UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lin-25	F56H9.5	0	chrV 12,654,300	lin-25 encodes a novel transcription factor that is conserved in C. briggsae and C. remanei; during development, lin-25 functions downstream of let-60 ras to regulate fate specification and differentiation of a number of cell types such as the vulval precursor cells; targets of LIN-25 activity include the lin-39 Hox gene, whose transcriptional upregulation during vulval cell fate specification is dependent upon lin-25; LIN-25 is expressed in vulval precursor cells, hypodermal seam cells, and cells in the somatic gonad; LIN-25 is detected in nuclei, but also seen in the cytoplasm.
2	C26E6.3	C26E6.3	n/a	chrIII 4,945,871	contains similarity to Pfam domain PF04078 Cell differentiation family, Rcd1-like contains similarity to Interpro domain IPR007216 (Cell differentiation proteins, Rcd1-like)
3	R08F11.1	R08F11.1	n/a	chrV 3,781,014	contains similarity to Pfam domain PF04685 Protein of unknown function, DUF608 contains similarity to Interpro domains IPR006775 (Protein of unknown function DUF608), IPR014551 (Beta-glucosidase, GBA2 type), IPR008928 (Six-hairpin glycosidase-like)
4	K10C2.2	K10C2.2	n/a	chrX 6,433,006	contains similarity to Interpro domain IPR000832 (GPCR, family 2, secretin-like)
5	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
6	ZK856.4	ZK856.4	n/a	chrV 10,183,835	contains similarity to Interpro domain IPR011001 (Saposin-like)
7	end-3	F58E10.5	n/a	chrV 14,015,253	end-3 encodes a GATA zinc finger protein, paralogous to end-1, that helps specify mesoendodermal (as opposed to mesectodermal) lineages derived from the E blastomere.
8	R10E4.11	R10E4.11	n/a	chrIII 4,299,234	contains similarity to Pfam domain PF00096 (Zinc finger, C2H2 type)
9	F21E9.2	F21E9.2	n/a	chrX 1,329,400
10	mcm-5	R10E4.4	n/a	chrIII 4,289,788	C. elegans MCM-5 protein; contains similarity to Pfam domain PF00493 MCM2/3/5 family contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR008048 (MCM protein 5), IPR003593 (AAA+ ATPase, core), IPR001208 (MCM)
11	srx-121	C04E12.8	n/a	chrV 3,371,855	C. elegans SRX-121 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
12	btb-13	ZC204.11	n/a	chrII 1,654,256	C. elegans BTB-13 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
13	bli-5	F45G2.5	n/a	chrIII 13,428,598	bli-5 encodes a protease inhibitor that affects the integrity of the cuticle and the development of the bursa in the adult male.
14	srh-45	T03F7.2	n/a	chrV 11,304,292	C. elegans SRH-45 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR008075 (Lipocalin-1 receptor)
15	nol-9	K09B11.2	n/a	chrIV 13,425,891	C. elegans NOL-9 protein; contains similarity to Pfam domain PF08160 NUC156 domain contains similarity to Interpro domains IPR012581 (NUC156), IPR003593 (AAA+ ATPase, core)
16	his-6	F45F2.13	n/a	chrV 8,534,749	his-6 encodes an H3 histone.
17	T01D1.4	T01D1.4	n/a	chrII 178,045	contains similarity to Pfam domain PF03079 ARD/ARD' family contains similarity to Interpro domains IPR011051 (Cupin, RmlC-type), IPR004313 (Acireductone dioxygenase, ARD), IPR014710 (RmlC-like jelly roll fold)
18	F45G2.9	F45G2.9	n/a	chrIII 13,436,244	contains similarity to Pfam domain PF01728 FtsJ-like methyltransferase contains similarity to Interpro domains IPR016448 (23S ribosomal RNA methyltransferase), IPR015507 (Ribosomal RNA methyltransferase J), IPR002877 (Ribosomal RNA methyltransferase RrmJ/FtsJ)
19	F56D6.6	F56D6.6	n/a	chrIV 3,904,376
20	srw-61	H25K10.7	n/a	chrIV 16,237,697	C. elegans SRW-61 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000611 (Neuropeptide Y receptor)
21	F54D12.1	F54D12.1	n/a	chrII 1,400,894	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
22	F38B2.3	F38B2.3	n/a	chrX 11,283,730	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
23	iftb-1	K04G2.1	n/a	chrI 8,027,270	iftb-1 encodes the C. elegans ortholog of translation initiation factor 2 beta (eIF2beta); by homology, IFTB-1 is predicted to function in translation initiation and start codon recognition; loss of iftb-1 via RNAi indicates that iftb-1 activity is required for a number of processes including growth, development, and body morphogenesis; loss of iftb-1 activity in adult animals extends lifespan.
