UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fhod-2	F56E10.2	0	chrV 67,785	fhod-2 encodes an ortholog of Drosophila DAAM and human DAAM1 (OMIM:606626); FHOD-2 enables Wnt-directed planar cell polarity; FHOD-2 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak.
2	K01A11.2	K01A11.2	n/a	chrIII 3,426,861	contains similarity to Xenopus laevis LOC495955 protein.; TR:Q5PQ79
3	Y56A3A.5	Y56A3A.5	n/a	chrIII 11,889,625	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domains IPR000120 (Amidase signature enzyme), IPR000504 (RNA recognition motif, RNP-1)
4	qui-1	Y45F10B.10	n/a	chrIV 13,568,114	The qui-1 gene encodes a protein of unknown function that contains several WD-40 domains.
5	tam-1	F26G5.9	n/a	chrV 4,960,832	tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin.
6	E03A3.5	E03A3.5	n/a	chrIII 4,061,679	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold)
7	hum-6	T10H10.1	n/a	chrX 2,309,009	hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB.
8	unc-130	C47G2.2	n/a	chrII 11,282,880	A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor.
9	clpp-1	ZK970.2	n/a	chrII 10,301,745	clpp-1 encodes a mitochondrial protein, homologous to bacterial ClpP, required to initiate the stress response to unfolded mitochondrial proteins; as with its bacterial ortholog, CLPP-1 is predicted to be a proteolytic subunit of a Clp-like protease, with an N-terminal region required for mitochondrial localization, and a C-terminal region of ClpP similarity; in response to a mutation stressing mitochondria, clpp-1(RNAi) animals show reduced HSP-60 levels, inhibited nuclear translocation and hsp-60 activation by DVE-1, and aberrant mitochondrial morphology; CLPP-1 is biochemically inhibited by the ClpP inhibitor Z-LY-CMK and the peptide aldehyde MG132, and may also be blocked by them when injected in vivo; CLPP-1 is expressed in the intestine.
10	ceh-34	C10G8.6	n/a	chrV 5,317,530	ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function.
11	math-32	F59H6.4	n/a	chrII 2,012,019	C. elegans MATH-32 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
12	F31F7.2	F31F7.2	n/a	chrV 6,272,906	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
13	lon-2	C39E6.1	n/a	chrX 4,743,993	lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.
14	F57G12.2	F57G12.2	n/a	chrX 12,158,178	contains similarity to Mus musculus Nuclear protein ZAP3.; SW:ZAP3_MOUSE
15	clec-229	H02K04.1	n/a	chrV 15,340,763	C. elegans CLEC-229 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR001202 (WW/Rsp5/WWP)
16	T13C2.2	T13C2.2	n/a	chrII 6,795,686
17	K07E8.6	K07E8.6	n/a	chrII 638,824	contains similarity to Pfam domain PF08565 Cdc37 Hsp90 binding domain contains similarity to Interpro domains IPR004918 (Cdc37), IPR013874 (Cdc37, Hsp90 binding)
18	tza-2	K03E6.4	n/a	chrX 1,067,909	C. elegans TZA-2 protein; contains similarity to Pfam domain PF07162 B9 protein contains similarity to Interpro domain IPR010796 (B9)
19	srb-5	C27D6.6	n/a	chrII 5,162,671	C. elegans SRB-5 protein; contains similarity to Pfam domain PF02175 C.elegans integral membrane protein Srb contains similarity to Interpro domain IPR002184 (Serpentine beta receptor)
20	lact-7	C40H5.4	n/a	chrX 11,762,779	lact-7 encodes a beta-lactamase domain-containing protein.
21	gur-4	K09E4.5	n/a	chrII 14,106,298	C. elegans GUR-4 protein ;
22	F54F3.3	F54F3.3	n/a	chrV 12,920,812	contains similarity to Pfam domains PF04083 (ab-hydrolase associated lipase region) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR006693 (AB-hydrolase associated lipase region), IPR000073 (Alpha/beta hydrolase fold-1), IPR008262 (Lipase, active site)
23	src-2	F49B2.5	n/a	chrI 14,325,568	C. elegans SRC-2 protein; contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF00018 (SH3 domain) , PF00017 (SH2 domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000719 (Protein kinase, core), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000980 (SH2 motif), IPR008266 (Tyrosine protein kinase, active site)
24	M57.1	M57.1	n/a	chrIV 3,536,339	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
25	rps-8	F42C5.8	n/a	chrIV 7,313,435	rps-8 encodes a small ribosomal subunit S8 protein; by homology, RPS-8 is predicted to function in protein biosynthesis; in C. elegans, RPS-8 activity is required for germline development and the overall health of the animal.
