UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	let-711	F57B9.2	0	chrIII 6,952,757	let-711 encodes the C. elegans ortholog of NOT1, the conserved core component of the multisubunit CCR4/NOT complex that plays a role in regulation of gene expression via various processes including transcriptional control, mRNA deadenylation, and protein ubiquitination; in C. elegans, let-711 activity is essential for embryonic and larval development and in particular, for proper spindle positioning, microtubule length, and centrosome morphology in early embryos; in addition, let-711 is essential for normal germline development and levels of fertility; in embryos, let-711 mutations can suppress the short microtubule phenotype produced by mutations in zyg-9, which encodes the C. elegans XMAP125 homolog, and centrosomoal ZYG-9 levels are increased in let-711 mutants, suggesting that let-711 functions, in part, by negatively regulating ZYG-9 levels or localization; in situ hybridization studies indicate that let-711 mRNA is broadly expressed in the gonad and that its gonadal expression is negatively regulated by lin-35/Rb.
2	T24D1.2	T24D1.2	n/a	chrI 9,954,687	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
3	F32G8.2	F32G8.2	n/a	chrV 10,552,095	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domain IPR004245 (Protein of unknown function DUF229)
4	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
5	nph-1	M28.7	n/a	chrII 10,650,519	nph-1 encodes a novel, SH3 domain-containing protein that is orthologous to mammalian nephrocystin-1.
6	ZK1193.3	ZK1193.3	n/a	chrX 418,922	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
7	K09F6.2	K09F6.2	n/a	chrII 2,268,709	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
8	F22D3.6	F22D3.6	n/a	chrII 6,949,185	The F22D3.6 gene encodes a paracaspase homolog that may be involved in apoptosis, and that is orthologous to the human gene MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION GENE 1 (MALT1; OMIM:604860).
9	W06A11.2	W06A11.2	n/a	chrII 4,060,321
10	mrp-2	F57C12.4	n/a	chrX 568,214	mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state.
11	sri-27	ZK697.4	n/a	chrV 1,726,643	C. elegans SRI-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	T15D6.11	T15D6.11	n/a	chrI 12,397,457	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
13	R07B7.2	R07B7.2	n/a	chrV 12,058,156	contains similarity to Saccharomyces cerevisiae Protein required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; protects centromeric Spo69p; SGD:YOR073W
14	F16A11.1	F16A11.1	n/a	chrI 9,398,979	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR001870 (B302, (SPRY)-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR003877 (SPla/RYanodine receptor SPRY)
15	emb-5	T04A8.14	n/a	chrIII 4,717,943	emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4.
16	tag-296	F49D11.9	n/a	chrI 10,934,755	C. elegans TAG-296 protein; contains similarity to Pfam domain PF08718 Glycolipid transfer protein (GLTP) contains similarity to Interpro domain IPR014830 (Glycolipid transfer protein, GLTP)
17	str-230	T16A9.2	n/a	chrV 14,209,976	C. elegans STR-230 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	lgc-45	W10G11.16	n/a	chrII 3,566,681	C. elegans LGC-45 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
19	ZC84.6	ZC84.6	n/a	chrIII 9,196,038	contains similarity to Pfam domains PF01683 (EB module) (3), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (5)contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR006150 (Cysteine-rich repeat), IPR006149 (Nematode-specific EB region)
20	C02G6.2	C02G6.2	n/a	chrV 5,873,482	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
21	rhr-2	B0240.1	n/a	chrV 11,729,008	rhr-2 encodes a predicted transmembrane protein with similarity to human Rh blood group antigens proposed to function in inorganic ion transport and metabolism; the role of RHR-2 in C. elegans development or behavior remains unclear, as loss of RHR-2 function via RNA-mediated interference does not result in any abnormalities.
