UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	che-14	F56H1.1	0	chrI 5,750,511	che-14 encodes a protein with a sterol-sensing domain; CHE-14 protein is involved in the exocytotic secretion of lipid-modified proteins at the apical surface of certain epithelial cells.
2	F46C5.9	F46C5.9	n/a	chrII 8,809,612	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
3	R07B1.7	R07B1.7	n/a	chrX 9,869,453	contains similarity to Candida albicans Chitinase 2 precursor (EC 3.2.1.14).; SW:CHI2_CANAL
4	F40F9.5	F40F9.5	n/a	chrV 9,721,836	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
5	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
6	C52G5.2	C52G5.2	n/a	chrX 12,844,270	contains similarity to Pfam domain PF08768 Domain of unknown function (DUF1794) contains similarity to Interpro domain IPR014878 (Region of unknown function DUF1794)
7	T11G6.4	T11G6.4	n/a	chrIV 10,850,812	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR008075 (Lipocalin-1 receptor), IPR016196 (MFS general substrate transporter)
8	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
9	C44C1.2	C44C1.2	n/a	chrX 959,222	contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
10	rab-11.1	F53G12.1	n/a	chrI 109,369	rab-11.1 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; RAB-11.1 activity is required for completion of the final stages of cytokinesis during early embryogenesis and for efficient uptake of yolk proteins during oocyte development; RAB-11.1 is also required for normal peripheral localization of nuclei in the synctial germ cell in the ovary.
11	F52H2.6	F52H2.6	n/a	chrX 2,561,931	F52H2.6 is orthologous to the human gene 3BETA-HYDROXYSTEROL DELTA 24 REDUCTASE (DHCR24; OMIM:606418), which when mutated leads to disease.
12	dnc-2	C28H8.12	n/a	chrIII 5,925,025	dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration.
13	R07B1.3	R07B1.3	n/a	chrX 9,859,984	contains similarity to Pfam domain PF01130 CD36 family contains similarity to Interpro domain IPR002159 (CD36 antigen)
14	F11E6.8	F11E6.8	n/a	chrIV 17,447,304	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
15	ZC190.2	ZC190.2	n/a	chrV 8,682,033	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR000366 (Fungal pheromone mating factor STE2 GPCR)
16	C36B7.6	C36B7.6	n/a	chrX 7,098,999	contains similarity to Pfam domain PF05602 Cleft lip and palate transmembrane protein 1 (CLPTM1) contains similarity to Interpro domain IPR008429 (Cleft lip and palate transmembrane 1)
17	C31E10.6	C31E10.6	n/a	chrX 13,997,720	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
18	iftb-1	K04G2.1	n/a	chrI 8,027,270	iftb-1 encodes the C. elegans ortholog of translation initiation factor 2 beta (eIF2beta); by homology, IFTB-1 is predicted to function in translation initiation and start codon recognition; loss of iftb-1 via RNAi indicates that iftb-1 activity is required for a number of processes including growth, development, and body morphogenesis; loss of iftb-1 activity in adult animals extends lifespan.
19	mig-23	R07E4.4	n/a	chrX 5,947,305	mig-23 encodes a nucleoside diphosphatase (NDPase); during larval development, MIG-23 activity is required, in body wall muscle cells, for proper dorsalward migration of the gonadal distal tip cells (DTCs) and gonad morphogenesis via regulation of MIG-17 N-glycosylation; animals lacking MIG-23 exhibit weaker UDP-, ADP-, and GDP-hydrolysing activity and when expressed in yeast lacking apyrase genes, MIG-23 can rescue NDPase activity; when expressed in body wall muscle under the control of the unc-54 promoter, MIG-23 rescues DTC migration defects and shows a punctate cytoplasmic expression pattern similar to that of Golgi enzymes.
20	H13N06.2	H13N06.2	n/a	chrX 15,489,935	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
21	C34C12.6	C34C12.6	n/a	chrIII 3,483,701	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
22	pgp-2	C34G6.4	n/a	chrI 5,891,285	pgp-2 encodes a member of the ABC transporter family with highest similarity to the vertebrate MDR (multidrug resistance) family and that is orthologous to human MDR1 (ABCB1; OMIM:171050, mutated in Crohn disease); during development, pgp-2 activity is required, in parallel with that of the AP-3 adaptor complex, for the proper formation of gut granules, lysosome-related fat storage organelles found in the C. elegans intestine; pgp-2 is expressed in the intestine, from the E2 stage of embryonic development through adulthood; PGP-2 localizes to the gut granule membrane.
23	inx-15	R12E2.9	n/a	chrI 4,160,065	C. elegans INX-15 protein; contains similarity to Pfam domain PF00876 Innexin contains similarity to Interpro domain IPR000990 (Innexin)
24	Y37E11B.2	Y37E11B.2	n/a	chrIV 3,578,985
25	aps-2	F02E8.3	n/a	chrX 4,458,734	aps-2 encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP2), which mediates endocytosis from the plasma membrane; APS-2 is required for embryonic and larval development and for normal body morphogenesis, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage.