26	T15B7.10	T15B7.10	n/a	chrV 6,811,130	contains similarity to Ostreococcus tauri Predicted CDS, putative cytoplasmic protein family member, with ascoiled coil-4 domain, of ancient origin (ISS).; TR:Q010X5
27	ocr-2	T09A12.3	n/a	chrIV 8,216,912	ocr-2 encodes a TRPV (transient receptor potential channel, vanilloid subfamily) ion channel; OCR-2 activity is required for several types of sensory transduction including olfaction, osmosensation, mechanosensation, and chemosensation; an OCR-2 fusion protein is expressed in sensory cilia and requires the OSM-9 TRPV channel protein for proper localization; likewise, OSM-9 requires OCR-2 for its cilial localization.
28	F12A10.6	F12A10.6	n/a	chrII 5,494,268
29	F59C6.8	F59C6.8	n/a	chrI 10,511,155	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
30	C01A2.2	C01A2.2	n/a	chrI 13,397,863	contains similarity to Streptomyces coelicolor Putative sugar transporter integral membrane protein.; TR:Q9K489
31	skr-19	R12H7.3	n/a	chrX 13,224,084	The skr-19 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-19(RNAi) animals are at least superficially normal.
32	unc-50	T07A5.2	n/a	chrIII 10,316,260	unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific nicotinic receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi.
33	F58F6.5	F58F6.5	n/a	chrIV 1,343,974	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
34	elp-1	F38A6.2	n/a	chrV 20,762,946	elp-1 encodes a WD repeat-containing protein that is the sole C. elegans EMAP (echinoderm microtubule-associated protein) homolog; ELP-1 binds microtubules in vitro, but as loss of ELP-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of ELP-1 in C. elegans development and/or behavior is not yet known; ELP-1 is expressed in many tissues, including body wall muscle, male-specific sex muscles, the vulva, spermatheca, sensory neurons, and intestinal cells.
35	F56D5.5	F56D5.5	n/a	chrIV 9,407,671	contains similarity to Interpro domain IPR000533 (Tropomyosin)
36	F40E3.2	F40E3.2	n/a	chrI 2,643,222
37	aat-1	F27C8.1	n/a	chrIV 9,600,317	aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly.
38	T21D12.7	T21D12.7	n/a	chrIV 290,077	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR013090 (Phospholipase A2, active site), IPR006150 (Cysteine-rich repeat)
39	ace-4	Y48B6A.7	n/a	chrII 14,201,652	ace-4 encodes an divergent acetylcholinesterase homolog with biochemically undetectable activity.
40	F29F11.3	F29F11.3	n/a	chrV 10,658,900	contains similarity to Drosophila melanogaster Flybase gene name is CG10189-PA;; FLYBASE:CG10189
41	Y106G6H.4	Y106G6H.4	n/a	chrI 10,437,301	contains similarity to Interpro domain IPR006578 (MADF)
42	lgc-1	T05B4.1	n/a	chrV 4,136,911	C. elegans LGC-1 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
43	B0554.3	B0554.3	n/a	chrV 434,275
44	clec-22	F49A5.3	n/a	chrV 16,859,205	C. elegans CLEC-22 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
45	let-19	K08F8.6	n/a	chrII 8,776,425	The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling.
46	W04G5.8	W04G5.8	n/a	chrI 11,650,893	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
47	K09H11.5	K09H11.5	n/a	chrV 5,728,063
48	nhr-172	C54F6.9	n/a	chrV 7,509,779	C. elegans NHR-172 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR015880 (Zinc finger, C2H2-like), IPR001781 (Zinc finger, LIM-type), IPR007087 (Zinc finger, C2H2-type)
49	sri-28	B0454.3	n/a	chrII 3,049,551	C. elegans SRI-28 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
50	srh-7	K09D9.7	n/a	chrV 4,009,007	C. elegans SRH-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)