UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lips-9	F58G1.5	6e-180	chrII 12,934,548	C. elegans LIPS-9 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domain IPR002918 (Lipase, class 2)
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	M153.1	M153.1	n/a	chrX 12,147,684	contains similarity to Pfam domains PF03807 (NADP oxidoreductase coenzyme F420-dependent) , PF01210 (NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus) contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR011128 (NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal), IPR016040 (NAD(P)-binding)
4	ZC13.3	ZC13.3	n/a	chrX 885,679	contains similarity to Interpro domain IPR000998 (MAM)
5	ZK154.1	ZK154.1	n/a	chrX 7,780,026	contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
6	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
7	C06A6.5	C06A6.5	n/a	chrIV 7,833,492	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
8	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
9	nhr-130	T01G6.8	n/a	chrV 482,090	C. elegans NHR-130 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
11	pqn-54	R09B5.5	n/a	chrV 1,465,672	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
12	T13H5.3	T13H5.3	n/a	chrII 8,522,122	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001579 (Glycoside hydrolase, chitinase active site), IPR001002 (Chitin-binding, type 1)
13	pqn-46	F57B9.9	n/a	chrIII 6,943,249	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
14	F46C8.8	F46C8.8	n/a	chrX 7,552,792
15	fkb-4	ZC455.10	n/a	chrV 12,786,120	fkb-4 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-4 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and in part, through the activity of the DAF-16 fork-head transcription factor suggesting that FKB-4 could play a role in metabolism and longevity; as loss of FKB-4 function via RNA-mediated interference does not result in any abnormalities, the precise role of FKB-4 in C. elegans development and/or behavior is not yet known; FKB-4 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER.
16	F42A9.8	F42A9.8	n/a	chrIV 8,618,533
17	Y38H8A.1	Y38H8A.1	n/a	chrIV 13,484,496	contains similarity to Homo sapiens NCOR isoform b; ENSEMBL:ENSP00000323172
18	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
19	R09D1.12	R09D1.12	n/a	chrII 9,451,202	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
20	lgc-22	F15E6.2	n/a	chrIV 4,302,863	C. elegans LGC-22 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR003582 (Metridin-like ShK toxin)
21	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
22	col-68	C50D2.4	n/a	chrII 105,181	C. elegans COL-68 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
23	wrt-2	F52E4.6	n/a	chrX 3,093,375	wrt-2 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-2 is expressed in seam cells and hypodermal syncytia; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly required for normal molting; WRT-2 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallel the derepression of Drosophila eyes absent by HEDGEHOG.
24	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
25	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
26	T14D7.2	T14D7.2	n/a	chrII 8,850,480	T14D7.2 encodes an acyltransferase; large-scale RNAi experiments indicate that T14D7.2 activity is required for egg laying, coordination locomotion, and normal vulval morphology.
27	C14F11.6	C14F11.6	n/a	chrX 6,238,566	contains similarity to Pfam domain PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase contains similarity to Interpro domains IPR000888 (dTDP-4-dehydrorhamnose 3,5-epimerase related), IPR011051 (Cupin, RmlC-type), IPR014710 (RmlC-like jelly roll fold)
28	F30A10.2	F30A10.2	n/a	chrI 9,479,884	contains similarity to Staphylococcus aureus ATP-depentend DNA helicase.; TR:Q8NVT1
29	zbed-6	F25H8.6	n/a	chrIV 9,919,215	zbed-6 encodes a protein that contains a BED-type zinc finger domain; loss of zbed-6 activity in large-scale RNAi screens indicates that zbed-6 is required for larval development.
30	C32D5.12	C32D5.12	n/a	chrII 6,357,672	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) contains similarity to Interpro domains IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
31	F18C5.5	F18C5.5	n/a	chrII 6,566,049	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR002373 (cAMP/cGMP-dependent protein kinase)
32	C17F4.2	C17F4.2	n/a	chrII 3,249,035
33	mig-23	R07E4.4	n/a	chrX 5,947,305	mig-23 encodes a nucleoside diphosphatase (NDPase); during larval development, MIG-23 activity is required, in body wall muscle cells, for proper dorsalward migration of the gonadal distal tip cells (DTCs) and gonad morphogenesis via regulation of MIG-17 N-glycosylation; animals lacking MIG-23 exhibit weaker UDP-, ADP-, and GDP-hydrolysing activity and when expressed in yeast lacking apyrase genes, MIG-23 can rescue NDPase activity; when expressed in body wall muscle under the control of the unc-54 promoter, MIG-23 rescues DTC migration defects and shows a punctate cytoplasmic expression pattern similar to that of Golgi enzymes.
34	col-111	F29B9.9	n/a	chrIV 4,656,697	C. elegans COL-111 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
35	exc-7	F35H8.5	n/a	chrII 9,578,446	exc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei.
36	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
37	F22F4.1	F22F4.1	n/a	chrX 6,005,723
38	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
39	spp-13	F08F1.6	n/a	chrX 8,417,877	C. elegans SPP-13 protein; contains similarity to Pfam domain PF03489 Saposin-like type B, region 2 contains similarity to Interpro domains IPR008138 (Saposin-like type B, 2), IPR011001 (Saposin-like), IPR008139 (Saposin B)
40	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
41	R04B3.3	R04B3.3	n/a	chrX 2,474,889
42	plx-2	K04B12.1	n/a	chrII 14,421,292	C. elegans PLX-2 protein; contains similarity to Pfam domains PF01833 (IPT/TIG domain) (3), PF01437 (Plexin repeat) (3), PF08337 (Plexin cytoplasmic region) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR002165 (Plexin), IPR008936 (Rho GTPase activation protein), IPR002909 (Cell surface receptor IPT/TIG), IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR013548 (Plexin cytoplasmic region), IPR015943 (WD40/YVTN repeat-like)
43	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
44	gna-1	B0024.12	n/a	chrV 10,319,821	gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; gna-1, like chs-2, is expressed pharyngeally rather than in germline, and (unlike its paralog gna-2) does not have an osmotically-sensitive embryonic lethal RNAi phenotype; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known.
45	C52D10.1	C52D10.1	n/a	chrIV 17,188,302	contains similarity to Interpro domain IPR011935 (Conserved hypothetical protein CHP02231)
46	ZK180.6	ZK180.6	n/a	chrIV 4,522,552	contains similarity to Interpro domain IPR000694 (Proline-rich region)
47	R07E3.6	R07E3.6	n/a	chrX 10,319,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
48	T07G12.3	T07G12.3	n/a	chrIV 10,535,145	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR004245 (Protein of unknown function DUF229), IPR017850 (Alkaline-phosphatase-like, core domain)
49	Y54E5A.1	Y54E5A.1	n/a	chrI 14,690,180	contains similarity to Pfam domains PF00487 (Fatty acid desaturase) , PF08557 (Sphingolipid Delta4-desaturase (DES)) contains similarity to Interpro domains IPR013866 (Sphingolipid delta4-desaturase, N-terminal), IPR010257 (Fatty acid desaturase, type 1, N-terminal), IPR011388 (Sphingolipid delta4-desaturase), IPR005804 (Fatty acid desaturase, type 1)
50	F01D5.6	F01D5.6	n/a	chrII 14,007,416	contains similarity to Pfam domain PF04536 Domain of unknown function (DUF477) contains similarity to Interpro domain IPR007621 (Protein of unknown function DUF477)