UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	spt-4	F54C4.2	5e-67	chrIII 69,455	C. elegans SPT-4 protein; contains similarity to Pfam domain PF06093 Transcription elongation protein Spt4 contains similarity to Interpro domains IPR016046 (Transcription initiation Spt4-like), IPR009287 (Transcription initiation Spt4)
2	K08E7.1	K08E7.1	n/a	chrIV 12,565,008	contains similarity to Pfam domain PF07534 TLD contains similarity to Interpro domain IPR006571 (TLDc)
3	Y23H5A.2	Y23H5A.2	n/a	chrI 2,622,537	Y23H5A.2 encodes a Caenorhabditis-specific protein, without obvious similarities or motifs; Y23H5A.2 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
4	Y26D4A.10	Y26D4A.10	n/a	chrI 13,099,300	contains similarity to Pfam domains PF00610 (Domain found in Dishevelled, Egl-10, and Pleckstrin) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF02377 (Dishevelled specific domain) contains similarity to Interpro domains IPR003351 (Dishevelled protein), IPR011991 (Winged helix repressor DNA-binding), IPR001478 (PDZ/DHR/GLGF), IPR015506 (Dishevelled related protein), IPR008339 (Dishevelled region), IPR000591 (Pleckstrin/ G-protein, interacting region)
5	elb-1	Y41C4A.10	n/a	chrIII 11,719,034	elb-1 encodes an Elongin B ortholog required for chromosome condensation and segregation during mitosis and meiotic division II, and also for cell proliferation (probably through degradation of CKI-1); elb-1(RNAi) animals tend to arrest at the second meiotic cell division, with escapers showing many other defects in chromosomal dynamics and cell cycle control such as abnormal pronuclear rotation and cortical protrusion, aberrant chromosomal structures in the intestine, and deficient germ cell proliferation; ELB-1 interacts with ELC-1 and ELC-2 in bacterial two-hybrid experiments.
6	K08F11.2	K08F11.2	n/a	chrIV 4,718,190	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
7	C24D10.4	C24D10.4	n/a	chrIV 5,160,919
8	prp-17	F49D11.1	n/a	chrI 10,938,676	C. elegans PRP-17 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
9	F59A2.5	F59A2.5	n/a	chrIII 3,405,129	F59A2.5 encodes a moderately small (123-residue) protein; F59A2.5 is orthologous to Brugia 14979.m04575, and more distantly similar to budding yeast Pcc1p, to human CTAG1B (OMIM:300156, cancer antigen), CTAG2 (OMIM:300396, melanoma antigen), and LAGE3 (OMIM:300060), and to many other uncharacterized proteins, ~80-200 residues long, in animals, fungi, and plants; F59A2.5 is required for fertility and embryonic development in mass RNAi assays and is bound by CKU-80 in two-hybrid assays; F59A2.5 is transcriptionally activated by HLH-2 and HLH-8, but has no known expression pattern; while F59A2.5 is putatively secreted and its human homologs are antigens, its yeast homolog Pcc1p is thought to be a transcription factor.
