UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	iff-2	F54C9.1	2e-92	chrII 8,560,312	C. elegans IFF-2 protein; contains similarity to Pfam domains PF01287 (Eukaryotic initiation factor 5A hypusine, DNA-binding OB fold) , PF00467 (KOW motif) contains similarity to Interpro domains IPR001884 (Eukaryotic initiation factor 5A hypusine (eIF-5A)), IPR008991 (Translation protein SH3-like), IPR005824 (KOW), IPR012340 (Nucleic acid-binding, OB-fold), IPR014722 (Translation protein SH3-like, subgroup)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	C05G5.1	C05G5.1	n/a	chrX 14,737,200	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
4	T20H4.5	T20H4.5	n/a	chrIII 7,233,493	T20H4.5 gene encodes a 23 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation and for resistance to volatile anesthetics; T20H4.5 is orthologous to human NDUFS8 (OMIM:602141, mutated in Leigh syndrome).
5	fbxa-216	Y47H9C.10	n/a	chrI 11,902,379	C. elegans FBXA-216 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domains IPR002900 (Protein of unknown function DUF38, Caenorhabditis species), IPR001810 (Cyclin-like F-box)
6	ZK177.2	ZK177.2	n/a	chrII 5,519,681	contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core)
7	E02C12.6	E02C12.6	n/a	chrV 9,370,290	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
8	C34C12.8	C34C12.8	n/a	chrIII 3,460,983	contains similarity to Pfam domain PF01025 GrpE contains similarity to Interpro domains IPR009012 (GrpE nucleotide exchange factor, head), IPR013805 (GrpE nucleotide exchange factor, coiled-coil), IPR000740 (GrpE nucleotide exchange factor)
9	F23F12.3	F23F12.3	n/a	chrIII 6,504,028	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
10	F53F1.2	F53F1.2	n/a	chrV 13,407,532	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
11	F52C12.2	F52C12.2	n/a	chrIV 1,956,651	contains similarity to Pfam domains PF04068 (Possible metal-binding domain in RNase L inhibitor, RLI) , PF04034 (Domain of unknown function (DUF367)) contains similarity to Interpro domains IPR007209 (Possible metal-binding region in RNase L inhibitor, RLI), IPR007177 (Protein of unknown function DUF367)
12	B0303.15	B0303.15	n/a	chrIII 8,717,978	contains similarity to Pfam domains PF00298 (Ribosomal protein L11, RNA binding domain) , PF03946 (Ribosomal protein L11, N-terminal domain) contains similarity to Interpro domain IPR000911 (Ribosomal protein L11)
13	F09E5.8	F09E5.8	n/a	chrII 5,351,303	contains similarity to Pfam domain PF01168 Alanine racemase, N-terminal domain contains similarity to Interpro domains IPR011078 (Predicted pyridoxal phosphate-dependent enzyme, YBL036C type), IPR001608 (Alanine racemase, N-terminal)
14	K03C7.3	K03C7.3	n/a	chrX 3,828,246
15	C17E4.9	C17E4.9	n/a	chrI 9,432,529	contains similarity to Pfam domain PF00287 Sodium / potassium ATPase beta chain contains similarity to Interpro domain IPR000402 (ATPase, P-type cation exchange, beta subunit)
16	T10D4.6	T10D4.6	n/a	chrII 3,121,247	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR009057 (Homeodomain-like)
17	R02F2.7	R02F2.7	n/a	chrIII 5,482,043
18	C01F1.2	C01F1.2	n/a	chrII 4,300,243	C01F1.2 is orthologous to the human gene SCO (CYTOCHROME OXIDASE DEFICIENT, YEAST) HOMOLOG 1 (SCO1; OMIM:603644), which when mutated leads to early-onset hepatic failure; the C01F1.2 protein is predicted to be mitochondrial with 68% accuracy.
19	B0205.6	B0205.6	n/a	chrI 10,738,293	contains similarity to Pfam domains PF01212 (Beta-eliminating lyase) , PF00266 (Aminotransferase class-V) contains similarity to Interpro domains IPR001597 (Aromatic amino acid beta-eliminating lyase/threonine aldolase), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR000192 (Aminotransferase, class V/Cysteine desulphurase), IPR016454 (Cysteine desulphurase, NifS), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
20	ppk-1	F55A12.3	n/a	chrI 5,361,848	ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine and vulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2.
21	Y6B3B.9	Y6B3B.9	n/a	chrI 13,743,033	contains similarity to Pfam domain PF04031 Las1-like contains similarity to Interpro domain IPR007174 (Las1-like)
22	ZK742.3	ZK742.3	n/a	chrV 7,809,120	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal)
23	cdr-1	F35E8.11	n/a	chrV 15,922,065	cdr-1 encodes a member of the cadmium-inducible lysosomal family that affects susceptibility to cadmium toxicity; expressed in intestinal cells.
