UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F55A4.1	F55A4.1	2e-118	chrX 1,036,270	contains similarity to Pfam domain PF00957 Synaptobrevin contains similarity to Interpro domains IPR010908 (Longin), IPR011012 (Longin-like), IPR001388 (Synaptobrevin)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	tra-4	F53B3.1	n/a	chrX 2,855,643	C. elegans TRA-4 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR008162 (Inorganic pyrophosphatase), IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
4	C52E12.4	C52E12.4	n/a	chrII 7,017,594	contains similarity to Pfam domains PF01477 (PLAT/LH2 domain) , PF02141 (DENN (AEX-3) domain) , PF03456 (uDENN domain) , PF03455 (dDENN domain) , PF02759 (RUN domain) contains similarity to Interpro domains IPR005112 (dDENN), IPR001024 (Lipoxygenase, LH2), IPR008976 (Lipase/lipooxygenase, PLAT/LH2), IPR004012 (RUN), IPR005113 (uDENN), IPR001194 (DENN)
5	C53C11.1	C53C11.1	n/a	chrX 17,340,978	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
6	F22B8.6	F22B8.6	n/a	chrV 16,101,647	F22B8.6 encodes a putative cystathionine gamma-lyase; F22B8.6 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog ZK1127.10, and also paralogous to C12C8.2; either F22B8.6, or ZK1236.10, or both proteins weakly inhibit DHC-1 in vivo; otherwise, F22B8.6 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with ZK1127.10.
7	gly-19	F22D6.12	n/a	chrI 7,113,932	gly-19 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; it is probably coexpressed with gly-18 in the anal sphincter muscle.
8	cyp-13A12	F14F7.3	n/a	chrIII 13,026,202	C. elegans CYP-13A12 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
9	lin-59	T12F5.4	n/a	chrI 3,717,339	C. elegans LIN-59 protein; contains similarity to Pfam domains PF01426 (BAH domain) , PF00628 (PHD-finger) , PF00856 (SET domain) contains similarity to Interpro domains IPR001214 (SET), IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR001025 (Bromo adjacent region), IPR011011 (Zinc finger, FYVE/PHD-type), IPR006560 (AWS)
10	T13C5.4	T13C5.4	n/a	chrX 6,192,236	T13C5.4 encodes a paired-like homeodomain protein of the Q50 class, which has no obvious function in mass RNAi assays.
11	K04F10.7	K04F10.7	n/a	chrI 6,367,224	contains similarity to Homo sapiens Isoform 1 of Protein FAM76B; ENSEMBL:ENSP00000351631
12	srbc-76	M01B2.4	n/a	chrV 15,252,812	C. elegans SRBC-76 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
13	cah-5	R173.1	n/a	chrX 7,021,932	cah-5 encodes a member of the carbonic anhydrase family.
14	D1025.1	D1025.1	n/a	chrX 14,521,627	contains similarity to Homo sapiens Splice isoform 3 of Q9ULU4 Protein kinase C binding protein 1; ENSEMBL:ENSP00000262975
15	R11E3.2	R11E3.2	n/a	chrIV 4,773,617	contains similarity to Pfam domain PF00860 Permease family contains similarity to Interpro domain IPR006043 (Xanthine/uracil/vitamin C permease)
16	M01B2.10	M01B2.10	n/a	chrV 15,261,657	contains similarity to Homo sapiens Phytanoyl-CoA 2-hydroxylase-interacting protein-like; ENSEMBL:ENSP00000362987
17	ZK1225.1	ZK1225.1	n/a	chrI 13,206,699	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
18	E04D5.2	E04D5.2	n/a	chrII 10,420,700	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
19	H13N06.2	H13N06.2	n/a	chrX 15,489,935	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
20	syn-13	F36F2.4	n/a	chrI 9,003,016	C. elegans SYN-13 protein; contains similarity to Pfam domain PF05739 SNARE domain contains similarity to Interpro domains IPR010989 (t-SNARE), IPR006011 (Syntaxin, N-terminal), IPR000727 (Target SNARE coiled-coil region), IPR006012 (Syntaxin/epimorphin, conserved site)
21	Y18D10A.9	Y18D10A.9	n/a	chrI 12,855,664	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
22	rhgf-1	F13E6.6	n/a	chrX 10,704,787	rhgf-1 encodes an RGS RhoGEF (Regulator of G-protein Signaling Rho Guanine Nucleotide Exchange Factor); RHGF-1 functions within cholingergic motor neurons in one of four G-protein-mediated signaling pathways that control locomotion via regulation of acetylcholine (ACh) release at neuromuscular junctions; in regulating ACh release, RHGF-1 functions downstream of the C. elegans Galpha12 ortholog, GPA-12, and upstream of the Rho GTPase ortholog, RHO-1; additionally, rhgf-1 activity is required for normal mechanosensory behavior, egg laying, and embryonic development; an rhgf-1 reporter fusion is expressed in ventral cord motor neurons as well as several head neurons.
23	Y47H9C.7	Y47H9C.7	n/a	chrI 11,892,653	Y47H9C.7 is orthologous to the human gene EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, SUBUNIT 2 (BETA, 39KD) (EIF2B2; OMIM:606454), which when mutated leads to disease.