10	cpf-1	F28C6.3	n/a	chrII 8,601,385	C. elegans CPF-1 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001632 (G-protein, beta subunit), IPR015943 (WD40/YVTN repeat-like)
11	F29B9.5	F29B9.5	n/a	chrIV 4,652,758	contains similarity to Pfam domains PF00085 (Thioredoxin) , PF00578 (AhpC/TSA family) contains similarity to Interpro domains IPR011594 (Thioredoxin-like), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000866 (Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
12	K03B8.4	K03B8.4	n/a	chrV 11,394,932	contains similarity to Homo sapiens Isoform 2 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; ENSEMBL:ENSP00000349254
13	ekl-6	T16G12.5	n/a	chrIII 10,066,125	C. elegans EKL-6 protein; contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
14	fbxb-31	M151.5	n/a	chrII 3,638,541	C. elegans FBXB-31 protein; contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
15	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
16	C25G4.3	C25G4.3	n/a	chrIV 12,445,137	contains similarity to Pfam domain PF02033 Ribosome-binding factor A contains similarity to Interpro domains IPR000238 (Ribosome-binding factor A), IPR015946 (K homology-like, alpha/beta)
17	C06H2.3	C06H2.3	n/a	chrV 11,128,767	contains similarity to Pfam domains PF02373 (JmjC domain) , PF00583 (Acetyltransferase (GNAT) family) contains similarity to Interpro domains IPR013129 (Transcription factor jumonji), IPR003347 (Transcription factor jumonji/aspartyl beta-hydroxylase), IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
18	C35D10.1	C35D10.1	n/a	chrIII 4,880,584	contains similarity to Interpro domain IPR013784 (Carbohydrate-binding-like fold)
19	F44E7.9	F44E7.9	n/a	chrV 5,791,637	contains similarity to Pfam domain PF07019 Rab5-interacting protein (Rab5ip) contains similarity to Interpro domain IPR010742 (Rab5-interacting)
20	C41H7.3	C41H7.3	n/a	chrII 3,006,666	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
21	EGAP2.1	EGAP2.1	n/a	chrII 5,232,292
22	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
23	bath-34	W02A11.5	n/a	chrI 12,751,040	C. elegans BATH-34 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
24	C43H8.2	C43H8.2	n/a	chrI 10,623,645	contains similarity to Pfam domain PF09174 Maf1 regulator contains similarity to Interpro domains IPR017152 (RNA polymerase III transcriptional repressor, MAF1), IPR015257 (Maf1 regulator)
25	fbxb-78	E04A4.1	n/a	chrIV 4,738,137	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
26	C14C11.4	C14C11.4	n/a	chrV 5,649,282	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
27	T23E1.2	T23E1.2	n/a	chrIV 3,144,252
28	R05D11.7	R05D11.7	n/a	chrI 8,601,675	contains similarity to Pfam domain PF08648 Protein of unknown function (DUF1777) contains similarity to Interpro domain IPR013957 (Protein of unknown function DUF1777)
29	hmg-4	T20B12.8	n/a	chrIII 7,380,295	hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
30	K10E9.1	K10E9.1	n/a	chrI 196,071
31	R151.8	R151.8	n/a	chrIII 7,228,224	contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR009057 (Homeodomain-like)
32	F02C12.3	F02C12.3	n/a	chrX 13,397,291
33	C49D10.10	C49D10.10	n/a	chrII 3,875,377	C49D10.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C49D10.10 has no clear orthologs in other organisms.
34	rnp-3	K08D10.3	n/a	chrIV 4,175,171	rnp-3 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-3/U2B''; genetically, rnp-3 appears to function redundantly with rnp-2/U1A: loss of rnp-3 activity alone results in low levels of embryonic and total lethality, while animals doubly mutant for rnp-3 and rnp-2/U1A show much higher levels of embryonic and total lethality; in addition, animals doubly mutant for SAP-1/U2A' and RNP-3/U2B'', display a much more severe phenotype than either single mutation, indicating that in vivo, these proteins have some independent functions; immunoprecipitation experiments indicate that RNP-3 associates with U2 RNA in vivo and that this association does not require the presence of SAP-1/U2A'.
35	hda-3	R06C1.1	n/a	chrI 11,915,408	hda-3 encodes a member of the histone deacetylase family most similar to human histone deacetylase 1 (HD1) that affects radiation sensitivity.
36	lin-46	R186.4	n/a	chrV 12,969,772	lin-46 encodes one of two C. elegans paralogs of bacterial MoeA proteins and mammalian gephyrins (E domain, only); LIN-46 is predicted to function as a scaffolding protein for a developmental timing complex, and may also play a role in molybdenum cofactor biosynthesis; identified in screens for suppressors of precocious heterochronic mutations in lin-14 and lin-28, lin-46 is required for stage-specific developmental events at the third larval and adult stages of development; as a component of the heterochronic pathway, lin-46 appears to act immediately downstream of lin-28, which encodes a predicted RNA binding protein required for cell fate specification at the L2 stage; a LIN-46:GFP fusion protein is detected in the cytoplasm and non-nucleolar part of the nucleus of ventral and lateral hypodermal cells around the time of the larval molts; in addition, the LIN-46 fusion protein is detected in cell bodies and axons of the AVBL/R motor interneurons.
