UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	dnj-13	F54D5.8	5e-141	chrII 11,546,449	This gene encodes a protein containing a DnaJ ('J') domain.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	unc-45	F30H5.1	n/a	chrIII 497,067	C. elegans UNC-45 protein; contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) , PF00515 (Tetratricopeptide repeat) (2)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR011989 (Armadillo-like helical), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR016024 (Armadillo-type fold), IPR013026 (Tetratricopeptide region)
4	pabp-2	C17E4.5	n/a	chrI 9,421,408	pabp-2 encodes the C. elegans PABPN1 (polyadenylate-binding protein, nuclear 1) ortholog; by homology, PABP-2 is predicted to function as a poly(A)-binding protein involved in several aspects of pre-mRNA processing; large-scale RNAi screens indicate that pabp-2 activity is essential for embryonic and larval development, as well as normal rates of growth and locomotion; in humans, expansion of a polyalanine repeat in PABPN1 is associated with oculopharyngeal muscular dystrophy (OPMD, OMIM:602279).
5	T06D8.3	T06D8.3	n/a	chrII 11,224,333	contains similarity to Pfam domain PF01569 PAP2 superfamily contains similarity to Interpro domain IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase)
6	aly-1	C01F6.5	n/a	chrIV 9,109,321	aly-1 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-1 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-2 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-2, ALY-1 and its paralog ALY-2 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; ALY-1 and NXF-2 bind the TRE element in vitro; ALY-1 is also bound competitively by either NXF-2 or TRA-1 in vitro; aly-1(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-1 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-1 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6.
7	uaf-2	Y116A8C.35	n/a	chrIV 17,117,717	uaf-2 encodes an essential U2AF35 homolog clustered in an operon with cyp-13 (RRM/cyclophilin); UAF-2's sequence is somewhat atypical for U2AF proteins (it lacks an identifiable N-terminal RNA-binding RS domain, while having an glycine-rich C-terminal region).
8	F25G6.2	F25G6.2	n/a	chrV 8,576,005	contains similarity to Homo sapiens Isoform 1 of Symplekin; ENSEMBL:ENSP00000245934
9	dnj-19	T05C3.5	9.999999999999999e-27	chrV 5,504,025	This gene encodes a protein containing a DnaJ ('J') domain.
10	B0303.2	B0303.2	n/a	chrIII 8,685,551	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
11	B0238.11	B0238.11	n/a	chrV 5,270,093	contains similarity to Interpro domain IPR009071 (High mobility group box, HMG)
12	F36G3.2	F36G3.2	n/a	chrX 9,793,271	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
13	his-72	Y49E10.6	n/a	chrIII 12,367,802	his-72 encodes an H3 histone required for embryonic viability.
14	C46E10.4	C46E10.4	n/a	chrII 3,718,412
15	rpb-2	C26E6.4	n/a	chrIII 4,941,947	C. elegans RPB-2 protein; contains similarity to Pfam domains PF04566 (RNA polymerase Rpb2, domain 4) , PF04561 (RNA polymerase Rpb2, domain 2) , PF04567 (RNA polymerase Rpb2, domain 5) , PF04565 (RNA polymerase Rpb2, domain 3) , PF00562 (RNA polymerase Rpb2, domain 6) , PF04560 (RNA polymerase Rpb2, domain 7) , PF04563 (RNA polymerase beta subunit) contains similarity to Interpro domains IPR007120 (DNA-directed RNA polymerase, subunit 2, domain 6), IPR007641 (RNA polymerase Rpb2, domain 7), IPR007644 (RNA polymerase, beta subunit, protrusion), IPR015712 (DNA-directed RNA polymerase, subunit 2), IPR007645 (RNA polymerase Rpb2, domain 3), IPR007642 (RNA polymerase Rpb2, domain 2), IPR014724 (RNA polymerase Rpb2, OB-fold), IPR007646 (RNA polymerase Rpb2, domain 4), IPR007647 (RNA polymerase Rpb2, domain 5), IPR007121 (RNA polymerase, beta subunit, conserved site)
16	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
17	lbp-5	W02D3.7	n/a	chrI 6,731,777	lbp-5 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-5 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; loss of lbp-5 activity via large-scale RNAi screens indicates that, in C. elegans, LBP-5 is required for movement.
18	B0464.2	B0464.2	n/a	chrIII 9,494,244	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (8)contains similarity to Interpro domains IPR001440 (Tetratricopeptide TPR-1), IPR011990 (Tetratricopeptide-like helical), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region), IPR008940 (Protein prenyltransferase)
19	K03C7.3	K03C7.3	n/a	chrX 3,828,246
20	D2013.6	D2013.6	n/a	chrII 9,330,348	contains similarity to Pfam domain PF02893 GRAM domain contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR004182 (GRAM)
21	F34D10.4	F34D10.4	n/a	chrIII 3,737,977	contains similarity to Interpro domain IPR000694 (Proline-rich region)
22	M01A10.3	M01A10.3	n/a	chrI 5,549,799	contains similarity to Pfam domain PF05817 Ribophorin II (RPN2) contains similarity to Interpro domain IPR008814 (Ribophorin II)
23	clec-17	E03H4.10	n/a	chrI 12,430,738	C. elegans CLEC-17 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
24	C01F1.5	C01F1.5	n/a	chrII 4,280,801	contains similarity to Interpro domain IPR001506 (Peptidase M12A, astacin)
25	rnp-5	K02F3.11	n/a	chrIII 853,412	rnp-5 encodes a putative member of the exon-exon junction complex, orthologous to human RNPS1 (OMIM:606447); RNP-5 is dispensable for embryonic viability.
