B1.3	n/a	chrV 17,053,645	contains similarity to Interpro domain IPR009021 ()
23	C04F1.1	C04F1.1	n/a	chrI 5,727,848	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
24	C01G6.9	C01G6.9	n/a	chrII 9,294,851	contains similarity to Plasmodium falciparum SET-domain protein, putative.; TR:Q8IC77
25	T28F3.9	T28F3.9	n/a	chrIV 17,310,065	contains similarity to Pfam domain PF02485 Core-2/I-Branching enzyme contains similarity to Interpro domain IPR003406 (Glycosyl transferase, family 14)
26	C45G9.1	C45G9.1	n/a	chrIII 5,075,294	contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core)
27	ekl-1	F22D6.6	n/a	chrI 7,096,946	C. elegans EKL-1 protein; contains similarity to Pfam domain PF00567 Tudor domain contains similarity to Interpro domains IPR008191 (Maternal tudor protein), IPR002999 (Tudor)
28	F22G12.3	F22G12.3	n/a	chrI 13,153,129	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
29	C06E1.3	C06E1.3	n/a	chrIII 8,582,414	contains similarity to Drosophila melanogaster Flybase gene name is mol-PD;; FLYBASE:CG4482
30	H25P06.1	H25P06.1	n/a	chrI 11,317,448	contains similarity to Pfam domains PF00349 (Hexokinase) , PF03727 (Hexokinase) contains similarity to Interpro domain IPR001312 (Hexokinase)
31	glr-4	C06A8.9	n/a	chrII 7,789,680	glr-4 encodes a putative non-NMDA ionotropic glutamate receptor subunit, most closely related to GLR-3 and less so to GLR-7, possibly of the kainate subfamily; glr-4 is expressed in various sensory neurons and interneurons from embyrogenesis onward; glr-4 expression requires UNC-42, as well as CFI-1 in URA cells.
32	T27F6.6	T27F6.6	n/a	chrI 12,492,740	contains similarity to Pfam domain PF03372 Endonuclease/Exonuclease/phosphatase family contains similarity to Interpro domain IPR005135 (Endonuclease/exonuclease/phosphatase)
33	Y39A1A.6	Y39A1A.6	n/a	chrIII 10,616,526	contains similarity to Interpro domains IPR005727 (Ribosomal protein L22, bacterial-type), IPR001063 (Ribosomal protein L22/L17)
34	nhr-215	T07C5.4	n/a	chrX 12,699,419	C. elegans NHR-215 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
35	srw-58	H24D24.2	n/a	chrV 15,947,853	C. elegans SRW-58 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
36	mig-17	F57B7.4	n/a	chrV 11,447,925	mig-17 encodes a secreted metalloprotease that is a member of the ADAM (A Disintegrin And Metalloprotease) protein family; MIG-17 activity is required for proper migration of gonadal leader cells, namely the hermaphrodite distal tip cells (DTCs) and the male linker cell (MLC); a MIG-17::GFP translational fusion protein is first detected in late embryos with expression continuing through adulthood; expression is initially seen on the pseudocoelomic face of body wall muscles and then on the surface of the gonad, when the DTCs migrate on the lateral hypodermis towards the dorsal muscles; proper MIG-17 localization and glycosylation requires activity of MIG-23, a membrane-bound nucleoside diphosphatase, as well as activity of COGC-3 and COGC-1, two members of the conserved oligomeric Golgi complex; expression studies with MIG-17 deletion derivatives indicate that MIG-17 is expressed by the body wall muscles and then localizes to the DTCs where its activity is sufficient for guiding DTC migration.
37	F29B9.11	F29B9.11	n/a	chrIV 4,659,939
38	T20F7.3	T20F7.3	n/a	chrX 16,860,808	contains similarity to Pfam domain PF03770 Inositol polyphosphate kinase contains similarity to Interpro domain IPR005522 (Inositol polyphosphate kinase)
39	ZC190.7	ZC190.7	n/a	chrV 8,686,461
40	M163.2	M163.2	n/a	chrX 14,497,680	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
41	F58E2.4	F58E2.4	n/a	chrIV 3,465,102	contains similarity to Pfam domains PF01827 (FTH domain) (2), PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
42	T07D10.3	T07D10.3	n/a	chrI 12,627,858	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
43	gcy-1	AH6.1	n/a	chrII 9,514,635	gcy-1 is predicted to encode a guanylate cyclase; however, transcriptional fusions of the putative upstream regulatory region with a GFP reporter did not confirm its expression.
44	F18H3.4	F18H3.4	n/a	chrX 13,530,481	contains similarity to Mus musculus GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).; SW:Q8VD04
45	T16A9.4	T16A9.4	n/a	chrV 14,218,017	T16A9.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T16A9.4 has no clear orthologs in other organisms, it falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
46	srg-61	C24B9.11	n/a	chrV 2,739,518	C. elegans SRG-61 protein; contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
47	T07D3.6	T07D3.6	n/a	chrII 881,565	contains similarity to Pfam domain PF06828 Fukutin-related contains similarity to Interpro domain IPR009644 (Fukutin-related)
48	F20D6.11	F20D6.11	n/a	chrV 8,197,919	F20D6.11 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to human AIFM3 (AIFL), and paralogous to WAH-1 and mammalian PDCD8 (AIF; OMIM:300169, mutated in Harlequin mice); F20D6.11 is expressed in pharynx, anal depressor and body wall muscles, the reproductive system (including spermatheca), and unidentified tail cells; given its orthology to AIFM3, F20D6.11 may promote apoptosis; however, F20D6.11 has no obvious function in mass RNAi assays.
49	F59B2.8	F59B2.8	n/a	chrIII 9,008,958	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
50	str-101	Y6E2A.2	n/a	chrV 15,711,366	C. elegans STR-101 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)