37	F32B6.3	F32B6.3	n/a	chrIV 9,883,182	contains similarity to Pfam domains PF02840 (Prp18 domain) , PF08799 (pre-mRNA processing factor 4 (PRP4) like) contains similarity to Interpro domains IPR014906 (Pre-mRNA processing factor 4 (PRP4) like), IPR003648 (Splicing factor motif), IPR004098 (Prp18)
38	C25A11.2	C25A11.2	n/a	chrX 9,115,559	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
39	B0001.7	B0001.7	n/a	chrIV 12,152,686	contains similarity to Herpestes ichneumon Acetylcholine receptor protein, alpha chain (Fragment).; SW:ACHA_HERIC
40	spr-5	Y40B1B.6	n/a	chrI 13,443,987	spr-5 encodes the C. elegans ortholog of the human histone demethylase LSD1 (lysine-specific demethylase 1) that functions to mediate chromatin remodeling and transcriptional regulation; loss of spr-5 activity can suppress the egg-laying defective (Egl) phenotype of mutations in sel-12/presenilin and derepresses expression of hop-1, which encodes the second C. elegans presenilin, by 20- to 30-fold; in binding assays and yeast two-hybrid experiments, SPR-5 interacts with SPR-1, the C. elegans ortholog of CoREST.
41	T23B12.1	T23B12.1	n/a	chrV 8,469,517	contains similarity to Pfam domain PF00628 PHD-finger contains similarity to Interpro domains IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011011 (Zinc finger, FYVE/PHD-type)
42	ZK1010.3	ZK1010.3	n/a	chrIII 12,979,542	contains similarity to Pfam domain PF06229 FRG1-like family contains similarity to Interpro domains IPR010414 (FRG1-like), IPR008999 (Actin-crosslinking proteins)
43	B0035.11	B0035.11	n/a	chrIV 11,328,468	contains similarity to Pfam domain PF04004 Leo1-like protein contains similarity to Interpro domain IPR007149 (Leo1-like protein)
44	T03G11.6	T03G11.6	n/a	chrX 5,178,330	contains similarity to Pfam domains PF05219 (DREV methyltransferase) , PF08242 (Methyltransferase domain) contains similarity to Interpro domains IPR013217 (Methyltransferase type 12), IPR007884 (DREV methyltransferase)
45	T10C6.5	T10C6.5	n/a	chrV 16,023,741	contains similarity to Pfam domain PF04889 Cwf15/Cwc15 cell cycle control protein contains similarity to Interpro domain IPR006973 (Cwf15/Cwc15 cell cycle control protein)
46	nac-1	F31F6.6	n/a	chrX 14,896,719	nac-1 encodes a low-affinity sodium-coupled dicarboxylate transporter homologous to INDY in D. melanogaster and to mammalian NaDC1 and NaDC3; nac-1 has no obvious function in either mass or individual RNAi assays; nac-1 is expressed in the intestine, in larvae and adults.
47	gck-4	C04A11.3	n/a	chrX 13,679,590	C. elegans GCK-4 protein; contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
48	B0511.2	B0511.2	n/a	chrI 10,651,985	contains similarity to Interpro domain IPR015804 (Cysteinyl-tRNA synthetase, class Ia, C-terminal)
49	K11B4.2	K11B4.2	n/a	chrI 14,798,156	contains similarity to Tetraodon nigroviridis UPF0402 protein.; SW:Q4S3C1
50	K08D10.1	K08D10.1	n/a	chrIV 4,182,875	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)