26	cls-2	R107.6	n/a	chrIII 9,056,749	cls-2 encodes one of three predicted orthologs of mammalian CLASPs and of Drosophila ORBIT/MAST, microtubule-binding proteins required for fibroblast polarization and mitosis; cls-2 is required in mass RNAi assays for embryonic development and normal mitotic spindles; it has been claimed that, in an RNAi screen of potential microtubule tip-binding proteins, only cls-2(RNAi) yielded embryonic lethality and meiotic defects.
27	ZK185.3	ZK185.3	n/a	chrIV 4,529,575	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
28	W08E3.2	W08E3.2	n/a	chrI 13,334,747	contains similarity to Interpro domain IPR004054 (Potassium channel, voltage dependent, Kv4.1)
29	T20B12.3	T20B12.3	n/a	chrIII 7,382,935	contains similarity to Pfam domain PF03914 CBF/Mak21 family contains similarity to Interpro domain IPR005612 (CBF)
30	C17E4.9	C17E4.9	n/a	chrI 9,432,529	contains similarity to Pfam domain PF00287 Sodium / potassium ATPase beta chain contains similarity to Interpro domain IPR000402 (ATPase, P-type cation exchange, beta subunit)
31	ZK682.5	ZK682.5	n/a	chrV 9,285,827	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR000480 (Glutelin)
32	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
33	C47E12.7	C47E12.7	n/a	chrIV 9,981,472	contains similarity to Pfam domain PF05997 Nucleolar protein,Nop52 contains similarity to Interpro domain IPR010301 (Nucleolar, Nop52)
34	F07A5.3	F07A5.3	n/a	chrI 7,355,830	contains similarity to Pfam domain PF01130 CD36 family contains similarity to Interpro domain IPR002159 (CD36 antigen)
35	rad-23	ZK20.3	n/a	chrII 11,652,044	C. elegans RAD-23 protein; contains similarity to Pfam domains PF09280 (XPC-binding domain) , PF00627 (UBA/TS-N domain) (2), PF00240 (Ubiquitin family) contains similarity to Interpro domains IPR004806 (UV excision repair protein Rad23), IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000104 (Antifreeze protein, type I), IPR014761 (UV excision repair protein Rad23, C-terminal), IPR000626 (Ubiquitin), IPR009060 (UBA-like), IPR006636 (Heat shock chaperonin-binding), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote), IPR015360 (XPC-binding domain)
36	nhr-3	H01A20.1	n/a	chrX 14,559,886	nhr-3 encodes a member of the superfamily of nuclear receptors which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; nhr-3 has been identified and characterised as a gene affected by ethanol exposure in a microarray analysis of all C. elegans ORFs.
37	glit-1	F55D10.3	n/a	chrX 4,713,649	C. elegans GLIT-1 protein; contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
38	tag-175	D2013.10	n/a	chrII 9,324,253	tag-175 encodes an ortholog of human TMEM41B, whose protein family is ancient (conserved in both animals and plants) but functionally uncharacterized; TAG-175 is broadly expressed (in hypodermis, muscle, neurons, intestine, spermetheca, and vulva); TAG-175 has no known function in vivo, since neither tag-175(RNAi) nor tag-175(gk278) has obvious phenotypes.
39	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
40	ark-1	C01C7.1	n/a	chrIV 12,626,527	ark-1 encodes a homolog of the nonreceptor tyrosine kinase ACK which inhibits signalling through the EGF receptor homolog LET-23, both in (RAS-dependent) vulval development and in (RAS-independent) ovulation.
41	ZK381.2	ZK381.2	n/a	chrIV 6,966,550	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
42	E03H4.8	E03H4.8	n/a	chrI 12,425,649	contains similarity to Pfam domain PF04053 Coatomer WD associated region contains similarity to Interpro domains IPR006692 (Coatomer, WD associated region), IPR011046 (WD40 repeat-like)
43	F53F1.2	F53F1.2	n/a	chrV 13,407,532	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
44	F53H8.3	F53H8.3	n/a	chrX 940,562	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
45	clec-53	T03F1.10	n/a	chrI 3,872,447	C. elegans CLEC-53 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR002352 (Eosinophil major basic protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
46	F17A2.4	F17A2.4	n/a	chrX 12,311,694	contains similarity to Naja philippinensis;Naja samarensis;Naja sputatrix Short neurotoxin 1 (NTX I).; SW:NXS1_NAJPH
47	ZC513.7	ZC513.7	n/a	chrV 8,039,921	C. elegans probable non-coding RNA
48	gosr-2.1	B0272.2	n/a	chrX 9,440,914	C. elegans GOSR-2.1 protein; contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domain IPR007705 (Vesicle transport v-SNARE)
49	acl-8	T05H4.1	n/a	chrV 6,451,547	C. elegans ACL-8 protein; contains similarity to Pfam domain PF01553 Acyltransferase contains similarity to Interpro domain IPR002123 (Phospholipid/glycerol acyltransferase)
50	prx-12	F08B12.2	n/a	chrX 11,393,885	C. elegans PRX-12 protein; contains similarity to Pfam domain PF04757 Pex2 / Pex12 amino terminal region contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017375 (Peroxisome assembly, p12), IPR006845 (Pex, N-terminal)