26	T09E8.3	T09E8.3	n/a	chrV 13,180,913	contains similarity to Pfam domain PF03311 Cornichon protein contains similarity to Interpro domain IPR003377 (Cornichon)
27	F30H5.3	F30H5.3	n/a	chrIII 508,704	contains similarity to Pfam domains PF01683 (EB module) (3), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (5)contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR008197 (Whey acidic protein, 4-disulphide core), IPR006150 (Cysteine-rich repeat), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR006149 (Nematode-specific EB region)
28	hog-1	W06B11.4	n/a	chrX 5,852,661	hog-1 encodes a hedgehog-like protein, with a solitary Hint/Hog domain; the function of HOG-1's isolated Hint/Hog domain is unknown; in proteins where they coexist with other, N-terminal, domains, the Hint/Hog domain is predicted to cut its host protein into two halves and then covalently link cholesterol to the C-terminus of the N-terminal domain; HOG-1 is weakly required for normal molting; HOG-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
29	C33D3.3	C33D3.3	n/a	chrX 10,485,911	contains similarity to Interpro domains IPR000679 (Zinc finger, GATA-type), IPR013088 (Zinc finger, NHR/GATA-type), IPR011011 (Zinc finger, FYVE/PHD-type)
30	F17C11.1	F17C11.1	n/a	chrV 10,942,089	contains similarity to Methanosarcina mazei Conserved protein.; TR:Q8PT55
31	elt-2	C33D3.1	n/a	chrX 10,482,266	elt-2 encodes a GATA-type transcription factor most similar to the vertebrate GATA4-6 transcription factors required for cardiac and endoderm development (OMIM:601656, 600576); in C. elegans, ELT-2 is required redundantly with ELT-7 for initiating and maintaining terminal differentiation of the intestine; ELT-2 is expressed solely in the intestine, beginning embryonically at the 2E-cell stage and continuing in all intestinal cells throughout the life of the animal; in the regulatory hierarchy controlling endoderm development, ELT-2 lies downstream of the maternal regulators SKN-1 and POP-1 and the embryonic GATA factors MED-1/-2, and END-1/-3; in turn, ELT-2, along with ELT-7, likely regulates transcription of a number of intestine-specific terminal differentiation genes such as ges-1, ifb-2, pha-4, and the stress-induced mtl-2; ELT-2 also positively autoregulates, presumably to ensure maintenance of intestinal differentiation
32	pxn-2	K09C8.5	n/a	chrX 10,975,651	C. elegans PXN-2 protein; contains similarity to Pfam domains PF00047 (Immunoglobulin domain) (2), PF00560 (Leucine Rich Repeat) (3), PF01462 (Leucine rich repeat N-terminal domain) , PF07679 (Immunoglobulin I-set domain) (2), PF03098 (Animal haem peroxidase) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR013098 (Immunoglobulin I-set), IPR010255 (Haem peroxidase), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR003591 (Leucine-rich repeat, typical subtype), IPR007110 (Immunoglobulin-like), IPR002007 (Haem peroxidase, animal), IPR000372 (Leucine-rich repeat, cysteine-rich flanking region, N-terminal), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
33	D2023.5	D2023.5	n/a	chrV 11,826,462	contains similarity to Interpro domain IPR001763 (Rhodanese-like)
34	wrt-9	B0344.2	n/a	chrX 1,583,762	wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-9 has no obvious function in RNAi assays.
35	zbed-6	F25H8.6	n/a	chrIV 9,919,215	zbed-6 encodes a protein that contains a BED-type zinc finger domain; loss of zbed-6 activity in large-scale RNAi screens indicates that zbed-6 is required for larval development.
36	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
37	F46C8.8	F46C8.8	n/a	chrX 7,552,792
38	acl-10	F55A11.5	n/a	chrV 11,775,146	C. elegans ACL-10 protein; contains similarity to Pfam domain PF01553 Acyltransferase contains similarity to Interpro domain IPR002123 (Phospholipid/glycerol acyltransferase)
39	srz-64	Y57G7A.7	n/a	chrII 1,291,002	C. elegans SRZ-64 protein ;
40	arx-5	Y37D8A.1	n/a	chrIII 12,817,350	arx-5 encodes the C. elegans ortholog of the p21Arc subunit of the actin-related protein (Arp) 2/3 complex.
41	F39B2.3	F39B2.3	n/a	chrI 14,788,812	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
42	Y38H8A.1	Y38H8A.1	n/a	chrIV 13,484,496	contains similarity to Homo sapiens NCOR isoform b; ENSEMBL:ENSP00000323172
43	T19B10.9	T19B10.9	n/a	chrV 11,249,483	contains similarity to Interpro domain IPR000694 (Proline-rich region)
44	rer-1	F46C5.8	n/a	chrII 8,811,744	C. elegans RER-1 protein; contains similarity to Pfam domain PF03248 Rer1 family contains similarity to Interpro domain IPR004932 (Retrieval of early ER protein Rer1)
45	gst-42	D1053.1	n/a	chrX 11,727,007	gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia.
46	tag-289	F14F3.3	n/a	chrX 10,523,120	C. elegans TAG-289 protein; contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)
47	C38D9.2	C38D9.2	n/a	chrV 17,568,988	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
48	K11G9.2	K11G9.2	n/a	chrV 6,675,280	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
49	R05D3.9	R05D3.9	n/a	chrIII 8,365,541	contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold)
50	clec-170	F38A1.1	n/a	chrIV 1,270,618	C. elegans CLEC-170 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)