24	T22H2.4	T22H2.4	n/a	chrI 11,694,849	contains similarity to Pfam domain PF03860 Domain of Unknown Function (DUF326) contains similarity to Interpro domain IPR005560 (Protein of unknown function DUF326)
25	B0285.3	B0285.3	n/a	chrIII 4,342,632	contains similarity to Interpro domain IPR002952 (Eggshell protein)
26	T21B6.2	T21B6.2	n/a	chrX 10,939,710	contains similarity to Pfam domains PF00300 (Phosphoglycerate mutase family) , PF00328 (Histidine acid phosphatase) contains similarity to Interpro domains IPR000560 (Histidine acid phosphatase), IPR013078 (Phosphoglycerate mutase)
27	T20D4.8	T20D4.8	n/a	chrV 3,406,799	T20D4.8 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T20D4.8 has no clear orthologs in other organisms.
28	W04A8.1	W04A8.1	n/a	chrI 13,837,656	W04A8.1 encodes a protein weakly similar to human microcephalin (MCPH1; OMIM:607117, mutated in primary microcephaly); while their primary sequence similarity is very subtle (only being detectable with psi-BLAST on NCBI-nr, using C. briggsae CBG13622 as a query sequence), both W04A8.1 and microcephalin has similar ordering of BRCT domains (one N-terminal, two C-terminal); W04A8.1 has no obvious function in mass RNAi screens.
29	F48A11.2	F48A11.2	n/a	chrII 198,605
30	ZK632.12	ZK632.12	n/a	chrIII 9,831,513	ZK632.12 encodes one of 12 C. elegans FYVE-domain containing proteins and is orthologous to mammalian Phafin2; as loss of ZK632.12 activity via RNAi screens results in no obvious defects, the precise role of ZK632.12 in C. elegans development and/or behavior is not yet known.
31	C14E2.1	C14E2.1	n/a	chrX 1,826,905
32	C53C11.1	C53C11.1	n/a	chrX 17,340,978	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
33	F11A5.6	F11A5.6	n/a	chrV 16,203,986	contains similarity to Bradyrhizobium japonicum Bll7368 protein.; TR:Q89DS1
34	F31D5.1	F31D5.1	n/a	chrII 4,220,835	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR003976 (Potassium channel, two pore-domain, TREK), IPR016196 (MFS general substrate transporter)
35	F59D12.5	F59D12.5	n/a	chrX 15,646,886
36	W02D7.6	W02D7.6	n/a	chrV 8,300,526	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
37	math-1	B0047.4	n/a	chrII 2,046,310	C. elegans MATH-1 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
38	ZK512.1	ZK512.1	n/a	chrIII 9,116,087	contains similarity to Interpro domain IPR007110 (Immunoglobulin-like)
39	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
40	scpl-2	F45E12.1	n/a	chrII 7,312,591	scpl-2 encodes a putative serine/threonine phosphatase, orthologous to budding yeast Nem1p and human DULLARD; SCPL-2 is expressed in pharynx and intestine; SCPL-2 is distantly similar to FCP-1 and SCPL-1, -3, and -4; by orthology, SCPL-2 is expected to localize to the nuclear envelope, to regulate nuclear membrane biogenesis, and to dephosphorylate the phosphatidic acid phosphatase ortholog H37A05.1.
41	sru-42	C55A1.8	n/a	chrV 15,651,414	C. elegans SRU-42 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domains IPR002208 (SecY protein), IPR003839 (Protein of unknown function DUF215)
42	Y37E11B.3	Y37E11B.3	n/a	chrIV 3,581,983	contains similarity to Homo sapiens Uncharacterized protein C17orf59; ENSEMBL:ENSP00000350621
43	T26A5.6	T26A5.6	n/a	chrIII 6,449,449	contains similarity to Interpro domain IPR001194 (DENN)
44	tag-143	ZK856.9	n/a	chrV 10,211,282	C. elegans TAG-143 protein; contains similarity to Pfam domain PF04438 HIT zinc finger contains similarity to Interpro domain IPR007529 (Zinc finger, HIT-type)
45	dpm-3	F28D1.11	n/a	chrIV 12,391,825	dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health.
46	C10A4.2	C10A4.2	n/a	chrX 7,412,571
47	F46C8.1	F46C8.1	n/a	chrX 7,550,722
48	K10E9.1	K10E9.1	n/a	chrI 196,071
49	his-34	F17E9.9	n/a	chrIV 8,336,138	his-34 encodes an H2B histone; his-34 is contained within the histone gene cluster HIS5.
50	F29B9.1	F29B9.1	n/a	chrIV 4,666,256	contains similarity to Pfam domain PF08242 Methyltransferase domain contains similarity to Interpro domain IPR013217 (Methyltransferase type 12)