24	W02D3.2	W02D3.2	n/a	chrI 6,738,931	contains similarity to Pfam domain PF01180 Dihydroorotate dehydrogenase contains similarity to Interpro domains IPR001295 (Dihydroorotate dehydrogenase, core), IPR013785 (Aldolase-type TIM barrel), IPR005719 (Dihydroorotate dehydrogenase, class 2), IPR012135 (Dihydroorotate dehydrogenase, classes 1 and 2)
25	W04B5.4	W04B5.4	n/a	chrIII 2,408,633	W04B5.4 encodes a putative mitochondrial ribosomal protein L30 that inhibits DHC-1 in vivo; W04B5.4 is orthologous to human MRPL3; W04B5.4(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that W04B5.4 negatively regulates dynein; W04B5.4 is required for embryonic and larval development in mass RNAi assays.
26	eif-3.K	T16G1.11	n/a	chrV 12,954,593	The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77).
27	F37F2.2	F37F2.2	n/a	chrI 1,442,805	contains similarity to Pfam domain PF01922 SRP19 protein contains similarity to Interpro domain IPR002778 (Signal recognition particle, SRP19 subunit)
28	T07F12.4	T07F12.4	n/a	chrX 4,897,382	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
29	lys-10	F17E9.11	n/a	chrIV 8,333,154	C. elegans LYS-10 protein; contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site)
30	ZK836.3	ZK836.3	n/a	chrV 12,195,261
31	ars-2	F28H1.3	n/a	chrI 3,984,796	ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development.
32	C11H1.5	C11H1.5	n/a	chrX 14,300,542	contains similarity to Pfam domain PF00090 Thrombospondin type 1 domain contains similarity to Interpro domain IPR000884 (Thrombospondin, type I)
33	T20B12.1	T20B12.1	n/a	chrIII 7,388,607	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (4)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001664 (Intermediate filament protein), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR001356 (Homeobox), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
34	cdr-6	K01D12.12	n/a	chrV 12,413,079	C. elegans CDR-6 protein; contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR010987 (Glutathione S-transferase, C-terminal-like)
35	gly-19	F22D6.12	n/a	chrI 7,113,932	gly-19 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; it is probably coexpressed with gly-18 in the anal sphincter muscle.
36	C44H4.4	C44H4.4	n/a	chrX 14,586,632	contains similarity to Homo sapiens 155 kDa protein; ENSEMBL:ENSP00000381978
37	mtss-1	PAR2.1	n/a	chrIII 8,768,640	C. elegans MTSS-1 protein; contains similarity to Pfam domain PF00436 Single-strand binding protein family contains similarity to Interpro domains IPR000424 (Primosome PriB/single-strand DNA-binding), IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR011344 (Single-strand DNA-binding)
38	ckb-3	B0285.10	n/a	chrIII 4,371,823	ckb-3 encodes a putative choline kinase; CKB-1 through CKB-4 comprise a related group ('B') of choline kinases.
39	F23F1.4	F23F1.4	n/a	chrII 26,912
40	R12E2.12	R12E2.12	n/a	chrI 4,174,271	contains similarity to Interpro domain IPR000529 (Ribosomal protein S6)
41	ruvb-1	C27H6.2	n/a	chrV 9,979,753	C. elegans RUVB-1 protein; contains similarity to Pfam domain PF06068 TIP49 C-terminus contains similarity to Interpro domains IPR010339 (TIP49, C-terminal), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
42	F22B8.6	F22B8.6	n/a	chrV 16,101,647	F22B8.6 encodes a putative cystathionine gamma-lyase; F22B8.6 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog ZK1127.10, and also paralogous to C12C8.2; either F22B8.6, or ZK1236.10, or both proteins weakly inhibit DHC-1 in vivo; otherwise, F22B8.6 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with ZK1127.10.
43	taf-2	Y37E11B.4	n/a	chrIV 3,588,951	taf-2 encodes a member of the peptidase M1 family, a predicted aminopeptidase with similarity to human TBP-associated factor 2.
44	abts-1	F52B5.1	n/a	chrI 8,302,240	abts-1 encodes an anion transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells.
45	clec-149	K02F3.5	n/a	chrIII 824,783	K02F3.5 encodes a protein with a C-terminal C-type lectin domain that inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
46	W04C9.4	W04C9.4	n/a	chrI 462,326
47	pro-1	R166.4	n/a	chrII 10,540,649	pro-1 encodes a WD-repeat-containing protein that is orthologous to Saccharomyces cerevisiae IPI3; pro-1 activity is required for ribosome biogenesis and specifically, for efficient processing of intervening sequence 2 (ITS2) from rRNA intermediates during 26S rRNA maturation; during development, pro-1 is essential for larval growth, fertility, and normal cell division patterns; in addition, pro-1 is required cell autonomously in the somatic gonad for proper spatial and temporal regulation of germline development and proliferation; a pro-1 promoter::gfp fusion construct reveals that pro-1 is widely expressed in the embryo as well as in every major post-embryonic lineage including the somatic gonad.
48	C30C11.1	C30C11.1	n/a	chrIII 8,450,050	contains similarity to Pfam domain PF01783 Ribosomal L32p protein family contains similarity to Interpro domain IPR002677 (Ribosomal protein L32p)
49	mut-15	T01C3.8	n/a	chrV 15,003,779	C. elegans MUT-15 protein ;
50	twk-28	C52B9.6	n/a	chrX 4,276,975	C. elegans TWK-28 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)