22	C49C3.5	C49C3.5	n/a	chrIV 17,329,906	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
23	T05E11.6	T05E11.6	n/a	chrIV 11,109,297	contains similarity to Pfam domain PF01650 Peptidase C13 family contains similarity to Interpro domain IPR001096 (Peptidase C13, legumain)
24	K09H11.7	K09H11.7	n/a	chrV 5,752,981	contains similarity to Pfam domain PF00702 haloacid dehalogenase-like hydrolase contains similarity to Interpro domains IPR006357 (HAD-superfamily hydrolase, subfamily IIA), IPR006349 (2-phosphoglycolate phosphatase, eukaryotic), IPR005834 (Haloacid dehalogenase-like hydrolase)
25	math-24	C46F9.3	n/a	chrII 1,901,084	The C46F9.3 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
26	C18B10.6	C18B10.6	n/a	chrV 7,480,150	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
27	F56F10.4	F56F10.4	n/a	chrX 867,910	contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000664 (Lethal(2) giant larvae protein)
28	srt-17	F48G7.6	n/a	chrV 624,474	C. elegans SRT-17 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
29	ugt-3	ZC455.3	n/a	chrV 12,799,239	C. elegans UGT-3 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
30	apt-9	W04G3.4	n/a	chrX 11,070,152	apt-9 gene encodes an ortholog of GGA (Golgi-localizing, gamma-adaptin ear homology, ARF-binding protein), which contains a domain paralogous to the gamma-adaptin subunits of adaptor protein complexes; based on structural similarity, APT-9 may beinvolved in the formation of intracellular transport vesicles.
31	mab-21	F35G12.6	n/a	chrIII 4,601,861	mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells.
32	wee-1.3	Y53C12A.1	n/a	chrII 9,715,024	C. elegans WEE-1.3 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
33	Y38H6A.1	Y38H6A.1	n/a	chrV 20,322,280	contains similarity to Trypanosoma brucei brucei Histone H1.; TR:Q9N6S6
34	T07C4.10	T07C4.10	n/a	chrIII 10,323,248	contains similarity to Interpro domains IPR002957 (Keratin, type I), IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
35	srw-127	C33G8.1	n/a	chrV 7,013,646	C. elegans SRW-127 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
36	str-73	F26D2.1	n/a	chrV 16,431,023	C. elegans STR-73 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	C05D12.2	C05D12.2	n/a	chrII 11,420,763	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans)
38	F55A12.5	F55A12.5	n/a	chrI 5,347,791	contains similarity to Gallus gallus Nucleolin (Protein C23).; SW:P15771
39	C02F12.8	C02F12.8	n/a	chrX 3,691,690	contains similarity to Interpro domain IPR000694 (Proline-rich region)
40	srsx-9	F26G5.10	n/a	chrV 4,972,392	C. elegans SRSX-9 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
41	nth-1	R10E4.5	n/a	chrIII 4,292,462	C. elegans NTH-1 protein; contains similarity to Pfam domains PF00633 (Helix-hairpin-helix motif) , PF00730 (HhH-GPD superfamily base excision DNA repair protein) contains similarity to Interpro domains IPR011257 (DNA glycosylase), IPR003651 (Iron-sulphur cluster loop), IPR000445 (Helix-hairpin-helix motif), IPR004035 (Endonuclease III, iron-sulphur binding, conserved site-1), IPR004036 (Endonuclease III, conserved site-2), IPR003265 (HhH-GPD)
42	F52C12.3	F52C12.3	n/a	chrIV 1,950,714
43	C34F6.6	C34F6.6	n/a	chrX 11,207,733	contains similarity to Pisum sativum 2-dehydro-3-deoxyphosphooctonate aldolase (EC 2.5.1.55) (Phospho-2-sdehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8-sphosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase)s(KDOPS).; SW:KDSA_PEA
44	K09F6.5	K09F6.5	n/a	chrII 2,272,724	contains similarity to Interpro domain IPR000358 (Ribonucleotide reductase)
45	str-7	F22B8.5	n/a	chrV 16,098,738	C. elegans STR-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
46	lgc-14	T01H10.2	n/a	chrX 12,112,417	C. elegans LGC-14 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
47	F13D12.5	F13D12.5	n/a	chrII 11,727,540	contains similarity to Interpro domain IPR001814 (Filamentous bacteriophage Vg4 protein)
48	K02E7.3	K02E7.3	n/a	chrII 1,077,813	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
49	T23G4.3	T23G4.3	n/a	chrIV 13,686,045	contains similarity to Homo sapiens BAG-family molecular chaperone regulator-4; ENSEMBL:ENSP00000287322
50	ZC373.3	ZC373.3	n/a	chrX 10,061,060	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)