24	ugt-41	F10D2.11	n/a	chrV 7,162,312	C. elegans UGT-41 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
25	str-193	C50C10.6	n/a	chrV 9,821,161	C. elegans STR-193 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	C05G5.2	C05G5.2	n/a	chrX 14,748,776	contains similarity to Xenopus laevis Nucleolar phosphoprotein.; TR:Q91803
27	T08D2.2	T08D2.2	n/a	chrX 167,955	contains similarity to Pfam domains PF00953 (Glycosyl transferase family 4) , PF00646 (F-box domain) contains similarity to Interpro domain IPR000715 (Glycosyl transferase, family 4)
28	R09A8.1	R09A8.1	n/a	chrX 12,615,226	contains similarity to Homo sapiens FLASH; ENSEMBL:ENSP00000237177
29	itsn-1	Y116A8C.36	n/a	chrIV 17,122,917	tag-11/Y116A8C.36 encodes a homolog of human NCF1, which when mutated leads to chronic granulomatous disease (OMIM:306400).
30	tgt-1	ZK829.6	n/a	chrIV 11,958,629	tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial.
31	tor-2	Y37A1B.13	n/a	chrIV 13,983,393	tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA, mutations in which are associated with torsion dystonia (OMIM:605204); overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation.
32	F08D12.7	F08D12.7	n/a	chrII 2,768,193	F08D12.7 encodes a novel protein conserved amongst Caenorhaditis species; although loss of F08D12.7 activity via RNAi results in no obvious defects, F08D12.7 transcripts are enriched in L1-stage muscle and upregulated in L2 larvae in response to overexpression of hlh-2 and hlh-8; in addition, in analyses of the early embryonic transcriptome, F08D12.7 transcripts are classified as strictly maternal; an F08D12.7::gfp reporter fusion is expressed in the vm1 and vm2 vulval muscles, the intestinal and anal depressor muscles, the hypodermis, distal tip cell, ventral nerve cord, head and tail neurons, and body wall muscle.
33	npp-4	Y54E5A.4	n/a	chrI 14,703,902	C. elegans NPP-4 protein; contains similarity to Interpro domains IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR007758 (Nucleoporin, Nsp1-like, C-terminal)
34	C25F6.6	C25F6.6	n/a	chrX 5,450,509
35	M04F3.4	M04F3.4	n/a	chrI 4,772,433	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR008080 (Parvalbumin), IPR003299 (Flagellar calcium-binding protein (calflagin))
36	fbxa-11	T12B5.4	n/a	chrIII 951,455	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
37	tag-131	H38K22.3	n/a	chrIII 4,318,987	C. elegans TAG-131 protein; contains similarity to Pfam domain PF00173 Cytochrome b5-like Heme/Steroid binding domain contains similarity to Interpro domain IPR001199 (Cytochrome b5)
38	str-255	C45H4.15	n/a	chrV 2,162,667	C. elegans STR-255 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000301 (CD9/CD37/CD63 antigen)
39	T07F10.5	T07F10.5	n/a	chrV 12,866,209	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002168 (Lipase, GDXG, active site), IPR002018 (Carboxylesterase, type B)
40	C01B10.4	C01B10.4	n/a	chrIV 6,630,045	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
41	F11A5.6	F11A5.6	n/a	chrV 16,203,986	contains similarity to Bradyrhizobium japonicum Bll7368 protein.; TR:Q89DS1
42	F53B3.2	F53B3.2	n/a	chrX 2,860,247	contains similarity to Pfam domain PF01596 O-methyltransferase contains similarity to Interpro domain IPR002935 (O-methyltransferase, family 3)
43	F13E6.2	F13E6.2	n/a	chrX 10,671,215	contains similarity to Pfam domain PF05186 Dpy-30 motif contains similarity to Interpro domains IPR000850 (Adenylate kinase), IPR007858 (Dpy-30), IPR011769 (Adenylate/cytidine kinase, N-terminal)
44	wrt-9	B0344.2	n/a	chrX 1,583,762	wrt-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of proline-rich, low-complexity sequence; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-9 has no obvious function in RNAi assays.
45	F16G10.9	F16G10.9	n/a	chrII 2,385,448	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
46	alr-1	R08B4.2	n/a	chrX 11,123,705	C. elegans ALR-1 protein; contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR000047 (Helix-turn-helix motif, lambda-like repressor), IPR013847 (POU), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
47	F11E6.8	F11E6.8	n/a	chrIV 17,447,304	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
48	T13C5.6	T13C5.6	n/a	chrX 6,207,063	contains similarity to Pfam domain PF01569 PAP2 superfamily contains similarity to Interpro domains IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase), IPR016118 (Phosphatidic acid phosphatase/chloroperoxidase, N-terminal)
49	pro-1	R166.4	n/a	chrII 10,540,649	pro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.
50	T20H4.5	T20H4.5	n/a	chrIII 7,233,493	T20H4.5 gene encodes a 23 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation and for resistance to volatile anesthetics; T20H4.5 is orthologous to human NDUFS8 (OMIM:602141, mutated in Leigh syndrome).